CA2495597A1 - Novel phenanthridines - Google Patents
Novel phenanthridines Download PDFInfo
- Publication number
- CA2495597A1 CA2495597A1 CA002495597A CA2495597A CA2495597A1 CA 2495597 A1 CA2495597 A1 CA 2495597A1 CA 002495597 A CA002495597 A CA 002495597A CA 2495597 A CA2495597 A CA 2495597A CA 2495597 A1 CA2495597 A1 CA 2495597A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- radical
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000005053 phenanthridines Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 158
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims abstract description 6
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims abstract description 6
- -1 1-4C-alkyl Chemical group 0.000 claims description 406
- 229910052739 hydrogen Inorganic materials 0.000 claims description 152
- 239000001257 hydrogen Substances 0.000 claims description 150
- 150000002431 hydrogen Chemical group 0.000 claims description 107
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 74
- 229910052736 halogen Inorganic materials 0.000 claims description 57
- 150000002367 halogens Chemical group 0.000 claims description 57
- 150000003839 salts Chemical class 0.000 claims description 51
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 35
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 32
- 229910052757 nitrogen Inorganic materials 0.000 claims description 31
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 31
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 30
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 29
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 20
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- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 17
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims description 16
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 15
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP02018530.2 | 2002-08-17 | ||
| EP02018530 | 2002-08-17 | ||
| PCT/EP2003/008967 WO2004018431A2 (en) | 2002-08-17 | 2003-08-13 | Novel phenanthridines |
Publications (1)
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| CA2495597A1 true CA2495597A1 (en) | 2004-03-04 |
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| EP (1) | EP1537086A2 (enExample) |
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| AU2007342223B2 (en) | 2007-01-10 | 2011-02-24 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| EP2332933A1 (en) | 2007-05-07 | 2011-06-15 | Novartis AG | Epithelial sodium channel (ENaC) inhibitors |
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| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
| EE03523B1 (et) * | 1996-01-31 | 2001-10-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine |
| US6127378A (en) * | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| AU753615B2 (en) * | 1997-07-25 | 2002-10-24 | Altana Pharma Ag | Novel tetrazole derivatives |
| PT1000035E (pt) * | 1997-07-25 | 2003-04-30 | Altana Pharma Ag | 6-fenilfenantridinas substituidas |
| ATE356810T1 (de) * | 1999-01-15 | 2007-04-15 | Altana Pharma Ag | Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung |
| DE60025327T2 (de) * | 1999-01-15 | 2006-08-24 | Altana Pharma Ag | 6-arylphenanthridine mit pde-iv hemmender wirkung |
| EE05105B1 (et) * | 1999-01-15 | 2008-12-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fenlfenantridiinid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim |
| AU2001239550A1 (en) * | 2000-03-23 | 2001-10-03 | Takeda Chemical Industries Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof |
| SI1303506T1 (en) * | 2000-07-14 | 2005-06-30 | Altana Pharma Ag | 6-heteroarylphenanthridines |
| AU2001267589A1 (en) * | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
| US6936622B2 (en) * | 2001-02-21 | 2005-08-30 | Altana Pharma Ag | 6-phenylbenzonaphthyridines |
| AU2003255493B8 (en) * | 2002-08-29 | 2009-03-26 | Takeda Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| EP1720835B1 (en) * | 2004-02-18 | 2012-12-12 | Nycomed GmbH | Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors |
-
2003
- 2003-08-13 CA CA002495597A patent/CA2495597A1/en not_active Abandoned
- 2003-08-13 EP EP03792307A patent/EP1537086A2/en not_active Withdrawn
- 2003-08-13 AU AU2003253408A patent/AU2003253408A1/en not_active Abandoned
- 2003-08-13 HR HR20050228A patent/HRP20050228A2/xx not_active Application Discontinuation
- 2003-08-13 RS YUP-2005/0116A patent/RS20050116A/sr unknown
- 2003-08-13 PL PL03374014A patent/PL374014A1/xx not_active Application Discontinuation
- 2003-08-13 US US10/524,634 patent/US20060116518A1/en not_active Abandoned
- 2003-08-13 WO PCT/EP2003/008967 patent/WO2004018431A2/en not_active Ceased
- 2003-08-13 JP JP2004530135A patent/JP2005537312A/ja not_active Withdrawn
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2005
- 2005-03-08 IS IS7730A patent/IS7730A/is unknown
Also Published As
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|---|---|
| US20060116518A1 (en) | 2006-06-01 |
| WO2004018431A3 (en) | 2004-04-22 |
| AU2003253408A1 (en) | 2004-03-11 |
| EP1537086A2 (en) | 2005-06-08 |
| IS7730A (is) | 2005-03-08 |
| HRP20050228A2 (en) | 2006-07-31 |
| JP2005537312A (ja) | 2005-12-08 |
| RS20050116A (sr) | 2007-11-15 |
| PL374014A1 (en) | 2005-09-19 |
| WO2004018431A2 (en) | 2004-03-04 |
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