CA2493359A1 - Nouveau polymorphe de n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-.alpha.]-pyrimidin-7-yl}phenyl)acetamide et compositions et methodes associees - Google Patents

Nouveau polymorphe de n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-.alpha.]-pyrimidin-7-yl}phenyl)acetamide et compositions et methodes associees Download PDF

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Publication number
CA2493359A1
CA2493359A1 CA002493359A CA2493359A CA2493359A1 CA 2493359 A1 CA2493359 A1 CA 2493359A1 CA 002493359 A CA002493359 A CA 002493359A CA 2493359 A CA2493359 A CA 2493359A CA 2493359 A1 CA2493359 A1 CA 2493359A1
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CA
Canada
Prior art keywords
thienylcarbonyl
pyrazol
pyrimidin
acetamide
phenyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002493359A
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English (en)
Other versions
CA2493359C (fr
Inventor
Scott E. Zook
Donald Hettinger
Henry R. Dubois, Iii
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Neurocrine Biosciences Inc
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Individual
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Publication of CA2493359A1 publication Critical patent/CA2493359A1/fr
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Publication of CA2493359C publication Critical patent/CA2493359C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CA002493359A 2002-08-26 2003-08-26 Nouveau polymorphe de n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-.alpha.]-pyrimidin-7-yl}phenyl)acetamide et compositions et methodes associees Expired - Lifetime CA2493359C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40607202P 2002-08-26 2002-08-26
US60/406,072 2002-08-26
PCT/US2003/026870 WO2004018476A1 (fr) 2002-08-26 2003-08-26 Nouveau polymorphe de n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide et compositions et methodes associees

Publications (2)

Publication Number Publication Date
CA2493359A1 true CA2493359A1 (fr) 2004-03-04
CA2493359C CA2493359C (fr) 2009-10-27

Family

ID=31946959

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002493359A Expired - Lifetime CA2493359C (fr) 2002-08-26 2003-08-26 Nouveau polymorphe de n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-.alpha.]-pyrimidin-7-yl}phenyl)acetamide et compositions et methodes associees

Country Status (32)

Country Link
US (2) US6903106B2 (fr)
EP (1) EP1532152B1 (fr)
JP (2) JP4522859B2 (fr)
KR (1) KR101063033B1 (fr)
CN (1) CN1319974C (fr)
AP (1) AP2005003220A0 (fr)
AR (1) AR044191A1 (fr)
AT (1) ATE343581T1 (fr)
AU (1) AU2003268212B2 (fr)
BR (1) BR0313695A (fr)
CA (1) CA2493359C (fr)
DE (1) DE60309332T2 (fr)
DK (1) DK1532152T3 (fr)
EA (1) EA200500421A1 (fr)
EC (1) ECSP055703A (fr)
ES (1) ES2274260T3 (fr)
HK (1) HK1071373A1 (fr)
HR (1) HRP20050288A2 (fr)
IL (2) IL166621A0 (fr)
IS (1) IS7769A (fr)
MA (1) MA27519A1 (fr)
MX (1) MXPA05002251A (fr)
NO (1) NO20050615L (fr)
NZ (1) NZ538027A (fr)
OA (1) OA12917A (fr)
PE (1) PE20040979A1 (fr)
PL (1) PL374436A1 (fr)
PT (1) PT1532152E (fr)
TN (1) TNSN05058A1 (fr)
TW (1) TWI288135B (fr)
WO (1) WO2004018476A1 (fr)
ZA (1) ZA200501125B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0313695A (pt) * 2002-08-26 2005-06-21 Neurocrine Biosciences Inc Polimorfo de n-metil-n-(3-{3-[2-tienil carbonil]pirazol-[1,5-alfa]pirimidin-7-il}fenil) acetamida e composições e processos relacionados ao mesmo
US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
WO2006044903A1 (fr) * 2004-10-18 2006-04-27 Neurocrine Biosciences, Inc. Hydrate du n-méthyl-n-(3-{3-[2-thiénylcarbonyl]pyrazol-[1,5-α]-pyrimidin-7-yl}phényl)acétamide et procédés et méthodes s'y rapportant
CN100528875C (zh) * 2005-02-18 2009-08-19 美德（江西）生物科技有限公司 无结晶型态的印地普隆及其制备方法
EP1918290A1 (fr) * 2006-10-11 2008-05-07 Ferrer Internacional, S.A. La polymorphe B de la N-{2-fluoro-5-[3-thiophèn-2-carbonyle)-pyrazolo[1,5-a]pyrimidin-7-yl]-phènyl}-N-methyle-acetamide
EP1956021A1 (fr) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Procédé de préparation d'un pyrazole[1,5-a]pyrimidine en forme crystalline
CN102180879B (zh) * 2006-11-09 2013-05-01 中国人民解放军军事医学科学院放射与辐射医学研究所 一种催眠药的多晶型α的乙酸溶剂化物
CN101177427B (zh) * 2006-11-09 2011-07-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
CN102834987B (zh) 2010-03-25 2015-04-15 矢崎总业株式会社 接头连接器和用于识别接头连接器中的汇流条图案的方法
EP2377830B1 (fr) * 2010-04-16 2016-04-13 Ivoclar Vivadent AG Vitrocéramique et verre à base du silicate de lithium ayant d'oxyde de métal de transition
PL2672847T3 (pl) 2011-02-11 2015-10-30 Batmark Ltd Część składowa inhalatora
AT510837B1 (de) 2011-07-27 2012-07-15 Helmut Dr Buchberger Inhalatorkomponente
CN102174048B (zh) * 2011-03-08 2014-09-17 中国人民解放军军事医学科学院放射与辐射医学研究所 一种催眠药的新多晶型β
RU2595971C2 (ru) 2011-09-06 2016-08-27 Бритиш Америкэн Тобэкко (Инвестментс) Лимитед Нагревание курительного материала
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
GB2533135B (en) 2014-12-11 2020-11-11 Nicoventures Holdings Ltd Aerosol provision systems
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
KR20210009450A (ko) 2016-04-27 2021-01-26 니코벤처스 트레이딩 리미티드 전자 에어로졸 제공 시스템 및 전자 에어로졸 제공 시스템을 위한 증기화기

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472528B1 (en) 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en) * 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
IL148242A0 (en) * 1999-09-02 2002-09-12 Neurocrine Biosciences Inc Polymorphs of n-methyl-n(3-(3-[2 thienylcarbonyl] pyrazol-[1, 5-a]-pyrimidin-7-yl} phenyl) acetamide, pharmaceutical compositions containing the same and processes for the preparation thereof
JP2001177971A (ja) * 1999-12-20 2001-06-29 Auto Network Gijutsu Kenkyusho:Kk 回転接続装置
BR0313695A (pt) * 2002-08-26 2005-06-21 Neurocrine Biosciences Inc Polimorfo de n-metil-n-(3-{3-[2-tienil carbonil]pirazol-[1,5-alfa]pirimidin-7-il}fenil) acetamida e composições e processos relacionados ao mesmo

Also Published As

Publication number Publication date
JP2005538149A (ja) 2005-12-15
IL166621A0 (en) 2006-01-15
JP2010070561A (ja) 2010-04-02
US7459458B2 (en) 2008-12-02
HK1071373A1 (en) 2005-07-15
EA200500421A1 (ru) 2005-08-25
AP2005003220A0 (en) 2005-03-31
DE60309332T2 (de) 2007-05-24
ECSP055703A (es) 2005-05-30
PE20040979A1 (es) 2005-01-07
AR044191A1 (es) 2005-09-07
KR101063033B1 (ko) 2011-09-07
PL374436A1 (en) 2005-10-17
AU2003268212B2 (en) 2008-08-14
AU2003268212A1 (en) 2004-03-11
DK1532152T3 (da) 2007-02-26
IS7769A (is) 2005-03-23
TWI288135B (en) 2007-10-11
US20040116446A1 (en) 2004-06-17
ZA200501125B (en) 2006-07-26
ATE343581T1 (de) 2006-11-15
MA27519A1 (fr) 2005-09-01
PT1532152E (pt) 2007-02-28
CA2493359C (fr) 2009-10-27
CN1678614A (zh) 2005-10-05
TW200406404A (en) 2004-05-01
US20050153988A1 (en) 2005-07-14
JP4522859B2 (ja) 2010-08-11
WO2004018476A1 (fr) 2004-03-04
ES2274260T3 (es) 2007-05-16
US6903106B2 (en) 2005-06-07
EP1532152B1 (fr) 2006-10-25
TNSN05058A1 (en) 2007-05-14
KR20050059082A (ko) 2005-06-17
HRP20050288A2 (en) 2006-10-31
EP1532152A1 (fr) 2005-05-25
DE60309332D1 (de) 2006-12-07
OA12917A (en) 2006-10-13
CN1319974C (zh) 2007-06-06
MXPA05002251A (es) 2005-06-08
BR0313695A (pt) 2005-06-21
NO20050615L (no) 2005-03-22
IL166621A (en) 2012-02-29
NZ538027A (en) 2007-08-31

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