ES2283907T3 - Interfase de preconcentracion para acoplar una cromatografia liquida y una electroforesis pilar. - Google Patents
Interfase de preconcentracion para acoplar una cromatografia liquida y una electroforesis pilar. Download PDFInfo
- Publication number
- ES2283907T3 ES2283907T3 ES04015701T ES04015701T ES2283907T3 ES 2283907 T3 ES2283907 T3 ES 2283907T3 ES 04015701 T ES04015701 T ES 04015701T ES 04015701 T ES04015701 T ES 04015701T ES 2283907 T3 ES2283907 T3 ES 2283907T3
- Authority
- ES
- Spain
- Prior art keywords
- cze
- separation
- rplc
- electrodes
- nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004094 preconcentration Methods 0.000 title description 13
- 238000001962 electrophoresis Methods 0.000 title description 11
- 238000004811 liquid chromatography Methods 0.000 title description 4
- 238000000926 separation method Methods 0.000 claims abstract description 44
- 238000005515 capillary zone electrophoresis Methods 0.000 claims abstract description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 24
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims description 19
- 238000005251 capillar electrophoresis Methods 0.000 claims description 18
- 230000005684 electric field Effects 0.000 claims description 9
- 239000000523 sample Substances 0.000 claims description 7
- 229920000557 Nafion® Polymers 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 238000003795 desorption Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000004587 chromatography analysis Methods 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000005342 ion exchange Methods 0.000 claims 1
- 239000012491 analyte Substances 0.000 abstract description 2
- 238000002045 capillary electrochromatography Methods 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
- 239000000872 buffer Substances 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 4
- 238000004255 ion exchange chromatography Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000005370 electroosmosis Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000004780 2D liquid chromatography Methods 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 125000000542 sulfonic acid group Chemical group 0.000 description 2
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 241001315286 Damon Species 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 108010026552 Proteome Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004193 electrokinetic chromatography Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000002608 ionic liquid Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 1
- 238000001906 matrix-assisted laser desorption--ionisation mass spectrometry Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003228 microsomal effect Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000004012 multidimensional HPLC Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000012510 peptide mapping method Methods 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- 238000001323 two-dimensional chromatography Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Pyridine Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04015701A EP1612550B1 (en) | 2004-07-03 | 2004-07-03 | Preconcentration interface coupling liquid chomatography to capillary electrophoresis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2283907T3 true ES2283907T3 (es) | 2007-11-01 |
Family
ID=34925611
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04015701T Expired - Lifetime ES2283907T3 (es) | 2004-07-03 | 2004-07-03 | Interfase de preconcentracion para acoplar una cromatografia liquida y una electroforesis pilar. |
| ES06013800T Expired - Lifetime ES2301118T3 (es) | 2004-07-03 | 2004-07-03 | Interfaz preconcentrada de acoplamiento de electromatografia capilar con electroforesis capilar de zona. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06013800T Expired - Lifetime ES2301118T3 (es) | 2004-07-03 | 2004-07-03 | Interfaz preconcentrada de acoplamiento de electromatografia capilar con electroforesis capilar de zona. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7820023B2 (enExample) |
| EP (2) | EP1717580B1 (enExample) |
| JP (1) | JP4527619B2 (enExample) |
| AT (2) | ATE388397T1 (enExample) |
| CA (1) | CA2511079A1 (enExample) |
| DE (2) | DE602004012326T2 (enExample) |
| ES (2) | ES2283907T3 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7641780B2 (en) * | 2001-05-01 | 2010-01-05 | Calibrant Biosystems, Inc. | Two-dimensional microfluidics for protein separations and gene analysis |
| US20080156080A1 (en) * | 2007-01-02 | 2008-07-03 | Calibrant Biosystems, Inc. | Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis |
| US20080160629A1 (en) * | 2007-01-02 | 2008-07-03 | Calibrant Biosystems, Inc. | Methods and systems for off-line multidimensional concentration and separation of biomolecules |
| WO2009042921A1 (en) * | 2007-09-26 | 2009-04-02 | Massachusetts Institute Of Technology | Electrokinetic concentration device and methods of use thereof |
| JP5047928B2 (ja) * | 2008-11-11 | 2012-10-10 | シャープ株式会社 | 電気泳動装置およびその構成器具 |
| CZ303056B6 (cs) | 2010-12-14 | 2012-03-14 | Mikrobiologický ústav AV CR, v.v.i. | Zpusob modifikace povrchu pro prekoncentraci fosforylovaných peptidu pro desorpcne-ionizacní techniky hmotnostní spektrometrie |
| US8871072B2 (en) * | 2011-09-28 | 2014-10-28 | The United States Of America, As Represented By The Secretary Of The Navy | Flow step focusing |
| CZ307023B6 (cs) * | 2013-05-20 | 2017-11-22 | Ăšstav analytickĂ© chemie AV ÄŚR, v. v. i. | Způsob předkoncentrace složek kapalných vzorků |
| CN103638691B (zh) * | 2013-11-01 | 2015-07-22 | 朱江 | 混合物分离纯化用交变弱电场阵列电子色谱分离方法 |
| CN110114667B (zh) * | 2016-12-23 | 2023-07-25 | 豪夫迈·罗氏有限公司 | 用于在分析系统中的过程期间标识试剂的方法 |
| JP7051871B2 (ja) | 2016-12-23 | 2022-04-11 | エフ．ホフマン－ラ ロシュ アーゲー | 分析系におけるプロセス中に試薬を同定するための方法 |
| CN112354572B (zh) * | 2019-07-11 | 2022-02-11 | 北京理工大学 | 一种多维微流控电泳芯片及检测装置，检测方法 |
| CN112098501B (zh) * | 2020-09-15 | 2023-12-05 | 中国科学院合肥物质科学研究院 | 一种面向高毒性VOCs混合物现场检测的nafion-FAIMS检测装置及方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3735640A (en) | 1972-03-10 | 1973-05-29 | L Chizhov | Apparatus for injecting a sample into a gas chromatograph |
| US4043678A (en) | 1976-03-01 | 1977-08-23 | Technicon Instruments Corporation | Cuvette |
| GB2225339A (en) * | 1988-11-15 | 1990-05-30 | Aligena Ag | Separating electrically charged macromolecular compounds by forced-flow membrane electrophoresis |
| US5240577A (en) * | 1990-11-13 | 1993-08-31 | University Of North Carolina At Chapel Hill | Two-dimensional high-performance liquid chromatography/capillary electrophoresis |
| EP0488947B1 (de) | 1990-11-26 | 1995-02-15 | Ciba-Geigy Ag | Detektorzelle |
| US6074827A (en) * | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| US6387234B1 (en) * | 1998-08-31 | 2002-05-14 | Iowa State University Research Foundation, Inc. | Integrated multiplexed capillary electrophoresis system |
| WO2001053794A1 (en) | 2000-01-18 | 2001-07-26 | Northeastern University | Parallel sample loading and injection device for multichannel microfluidic devices |
| US6749735B1 (en) * | 2000-03-16 | 2004-06-15 | David Le Febre | Electromobility focusing controlled channel electrophoresis system |
| US6558523B1 (en) * | 2000-04-10 | 2003-05-06 | The Regents Of The University Of California | Injector-concentrator electrodes for microchannel electrophoresis |
| JP3744310B2 (ja) | 2000-04-13 | 2006-02-08 | 株式会社日立製作所 | 電気泳動装置 |
| DE60138824D1 (de) * | 2000-10-31 | 2009-07-09 | Caliper Life Sciences Inc | Mikrofluidisches verfahren für in-situ-materialkonzentration |
| US7070682B2 (en) * | 2001-01-16 | 2006-07-04 | Cheng Lee | Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus |
| KR100425536B1 (ko) | 2001-07-16 | 2004-03-30 | 학교법인 포항공과대학교 | 유체 마이크로칩용 브레드보드 |
| DE10136275C1 (de) * | 2001-07-25 | 2002-12-12 | Fraunhofer Ges Forschung | Verfahren und Vorrichtung zur Probentrennung |
| JP2003066005A (ja) * | 2001-08-23 | 2003-03-05 | Kikuchi Jun | 細胞の電気泳動方法及び装置 |
| JP2003149218A (ja) | 2001-11-08 | 2003-05-21 | Nano Solution:Kk | ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置 |
| US6802967B2 (en) | 2002-03-06 | 2004-10-12 | Shimadzu Corporation | Multi-dimension liquid chromatography separation system |
| JP2004101477A (ja) | 2002-09-12 | 2004-04-02 | Yoshio Yamauchi | ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置 |
| JP2004157096A (ja) * | 2002-11-02 | 2004-06-03 | Minoru Seki | 化学物質の二次元分離機構及びその装置 |
-
2004
- 2004-07-03 DE DE602004012326T patent/DE602004012326T2/de not_active Expired - Lifetime
- 2004-07-03 AT AT06013800T patent/ATE388397T1/de not_active IP Right Cessation
- 2004-07-03 DE DE602004005843T patent/DE602004005843T2/de not_active Expired - Lifetime
- 2004-07-03 ES ES04015701T patent/ES2283907T3/es not_active Expired - Lifetime
- 2004-07-03 EP EP06013800A patent/EP1717580B1/en not_active Expired - Lifetime
- 2004-07-03 AT AT04015701T patent/ATE359504T1/de not_active IP Right Cessation
- 2004-07-03 ES ES06013800T patent/ES2301118T3/es not_active Expired - Lifetime
- 2004-07-03 EP EP04015701A patent/EP1612550B1/en not_active Expired - Lifetime
-
2005
- 2005-06-28 US US11/169,103 patent/US7820023B2/en not_active Expired - Fee Related
- 2005-06-29 CA CA002511079A patent/CA2511079A1/en not_active Abandoned
- 2005-07-01 JP JP2005193598A patent/JP4527619B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004005843D1 (de) | 2007-05-24 |
| ATE359504T1 (de) | 2007-05-15 |
| ES2301118T3 (es) | 2008-06-16 |
| EP1717580B1 (en) | 2008-03-05 |
| EP1612550B1 (en) | 2007-04-11 |
| JP2006017731A (ja) | 2006-01-19 |
| DE602004012326T2 (de) | 2009-03-26 |
| DE602004012326D1 (de) | 2008-04-17 |
| EP1717580A2 (en) | 2006-11-02 |
| EP1612550A1 (en) | 2006-01-04 |
| ATE388397T1 (de) | 2008-03-15 |
| US20060086611A1 (en) | 2006-04-27 |
| DE602004005843T2 (de) | 2007-08-30 |
| JP4527619B2 (ja) | 2010-08-18 |
| EP1717580A3 (en) | 2006-12-13 |
| CA2511079A1 (en) | 2006-01-03 |
| US7820023B2 (en) | 2010-10-26 |
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