CA2511079A1 - Preconcentration interface coupling liquid chromatography to capillary electrophoresis - Google Patents

Preconcentration interface coupling liquid chromatography to capillary electrophoresis Download PDF

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Publication number
CA2511079A1
CA2511079A1 CA002511079A CA2511079A CA2511079A1 CA 2511079 A1 CA2511079 A1 CA 2511079A1 CA 002511079 A CA002511079 A CA 002511079A CA 2511079 A CA2511079 A CA 2511079A CA 2511079 A1 CA2511079 A1 CA 2511079A1
Authority
CA
Canada
Prior art keywords
separation
electrodes
zone
sample
cze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002511079A
Other languages
English (en)
French (fr)
Inventor
Mario Curcio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2511079A1 publication Critical patent/CA2511079A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CA002511079A 2004-07-03 2005-06-29 Preconcentration interface coupling liquid chromatography to capillary electrophoresis Abandoned CA2511079A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04015701A EP1612550B1 (en) 2004-07-03 2004-07-03 Preconcentration interface coupling liquid chomatography to capillary electrophoresis
EP04015701.8 2004-07-03

Publications (1)

Publication Number Publication Date
CA2511079A1 true CA2511079A1 (en) 2006-01-03

Family

ID=34925611

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002511079A Abandoned CA2511079A1 (en) 2004-07-03 2005-06-29 Preconcentration interface coupling liquid chromatography to capillary electrophoresis

Country Status (7)

Country Link
US (1) US7820023B2 (enExample)
EP (2) EP1612550B1 (enExample)
JP (1) JP4527619B2 (enExample)
AT (2) ATE388397T1 (enExample)
CA (1) CA2511079A1 (enExample)
DE (2) DE602004012326T2 (enExample)
ES (2) ES2301118T3 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7641780B2 (en) * 2001-05-01 2010-01-05 Calibrant Biosystems, Inc. Two-dimensional microfluidics for protein separations and gene analysis
US20080160629A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for off-line multidimensional concentration and separation of biomolecules
US20080156080A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis
US20090120796A1 (en) * 2007-09-26 2009-05-14 Jongyoon Han Electrokinetic concentration device and methods of use thereof
JP5047928B2 (ja) * 2008-11-11 2012-10-10 シャープ株式会社 電気泳動装置およびその構成器具
CZ2010929A3 (cs) * 2010-12-14 2012-03-14 Mikrobiologický ústav AV CR, v.v.i. Zpusob modifikace povrchu pro prekoncentraci fosforylovaných peptidu pro desorpcne-ionizacní techniky hmotnostní spektrometrie
US8871072B2 (en) * 2011-09-28 2014-10-28 The United States Of America, As Represented By The Secretary Of The Navy Flow step focusing
CZ307023B6 (cs) * 2013-05-20 2017-11-22 Ăšstav analytickĂ© chemie AV ÄŚR, v. v. i. Způsob předkoncentrace složek kapalných vzorků
CN103638691B (zh) * 2013-11-01 2015-07-22 朱江 混合物分离纯化用交变弱电场阵列电子色谱分离方法
JP7051871B2 (ja) 2016-12-23 2022-04-11 エフ．ホフマン－ラ ロシュ アーゲー 分析系におけるプロセス中に試薬を同定するための方法
CN110114667B (zh) * 2016-12-23 2023-07-25 豪夫迈·罗氏有限公司 用于在分析系统中的过程期间标识试剂的方法
CN112354571B (zh) * 2019-07-11 2022-02-11 北京理工大学 一种多维微流控电泳芯片及检测装置，检测方法
CN112098501B (zh) * 2020-09-15 2023-12-05 中国科学院合肥物质科学研究院 一种面向高毒性VOCs混合物现场检测的nafion-FAIMS检测装置及方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3735640A (en) * 1972-03-10 1973-05-29 L Chizhov Apparatus for injecting a sample into a gas chromatograph
US4043678A (en) * 1976-03-01 1977-08-23 Technicon Instruments Corporation Cuvette
GB2225339A (en) * 1988-11-15 1990-05-30 Aligena Ag Separating electrically charged macromolecular compounds by forced-flow membrane electrophoresis
US5240577A (en) * 1990-11-13 1993-08-31 University Of North Carolina At Chapel Hill Two-dimensional high-performance liquid chromatography/capillary electrophoresis
DE59104604D1 (de) * 1990-11-26 1995-03-23 Ciba Geigy Ag Detektorzelle.
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6387234B1 (en) * 1998-08-31 2002-05-14 Iowa State University Research Foundation, Inc. Integrated multiplexed capillary electrophoresis system
WO2001053794A1 (en) 2000-01-18 2001-07-26 Northeastern University Parallel sample loading and injection device for multichannel microfluidic devices
US6749735B1 (en) * 2000-03-16 2004-06-15 David Le Febre Electromobility focusing controlled channel electrophoresis system
US6558523B1 (en) * 2000-04-10 2003-05-06 The Regents Of The University Of California Injector-concentrator electrodes for microchannel electrophoresis
JP3744310B2 (ja) 2000-04-13 2006-02-08 株式会社日立製作所 電気泳動装置
AU2002220106A1 (en) * 2000-10-31 2002-05-15 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US7070682B2 (en) * 2001-01-16 2006-07-04 Cheng Lee Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus
KR100425536B1 (ko) * 2001-07-16 2004-03-30 학교법인 포항공과대학교 유체 마이크로칩용 브레드보드
DE10136275C1 (de) * 2001-07-25 2002-12-12 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Probentrennung
JP2003066005A (ja) * 2001-08-23 2003-03-05 Kikuchi Jun 細胞の電気泳動方法及び装置
JP2003149218A (ja) 2001-11-08 2003-05-21 Nano Solution:Kk ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置
US6802967B2 (en) * 2002-03-06 2004-10-12 Shimadzu Corporation Multi-dimension liquid chromatography separation system
JP2004101477A (ja) 2002-09-12 2004-04-02 Yoshio Yamauchi ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置
JP2004157096A (ja) * 2002-11-02 2004-06-03 Minoru Seki 化学物質の二次元分離機構及びその装置

Also Published As

Publication number Publication date
DE602004005843T2 (de) 2007-08-30
US20060086611A1 (en) 2006-04-27
DE602004005843D1 (de) 2007-05-24
ATE388397T1 (de) 2008-03-15
ES2283907T3 (es) 2007-11-01
JP2006017731A (ja) 2006-01-19
DE602004012326D1 (de) 2008-04-17
US7820023B2 (en) 2010-10-26
EP1717580B1 (en) 2008-03-05
ATE359504T1 (de) 2007-05-15
JP4527619B2 (ja) 2010-08-18
EP1717580A3 (en) 2006-12-13
EP1612550B1 (en) 2007-04-11
ES2301118T3 (es) 2008-06-16
EP1612550A1 (en) 2006-01-04
DE602004012326T2 (de) 2009-03-26
EP1717580A2 (en) 2006-11-02

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Legal Events

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EEER Examination request
FZDE Discontinued