CA2496739A1 - Procede de synthese de peptides - Google Patents

Procede de synthese de peptides Download PDF

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Publication number
CA2496739A1
CA2496739A1 CA002496739A CA2496739A CA2496739A1 CA 2496739 A1 CA2496739 A1 CA 2496739A1 CA 002496739 A CA002496739 A CA 002496739A CA 2496739 A CA2496739 A CA 2496739A CA 2496739 A1 CA2496739 A1 CA 2496739A1
Authority
CA
Canada
Prior art keywords
peptide
alpha
amino acid
amine
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002496739A
Other languages
English (en)
Inventor
Vladimir Vasilyevich Samukov
Pavel Ivanovich Pozdnyakov
Nikolai Nilolaevich Karpyshev
Daria Vladimirovna Lebedeva
Hack-Joo Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
A & Pep Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A & Pep Inc filed Critical A & Pep Inc
Publication of CA2496739A1 publication Critical patent/CA2496739A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention se rapporte à un nouveau procédé pour la synthèse de peptides en solution, ce procédé consistant : (a) à traiter un dérivé de peptide ou d'acide aminé, qui possède une fonction .alpha.-amine bloquée par un groupe uréthane de la formule R?1¿-SO¿2?-CH¿2?CH¿2?-O-CO-, où R?1¿ représente aryle, avec une quantité excédentaire d'une amine secondaire aliphatique dans un solvant organique, pour produire la libération de la fonction .alpha.-amine libre de ce dérivé d'acide aminé ou de peptide et la formation d'un produit d'addition à base d'amine tertiaire entre la seconde amine secondaire et le composés vinyle libéré de la formule R?1¿-SO¿2?-CH¿2?=CH¿2 ?; (b) à retirer le solvant et la quantité excédentaire de l'amine secondaire ; (c) à mettre en contact le mélange ainsi formé du dérivé d'acide aminé ou de peptide déprotégé en position N¿.alpha.? et du produit d'addition à base d'amine tertiaire avec un dérivé de peptide ou d'acide aminé ultérieur protégé en position N¿.alpha.? par le groupe uréthane indiqué ci-dessus ou par un autre groupe uréthane, dans des conditions entraînant la formation d'une liaison peptide entre la fonction .alpha.-amine libre du dérivé d'acide aminé ou de peptide déprotégé en position N¿.alpha.? et une fonction .alpha.-carboxylique du dérivé de peptide ou d'acide aminé ultérieur protégé en position N¿.alpha. ?; (d) à séparer le peptide nouvellement formé du mélange de réaction ; (e) et à répéter les procédures décrites ci-dessus, jusqu'à obtenir le polypeptide souhaité.
CA002496739A 2002-08-26 2002-08-26 Procede de synthese de peptides Abandoned CA2496739A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2002/001604 WO2004018501A1 (fr) 2002-08-26 2002-08-26 Procede de synthese de peptides

Publications (1)

Publication Number Publication Date
CA2496739A1 true CA2496739A1 (fr) 2004-03-04

Family

ID=31944805

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002496739A Abandoned CA2496739A1 (fr) 2002-08-26 2002-08-26 Procede de synthese de peptides

Country Status (6)

Country Link
EP (1) EP1546186A4 (fr)
JP (1) JP2006511459A (fr)
CN (1) CN1649892A (fr)
AU (1) AU2002329070A1 (fr)
CA (1) CA2496739A1 (fr)
WO (1) WO2004018501A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE46830E1 (en) 2004-10-19 2018-05-08 Polypeptide Laboratories Holding (Ppl) Ab Method for solid phase peptide synthesis

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100355773C (zh) * 2006-01-19 2007-12-19 九江石化波涛生化科技有限公司 高分子量多肽聚合物的合成方法
MX339762B (es) * 2011-09-28 2016-05-27 Univ Autonoma Del Estado De Morelos Metalopeptidos inmunomoduladores (immp) y composiciones que los contienen.
FR3090636B1 (fr) * 2018-12-24 2021-01-01 Strainchem Procédé de synthèse de peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652581B1 (fr) * 1989-10-02 1991-12-13 Rhone Poulenc Chimie Procede de solubilisation de peptides et procede de synthese de peptides.
US5859191A (en) * 1996-12-05 1999-01-12 The Regents Of The University Of California Method for the site-specific modification of peptide alpha amines
KR100418962B1 (ko) * 2001-06-07 2004-02-14 김학주 2-(4-나이트로페닐설포닐)에톡시카르보닐-아미노산류를사용하여 펩티드를 고수율 및 고순도로 제조하는 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE46830E1 (en) 2004-10-19 2018-05-08 Polypeptide Laboratories Holding (Ppl) Ab Method for solid phase peptide synthesis

Also Published As

Publication number Publication date
EP1546186A4 (fr) 2006-02-08
WO2004018501A1 (fr) 2004-03-04
CN1649892A (zh) 2005-08-03
JP2006511459A (ja) 2006-04-06
EP1546186A1 (fr) 2005-06-29
AU2002329070A1 (en) 2004-03-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued