CA2505478A1 - Antioxidant pharmaceutical compound, method for producing polypeptide and method of cure - Google Patents
Antioxidant pharmaceutical compound, method for producing polypeptide and method of cure Download PDFInfo
- Publication number
- CA2505478A1 CA2505478A1 CA002505478A CA2505478A CA2505478A1 CA 2505478 A1 CA2505478 A1 CA 2505478A1 CA 002505478 A CA002505478 A CA 002505478A CA 2505478 A CA2505478 A CA 2505478A CA 2505478 A1 CA2505478 A1 CA 2505478A1
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- Prior art keywords
- peroxiredoxin
- prx
- fragment
- cells
- antioxidant
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01015—Peroxiredoxin (1.11.1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
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- Veterinary Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
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- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2002129774/15A RU2280448C2 (ru) | 2002-11-10 | 2002-11-10 | Композиция с антиоксидантными свойствами и способ лечения болезней млекопитающих |
| RU2002129774 | 2002-11-10 | ||
| RU2003123534/13A RU2250262C1 (ru) | 2003-07-29 | 2003-07-29 | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pET23-a(+)PrxVIhumΔ178, КОДИРУЮЩАЯ N-КОНЦЕВОЙ ФРАГМЕНТ ПЕРОКСИРЕДОКСИНА VI ЧЕЛОВЕКА, И ШТАММ E.coli BL21/DE3/pET23-a(+)/PrxVIhumΔ178 - ПРОДУЦЕНТ N-КОНЦЕВОГО ФРАГМЕНТА ПЕРОКСИРЕДОКСИНА VI ЧЕЛОВЕКА |
| RU2003123534 | 2003-07-29 | ||
| PCT/RU2003/000473 WO2004043485A1 (en) | 2002-11-10 | 2003-11-05 | Antioxidant pharmaceutical compound, method for producing polypeptide and method of cure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2505478A1 true CA2505478A1 (en) | 2004-05-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002505478A Abandoned CA2505478A1 (en) | 2002-11-10 | 2003-11-05 | Antioxidant pharmaceutical compound, method for producing polypeptide and method of cure |
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| Country | Link |
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| US (1) | US8003345B2 (enExample) |
| EP (1) | EP1566182A4 (enExample) |
| JP (1) | JP2006505290A (enExample) |
| CA (1) | CA2505478A1 (enExample) |
| WO (1) | WO2004043485A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010101301A1 (en) * | 2009-03-05 | 2010-09-10 | National University Corporation University Of Fukui | Prophylaxis and treatment of macular degeneration and retinopathy using a prdx protein |
| EP3563862B1 (en) * | 2009-03-20 | 2021-05-05 | The General Hospital Corporation d/b/a Massachusetts General Hospital | D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries |
| EP2464739B1 (en) * | 2009-08-14 | 2016-01-13 | Basf Se | Methods in cell cultures, and related inventions, employing certain additives |
| US9181542B2 (en) * | 2010-10-25 | 2015-11-10 | Korea Atomic Energy Research Institute | Method for controlling the chaperone activity of peroxiredoxins using irradiation |
| CN102793911B (zh) * | 2011-05-24 | 2015-12-16 | 李建远 | 重组人Prx-6蛋白在治疗角膜损伤方面的用途 |
| CN102485272A (zh) * | 2010-12-06 | 2012-06-06 | 李建远 | 重组人Prx-6蛋白在治疗烧烫伤方面的用途 |
| WO2012075911A1 (zh) * | 2010-12-06 | 2012-06-14 | Li Jianyuan | 重组人prx-6蛋白在治疗烧烫伤和/或角膜损伤中的用途 |
| CN103417961B (zh) * | 2012-05-23 | 2018-02-09 | 烟台聚杰生物工程有限公司 | Prdx2和/或prdx6的新用途 |
| CN105211054B (zh) * | 2015-11-10 | 2017-05-24 | 刘娟 | 一种含重组人prdx4蛋白的人精液冷冻保护剂 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9612214D0 (en) | 1996-06-11 | 1996-08-14 | Mallinckrodt Veterinary Inc | Vaccine |
| CA2285631A1 (en) * | 1997-04-02 | 1998-10-08 | The Jackson Laboratory | Antioxidant protein 2, gene and methods of use therefor |
| BE1011331A6 (fr) * | 1997-08-20 | 1999-07-06 | Univ Catholique De Louvain Hal | Polypeptide associe au peroxysome, sequence nucleotidique encodant ledit polypeptide et leur utilisation dans le diagnostic et/ou le traitement de maladies ou de lesions pulmonaires. |
| AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
| FR2798672B1 (fr) | 1999-09-17 | 2003-10-31 | Commissariat Energie Atomique | Formes acides des peroxyredoxines et leur utilisation comme moyen de diagnostic |
| AU2001280199A1 (en) | 2000-08-28 | 2002-03-13 | Akira Awaya | Medicinal compositions |
| US20020168353A1 (en) | 2001-03-23 | 2002-11-14 | Lynn Ralf Geiben | Peroxiredoxin drugs for treatment of HIV-1 infection and methods of use thereof |
| WO2002061063A1 (en) * | 2001-01-30 | 2002-08-08 | Universite Catholique De Louvain | Crystal structure of peroxiredoxin 5 and its use for design of structural homologues |
| EP1394182A1 (en) | 2002-07-08 | 2004-03-03 | Europroteome AG | Agents and methods for diagnosis and therapy of cancer and cancer risk assessment |
| RU2280448C2 (ru) | 2002-11-10 | 2006-07-27 | Институт биофизики клетки РАН | Композиция с антиоксидантными свойствами и способ лечения болезней млекопитающих |
| RU2250262C1 (ru) | 2003-07-29 | 2005-04-20 | Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова РАН | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pET23-a(+)PrxVIhumΔ178, КОДИРУЮЩАЯ N-КОНЦЕВОЙ ФРАГМЕНТ ПЕРОКСИРЕДОКСИНА VI ЧЕЛОВЕКА, И ШТАММ E.coli BL21/DE3/pET23-a(+)/PrxVIhumΔ178 - ПРОДУЦЕНТ N-КОНЦЕВОГО ФРАГМЕНТА ПЕРОКСИРЕДОКСИНА VI ЧЕЛОВЕКА |
| EP1664795B1 (en) | 2003-09-20 | 2017-11-08 | Electrophoretics Limited | Diagnostic method for brain damage-related disorders |
| KR100569165B1 (ko) | 2003-11-14 | 2006-04-07 | (주)아비코아생명공학연구소 | 닭 퍼옥시레독신 1 단백질 및 그를 코딩하는 핵산분자 |
| KR100605308B1 (ko) | 2003-12-01 | 2006-07-26 | 전남대학교산학협력단 | ＰｒｘⅡ 단백질의 혈관 내피세포 탐지용 마아커로서의 용도 |
| CA2567987A1 (en) | 2004-06-18 | 2005-12-29 | Gabriele Pestlin | Use of protein pdx1 as a marker for breast cancer |
| KR100953326B1 (ko) | 2004-08-31 | 2010-04-20 | 이화여자대학교 산학협력단 | 페록시레독신의 활성검출 키트 |
| KR100610774B1 (ko) | 2005-02-03 | 2006-08-28 | 이화여자대학교 산학협력단 | 퍼록시레독신 2 단백질을 유효성분으로 함유하는 혈관재협착 예방 및 치료용 약학조성물, 퍼록시레독신 2유전자 또는 그로부터 발현되는 단백질을 포함하는 혈관재협착 치료제 스크리닝용 조성물 및 이를 이용하는 혈관재협착 치료제 스크리닝 방법 |
| WO2007140976A2 (en) | 2006-06-06 | 2007-12-13 | F. Hoffmann-La Roche Ag | Enzymes as biomarker for alzheimer's disease |
| US20100297673A1 (en) | 2006-09-20 | 2010-11-25 | Reddy Us Therapeutics | Methods and compositions for upregulation of peroxiredoxin activity |
| JP2008275413A (ja) | 2007-04-27 | 2008-11-13 | Osaka Industrial Promotion Organization | 扁平上皮癌の診断用キット及び判定方法 |
-
2003
- 2003-11-05 US US10/534,238 patent/US8003345B2/en not_active Expired - Fee Related
- 2003-11-05 CA CA002505478A patent/CA2505478A1/en not_active Abandoned
- 2003-11-05 JP JP2005506685A patent/JP2006505290A/ja active Pending
- 2003-11-05 EP EP03774414A patent/EP1566182A4/en not_active Ceased
- 2003-11-05 WO PCT/RU2003/000473 patent/WO2004043485A1/ru not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006505290A (ja) | 2006-02-16 |
| US20060147440A1 (en) | 2006-07-06 |
| WO2004043485A1 (en) | 2004-05-27 |
| EP1566182A1 (en) | 2005-08-24 |
| EP1566182A4 (en) | 2009-08-19 |
| US8003345B2 (en) | 2011-08-23 |
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