JP2020527377A - 吸入器と併用するための粒子を含む容器 - Google Patents
吸入器と併用するための粒子を含む容器 Download PDFInfo
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- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
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- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
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- A—HUMAN NECESSITIES
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- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/20—Devices without heating means
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/60—Constructional details
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
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Abstract
Description
第一の複数の粒子(ニコチン粉末)とより大きな粒子サイズを有する第二の複数の粒子を混合することの、ニコチン送達への影響を試験する。試験標本(実施例7)は、第一の複数の粒子(40mg)と第二の複数の粒子(10mg)の両方を含む。対照標本(実施例7C)は、第一の複数の粒子(40mg)のみを含む。ニコチン送達を、回数を変えた吸煙について試験する。結果を下記の表9に示している。
第一の複数の粒子は、乳酸ニコチン、トレハロース、およびロイシンで調製され、5重量%のニコチン(乳酸ニコチン中のニコチンの総重量に基づく)を含む。粉末は噴霧乾燥によって調製され、2.25±0.2マイクロメートルの粒子サイズX50を有する。
試料は、吸入間に30秒の間隔をおいて80mL/2秒の吸引速度で「喫煙」され、吸入器から送達される粉末を、最初の20回の吸煙から4回の吸煙グループに、その後10回の吸煙グループに収集する。収集した吸煙中のニコチンの量を、ガスクロマトグラフィによって試験する。最初の12回の吸煙、最初の20回の吸煙、および最初の50回の吸煙において送達されるニコチンの結果を以下の表9に示す。ニコチンの量を4つの複製について平均化し、粉末中に存在するニコチンの量に対して正規化する。
Claims (17)
- 粉末システムを含む容器であって、
粒子サイズが約10マイクロメートル以下の第一の複数の粒子と、
粒子サイズが約20マイクロメートル以上の第二の複数の粒子と、
前記容器を貫通する単一の開口部と、を含む、容器。 - 前記容器がカプセルである、請求項1に記載の容器。
- 前記第一の複数の粒子がニコチンまたはニコチン塩を含む、請求項1または請求項2のいずれか一項に記載の容器。
- 前記第一の複数の粒子が、ロイシンなどのアミノ酸を含む、請求項1〜3のいずれか一項に記載の容器。
- 前記粉末システムが、約1:1〜約10:1、または約2:1〜約6:1、または約3:1〜約5:1、好ましくは約4:1の前記第一の複数の粒子対前記第二の複数の粒子の重量比を含む、請求項1〜4のいずれか一項に記載の容器。
- 前記第一の複数の粒子の少なくとも50%、または少なくとも75%、または少なくとも90%が、約5マイクロメートル以下、または約3マイクロメートル以下の粒子サイズを有する、請求項1〜5のいずれか一項に記載の容器。
- 前記第二の複数の粒子の少なくとも50%、または少なくとも75%、または少なくとも90%が、約50マイクロメートル以上、または約75〜200マイクロメートルの粒子サイズを有する、請求項1〜6のいずれか一項に記載の容器。
- 前記単一の開口部が、約0.5mm〜約1.5mmの直径を有し、または、前記単一の開口部の開放表面積が、前記容器またはカプセルの総表面積の約0.1%〜約0.5%、または約0.2%〜約0.5%、または約0.3%〜約0.4%である、請求項1〜7のいずれか一項に記載の容器。
- 前記単一の開口部が約0.5mm2〜約1mm2の開放表面積を有し、前記容器が約0.2mL〜約0.5mL、または約0.3mLの体積を有するカプセルである、請求項1〜8のいずれか一項に記載の容器。
- 前記第一の複数の粒子が、乳酸ニコチン、ロイシン、およびトレハロースなどの糖を含み、約1重量%〜約10重量%、または約3重量%〜約7重量%、または約5重量%のニコチン含有量を有する、請求項1〜9のいずれか一項に記載の容器。
- 前記容器が、サイズ2〜サイズ4、またはサイズ3のカプセルであり、約20mg〜約80mgの粉末システム、または40mg〜約60mgの粉末システム、または約50mgの粉末システムを含有する、請求項1〜10のいずれか一項に記載の容器。
- 前記第二の複数の粒子が風味を含み、前記風味がメントールを含みうる、請求項1〜11のいずれか一項に記載の容器。
- 吸入器物品であって、
容器を受けるための空洞、および、
前記容器の単一の側または端に開口部を形成するための貫通要素を含む、吸入器物品を備え、
前記容器が請求項1に記載の容器である、システム。 - 前記空洞が、前記容器を前記空洞内で回転させる吸入気流を提供する端キャップによって上流端上で区切られ、前記空洞が、前記容器を含み、前記吸入空気内の混入粒子を前記吸入器のマウスピースに移送する多孔性要素によって下流端上で区切られる、請求項13に記載のシステム。
- 前記貫通要素が前記端キャップおよび前記容器の一つの壁のみを貫通して前記開口部を形成する、請求項14に記載のシステム。
- 前記容器がカプセルである、請求項13〜15のいずれか一項に記載のシステム。
- 前記吸入器が、少なくとも約20回の吸入吸煙、または少なくとも約30回の吸入吸煙、または少なくとも約40回の吸入吸煙それぞれにわたり、実質的に均一な前記粉末システム用量を送達する、請求項13〜16のいずれか一項に記載のシステム。
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JP2023038764A JP2023078269A (ja) | 2017-06-28 | 2023-03-13 | 吸入器と併用するための粒子を含む容器 |
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EP17178416 | 2017-06-28 | ||
EP17178416.8 | 2017-06-28 | ||
PCT/IB2018/054720 WO2019003118A1 (en) | 2017-06-28 | 2018-06-26 | CONTAINER WITH PARTICLES FOR USE WITH INHALER |
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JP2020527377A5 JP2020527377A5 (ja) | 2021-08-12 |
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JP2023038764A Pending JP2023078269A (ja) | 2017-06-28 | 2023-03-13 | 吸入器と併用するための粒子を含む容器 |
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US (1) | US20200196674A1 (ja) |
EP (1) | EP3644962A1 (ja) |
JP (2) | JP2020527377A (ja) |
KR (1) | KR20200023285A (ja) |
CN (2) | CN110709063A (ja) |
BR (1) | BR112019025635A2 (ja) |
CA (1) | CA3061895A1 (ja) |
IL (1) | IL269275B2 (ja) |
MX (1) | MX2019014671A (ja) |
PH (1) | PH12019502100A1 (ja) |
UA (1) | UA126238C2 (ja) |
WO (1) | WO2019003118A1 (ja) |
ZA (1) | ZA201905999B (ja) |
Families Citing this family (10)
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EP3478264A1 (en) * | 2016-06-30 | 2019-05-08 | Philip Morris Products S.a.s. | Nicotine particles and compositions |
US11946942B2 (en) * | 2019-01-07 | 2024-04-02 | Luxcan Innovation S.A. | Device for tableting a powder, liquid, paste, encapsulated or granular active ingredient composition |
KR20210129152A (ko) * | 2019-03-19 | 2021-10-27 | 아쿠아 뱅크 주식회사 | 서플리먼트 흡인 겸 수소 흡인 장치 |
US20220379050A1 (en) * | 2019-09-26 | 2022-12-01 | Philip Morris Products S.A. | Inhaler article with a twisted distal end element |
WO2021094160A1 (en) | 2019-11-14 | 2021-05-20 | Philip Morris Products S.A. | Improved tobacco flavoured dry powder formulation |
CN116137819A (zh) * | 2020-07-24 | 2023-05-19 | 菲利普莫里斯生产公司 | 吸入器制品 |
KR20230061366A (ko) * | 2020-09-03 | 2023-05-08 | 필립모리스 프로덕츠 에스.에이. | 저 흡습성 활성 분말 조성물 |
US20220132939A1 (en) * | 2020-11-04 | 2022-05-05 | Anthony Hamilton | E-Cigarette Vaporizer Cartridge Filling Device |
KR20240043153A (ko) * | 2021-08-19 | 2024-04-02 | 필립모리스 프로덕츠 에스.에이. | 2개의 미립자 재료로부터의 고체 단일형 몸체 형태의 에어로졸 형성 기재 |
WO2023178643A1 (zh) * | 2022-03-25 | 2023-09-28 | 云南中烟工业有限责任公司 | 一种不使用多通孔固件段的颗粒型气溶胶生成制品 |
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- 2018-06-26 WO PCT/IB2018/054720 patent/WO2019003118A1/en active Application Filing
- 2018-06-26 EP EP18747004.2A patent/EP3644962A1/en active Pending
- 2018-06-26 US US16/623,923 patent/US20200196674A1/en active Pending
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JP2017512212A (ja) * | 2014-04-08 | 2017-05-18 | サンサ コーポレイション (バルバドス) インコーポレイテッドSansa Corporation (Barbados) Inc. | ニコチン製剤及びその作製方法 |
JP2017513649A (ja) * | 2014-04-28 | 2017-06-01 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 風味付きニコチン粉末吸入器 |
WO2017048974A1 (en) * | 2015-09-16 | 2017-03-23 | Sansa Corporation (Barbador) Inc. | Inhalable nicotine formulations, and methods of making and using thereof |
WO2017048972A1 (en) * | 2015-09-16 | 2017-03-23 | Sansa Corporation (Barbados) Inc. | Nicotine formulations and methods of making and using the same |
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CN117958505A (zh) | 2024-05-03 |
AU2018292732A1 (en) | 2019-10-03 |
KR20200023285A (ko) | 2020-03-04 |
EP3644962A1 (en) | 2020-05-06 |
IL269275A (en) | 2019-11-28 |
PH12019502100A1 (en) | 2020-03-16 |
MX2019014671A (es) | 2020-02-07 |
IL269275B2 (en) | 2023-04-01 |
RU2019141658A (ru) | 2021-07-28 |
US20200196674A1 (en) | 2020-06-25 |
UA126238C2 (uk) | 2022-09-07 |
RU2019141658A3 (ja) | 2021-10-14 |
CN110709063A (zh) | 2020-01-17 |
CA3061895A1 (en) | 2019-01-03 |
BR112019025635A2 (pt) | 2020-06-23 |
IL269275B (en) | 2022-12-01 |
ZA201905999B (en) | 2021-01-27 |
WO2019003118A1 (en) | 2019-01-03 |
JP2023078269A (ja) | 2023-06-06 |
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