CA2511523C - Pharmaceutical formulation with an insoluble active agent for pulmonary administration - Google Patents
Pharmaceutical formulation with an insoluble active agent for pulmonary administration Download PDFInfo
- Publication number
- CA2511523C CA2511523C CA2511523A CA2511523A CA2511523C CA 2511523 C CA2511523 C CA 2511523C CA 2511523 A CA2511523 A CA 2511523A CA 2511523 A CA2511523 A CA 2511523A CA 2511523 C CA2511523 C CA 2511523C
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical formulation
- active agent
- particles
- phospholipid
- particulates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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| US60/437,210 | 2002-12-31 | ||
| PCT/US2003/041703 WO2004060351A2 (en) | 2002-12-31 | 2003-12-31 | Pharmaceutical formulation with an insoluble active agent for pulmonary administration |
Publications (2)
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| CA2511523C true CA2511523C (en) | 2013-10-15 |
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| TR (1) | TR200502522T2 (enExample) |
| WO (1) | WO2004060351A2 (enExample) |
| ZA (1) | ZA200505155B (enExample) |
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| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| CA2382133C (en) | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| WO2003053411A1 (en) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| TW200503781A (en) * | 2002-12-31 | 2005-02-01 | Nektar Therapeutics | Aerosolizable pharmaceutical formulation for fungal infection therapy |
| MXPA05012821A (es) | 2003-05-28 | 2006-02-13 | Nektar Therapeutics | Formulacion farmaceutica que comprende un agente activo insoluble en agua. |
| US8513204B2 (en) * | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| US9061027B2 (en) | 2004-08-27 | 2015-06-23 | Board Of Regents, The University Of Texas System | Enhanced delivery of drug compositions to treat life threatening infections |
| US20090032427A1 (en) * | 2005-09-29 | 2009-02-05 | Nektar Therapeutics | Receptacles and Kits, Such as for Dry Powder Packaging |
| ITMI20051999A1 (it) * | 2005-10-21 | 2007-04-22 | Eratech S R L | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| US20120128728A1 (en) * | 2005-12-28 | 2012-05-24 | Novartis Pharma Ag | Compositions Comprising Amphotericin B |
| DK1986679T3 (da) * | 2006-02-22 | 2017-11-20 | Mannkind Corp | Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof |
| DE102006053375A1 (de) * | 2006-11-10 | 2008-05-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mischung von Pulvern |
| MX2010001311A (es) * | 2007-07-31 | 2010-04-21 | Otsuka Pharma Co Ltd | Metodo para producir una suspensi?n de aripiprazol y formulacion liofilizada. |
| EP2050437A1 (en) * | 2007-10-15 | 2009-04-22 | Laboratoires SMB | Improved pharmaceutical dry powder compositions for inhalation. |
| PL220269B1 (pl) | 2008-04-21 | 2015-09-30 | Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna | Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego |
| KR101621986B1 (ko) | 2008-05-15 | 2016-05-17 | 노파르티스 아게 | 플루오로퀴놀론의 폐 전달 |
| CA2835771C (en) | 2009-03-18 | 2017-01-24 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
| EP2411137B1 (en) | 2009-03-27 | 2016-09-07 | Bend Research, Inc. | Spray-drying process |
| GB0908129D0 (en) * | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
| TR200904500A2 (tr) | 2009-06-10 | 2009-10-21 | Öner Levent | Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları. |
| EP2611530B1 (en) | 2010-09-03 | 2019-01-16 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| US9084976B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| EP2618924A1 (en) | 2010-09-24 | 2013-07-31 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| CN103228266B (zh) | 2010-10-29 | 2017-11-14 | 健康科学西部大学 | 三元混合物制剂 |
| JOP20120023B1 (ar) | 2011-02-04 | 2022-03-14 | Novartis Ag | صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية |
| US20150224202A1 (en) * | 2014-02-03 | 2015-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Formulations and uses for microparticle delivery of zinc protoporphyrins |
| US11364203B2 (en) | 2014-10-31 | 2022-06-21 | Bend Reserch, Inc. | Process for forming active domains dispersed in a matrix |
| CN104587457B (zh) * | 2015-01-13 | 2017-03-22 | 广东海大畜牧兽医研究院有限公司 | 一种利用难溶或不溶蛋白、多肽抗原制备纳米微粒疫苗的方法 |
| SG11201805204WA (en) * | 2015-12-24 | 2018-07-30 | Philip Morris Products Sa | Nicotine particle capsule |
| SG11201805788WA (en) | 2016-02-01 | 2018-08-30 | Incarda Therapeutics Inc | Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation |
| CA3060702A1 (en) | 2017-05-10 | 2018-11-15 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
| JP2020527377A (ja) * | 2017-06-28 | 2020-09-10 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸入器と併用するための粒子を含む容器 |
| WO2019183470A2 (en) | 2018-03-22 | 2019-09-26 | Incarda Therapeutics, Inc. | A novel method to slow ventricular rate |
| GB201817860D0 (en) | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| GB201817865D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| US11020384B2 (en) | 2019-08-01 | 2021-06-01 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
| CA3250825A1 (en) | 2022-03-21 | 2023-09-28 | Cystetic Medicines Inc | PROSTHETIC COMPOSITIONS WITH ION CHANNELS COMPRISING AMPHOTEROTIN B LIPID-COATED CRYSTALS |
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| US437210A (en) | 1890-09-30 | Electric street-car | ||
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| US4247066A (en) * | 1978-02-21 | 1981-01-27 | General Dynamics Corporation | Airfoil variable cambering device and method |
| IT1116047B (it) * | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
| DE3634952A1 (de) * | 1986-10-14 | 1988-04-21 | Bayer Ag | Imidazo-pyrrolo-pyridin-derivate |
| US5049388A (en) * | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
| CA2112674C (en) * | 1991-07-02 | 2005-10-04 | John S. Patton | Method and device for delivering aerosolized medicaments |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5785049A (en) * | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| JP3388896B2 (ja) * | 1994-08-08 | 2003-03-24 | 株式会社日立ユニシアオートモティブ | 吸入式投薬器 |
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| ES2237767T3 (es) * | 1995-04-14 | 2005-08-01 | Nektar Therapeutics | Composiciones farmaceuticas en polvo que tienen una dispersabilidad mejorada. |
| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6503480B1 (en) * | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| WO1998029098A1 (en) * | 1996-12-31 | 1998-07-09 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| DE69814428T2 (de) * | 1997-09-29 | 2004-05-13 | Nektar Therapeutics, San Carlos | In verneblern verwendbare, stabilisierte zubereitungen |
| US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
| US6257233B1 (en) * | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| WO2000001365A1 (en) † | 1998-06-30 | 2000-01-13 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) | Prolonged release ophthalmic compositions containing a fluoroquinolone |
| US20010036481A1 (en) * | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| CA2382133C (en) † | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| US6357490B1 (en) * | 2000-08-22 | 2002-03-19 | Advanced Inhalation Research, Inc. | System, method and apparatus for filling containers |
| WO2002054868A2 (en) † | 2000-12-21 | 2002-07-18 | Inhale Therapeutic Syst | Pulmonary delivery of polyene antifungal agents |
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2003
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- 2003-12-31 PL PL378270A patent/PL378270A1/pl unknown
- 2003-12-31 WO PCT/US2003/041703 patent/WO2004060351A2/en not_active Ceased
- 2003-12-31 ES ES03800395T patent/ES2589578T5/es not_active Expired - Lifetime
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- 2003-12-31 PT PT38003950T patent/PT1589947T/pt unknown
- 2003-12-31 EP EP03800395.0A patent/EP1589947B2/en not_active Expired - Lifetime
- 2003-12-31 US US10/750,934 patent/US20040156792A1/en not_active Abandoned
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- 2003-12-31 EA EA200501001A patent/EA200501001A1/ru unknown
- 2003-12-31 KR KR1020057012444A patent/KR20050095838A/ko not_active Withdrawn
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- 2003-12-31 CN CNA2003801091328A patent/CN1741789A/zh active Pending
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2005
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- 2005-06-24 ZA ZA200505155A patent/ZA200505155B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1589947B1 (en) | 2016-06-15 |
| MXPA05007158A (es) | 2005-09-21 |
| ES2589578T5 (es) | 2019-07-23 |
| US20040156792A1 (en) | 2004-08-12 |
| HUP0500846A3 (en) | 2008-10-28 |
| EA200501001A1 (ru) | 2005-12-29 |
| KR20050095838A (ko) | 2005-10-04 |
| JP2006513236A (ja) | 2006-04-20 |
| WO2004060351A2 (en) | 2004-07-22 |
| ZA200505155B (en) | 2006-04-26 |
| ES2589578T3 (es) | 2016-11-15 |
| EP1589947A2 (en) | 2005-11-02 |
| PT1589947T (pt) | 2016-09-05 |
| WO2004060351A3 (en) | 2004-09-30 |
| BR0317810A (pt) | 2005-11-29 |
| NO20053076D0 (no) | 2005-06-23 |
| CA2511523A1 (en) | 2004-07-22 |
| AU2003300137A1 (en) | 2004-07-29 |
| PL378270A1 (pl) | 2006-03-20 |
| EP1589947B2 (en) | 2019-01-30 |
| EP1589947B8 (en) | 2016-08-24 |
| NO20053076L (no) | 2005-09-13 |
| CN1741789A (zh) | 2006-03-01 |
| HUP0500846A2 (en) | 2008-05-28 |
| TR200502522T2 (tr) | 2005-09-21 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
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