CA2493471C - Compounds binding to p-selectin - Google Patents
Compounds binding to p-selectin Download PDFInfo
- Publication number
- CA2493471C CA2493471C CA2493471A CA2493471A CA2493471C CA 2493471 C CA2493471 C CA 2493471C CA 2493471 A CA2493471 A CA 2493471A CA 2493471 A CA2493471 A CA 2493471A CA 2493471 C CA2493471 C CA 2493471C
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- Prior art keywords
- selectin
- compound
- acid
- compounds
- compound according
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
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- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
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- Urology & Nephrology (AREA)
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- Oncology (AREA)
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- Cardiology (AREA)
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- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02078308 | 2002-08-09 | ||
| EP02078308.0 | 2002-08-09 | ||
| PCT/EP2003/007260 WO2004018502A1 (en) | 2002-08-09 | 2003-07-04 | Compounds binding to p-selectin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2493471A1 CA2493471A1 (en) | 2004-03-04 |
| CA2493471C true CA2493471C (en) | 2013-02-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2493471A Expired - Fee Related CA2493471C (en) | 2002-08-09 | 2003-07-04 | Compounds binding to p-selectin |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20060217294A1 (enExample) |
| EP (1) | EP1527086B1 (enExample) |
| JP (2) | JP4563806B2 (enExample) |
| AT (1) | ATE383370T1 (enExample) |
| AU (1) | AU2003250899A1 (enExample) |
| BR (1) | BR0313019A (enExample) |
| CA (1) | CA2493471C (enExample) |
| DE (1) | DE60318585T2 (enExample) |
| ES (1) | ES2299749T3 (enExample) |
| MX (1) | MXPA05001599A (enExample) |
| WO (1) | WO2004018502A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003250899A1 (en) * | 2002-08-09 | 2004-03-11 | Astellas Pharma Europe B.V. | Compounds binding to p-selectin |
| MXPA05003844A (es) | 2002-10-11 | 2005-06-22 | Yamanouchi Europ Bv | Compuestos con base de glucosa con afinidad para p-selectina. |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| US8557776B2 (en) * | 2006-09-08 | 2013-10-15 | Bayer Pharma AG | Compounds and methods for 18F labeled agents |
| DK2976325T3 (en) | 2013-03-21 | 2017-06-06 | Sanofi Aventis Deutschland | SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID |
| AU2014234400B2 (en) | 2013-03-21 | 2017-11-16 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| EP4090358A4 (en) * | 2020-01-16 | 2024-02-14 | Case Western Reserve University | NEUTROPHIL ELASTASE BINDING PEPTIDES AND COMPOSITIONS THEREOF |
| CN115039782A (zh) * | 2022-07-20 | 2022-09-13 | 中国农业科学院植物保护研究所 | 一种化合物在大豆孢囊线虫几丁质酶抑制剂中的应用 |
| WO2025168211A1 (en) | 2023-02-10 | 2025-08-14 | Novo Nordisk A/S | P-selectin peptide ligands |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005314A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of leukocyte adhesion |
| WO1996000581A1 (en) * | 1994-06-29 | 1996-01-11 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
| AU1471300A (en) * | 1998-11-06 | 2000-05-29 | Trustees Of The University Of Pennsylvania, The | Compositions and methods for treatment of cancer |
| EP1288222A1 (en) * | 2001-09-03 | 2003-03-05 | Yamanouchi Europe B.V. | Peptidic compounds selectively binding to P-selectin |
| AU2003250899A1 (en) * | 2002-08-09 | 2004-03-11 | Astellas Pharma Europe B.V. | Compounds binding to p-selectin |
-
2003
- 2003-07-04 AU AU2003250899A patent/AU2003250899A1/en not_active Abandoned
- 2003-07-04 JP JP2004530000A patent/JP4563806B2/ja not_active Expired - Fee Related
- 2003-07-04 DE DE60318585T patent/DE60318585T2/de not_active Expired - Lifetime
- 2003-07-04 MX MXPA05001599A patent/MXPA05001599A/es unknown
- 2003-07-04 WO PCT/EP2003/007260 patent/WO2004018502A1/en not_active Ceased
- 2003-07-04 EP EP03792179A patent/EP1527086B1/en not_active Expired - Lifetime
- 2003-07-04 ES ES03792179T patent/ES2299749T3/es not_active Expired - Lifetime
- 2003-07-04 CA CA2493471A patent/CA2493471C/en not_active Expired - Fee Related
- 2003-07-04 BR BR0313019-3A patent/BR0313019A/pt not_active Application Discontinuation
- 2003-07-04 AT AT03792179T patent/ATE383370T1/de not_active IP Right Cessation
- 2003-07-04 US US10/524,172 patent/US20060217294A1/en not_active Abandoned
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2008
- 2008-06-25 US US12/146,302 patent/US20090062186A1/en not_active Abandoned
-
2010
- 2010-03-16 US US12/725,199 patent/US20100323969A1/en not_active Abandoned
- 2010-04-21 JP JP2010098138A patent/JP2010209088A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20060217294A1 (en) | 2006-09-28 |
| DE60318585D1 (de) | 2008-02-21 |
| JP4563806B2 (ja) | 2010-10-13 |
| AU2003250899A1 (en) | 2004-03-11 |
| DE60318585T2 (de) | 2009-01-08 |
| EP1527086A1 (en) | 2005-05-04 |
| US20090062186A1 (en) | 2009-03-05 |
| US20100323969A1 (en) | 2010-12-23 |
| BR0313019A (pt) | 2005-07-12 |
| ES2299749T3 (es) | 2008-06-01 |
| MXPA05001599A (es) | 2005-08-19 |
| JP2010209088A (ja) | 2010-09-24 |
| ATE383370T1 (de) | 2008-01-15 |
| WO2004018502A8 (en) | 2005-05-12 |
| CA2493471A1 (en) | 2004-03-04 |
| WO2004018502A1 (en) | 2004-03-04 |
| JP2006513141A (ja) | 2006-04-20 |
| EP1527086B1 (en) | 2008-01-09 |
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