DE602004012326D1 - Vorkonzentrationsverbindung zur Kopplung von kapillarer Elektrochromatografie und Kapillarzonenelektrophorese - Google Patents

Vorkonzentrationsverbindung zur Kopplung von kapillarer Elektrochromatografie und Kapillarzonenelektrophorese

Info

Publication number
DE602004012326D1
DE602004012326D1 DE602004012326T DE602004012326T DE602004012326D1 DE 602004012326 D1 DE602004012326 D1 DE 602004012326D1 DE 602004012326 T DE602004012326 T DE 602004012326T DE 602004012326 T DE602004012326 T DE 602004012326T DE 602004012326 D1 DE602004012326 D1 DE 602004012326D1
Authority
DE
Germany
Prior art keywords
capillary
separation
electrodes
preconcentration
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004012326T
Other languages
English (en)
Other versions
DE602004012326T2 (de
Inventor
Mario Curcio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Publication of DE602004012326D1 publication Critical patent/DE602004012326D1/de
Application granted granted Critical
Publication of DE602004012326T2 publication Critical patent/DE602004012326T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
DE602004012326T 2004-07-03 2004-07-03 Vorkonzentrationsverbindung zur Kopplung von kapillarer Elektrochromatografie und Kapillarzonenelektrophorese Expired - Lifetime DE602004012326T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04015701A EP1612550B1 (de) 2004-07-03 2004-07-03 Vorkonzentrierende Verbindungstelle für die Kupplung von flüssiger Chromatographie und Kapillarelektrophorese
EP06013800A EP1717580B1 (de) 2004-07-03 2004-07-03 Vorkonzentrationsverbindung zur Kopplung von kapillarer Elektrochromatografie und Kapillarzonenelektrophorese

Publications (2)

Publication Number Publication Date
DE602004012326D1 true DE602004012326D1 (de) 2008-04-17
DE602004012326T2 DE602004012326T2 (de) 2009-03-26

Family

ID=34925611

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602004012326T Expired - Lifetime DE602004012326T2 (de) 2004-07-03 2004-07-03 Vorkonzentrationsverbindung zur Kopplung von kapillarer Elektrochromatografie und Kapillarzonenelektrophorese
DE602004005843T Expired - Lifetime DE602004005843T2 (de) 2004-07-03 2004-07-03 Vorkonzentrierende Verbindungstelle für die Kupplung von flüssiger Chromatographie und Kapillarelektrophorese

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE602004005843T Expired - Lifetime DE602004005843T2 (de) 2004-07-03 2004-07-03 Vorkonzentrierende Verbindungstelle für die Kupplung von flüssiger Chromatographie und Kapillarelektrophorese

Country Status (7)

Country Link
US (1) US7820023B2 (de)
EP (2) EP1612550B1 (de)
JP (1) JP4527619B2 (de)
AT (2) ATE359504T1 (de)
CA (1) CA2511079A1 (de)
DE (2) DE602004012326T2 (de)
ES (2) ES2283907T3 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7641780B2 (en) * 2001-05-01 2010-01-05 Calibrant Biosystems, Inc. Two-dimensional microfluidics for protein separations and gene analysis
US20080160629A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for off-line multidimensional concentration and separation of biomolecules
US20080156080A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis
US20090120796A1 (en) * 2007-09-26 2009-05-14 Jongyoon Han Electrokinetic concentration device and methods of use thereof
JP5047928B2 (ja) * 2008-11-11 2012-10-10 シャープ株式会社 電気泳動装置およびその構成器具
CZ303056B6 (cs) * 2010-12-14 2012-03-14 Mikrobiologický ústav AV CR, v.v.i. Zpusob modifikace povrchu pro prekoncentraci fosforylovaných peptidu pro desorpcne-ionizacní techniky hmotnostní spektrometrie
US8871072B2 (en) * 2011-09-28 2014-10-28 The United States Of America, As Represented By The Secretary Of The Navy Flow step focusing
CZ307023B6 (cs) * 2013-05-20 2017-11-22 Ăšstav analytickĂ© chemie AV ÄŚR, v. v. i. Způsob předkoncentrace složek kapalných vzorků
CN103638691B (zh) * 2013-11-01 2015-07-22 朱江 混合物分离纯化用交变弱电场阵列电子色谱分离方法
CN110114667B (zh) * 2016-12-23 2023-07-25 豪夫迈·罗氏有限公司 用于在分析系统中的过程期间标识试剂的方法
CN112354571B (zh) * 2019-07-11 2022-02-11 北京理工大学 一种多维微流控电泳芯片及检测装置，检测方法
CN112098501B (zh) * 2020-09-15 2023-12-05 中国科学院合肥物质科学研究院 一种面向高毒性VOCs混合物现场检测的nafion-FAIMS检测装置及方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3735640A (en) 1972-03-10 1973-05-29 L Chizhov Apparatus for injecting a sample into a gas chromatograph
US4043678A (en) 1976-03-01 1977-08-23 Technicon Instruments Corporation Cuvette
GB2225339A (en) * 1988-11-15 1990-05-30 Aligena Ag Separating electrically charged macromolecular compounds by forced-flow membrane electrophoresis
US5240577A (en) * 1990-11-13 1993-08-31 University Of North Carolina At Chapel Hill Two-dimensional high-performance liquid chromatography/capillary electrophoresis
DE59104604D1 (de) 1990-11-26 1995-03-23 Ciba Geigy Ag Detektorzelle.
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6387234B1 (en) * 1998-08-31 2002-05-14 Iowa State University Research Foundation, Inc. Integrated multiplexed capillary electrophoresis system
WO2001053794A1 (en) 2000-01-18 2001-07-26 Northeastern University Parallel sample loading and injection device for multichannel microfluidic devices
US6749735B1 (en) * 2000-03-16 2004-06-15 David Le Febre Electromobility focusing controlled channel electrophoresis system
US6558523B1 (en) * 2000-04-10 2003-05-06 The Regents Of The University Of California Injector-concentrator electrodes for microchannel electrophoresis
JP3744310B2 (ja) 2000-04-13 2006-02-08 株式会社日立製作所 電気泳動装置
ATE432466T1 (de) * 2000-10-31 2009-06-15 Caliper Life Sciences Inc Mikrofluidisches verfahren für in-situ- materialkonzentration
US7070682B2 (en) * 2001-01-16 2006-07-04 Cheng Lee Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus
KR100425536B1 (ko) 2001-07-16 2004-03-30 학교법인 포항공과대학교 유체 마이크로칩용 브레드보드
DE10136275C1 (de) * 2001-07-25 2002-12-12 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Probentrennung
JP2003066005A (ja) * 2001-08-23 2003-03-05 Kikuchi Jun 細胞の電気泳動方法及び装置
JP2003149218A (ja) 2001-11-08 2003-05-21 Nano Solution:Kk ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置
US6802967B2 (en) * 2002-03-06 2004-10-12 Shimadzu Corporation Multi-dimension liquid chromatography separation system
JP2004101477A (ja) 2002-09-12 2004-04-02 Yoshio Yamauchi ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置
JP2004157096A (ja) * 2002-11-02 2004-06-03 Minoru Seki 化学物質の二次元分離機構及びその装置

Also Published As

Publication number Publication date
DE602004012326T2 (de) 2009-03-26
ATE359504T1 (de) 2007-05-15
EP1717580B1 (de) 2008-03-05
EP1717580A2 (de) 2006-11-02
EP1612550A1 (de) 2006-01-04
JP2006017731A (ja) 2006-01-19
EP1612550B1 (de) 2007-04-11
DE602004005843T2 (de) 2007-08-30
ES2283907T3 (es) 2007-11-01
US7820023B2 (en) 2010-10-26
JP4527619B2 (ja) 2010-08-18
DE602004005843D1 (de) 2007-05-24
CA2511079A1 (en) 2006-01-03
EP1717580A3 (de) 2006-12-13
ES2301118T3 (es) 2008-06-16
ATE388397T1 (de) 2008-03-15
US20060086611A1 (en) 2006-04-27

Similar Documents

Publication Publication Date Title
Wainright et al. Sample pre-concentration by isotachophoresis in microfluidic devices
Fu et al. Sample preconcentration from dilute solutions on micro/nanofluidic platforms: A review
Castro et al. Present state of microchip electrophoresis: state of the art and routine applications
Graß et al. A new PMMA-microchip device for isotachophoresis with integrated conductivity detector
Shadpour et al. Multichannel microchip electrophoresis device fabricated in polycarbonate with an integrated contact conductivity sensor array
DE602004012326D1 (de) Vorkonzentrationsverbindung zur Kopplung von kapillarer Elektrochromatografie und Kapillarzonenelektrophorese
JP2006017731A5 (de)
US20170110307A1 (en) Solid phase extraction with capillary electrophoresis
US8623192B2 (en) High resolution focusing and separation of proteins in nanofluidic channels
Lin et al. A poly-methylmethacrylate electrophoresis microchip with sample preconcentrator
Song et al. Concurrent DNA preconcentration and separation in bipolar electrode-based microfluidic device
Kim et al. On-channel base stacking in microchip capillary gel electrophoresis for high-sensitivity DNA fragment analysis
Krishnamurthy et al. Recent advances in microscale extraction driven by ion concentration polarization
Woo et al. Multi-immunoreaction-based dual-color capillary electrophoresis for enhanced diagnostic reliability of thyroid gland disease
Jeong et al. Transient isotachophoresis of highly saline samples using a microchip
Sheng et al. Rapid ultraviolet monitoring of multiple psychotropic drugs with a renewable microfluidic device
Tsukagoshi et al. Analysis of antioxidants by microchip capillary electrophoresis with chemiluminescence detection based on luminol reaction
Huang et al. Use of a mixture of n-dodecyl-β-D-maltoside and sodium dodecyl sulfate in poly (dimethylsiloxane) microchips to suppress adhesion and promote separation of proteins
Du et al. Separation and detection of narcotic drugs on a microchip using micellar electrokinetic chromatography and electrochemiluminescence
Silvertand et al. Selective protein removal and desalting using microchip CE
Courtney et al. Counterflow gradient electrophoresis for focusing and elution
ATE455787T1 (de) Verfahren und vorrichtung zur abtrennung von biomolekülen
Liang-Bo et al. Separation and detection of urinary proteins by microfluidic chip integrated with contactless conductivity detector
Brod et al. Charge-based separation of proteins and peptides by electrically induced dynamic pH profiles
Tsukagoshi et al. Simultaneous operation of plural separation modes in capillary electrophoresis with a chemiluminescence detector possessing a micro-space area for reaction/detection

Legal Events

Date Code Title Description
8364 No opposition during term of opposition