CA2485346C - Human adam-10 inhibitors - Google Patents
Human adam-10 inhibitors Download PDFInfo
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- CA2485346C CA2485346C CA2485346A CA2485346A CA2485346C CA 2485346 C CA2485346 C CA 2485346C CA 2485346 A CA2485346 A CA 2485346A CA 2485346 A CA2485346 A CA 2485346A CA 2485346 C CA2485346 C CA 2485346C
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Classifications
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/78—Halides of sulfonic acids
- C07C309/86—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/87—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
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- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
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| US60/388,326 | 2002-06-12 | ||
| PCT/US2003/018262 WO2003106381A2 (en) | 2002-06-12 | 2003-06-11 | Human adam-10 inhibitors |
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| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US7629341B2 (en) | 2002-06-12 | 2009-12-08 | Symphony Evolution, Inc. | Human ADAM-10 inhibitors |
| EP1613269B1 (en) | 2003-04-04 | 2015-02-25 | Incyte Corporation | Compositions, methods and kits relating to her-2 cleavage |
| EP1623995A1 (en) * | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Inhibitors of L1 and ADAM10 for the treatment of carcinomas |
| DK1805158T3 (en) | 2004-10-29 | 2018-08-06 | Kalypsys Inc | SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| CA2604883A1 (en) * | 2005-04-07 | 2006-10-19 | Albert Lai | Adam10 in cancer diagnosis, detection and treatment |
| US7863276B2 (en) * | 2005-10-25 | 2011-01-04 | Kalypsys, Inc | Salts of modulators of PPAR and methods of treating metabolic disorders |
| WO2007084488A2 (en) | 2006-01-13 | 2007-07-26 | Vanderbilt University | Adam10 and its uses related to infection |
| CN100506804C (zh) * | 2006-01-26 | 2009-07-01 | 于学敏 | 羟苯磺酸烷基吡嗪药物及其制备方法和应用 |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| TW200745059A (en) * | 2006-05-16 | 2007-12-16 | Kalypsys Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| WO2008091863A1 (en) * | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| WO2009052200A2 (en) * | 2007-10-16 | 2009-04-23 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| EP2344453B1 (en) | 2008-10-09 | 2016-12-28 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
| CN102639134A (zh) * | 2009-10-01 | 2012-08-15 | 和谐进化股份有限公司 | 使用基质金属蛋白酶-2抑制剂治疗动脉瘤样扩张、血管壁薄弱、特别是腹主动脉瘤和胸主动脉瘤的方法 |
| US20130109672A1 (en) | 2010-04-29 | 2013-05-02 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Activators of human pyruvate kinase |
| JP5888667B2 (ja) * | 2010-04-30 | 2016-03-22 | 国立大学法人名古屋大学 | Ａｄａｍ作用阻害物質のスクリーニング方法、仮足の保持方法、仮足保持剤、仮足の制御物質のスクリーニング方法、及びａｄａｍ作用阻害剤 |
| EP2637679A4 (en) | 2010-11-09 | 2015-09-23 | Univ Chicago | ROLE OF ADAM10 AND ITS RELEVANCE TO DISEASES AND THERAPEUTICS |
| WO2014028334A1 (en) * | 2012-08-11 | 2014-02-20 | Symphony Evolution, Inc. | Selective mmp inhibitors |
| US20170038382A1 (en) * | 2014-01-24 | 2017-02-09 | Ntercept, Llc | Methods and compositions for immune dis-inhibition |
| CN106999550B (zh) | 2014-10-03 | 2023-02-28 | 纳米提克斯有限责任公司 | 用于抑制可溶生物分子的生物活性的组合物以及方法 |
| CN116999396A (zh) | 2015-07-29 | 2023-11-07 | 纳米提克斯有限责任公司 | 用于清除可溶性生物分子的模块化组合物及其相关方法 |
| IL299915A (en) | 2017-01-04 | 2023-03-01 | Nanotics Llc | Methods for assembling cleaning particles |
| CN108947850B (zh) * | 2018-07-23 | 2021-05-18 | 蚌埠中实化学技术有限公司 | 一种3,4,5-三氟苯胺的制备方法 |
| JP7754723B2 (ja) | 2019-05-14 | 2025-10-15 | ウェアウルフ セラピューティクス， インコーポレイテッド | 分離部分及びその使用方法 |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| CN113563235B (zh) * | 2021-07-28 | 2023-04-11 | 上海毕得医药科技股份有限公司 | 一种3-(卤代苯氧基)苯磺酰氯衍生物的合成方法 |
| US20250177333A1 (en) * | 2022-03-08 | 2025-06-05 | Nova Southeastern University | Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10) |
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| GB1016245A (en) | 1962-11-06 | 1966-01-05 | Ici Ltd | Manufacture of polysulphones |
| US4213775A (en) * | 1977-07-28 | 1980-07-22 | Ube Industries, Ltd. | Diphenyl ether derivatives and herbicidal compositions containing the same |
| DE3107700A1 (de) * | 1981-02-28 | 1982-09-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von aromatischen sulfohalogeniden |
| EP0594590B1 (en) | 1990-03-01 | 1995-09-06 | The Upjohn Company | Ruminal bacterium for preventing acute lactic acidosis |
| DE4015834A1 (de) * | 1990-05-17 | 1991-11-21 | Bayer Ag | Phenoxyphenylsulfonylverbindungen |
| US5215549A (en) | 1991-05-08 | 1993-06-01 | Mobil Oil Corporation | Thioester derived hindered phenols and aryl-amines as antioxidant and antiwear additives |
| DE4327026A1 (de) | 1993-08-12 | 1995-02-16 | Bayer Ag | Arylsulfonyloxyphosphonsäurederivate |
| PT821671E (pt) | 1995-04-20 | 2001-04-30 | Pfizer | Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf |
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-
2003
- 2003-06-11 US US10/518,110 patent/US7629341B2/en not_active Expired - Fee Related
- 2003-06-11 ES ES03736979T patent/ES2425013T3/es not_active Expired - Lifetime
- 2003-06-11 EP EP11188701A patent/EP2428509A1/en not_active Withdrawn
- 2003-06-11 JP JP2004513217A patent/JP4718172B2/ja not_active Expired - Fee Related
- 2003-06-11 EP EP03736979.0A patent/EP1511488B1/en not_active Expired - Lifetime
- 2003-06-11 CA CA2485346A patent/CA2485346C/en not_active Expired - Fee Related
- 2003-06-11 AU AU2003237532A patent/AU2003237532B2/en not_active Ceased
- 2003-06-11 WO PCT/US2003/018262 patent/WO2003106381A2/en not_active Ceased
- 2003-06-11 EP EP11188699A patent/EP2436676A1/en not_active Withdrawn
-
2009
- 2009-10-23 US US12/605,118 patent/US7989661B2/en not_active Expired - Fee Related
- 2009-10-28 AU AU2009230801A patent/AU2009230801A1/en not_active Abandoned
-
2010
- 2010-06-22 JP JP2010142096A patent/JP2010265276A/ja active Pending
-
2011
- 2011-06-23 US US13/167,128 patent/US20120071653A1/en not_active Abandoned
-
2012
- 2012-07-03 US US13/541,503 patent/US20130144056A1/en not_active Abandoned
-
2014
- 2014-03-21 US US14/221,937 patent/US20140206865A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7629341B2 (en) | 2009-12-08 |
| JP2005533789A (ja) | 2005-11-10 |
| AU2009230801A1 (en) | 2009-11-19 |
| ES2425013T3 (es) | 2013-10-10 |
| EP2436676A1 (en) | 2012-04-04 |
| AU2003237532B2 (en) | 2009-07-30 |
| JP4718172B2 (ja) | 2011-07-06 |
| EP2428509A1 (en) | 2012-03-14 |
| EP1511488A4 (en) | 2008-11-19 |
| WO2003106381A3 (en) | 2004-04-15 |
| US20120071653A1 (en) | 2012-03-22 |
| US20100105953A1 (en) | 2010-04-29 |
| US7989661B2 (en) | 2011-08-02 |
| EP1511488B1 (en) | 2013-05-22 |
| US20140206865A1 (en) | 2014-07-24 |
| EP1511488A2 (en) | 2005-03-09 |
| JP2010265276A (ja) | 2010-11-25 |
| AU2003237532A1 (en) | 2003-12-31 |
| US20130144056A1 (en) | 2013-06-06 |
| WO2003106381A2 (en) | 2003-12-24 |
| CA2485346A1 (en) | 2003-12-24 |
| US20060199820A1 (en) | 2006-09-07 |
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