CA2477749A1 - Artificial receptors, building blocks, and methods - Google Patents

Artificial receptors, building blocks, and methods Download PDF

Info

Publication number
CA2477749A1
CA2477749A1 CA002477749A CA2477749A CA2477749A1 CA 2477749 A1 CA2477749 A1 CA 2477749A1 CA 002477749 A CA002477749 A CA 002477749A CA 2477749 A CA2477749 A CA 2477749A CA 2477749 A1 CA2477749 A1 CA 2477749A1
Authority
CA
Canada
Prior art keywords
amino
phenoxy
methyl
butyric acid
ethylcarbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002477749A
Other languages
English (en)
French (fr)
Inventor
Robert E. Carlson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Receptors LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2477749A1 publication Critical patent/CA2477749A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B01J2219/00662—Two-dimensional arrays within two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00—Assays involving molecular imprinted polymers/polymers created around a molecular template
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer
CA002477749A 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods Abandoned CA2477749A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US36098002P 2002-03-01 2002-03-01
US60/360,980 2002-03-01
US36260002P 2002-03-08 2002-03-08
US60/362,600 2002-03-08
US37565502P 2002-04-26 2002-04-26
US60/375,655 2002-04-26
US40060502P 2002-08-02 2002-08-02
US60/400,605 2002-08-02
US10/244,727 US7504364B2 (en) 2002-03-01 2002-09-16 Methods of making arrays and artificial receptors
US10/244,727 2002-09-16
PCT/US2003/005328 WO2003074990A2 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods

Publications (1)

Publication Number Publication Date
CA2477749A1 true CA2477749A1 (en) 2003-09-12

Family

ID=29255676

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002477749A Abandoned CA2477749A1 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods

Country Status (11)

Country Link
US (5) US7504364B2 (US07964535-20110621-C00027.png)
EP (1) EP1483578B1 (US07964535-20110621-C00027.png)
JP (1) JP4988147B2 (US07964535-20110621-C00027.png)
CN (1) CN100533145C (US07964535-20110621-C00027.png)
AT (1) ATE538379T1 (US07964535-20110621-C00027.png)
AU (2) AU2003213204B2 (US07964535-20110621-C00027.png)
CA (1) CA2477749A1 (US07964535-20110621-C00027.png)
IL (3) IL163686A0 (US07964535-20110621-C00027.png)
MX (1) MXPA04008467A (US07964535-20110621-C00027.png)
NZ (1) NZ535080A (US07964535-20110621-C00027.png)
WO (1) WO2003074990A2 (US07964535-20110621-C00027.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111718321A (zh) * 2020-06-18 2020-09-29 中国农业科学院农业质量标准与检测技术研究所 一种二噁英抗体及其制备方法与应用

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US7469076B2 (en) 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
PL1613420T3 (pl) * 2003-03-25 2016-03-31 Instraction Gmbh Sposób selektywnego wiązania substratu do sorbentów poprzez co najmniej dwuwartościowe wiązania
EP1613737A4 (en) 2003-03-28 2008-12-03 Receptors Llc ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS
JP4716990B2 (ja) * 2003-09-03 2011-07-06 レセプターズ エルエルシー コンビナトーリアル人工受容体を使用する方法
CA2537264A1 (en) * 2003-09-03 2005-03-17 Receptors Llc Building blocks for artificial receptors
JP4711326B2 (ja) * 2003-12-22 2011-06-29 キヤノン株式会社 検定試料および検量線の作製方法
EP1789797A1 (en) 2004-09-03 2007-05-30 Receptors LLC Combinatorial artifical receptors including tether building blocks
WO2006029383A2 (en) 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
US7879764B2 (en) * 2004-12-28 2011-02-01 Intel Corporation Electrically active combinatorial chemical (EACC) chip for biochemical analyte detection
JP2011511263A (ja) * 2007-11-29 2011-04-07 レセプターズ エルエルシー コンビナトリアル人工受容体を用いたセンサ
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CA2763685A1 (en) * 2009-05-29 2010-12-02 The Board Of Regents Of The University Of Texas System Peptoid ligands for isolation and treatment of autoimmune t-cells
JP5828837B2 (ja) * 2009-06-02 2015-12-09 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 神経変性疾患を有する被験者において抗体により認識される小分子の同定
US8759259B2 (en) * 2009-10-16 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
CN106198656B (zh) 2010-08-18 2018-12-11 生命科技股份有限公司 用于电化学检测装置的微孔的化学涂层
WO2012135034A1 (en) 2011-03-25 2012-10-04 Receptors Llc Fiber with microbial removal, micro-biocidal, or static growth capability
US8900352B2 (en) 2011-07-06 2014-12-02 Northwestern University System and method for generating and/or screening potential metal-organic frameworks
WO2013058845A1 (en) * 2011-07-06 2013-04-25 Northwestern University System and method for generating and/or screening potential metal-organic frameworks
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
CN105229467A (zh) * 2013-03-15 2016-01-06 普林斯顿大学理事会 快速且灵敏的分析物测量测定法
WO2022122035A1 (zh) * 2020-12-11 2022-06-16 上海领泰生物医药科技有限公司 凝血因子XIa抑制剂及其制备方法和应用

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US5340474A (en) * 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5225374A (en) * 1988-05-13 1993-07-06 The United States Of America As Represented By The Secretary Of The Navy Method of fabricating a receptor-based sensor
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
AU6753390A (en) * 1989-10-02 1991-04-28 University Of Michigan, The Bioanalytical detection system
JP3283041B2 (ja) * 1990-07-13 2002-05-20 学校法人藤田学園 人工抗体
DE4034565A1 (de) 1990-10-26 1992-04-30 Inst Halbleiterphysik Gmbh Stereospezifischer sensor fuer die bestimmung von zuckern
JPH06510363A (ja) * 1990-10-29 1994-11-17 ディカルブ　プラント　ジェネティクス 磁気性粒子を使用する生物学的材料の単離
US5178673A (en) 1991-04-12 1993-01-12 Union Carbide Chemicals & Plastics Technology Corporation Investment casting compositions and processes for the manufacture and use thereof
US5159656A (en) * 1991-04-29 1992-10-27 Advanced Technology Consortium, Inc. Optical fiber scanning/imaging/printing system
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5324633A (en) * 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5667988A (en) * 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
WO1993025910A1 (en) * 1992-06-05 1993-12-23 Pharmacia Biosensor Ab Assay for multiple analytes with co-immobilized ligands
US5512435A (en) * 1993-02-05 1996-04-30 Renschler; Markus F. Receptor-binding antiproliferative peptides
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
EP0699051A4 (en) * 1993-05-20 1998-11-25 Univ California MACROMOLECULAR CONTRAST AGENT FOR MAGNETIC RESONANCE IMAGING
WO1995002566A1 (en) 1993-07-16 1995-01-26 Ontogen Corporation Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses
DE4335729A1 (de) * 1993-10-20 1995-04-27 Boehringer Mannheim Gmbh Verwendung von mit enzymatisch abspaltbaren Schutzgruppen versehenen Nukleosiden und Nukleosid-Derivaten in der Synthese von Oligonukleotiden
US5942393A (en) * 1993-12-29 1999-08-24 The Regents Of The University Of California Method for the detection of the presence or absence of methylthioadenosine phosphorylase (MTASE) in a cell sample by detection of the presence or absence of MTASE encoding nucleic acid in the cell sample
ZA95260B (en) * 1994-01-13 1995-09-28 Univ Columbia Synthetic receptors libraries and uses thereof
US5453533A (en) * 1994-04-14 1995-09-26 The University Of Alabama At Birmingham Inhibitors of influenza virus neuraminidase and methods of making and using the same
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US6419881B1 (en) * 1994-10-18 2002-07-16 Symyx Technologies, Inc. Combinatorial arrays of organometallic compounds and catalysts
US5998594A (en) * 1994-12-30 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use
US5990163A (en) * 1995-01-13 1999-11-23 The Salk Institute For Biological Studies Selective modulation of processes mediated by retinoid X receptors, and compounds useful therefor
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
WO1996028538A1 (en) * 1995-03-10 1996-09-19 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5925529A (en) * 1995-06-07 1999-07-20 The Regents Of The University Of California Method for discovery of peptide agonists
DE19527155C2 (de) 1995-07-25 1998-12-10 Deutsches Krebsforsch Verfahren zur Sequenzierung durch Oligomerhybridisierung
US6168912B1 (en) * 1996-01-23 2001-01-02 Martek Biosciences Corporation Method and kit for making a multidimensional combinatorial chemical library
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
IT1284025B1 (it) * 1996-06-18 1998-05-08 Italtel Spa Convertitore di frequenza per applicazioni alle onde radio millimetriche
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5770380A (en) * 1996-09-13 1998-06-23 University Of Pittsburgh Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
AU4585197A (en) 1996-09-20 1998-04-14 President And Fellows Of Harvard College Combinatorial approach for generating novel coordination complexes
US6875620B1 (en) * 1996-10-31 2005-04-05 Agilent Technologies, Inc. Tiling process for constructing a chemical array
WO1998022795A1 (en) * 1996-11-22 1998-05-28 The Regents Of The University Of California Chemical microsensors for detection of explosives and chemical warfare agents
US6699719B2 (en) * 1996-11-29 2004-03-02 Proteomic Systems, Inc. Biosensor arrays and methods
ATE290205T1 (de) * 1996-12-12 2005-03-15 Prolume Ltd Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen
JP2001517300A (ja) * 1996-12-17 2001-10-02 アフィメトリックス・インコーポレーテッド リソグラフィ・マスクの設計および基板上での多様なプローブの合成
US6083763A (en) * 1996-12-31 2000-07-04 Genometrix Inc. Multiplexed molecular analysis apparatus and method
US6310191B1 (en) * 1998-02-02 2001-10-30 Cosmix Molecular Biologicals Gmbh Generation of diversity in combinatorial libraries
US5837860A (en) * 1997-03-05 1998-11-17 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US7144627B2 (en) * 1997-03-12 2006-12-05 William Marsh Rice University Multi-layer nanoshells comprising a metallic or conducting shell
US6083758A (en) * 1997-04-09 2000-07-04 California Institute Of Technology Method for screening peptides for metal coordinating properties and fluorescent chemosensors derived therefrom
JP4308918B2 (ja) * 1997-04-16 2009-08-05 スローン−ケッタリング インスティトゥート フォア キャンサー リサーチ （２，６）−ＳＴエピトープクラスターを有するα−Ｏ−結合複合糖質、その製造方法および使用
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5993653C1 (en) * 1997-08-11 2001-11-06 Phenomenex Composition and column used in hplc
US6410585B1 (en) * 1997-08-28 2002-06-25 Scott D. Larsen Inhibitors of protein tyrosine phosphatase
WO1999025384A2 (en) 1997-11-17 1999-05-27 University Of Miami Multimeric tethered ligands and their use in receptor-ligand interactions
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
FR2774092B1 (fr) * 1998-01-26 2000-02-18 Air Liquide Procede de preparation de polyazacycloalcanes greffes sur gel de silice et utilisation des composes greffes
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6428811B1 (en) * 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US7101575B2 (en) * 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
JP2002507577A (ja) * 1998-03-25 2002-03-12 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ 三量体抗原性ｏ−結合複合糖ペプチド、その製造方法及びその使用
US6316616B1 (en) * 1998-04-02 2001-11-13 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
US6111123A (en) * 1998-04-20 2000-08-29 The Regents Of The University Of Michigan Salicylaldimine-crown ether ditopic receptor molecules
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
AU4829099A (en) * 1998-06-22 2000-01-10 Regents Of The University Of California, The Triggered optical biosensor
ES2292250T5 (es) * 1998-07-15 2010-09-14 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Envolventes de polielectrolitos sobre plantillas (templates) biologicas.
US6346189B1 (en) * 1998-08-14 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube structures made using catalyst islands
EP1405666B1 (de) 1998-08-28 2007-03-21 febit biotech GmbH Träger für Analytbestimmungsverfahren und Verfahren zur Herstellung des Trägers
DE19839538A1 (de) 1998-08-31 2000-03-02 Gluesenkamp Karl Heinz Herstellung von maßgeschneiderten Chromatografiematerialien über intelligenten Oberflächen
EP1115366A2 (en) 1998-09-22 2001-07-18 The Procter & Gamble Company Personal care compositions containing active proteins tethered to a water insoluble substrate
IL141383A (en) 1999-05-05 2005-11-20 Univ California Sensor containing a polymer for detecting biological agents and methods utilizing the same
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
EP1192448B1 (en) 1999-07-05 2006-09-27 Novartis AG Process of using a sensor platform
US6346423B1 (en) * 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
BR0013171A (pt) * 1999-07-29 2002-05-28 Epix Medical Inc Agentes multimericos para formação de imagem de objetivação através de ligação multi-local
US7854934B2 (en) 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
US7824687B2 (en) * 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
US6543639B1 (en) * 1999-08-26 2003-04-08 A & A Global Industries, Inc. Animated candy dispenser and methods
DE19943743C2 (de) 1999-09-03 2002-02-07 Jerini Biotools Gmbh Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
US6656432B1 (en) 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
US6627396B1 (en) * 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
US6372907B1 (en) * 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
US7195780B2 (en) * 2002-10-21 2007-03-27 University Of Florida Nanoparticle delivery system
US6699677B1 (en) 1999-12-20 2004-03-02 Chemocentryx, Inc. Tethered ligands and methods of use
DE10001172A1 (de) * 2000-01-13 2001-07-26 Max Planck Gesellschaft Templatieren von Feststoffpartikeln mit Polymermultischichten
AU2001236757A1 (en) * 2000-02-07 2001-08-14 President And Fellows Of Harvard College Method for analysis of reaction products
EP1385869A2 (en) * 2000-02-08 2004-02-04 The Regents Of The University Of Michigan Protein mapping
WO2001077684A2 (en) * 2000-04-10 2001-10-18 The Scripps Research Institute Proteomic analysis using activity-based probe libraries
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
CN1137999C (zh) * 2000-07-04 2004-02-11 清华大学 集成式微阵列装置
US6584411B1 (en) * 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
PT1305109E (pt) * 2000-08-02 2004-11-30 Max Planck Gesellschaft Producao de capsulas de polielectrolito atraves de precipitacao de superficie
US6977155B2 (en) * 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
CA2420523C (en) * 2000-08-28 2010-05-25 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Controlled and sustained release properties of polyelectrolyte multilayer capsules
EP1197755A1 (en) * 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
DE60141171D1 (de) 2000-11-27 2010-03-11 Intelligent Medical Devices Ll Klinische intelligente diagnostische vorrichtungen und verfahren
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
EP1350029B1 (en) * 2001-01-08 2014-09-10 President and Fellows of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
US6543936B2 (en) * 2001-04-24 2003-04-08 Daniel Uzbelger Feldman Apparatus for diagnosis and/or treatment in the field of dentistry using fluoroscopic and conventional radiography
EP1458242A4 (en) * 2001-07-06 2006-06-07 Sloan Kettering Inst Cancer COMPREHENSIVE CONJUGATED VACCINE AGAINST CANCER
US6698201B1 (en) * 2001-08-16 2004-03-02 Zyvex Corporation Cascaded bimorph rotary actuator
EP1300684A1 (en) 2001-10-08 2003-04-09 Barts and The London National Health Service Trust Homogenous ligand binding assay
AR036833A1 (es) 2001-10-18 2004-10-06 Bayer Corp Anticuerpos humanos que se unen a mn y tienen actividad neutralizante de la adhesion celular.
US20030156991A1 (en) * 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
JP2003149242A (ja) 2001-11-09 2003-05-21 Gifu Univ 抗体検出方法及び抗原マイクロアレイ
GB0127989D0 (en) 2001-11-22 2002-01-16 Glaxo Group Ltd Medicament dispensing system
US7141368B2 (en) * 2002-01-30 2006-11-28 Agilent Technologies, Inc. Multi-directional deposition in array fabrication
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
ITRM20020133U1 (it) * 2002-07-15 2004-01-16 Plast Wood S R L Complesso di elementi per l'assiemaggio di strutture.
US20060051802A1 (en) * 2002-09-16 2006-03-09 Receptors Llc Artificial receptors, building blocks, and methods
AU2003284227A1 (en) * 2002-10-15 2004-05-04 The Regents Of The University Of Michigan Multidimensional protein separation system
US7256052B2 (en) * 2002-10-18 2007-08-14 Exxonmobil Chemical Patents Inc. Chemical reaction and analysis system
US20040185473A1 (en) 2002-12-17 2004-09-23 Affymetrix, Inc. Releasable polymer arrays
WO2006017180A2 (en) 2004-07-09 2006-02-16 Progenics Pharmaceuticals, Inc. Glycopeptide dimers and uses thereof
GB0426823D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111718321A (zh) * 2020-06-18 2020-09-29 中国农业科学院农业质量标准与检测技术研究所 一种二噁英抗体及其制备方法与应用

Also Published As

Publication number Publication date
JP4988147B2 (ja) 2012-08-01
EP1483578A2 (en) 2004-12-08
EP1483578A4 (en) 2007-06-06
US20040096908A1 (en) 2004-05-20
CN1650163A (zh) 2005-08-03
US20040110303A1 (en) 2004-06-10
WO2003074990A9 (en) 2004-01-22
IL163686A (en) 2011-01-31
US20030203405A1 (en) 2003-10-30
WO2003074990A3 (en) 2004-07-29
US20040096976A1 (en) 2004-05-20
MXPA04008467A (es) 2005-06-08
EP1483578B1 (en) 2011-12-21
IL163686A0 (en) 2005-12-18
AU2009200852A1 (en) 2009-03-26
IL199259A0 (en) 2011-07-31
US20040101446A1 (en) 2004-05-27
NZ535080A (en) 2007-05-31
CN100533145C (zh) 2009-08-26
AU2003213204B2 (en) 2009-01-29
US7964535B2 (en) 2011-06-21
JP2005519124A (ja) 2005-06-30
AU2003213204A1 (en) 2003-09-16
US7504364B2 (en) 2009-03-17
WO2003074990A2 (en) 2003-09-12
ATE538379T1 (de) 2012-01-15

Similar Documents

Publication Publication Date Title
AU2003213204B2 (en) Artificial receptors, building blocks, and methods
US20100133102A1 (en) Sensors employing combinatorial artificial receptors
US7504365B2 (en) Combinatorial artificial receptors including tether building blocks
US7960311B2 (en) Methods employing combinatorial artificial receptors
WO2005036175A2 (en) Sensors employing combinatorial artificial receptors
US20070238091A1 (en) Artificial receptors, building blocks, and methods
US20040137481A1 (en) Artificial receptor building blocks, components, and kits
US20050037428A1 (en) Artificial receptors including reversibly immobilized building blocks, the building blocks, and methods
US7985715B2 (en) Combinatorial artificial receptors including peptide building blocks
ZA200406710B (en) Artificial receptors, building blocks, and methods
JP4716990B2 (ja) コンビナトーリアル人工受容体を使用する方法

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130219