CA2516730A1 - Adenosine a1 receptor antagonist for the treatment of cardiac and renal diseases - Google Patents
Adenosine a1 receptor antagonist for the treatment of cardiac and renal diseases Download PDFInfo
- Publication number
- CA2516730A1 CA2516730A1 CA002516730A CA2516730A CA2516730A1 CA 2516730 A1 CA2516730 A1 CA 2516730A1 CA 002516730 A CA002516730 A CA 002516730A CA 2516730 A CA2516730 A CA 2516730A CA 2516730 A1 CA2516730 A1 CA 2516730A1
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- Prior art keywords
- patient
- aa1ra
- hydroxy
- adenosine
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44995303P | 2003-02-24 | 2003-02-24 | |
| US60/449,953 | 2003-02-24 | ||
| US45050003P | 2003-02-25 | 2003-02-25 | |
| US45049903P | 2003-02-25 | 2003-02-25 | |
| US60/450,499 | 2003-02-25 | ||
| US60/450,500 | 2003-02-25 | ||
| US45132603P | 2003-02-28 | 2003-02-28 | |
| US60/451,326 | 2003-02-28 | ||
| US46481103P | 2003-04-21 | 2003-04-21 | |
| US46481303P | 2003-04-21 | 2003-04-21 | |
| US46481203P | 2003-04-21 | 2003-04-21 | |
| US46481503P | 2003-04-21 | 2003-04-21 | |
| US60/464,812 | 2003-04-21 | ||
| US60/464,815 | 2003-04-21 | ||
| US60/464,811 | 2003-04-21 | ||
| US60/464,813 | 2003-04-21 | ||
| PCT/US2004/005755 WO2004075856A2 (en) | 2003-02-24 | 2004-02-24 | Adenosine a1 receptor antagonist for the treatment of cardiac and renal diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2516730A1 true CA2516730A1 (en) | 2004-09-10 |
Family
ID=32931788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002516730A Abandoned CA2516730A1 (en) | 2003-02-24 | 2004-02-24 | Adenosine a1 receptor antagonist for the treatment of cardiac and renal diseases |
Country Status (9)
Families Citing this family (13)
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| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| KR20070008689A (ko) * | 2004-04-16 | 2007-01-17 | 노바카르디아, 인코포레이션 | 아데노신 ａ１ 수용체 길항제 및 알도스테론 억제제를포함하는 병용 요법 |
| EP3725324A1 (en) * | 2005-09-16 | 2020-10-21 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method for reducing cd36 expression |
| WO2007117549A2 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| TW200808819A (en) * | 2006-06-19 | 2008-02-16 | Solvay Pharm Gmbh | Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| US20090197900A1 (en) * | 2007-03-29 | 2009-08-06 | Howard Dittrich | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| AU2008342250A1 (en) * | 2007-12-27 | 2009-07-09 | Bayer Animal Health Gmbh | Treatment of heart disease using beta-blockers |
| EP3518898A4 (en) * | 2016-10-03 | 2020-06-17 | The Children's Medical Center Corporation | PREVENTION AND TREATMENT OF DIABETIC NEPHROPATHY |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4769377A (en) * | 1983-02-18 | 1988-09-06 | The Johns Hopkins University | Adenosine receptor antagonists |
| DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| SE9000207L (sv) * | 1990-01-22 | 1991-07-23 | Nobel Chemicals Ab | Laekemedel samt anvaendningen av detsamma |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| AU2297192A (en) * | 1991-06-28 | 1993-01-25 | Sepracor, Inc. | Optically pure s(-) nadolol for treatment of cardiovascular disorders |
| CA2082325A1 (en) * | 1991-11-08 | 1993-05-09 | Fumio Suzuki | Xanthine derivatives |
| DE4238367A1 (de) * | 1992-11-13 | 1994-05-19 | Boehringer Ingelheim Kg | Diuretisches Mittel |
| US5395836A (en) * | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
| US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| US6107064A (en) * | 1994-05-17 | 2000-08-22 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing xanthine derivatives with bacteria and fungi |
| CN1049117C (zh) * | 1994-09-16 | 2000-02-09 | 赵明玉 | 预防和治疗偏头痛的偏头痛片 |
| PT784974E (pt) * | 1995-07-26 | 2003-09-30 | Kyowa Hakko Kogyo Kk | Preparacao de derivados de xantina numa dispersao solida |
| CA2262578A1 (en) * | 1996-08-07 | 1998-02-12 | Kunio Ito | Fat emulsion containing xanthine derivative |
| US6187780B1 (en) * | 1998-04-16 | 2001-02-13 | Boehringer Ingelheim Pharma Kg | Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity |
| US20020115687A1 (en) * | 1998-04-24 | 2002-08-22 | Evan Beckman | Method and composition for restoring diuretic and renal function |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| EP1775297A3 (en) * | 1999-11-12 | 2008-12-03 | Biogen Idec MA Inc. | Adenosine receptor antagonists and methods of making and using the same |
| EP2070930A1 (en) * | 1999-11-12 | 2009-06-17 | Biogen Idec MA, Inc. | Polycycloalkylpurines as adenosine receptor antagonists |
| US20050038017A1 (en) * | 1999-12-22 | 2005-02-17 | Wolff Andrew A. | Method and composition for restoring diuretic and renal function |
| ATE330633T1 (de) * | 2000-07-27 | 2006-07-15 | Pharmacia Corp | Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen |
| CZ20031513A3 (cs) * | 2000-12-01 | 2003-09-17 | Biogen, Inc. | Kondenzované purinové deriváty jako antagonisty A1 adenosinového receptoru |
| EP1365761A1 (en) * | 2000-12-18 | 2003-12-03 | Novartis AG | Therapeutic combination of amlodipine and benazepril |
| UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| US20050070524A1 (en) * | 2003-06-06 | 2005-03-31 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders |
| WO2005105107A2 (en) * | 2004-04-21 | 2005-11-10 | Roby Russell R | Hormone treatment of multiple sclerosis |
| JP2007535560A (ja) * | 2004-04-28 | 2007-12-06 | シーブイ・セラピューティクス・インコーポレイテッド | Ａ１アデノシンレセプターアンタゴニスト |
| WO2007117549A2 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| EP2035092A2 (en) * | 2006-06-16 | 2009-03-18 | Novacardia, Inc. | Use of kw-3902 for achieving diuresis in patients with congestive heart failure and acute fluid overload |
| JP2010501557A (ja) * | 2006-08-22 | 2010-01-21 | ノヴァカーディア，インク． | 血液脳関門を通過しないｋｗ−３９０２コンジュゲート |
-
2004
- 2004-02-23 US US10/785,446 patent/US20040229901A1/en not_active Abandoned
- 2004-02-24 EP EP09160652A patent/EP2087888A1/en not_active Withdrawn
- 2004-02-24 WO PCT/US2004/005755 patent/WO2004075856A2/en active Application Filing
- 2004-02-24 EP EP04714224A patent/EP1603545A2/en not_active Withdrawn
- 2004-02-24 CA CA002516730A patent/CA2516730A1/en not_active Abandoned
- 2004-02-24 KR KR1020057015605A patent/KR20050106038A/ko not_active Application Discontinuation
- 2004-02-24 AU AU2004216133A patent/AU2004216133B2/en not_active Ceased
- 2004-02-24 MX MXPA05008805A patent/MXPA05008805A/es not_active Application Discontinuation
- 2004-02-24 JP JP2006503887A patent/JP2006518765A/ja active Pending
- 2004-02-24 BR BRPI0407494-7A patent/BRPI0407494A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2087888A1 (en) | 2009-08-12 |
| WO2004075856A2 (en) | 2004-09-10 |
| BRPI0407494A (pt) | 2006-02-14 |
| JP2006518765A (ja) | 2006-08-17 |
| MXPA05008805A (es) | 2006-02-22 |
| EP1603545A2 (en) | 2005-12-14 |
| KR20050106038A (ko) | 2005-11-08 |
| US20040229901A1 (en) | 2004-11-18 |
| AU2004216133B2 (en) | 2008-12-04 |
| AU2004216133A1 (en) | 2004-09-10 |
| WO2004075856A3 (en) | 2005-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |