CA2488782A1 - Vaccine comprising mixtures of multivalent meningococcal outer membrane vesciles - Google Patents
Vaccine comprising mixtures of multivalent meningococcal outer membrane vesciles Download PDFInfo
- Publication number
- CA2488782A1 CA2488782A1 CA002488782A CA2488782A CA2488782A1 CA 2488782 A1 CA2488782 A1 CA 2488782A1 CA 002488782 A CA002488782 A CA 002488782A CA 2488782 A CA2488782 A CA 2488782A CA 2488782 A1 CA2488782 A1 CA 2488782A1
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- Canada
- Prior art keywords
- bleb
- meningococcal
- strain
- bactericidal activity
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000009885 systemic effect Effects 0.000 description 1
- 101150101515 tbpl2 gene Proteins 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0213622.4 | 2002-06-13 | ||
| GBGB0213622.4A GB0213622D0 (en) | 2002-06-13 | 2002-06-13 | Vaccine Corporation |
| PCT/EP2003/006094 WO2003105890A2 (en) | 2002-06-13 | 2003-06-10 | Vaccine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2488782A1 true CA2488782A1 (en) | 2003-12-24 |
Family
ID=9938532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002488782A Abandoned CA2488782A1 (en) | 2002-06-13 | 2003-06-10 | Vaccine comprising mixtures of multivalent meningococcal outer membrane vesciles |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060110412A1 (https=) |
| EP (1) | EP1565211A2 (https=) |
| JP (1) | JP2005531614A (https=) |
| KR (1) | KR20050049431A (https=) |
| CN (1) | CN100387298C (https=) |
| AR (1) | AR040204A1 (https=) |
| AU (1) | AU2003236734A1 (https=) |
| BR (1) | BR0311777A (https=) |
| CA (1) | CA2488782A1 (https=) |
| CL (1) | CL2003001192A1 (https=) |
| CU (1) | CU23552A1 (https=) |
| GB (1) | GB0213622D0 (https=) |
| MX (1) | MXPA04012568A (https=) |
| NO (1) | NO20050132L (https=) |
| NZ (1) | NZ560766A (https=) |
| PE (1) | PE20040562A1 (https=) |
| RU (1) | RU2005100509A (https=) |
| UY (1) | UY27843A1 (https=) |
| WO (1) | WO2003105890A2 (https=) |
| ZA (1) | ZA200409547B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6936261B2 (en) | 2000-07-27 | 2005-08-30 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| GB2414667A (en) * | 2004-06-03 | 2005-12-07 | Isis Innovation | Vaccine compositions of N. meningitidis PorA and FetA antigens |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| ES2616294T3 (es) | 2005-01-27 | 2017-06-12 | Children's Hospital & Research Center At Oakland | Vacunas de vesículas basadas en GNA1870 para protección de amplio espectro contra enfermedades provocadas por Neisseria meningitidis |
| PL1973564T3 (pl) * | 2005-12-22 | 2017-04-28 | Glaxosmithkline Biologicals S.A. | Szczepionki zawierające koniugaty polisacharydu otoczkowego streptococcus pneumoniae |
| US8945582B2 (en) | 2006-09-07 | 2015-02-03 | Glaxosmithkline Biologicals S.A. | Vaccine |
| WO2009050586A1 (en) | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| EP2217250A4 (en) | 2007-11-09 | 2011-01-05 | California Inst Of Techn | IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS |
| EP2235531B1 (en) * | 2008-02-01 | 2015-01-14 | Sanofi Pasteur Limited | Assay for diagnosing streptococcus pneumoniae |
| PT2268618E (pt) | 2008-03-03 | 2015-10-12 | Novartis Ag | Compostos e composições moduladores da actividade tlr |
| JP2012512240A (ja) | 2008-12-17 | 2012-05-31 | ノバルティス アーゲー | ヘモグロビン受容体を含む髄膜炎菌ワクチン |
| CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| CN102740882A (zh) | 2009-08-27 | 2012-10-17 | 诺华有限公司 | 含有铝、寡核苷酸和聚阳离子的佐剂 |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| JP5860402B2 (ja) * | 2009-10-08 | 2016-02-16 | イオン メディックス インコーポレイテッド | 室内空気由来細胞外ベシクルを含む組成物及びその用途 |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| SG10201501980SA (en) | 2009-12-15 | 2015-05-28 | Novartis Ag | Homogeneous suspension of immunopotentiating compounds and uses thereof |
| CN102802664B (zh) * | 2009-12-22 | 2017-04-05 | 赛诺菲巴斯德有限公司 | 免疫原性组合物 |
| CN102802662A (zh) | 2010-03-18 | 2012-11-28 | 诺华有限公司 | 用于脑膜炎球菌血清组b的含佐剂疫苗 |
| AU2011232421B2 (en) | 2010-03-23 | 2015-08-13 | Novartis Ag | Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| WO2011127302A2 (en) * | 2010-04-07 | 2011-10-13 | Yue Shen | Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems |
| BR112013005626B1 (pt) * | 2010-09-10 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição |
| EP2707009A1 (en) | 2011-05-12 | 2014-03-19 | Novartis AG | Antipyretics to enhance tolerability of vesicle-based vaccines |
| EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR |
| JP5957541B2 (ja) | 2012-02-02 | 2016-07-27 | ノバルティス アーゲー | 髄膜炎菌における増加したタンパク質発現のためのプロモータ |
| JP2015517089A (ja) | 2012-03-08 | 2015-06-18 | ノバルティス アーゲー | タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ |
| MX357538B (es) | 2012-06-14 | 2018-07-13 | Novartis Ag | Vacunas para meningococo de serogrupo x. |
| US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
| WO2016201342A1 (en) | 2015-06-10 | 2016-12-15 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| JP6918365B2 (ja) | 2015-08-19 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 脂質化ｐｓａ組成物および方法 |
| EP3484441A4 (en) | 2016-07-15 | 2020-03-18 | President and Fellows of Harvard College | GLYCOLIPID COMPOSITIONS AND METHOD FOR USE |
| US12161707B2 (en) | 2016-09-02 | 2024-12-10 | Glaxosmithkline Biologicals Sa | Vaccines for Neisseria gonorrhoeae |
| AU2021364838A1 (en) * | 2020-10-23 | 2023-06-08 | Omvax, Inc. | Compositions and methods for vaccination against neisseria gonorrhoeae |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL338146A1 (en) * | 1997-07-17 | 2000-09-25 | North American Vaccine | Immunogenic complex combinations consisting of meningococcal porine of b group and h. influenzae polysaccharide |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| US6936261B2 (en) * | 2000-07-27 | 2005-08-30 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
-
2002
- 2002-06-13 GB GBGB0213622.4A patent/GB0213622D0/en not_active Ceased
-
2003
- 2003-06-10 RU RU2005100509/13A patent/RU2005100509A/ru not_active Application Discontinuation
- 2003-06-10 CL CL200301192A patent/CL2003001192A1/es unknown
- 2003-06-10 EP EP03735599A patent/EP1565211A2/en not_active Ceased
- 2003-06-10 CN CNB038162822A patent/CN100387298C/zh not_active Expired - Fee Related
- 2003-06-10 JP JP2004512791A patent/JP2005531614A/ja active Pending
- 2003-06-10 CA CA002488782A patent/CA2488782A1/en not_active Abandoned
- 2003-06-10 US US10/529,064 patent/US20060110412A1/en not_active Abandoned
- 2003-06-10 MX MXPA04012568A patent/MXPA04012568A/es not_active Application Discontinuation
- 2003-06-10 BR BR0311777-4A patent/BR0311777A/pt not_active IP Right Cessation
- 2003-06-10 KR KR1020047019991A patent/KR20050049431A/ko not_active Ceased
- 2003-06-10 WO PCT/EP2003/006094 patent/WO2003105890A2/en not_active Ceased
- 2003-06-10 NZ NZ560766A patent/NZ560766A/en not_active IP Right Cessation
- 2003-06-10 AU AU2003236734A patent/AU2003236734A1/en not_active Abandoned
- 2003-06-11 AR ARP030102096A patent/AR040204A1/es not_active Application Discontinuation
- 2003-06-11 UY UY27843A patent/UY27843A1/es unknown
- 2003-06-11 PE PE2003000583A patent/PE20040562A1/es not_active Application Discontinuation
-
2004
- 2004-11-25 ZA ZA200409547A patent/ZA200409547B/en unknown
- 2004-12-10 CU CU20040285A patent/CU23552A1/es active IP Right Grant
-
2005
- 2005-01-11 NO NO20050132A patent/NO20050132L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003105890A2 (en) | 2003-12-24 |
| AR040204A1 (es) | 2005-03-16 |
| CU23552A1 (es) | 2010-07-20 |
| RU2005100509A (ru) | 2006-06-10 |
| GB0213622D0 (en) | 2002-07-24 |
| NO20050132L (no) | 2005-02-11 |
| BR0311777A (pt) | 2005-03-29 |
| AU2003236734A1 (en) | 2003-12-31 |
| PE20040562A1 (es) | 2004-10-19 |
| UY27843A1 (es) | 2003-12-31 |
| WO2003105890A3 (en) | 2004-03-25 |
| MXPA04012568A (es) | 2005-09-21 |
| CN1668329A (zh) | 2005-09-14 |
| CN100387298C (zh) | 2008-05-14 |
| US20060110412A1 (en) | 2006-05-25 |
| CL2003001192A1 (es) | 2005-01-07 |
| ZA200409547B (en) | 2006-07-26 |
| KR20050049431A (ko) | 2005-05-25 |
| NO20050132D0 (no) | 2005-01-11 |
| JP2005531614A (ja) | 2005-10-20 |
| EP1565211A2 (en) | 2005-08-24 |
| NZ560766A (en) | 2009-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |