ATE330633T1 - Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen - Google Patents
Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagenInfo
- Publication number
- ATE330633T1 ATE330633T1 AT01957290T AT01957290T ATE330633T1 AT E330633 T1 ATE330633 T1 AT E330633T1 AT 01957290 T AT01957290 T AT 01957290T AT 01957290 T AT01957290 T AT 01957290T AT E330633 T1 ATE330633 T1 AT E330633T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- epoxy
- antagonist
- combination therapy
- adrenergic
- Prior art date
Links
- 239000002876 beta blocker Substances 0.000 title abstract 4
- 238000002648 combination therapy Methods 0.000 title abstract 3
- 206010007559 Cardiac failure congestive Diseases 0.000 title abstract 2
- 206010019280 Heart failures Diseases 0.000 title abstract 2
- 239000002170 aldosterone antagonist Substances 0.000 title 1
- 229940083712 aldosterone antagonist Drugs 0.000 title 1
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 abstract 3
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 abstract 3
- 239000002464 receptor antagonist Substances 0.000 abstract 3
- 229940044551 receptor antagonist Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010003445 Ascites Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229960001208 eplerenone Drugs 0.000 abstract 1
- JUKPWJGBANNWMW-VWBFHTRKSA-N eplerenone Chemical compound C([C@@H]1[C@]2(C)C[C@H]3O[C@]33[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)C(=O)OC)C[C@@]21CCC(=O)O1 JUKPWJGBANNWMW-VWBFHTRKSA-N 0.000 abstract 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 abstract 1
- 229960002237 metoprolol Drugs 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical group O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22136500P | 2000-07-27 | 2000-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330633T1 true ATE330633T1 (de) | 2006-07-15 |
Family
ID=22827509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01957290T ATE330633T1 (de) | 2000-07-27 | 2001-07-27 | Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20040235809A1 (de) |
| EP (1) | EP1303306B1 (de) |
| JP (1) | JP2004511435A (de) |
| AT (1) | ATE330633T1 (de) |
| AU (2) | AU2001279050B2 (de) |
| CA (1) | CA2415789A1 (de) |
| DE (1) | DE60120982T2 (de) |
| DK (1) | DK1303306T3 (de) |
| ES (1) | ES2265437T3 (de) |
| PT (1) | PT1303306E (de) |
| WO (1) | WO2002009760A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1455795A1 (de) * | 2001-12-12 | 2004-09-15 | Pharmacia Corporation | Verfahren zur behandlung von augenerkrankungen mit einem epoxy-steroidalen aldosterone rezeptor antagonisten |
| CN1625404A (zh) * | 2002-01-30 | 2005-06-08 | 法马西亚公司 | 用于心血管疾病预防或治疗的醛甾酮受体拮抗剂和α－肾上腺素调节剂的组合治疗 |
| KR20040091141A (ko) * | 2002-03-18 | 2004-10-27 | 파마시아 코포레이션 | 알도스테론 수용체 길항물질 및 니코틴산 또는 니코틴산유도체의 혼합물 |
| US6967194B1 (en) * | 2002-09-18 | 2005-11-22 | Susan Matsuo | Bio-identical hormones and method of use |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| US20040266743A1 (en) * | 2003-05-09 | 2004-12-30 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and a renin inhibitor |
| CA2558034A1 (en) | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamine aspartyl protease inhibitors |
| US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| DE102004035322A1 (de) * | 2004-07-21 | 2006-02-16 | Universität des Saarlandes | Selektive Hemmstoffe humaner Corticoidsynthasen |
| EP1802775B1 (de) | 2004-09-14 | 2010-05-26 | The Regents of the University of Colorado | Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol |
| US9271963B2 (en) * | 2005-03-03 | 2016-03-01 | Universitat Des Saarlandes | Selective inhibitors of human corticosteroid synthases |
| WO2007047305A1 (en) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| US8541404B2 (en) * | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| FI3474846T3 (fi) * | 2016-06-22 | 2023-02-16 | Univ Vanderbilt | Muskariinisen asetyylikoliinireseptorin m4 positiiviset allosteeriset modulaattorit |
| MA47126A (fr) | 2016-11-07 | 2019-10-30 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique à l'acétylcholine m4 |
| CN109863139B (zh) | 2016-11-07 | 2023-02-17 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
| EP3534901B1 (de) | 2016-11-07 | 2022-06-22 | Vanderbilt University | Positive allosterische modulatoren des muskarinischen acetylcholinrezeptors m4 |
| TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
| WO2019113174A1 (en) | 2017-12-05 | 2019-06-13 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| WO2023060245A1 (en) * | 2021-10-08 | 2023-04-13 | The United States Government As Represented By The Department Of Veterans Affairs | Methods for predicting drug responsiveness in heart failure subjects |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA6808345B (en) * | 1967-12-22 | May & Baker Ltd | Benzene derivatives | |
| US3641152A (en) * | 1968-09-23 | 1972-02-08 | Warner Lambert Pharmaceutical | 3 4-dihydronaphthalenoneoxy-2-hydroxy-propylamines |
| US4012444A (en) * | 1969-07-08 | 1977-03-15 | Allen & Hanburys Limited | 5-[1-Hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide and physiologically acceptable acid addition salts thereof |
| US4340541A (en) * | 1975-08-15 | 1982-07-20 | Sandoz Ltd. | 4-(2-Benzoyloxy-3-tert.-butylaminopropoxy-2-methyl indole |
| FR2330383A1 (fr) * | 1975-11-06 | 1977-06-03 | Synthelabo | Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment |
| US4387103A (en) * | 1980-11-28 | 1983-06-07 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
| US4346106A (en) * | 1981-05-14 | 1982-08-24 | E. R. Squibb & Sons, Inc. | Method for inhibiting onset of migraine headaches with nadolol compositions |
| US4559332A (en) * | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| US4752263A (en) * | 1984-06-29 | 1988-06-21 | Cuda International Corporation | Custom underwater diving system |
| FR2634376B1 (fr) * | 1988-07-21 | 1992-04-17 | Farmalyoc | Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation |
| AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5123555A (en) * | 1991-05-01 | 1992-06-23 | Cap Snap Co. | Container cap having external bead |
| US5190765A (en) * | 1991-06-27 | 1993-03-02 | Alza Corporation | Therapy delayed |
| IT1252024B (it) * | 1991-11-29 | 1995-05-27 | Pirelli Transmissioni Ind Spa | Procedimento per la fabbricazione di cinghie dentate in materiale elastomerico,e cinghia dentata ottenuta mediante tale procedimento |
| US5373004A (en) * | 1993-11-24 | 1994-12-13 | Wisconsin Alumni Research Foundation | 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds |
| US5451652A (en) * | 1994-04-28 | 1995-09-19 | Arco Chemical Technology, L.P. | Polymers from propoxylated allyl alcohol |
| US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
| US5965034A (en) * | 1995-12-04 | 1999-10-12 | Mc Electronics Co., Ltd. | High frequency plasma process wherein the plasma is executed by an inductive structure in which the phase and anti-phase portion of the capacitive currents between the inductive structure and the plasma are balanced |
| US6541479B1 (en) * | 1997-12-02 | 2003-04-01 | Massachusetts College Of Pharmacy | Calcium channel blockers |
| US6047407A (en) * | 1997-12-29 | 2000-04-11 | Habel; Carolyn Louise | Hat with candles depicted thereon |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| US6429878B1 (en) * | 1999-12-28 | 2002-08-06 | Ge Medical Systems Global Technology Company, Llc | Display of text on medical images |
| US6495235B2 (en) * | 2000-03-24 | 2002-12-17 | Matsushita Electric Industrial Co., Ltd. | Optical disk, substrate of the same, and mold for forming the substrate |
-
2001
- 2001-07-27 JP JP2002515312A patent/JP2004511435A/ja not_active Withdrawn
- 2001-07-27 AU AU2001279050A patent/AU2001279050B2/en not_active Ceased
- 2001-07-27 EP EP01957290A patent/EP1303306B1/de not_active Expired - Lifetime
- 2001-07-27 WO PCT/US2001/023670 patent/WO2002009760A2/en not_active Ceased
- 2001-07-27 AT AT01957290T patent/ATE330633T1/de not_active IP Right Cessation
- 2001-07-27 CA CA002415789A patent/CA2415789A1/en not_active Abandoned
- 2001-07-27 US US10/343,166 patent/US20040235809A1/en not_active Abandoned
- 2001-07-27 US US09/917,403 patent/US20020123485A1/en not_active Abandoned
- 2001-07-27 PT PT01957290T patent/PT1303306E/pt unknown
- 2001-07-27 ES ES01957290T patent/ES2265437T3/es not_active Expired - Lifetime
- 2001-07-27 AU AU7905001A patent/AU7905001A/xx active Pending
- 2001-07-27 DE DE60120982T patent/DE60120982T2/de not_active Expired - Fee Related
- 2001-07-27 DK DK01957290T patent/DK1303306T3/da active
-
2005
- 2005-06-02 US US11/143,310 patent/US20050215537A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1303306A2 (de) | 2003-04-23 |
| DE60120982T2 (de) | 2007-02-08 |
| PT1303306E (pt) | 2006-11-30 |
| AU7905001A (en) | 2002-02-13 |
| ES2265437T3 (es) | 2007-02-16 |
| AU2001279050B2 (en) | 2006-10-19 |
| US20040235809A1 (en) | 2004-11-25 |
| CA2415789A1 (en) | 2002-02-07 |
| JP2004511435A (ja) | 2004-04-15 |
| DK1303306T3 (da) | 2006-10-23 |
| US20020123485A1 (en) | 2002-09-05 |
| US20050215537A1 (en) | 2005-09-29 |
| WO2002009760A3 (en) | 2003-01-23 |
| WO2002009760A9 (en) | 2003-09-04 |
| EP1303306B1 (de) | 2006-06-21 |
| DE60120982D1 (de) | 2006-08-03 |
| WO2002009760A2 (en) | 2002-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1303306 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |