JP2019505479A - 風味付きニコチン粉末 - Google Patents
風味付きニコチン粉末 Download PDFInfo
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- JP2019505479A JP2019505479A JP2018529277A JP2018529277A JP2019505479A JP 2019505479 A JP2019505479 A JP 2019505479A JP 2018529277 A JP2018529277 A JP 2018529277A JP 2018529277 A JP2018529277 A JP 2018529277A JP 2019505479 A JP2019505479 A JP 2019505479A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0011—Details of inhalators; Constructional features thereof with microcapsules, e.g. several in one dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0063—Storages for pre-packed dosages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
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- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Manufacture Of Tobacco Products (AREA)
- Seasonings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (18)
- 粉末システムであって、
粒子サイズが約10マイクロメートル以下で、かつニコチンおよびアミノ酸を含む、第一の複数の粒子と、
粒子サイズが約20マイクロメートル以上で、かつ風味を含む、第二の複数の粒子と、を備える、粉末システム。 - 粉末システムであって、
粒子サイズが約10マイクロメートル以下で、かつニコチンを含み、前記ニコチンがピルビン酸ニコチン、モノ−ピルビン酸ニコチン、アスパラギン酸ニコチン、および乳酸ニコチンから成る群から選択される、第一の複数の粒子と、
粒子サイズが約20マイクロメートル以上で、かつ風味を含む、第二の複数の粒子と、を備える、粉末システム。 - 前記粉末システムの前記ニコチンの少なくとも約60重量%が、約10マイクロメートル以下の粒子サイズの粒子から成る、請求項1〜2のいずれか一項に記載の粉末システム。
- 前記粉末システムの前記風味の少なくとも約60重量%が、約20マイクロメートル以上の粒子サイズの粒子から成る、請求項1〜3のいずれか一項に記載の粉末システム。
- 前記第一の複数の粒子の空気動力学的中央粒子径が約5マイクロメートル以下、または約3マイクロメートル以下、または約1マイクロメートル〜約3マイクロメートルの範囲内であり、また前記第二の複数の粒子の空気動力学的中央粒子径が約50マイクロメートル以上、または約50マイクロメートル〜約150マイクロメートルの範囲内である、請求項1〜4のいずれか一項に記載の粉末システム。
- 前記ニコチンがニコチン塩またはニコチン塩水和物を含む、請求項1〜5のいずれか一項に記載の粉末システム。
- 前記アミノ酸が前記ニコチン上に配置される、請求項1、3〜6のいずれか一項に記載の粉末システム。
- 前記アミノ酸がロイシンを含む、請求項1、3〜7のいずれか一項に記載の粉末システム。
- 前記第一の複数の粒子および前記第二の複数の粒子が単一のカプセル内に収容される、請求項1〜8のいずれか一項に記載の粉末システム。
- 前記第一の複数の粒子が第一のカプセル内に収容され、かつ前記第二の複数の粒子が第二のカプセル内に収容される、請求項1〜8のいずれか一項に記載の粉末システム。
- 前記第一の複数の粒子が前記粉末システムの全重量の約50重量%〜約99重量%であり、かつ前記第二の複数の粒子が前記粉末システムの全重量の約50重量%〜約1重量%である、請求項1〜10のいずれか一項に記載の粉末システム。
- 前記第二の複数の粒子がステアリン酸マグネシウムを含む、請求項1〜11のいずれか一項に記載の粉末システム。
- ニコチン粉末吸入器であって、
マウスピース部分と遠位端部分の間に延びる本体と、
前記マウスピース部分と前記遠位端部分の間に延びる気流チャネルと、
前記気流チャネルに沿って配置されるニコチン粉末容器であって、かつ請求項1〜12のいずれか一項に記載の粉末システムが前記ニコチン粉末容器の中に配置される、ニコチン粉末容器と、を備えるニコチン粉末吸入器。 - 前記第一の複数の粒子および前記第二の複数の粒子が単一のカプセル内に収容され、かつ前記カプセルが前記ニコチン粉末容器の中に配置され、また前記第一の複数の粒子および前記第二の複数の粒子が前記単一のカプセルから前記気流チャネルへと放出される、請求項13に記載のニコチン粉末吸入器。
- 前記第一の複数の粒子が第一のカプセル内に収容され、かつ前記第二の複数の粒子が第二のカプセル内に収容され、また前記第二のカプセルが前記第一のカプセルの上流または下流にありかつ前記気流チャネルの中にある、請求項13に記載のニコチン粉末吸入器。
- 前記ニコチン粉末容器と平行な気流の関係で第二の気流チャネルをさらに備え、また前記第一の複数の粒子は、前記ニコチン粉末容器の中の第一のカプセル内に収容され、かつ前記第二の複数の粒子は前記第二の気流チャネルの中の第二のカプセル内に収容される、請求項13に記載のニコチン粉末吸入器。
- 前記第一の複数の粒子が約5リットル/分未満の吸入量でユーザーの肺の中に吸い込まれる、請求項13〜16のいずれか一項に記載のニコチン粉末吸入器。
- ニコチンをユーザーの肺の中に吸入する方法であって、
前記第一の複数の粒子を前記ユーザーの前記肺に送達するように、かつ前記第二の複数の粒子が前記ユーザーの前記肺に送達されないように、約2リットル/分未満の流量で、請求項12〜17のいずれか一項に記載の前記ニコチン粉末吸入器を通して空気を吸入することを含む、方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2023088626A JP2023113755A (ja) | 2015-12-24 | 2023-05-30 | 風味付きニコチン粉末 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15202728.0 | 2015-12-24 | ||
EP15202728 | 2015-12-24 | ||
PCT/IB2016/057452 WO2017109625A1 (en) | 2015-12-24 | 2016-12-08 | Flavoured nicotine powder |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023088626A Division JP2023113755A (ja) | 2015-12-24 | 2023-05-30 | 風味付きニコチン粉末 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2019505479A true JP2019505479A (ja) | 2019-02-28 |
Family
ID=55066404
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018529277A Pending JP2019505479A (ja) | 2015-12-24 | 2016-12-08 | 風味付きニコチン粉末 |
JP2023088626A Pending JP2023113755A (ja) | 2015-12-24 | 2023-05-30 | 風味付きニコチン粉末 |
Family Applications After (1)
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JP2023088626A Pending JP2023113755A (ja) | 2015-12-24 | 2023-05-30 | 風味付きニコチン粉末 |
Country Status (20)
Country | Link |
---|---|
US (2) | US10751336B2 (ja) |
EP (1) | EP3393451B1 (ja) |
JP (2) | JP2019505479A (ja) |
KR (1) | KR20180098247A (ja) |
CN (2) | CN117695207A (ja) |
AU (1) | AU2016376027B2 (ja) |
BR (1) | BR112018010685A8 (ja) |
CA (1) | CA3008208A1 (ja) |
ES (1) | ES2952674T3 (ja) |
HU (1) | HUE063028T2 (ja) |
IL (1) | IL259936B2 (ja) |
MX (1) | MX2018007507A (ja) |
MY (1) | MY186270A (ja) |
PH (1) | PH12018501142A1 (ja) |
PL (1) | PL3393451T3 (ja) |
RU (1) | RU2762084C2 (ja) |
SG (1) | SG11201804598RA (ja) |
UA (1) | UA122699C2 (ja) |
WO (1) | WO2017109625A1 (ja) |
ZA (1) | ZA201803584B (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200023285A (ko) * | 2017-06-28 | 2020-03-04 | 필립모리스 프로덕츠 에스.에이. | 흡입기와 함께 사용하기 위한 입자를 가진 컨테이너 |
MX2022005510A (es) * | 2019-11-14 | 2022-06-08 | Philip Morris Products Sa | Formulacion mejorada de polvo seco saborizada con tabaco. |
WO2023138670A1 (en) * | 2022-01-21 | 2023-07-27 | The University Of Hong Kong | Dual targeting powder formulation of antiviral agent for nasal and lung deposition through single intranasal administration |
WO2024090890A1 (ko) * | 2022-10-27 | 2024-05-02 | 주식회사 케이티앤지 | 흡입용 저용량 니코틴 건조 분말 조성물 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2008521788A (ja) * | 2004-11-30 | 2008-06-26 | ヴェクトゥラ リミテッド | 医薬製剤 |
WO2015166350A2 (en) * | 2014-04-28 | 2015-11-05 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
WO2015173648A2 (en) * | 2014-04-08 | 2015-11-19 | Sansa Corporation (Barbados) Inc. | Nicotine formulations and methods of making the same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US4735217A (en) | 1986-08-21 | 1988-04-05 | The Procter & Gamble Company | Dosing device to provide vaporized medicament to the lungs as a fine aerosol |
NO168921C (no) | 1989-07-31 | 1992-04-22 | Svein Knudsen | Roekfri sigaretterstatning til bruk ved roekavvenning ellertil bruk i roekfrie miljoeer |
US5441060A (en) | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
CN1210017C (zh) | 2000-10-12 | 2005-07-13 | 贝林格尔英格海姆法玛两合公司 | 含噻托品鎓的新颖可吸入粉末 |
GB2461008B (en) | 2006-12-08 | 2011-08-10 | Exchange Supplies Ltd | Nicotine inhalation device |
CA2963423C (en) | 2007-03-30 | 2020-07-28 | Philip Morris Products S.A. | Device and method for delivery of a medicament |
GB0712308D0 (en) * | 2007-06-25 | 2007-08-01 | Kind Group Ltd | An inhalable composition |
EP2399637B1 (en) * | 2009-02-23 | 2014-10-22 | Japan Tobacco, Inc. | Non-heating tobacco flavor suction device |
WO2012078804A1 (en) | 2010-12-07 | 2012-06-14 | Respira Therapeutics, Inc. | Dry powder inhaler |
US20140088044A1 (en) | 2012-09-21 | 2014-03-27 | Basil Rigas | Product comprising a nicotine-containing material and an anti-cancer agent |
US20140261488A1 (en) * | 2013-03-15 | 2014-09-18 | Altria Client Services Inc. | Electronic smoking article |
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2016
- 2016-12-08 MY MYPI2018702108A patent/MY186270A/en unknown
- 2016-12-08 US US16/064,170 patent/US10751336B2/en active Active
- 2016-12-08 PL PL16812864.3T patent/PL3393451T3/pl unknown
- 2016-12-08 JP JP2018529277A patent/JP2019505479A/ja active Pending
- 2016-12-08 KR KR1020187016365A patent/KR20180098247A/ko not_active Application Discontinuation
- 2016-12-08 HU HUE16812864A patent/HUE063028T2/hu unknown
- 2016-12-08 EP EP16812864.3A patent/EP3393451B1/en active Active
- 2016-12-08 WO PCT/IB2016/057452 patent/WO2017109625A1/en active Application Filing
- 2016-12-08 CN CN202311657737.6A patent/CN117695207A/zh active Pending
- 2016-12-08 CN CN201680070878.XA patent/CN108289841A/zh active Pending
- 2016-12-08 MX MX2018007507A patent/MX2018007507A/es unknown
- 2016-12-08 CA CA3008208A patent/CA3008208A1/en active Pending
- 2016-12-08 SG SG11201804598RA patent/SG11201804598RA/en unknown
- 2016-12-08 ES ES16812864T patent/ES2952674T3/es active Active
- 2016-12-08 AU AU2016376027A patent/AU2016376027B2/en active Active
- 2016-12-08 UA UAA201803888A patent/UA122699C2/uk unknown
- 2016-12-08 RU RU2018126872A patent/RU2762084C2/ru active
- 2016-12-08 BR BR112018010685A patent/BR112018010685A8/pt active IP Right Grant
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2018
- 2018-05-30 ZA ZA2018/03584A patent/ZA201803584B/en unknown
- 2018-05-31 PH PH12018501142A patent/PH12018501142A1/en unknown
- 2018-06-11 IL IL259936A patent/IL259936B2/en unknown
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2020
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WO2015173648A2 (en) * | 2014-04-08 | 2015-11-19 | Sansa Corporation (Barbados) Inc. | Nicotine formulations and methods of making the same |
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HUE063028T2 (hu) | 2023-12-28 |
RU2762084C2 (ru) | 2021-12-15 |
ES2952674T3 (es) | 2023-11-03 |
ZA201803584B (en) | 2019-04-24 |
US20200375972A1 (en) | 2020-12-03 |
CN108289841A (zh) | 2018-07-17 |
BR112018010685A2 (pt) | 2018-11-13 |
UA122699C2 (uk) | 2020-12-28 |
PL3393451T3 (pl) | 2023-12-27 |
EP3393451B1 (en) | 2023-07-19 |
MY186270A (en) | 2021-07-01 |
EP3393451A1 (en) | 2018-10-31 |
US10751336B2 (en) | 2020-08-25 |
AU2016376027B2 (en) | 2022-06-30 |
CA3008208A1 (en) | 2017-06-29 |
WO2017109625A1 (en) | 2017-06-29 |
CN117695207A (zh) | 2024-03-15 |
BR112018010685A8 (pt) | 2019-02-26 |
MX2018007507A (es) | 2018-08-01 |
JP2023113755A (ja) | 2023-08-16 |
AU2016376027A1 (en) | 2018-06-21 |
US20180369225A1 (en) | 2018-12-27 |
RU2018126872A (ru) | 2020-01-24 |
RU2018126872A3 (ja) | 2020-03-20 |
IL259936B (en) | 2022-10-01 |
SG11201804598RA (en) | 2018-07-30 |
IL259936B2 (en) | 2023-02-01 |
KR20180098247A (ko) | 2018-09-03 |
PH12018501142A1 (en) | 2019-01-21 |
IL259936A (en) | 2018-07-31 |
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