CA2476115A1 - Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine d1 receptor agonists - Google Patents
Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine d1 receptor agonists Download PDFInfo
- Publication number
- CA2476115A1 CA2476115A1 CA002476115A CA2476115A CA2476115A1 CA 2476115 A1 CA2476115 A1 CA 2476115A1 CA 002476115 A CA002476115 A CA 002476115A CA 2476115 A CA2476115 A CA 2476115A CA 2476115 A1 CA2476115 A1 CA 2476115A1
- Authority
- CA
- Canada
- Prior art keywords
- dopamine
- compound
- substituted
- ester
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
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- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical class O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200478A SE0200478D0 (sv) | 2002-02-15 | 2002-02-15 | Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine D1 receptor agonist A-86929 |
| SE0200478-6 | 2002-02-15 | ||
| SE0200474A SE0200474D0 (sv) | 2002-02-17 | 2002-02-17 | Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine D1 receptor agonists Dihydrexidine and Dinapsoline |
| SE0200474-5 | 2002-02-17 | ||
| PCT/US2003/004592 WO2003070245A1 (en) | 2002-02-15 | 2003-02-14 | Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine d1 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2476115A1 true CA2476115A1 (en) | 2003-08-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002476115A Abandoned CA2476115A1 (en) | 2002-02-15 | 2003-02-14 | Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine d1 receptor agonists |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7220754B2 (enExample) |
| EP (1) | EP1480647B1 (enExample) |
| JP (1) | JP2005526728A (enExample) |
| AT (1) | ATE406896T1 (enExample) |
| AU (1) | AU2003217430B2 (enExample) |
| CA (1) | CA2476115A1 (enExample) |
| DE (1) | DE60323339D1 (enExample) |
| DK (1) | DK1480647T3 (enExample) |
| ES (1) | ES2314189T3 (enExample) |
| NO (1) | NO20043634L (enExample) |
| WO (1) | WO2003070245A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9046537B2 (en) | 2003-09-22 | 2015-06-02 | Enzo Biochem, Inc. | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain |
| CN1964713A (zh) * | 2003-12-23 | 2007-05-16 | 达法尔摩公司 | 多巴胺－受体结合化合物的共同使用 |
| US9052324B2 (en) | 2004-05-19 | 2015-06-09 | Enzo Biochem, Inc. | Compounds and assays for controlling Wnt activity |
| US8596306B2 (en) * | 2005-10-27 | 2013-12-03 | Synthetic Gas Solutions, Llc | Perfluorocarbon gas insufflation |
| EP2010541A2 (en) * | 2006-02-21 | 2009-01-07 | Purdue Research Foundation | Trans-fused chromenoisoquinolines, synthesis and methods for use |
| WO2010124005A1 (en) | 2009-04-21 | 2010-10-28 | Purdue Research Foundation | Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor |
| CN104981472A (zh) * | 2012-11-08 | 2015-10-14 | 辉瑞大药厂 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340600A (en) * | 1980-05-22 | 1982-07-20 | Smithkline Corporation | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines |
| US4282227A (en) * | 1980-05-22 | 1981-08-04 | Smithkline Corporation | Renal vasodilating 3,4-dihydroxyphenyltetrahydrothienopyridines |
| JPH02138A (ja) * | 1987-09-18 | 1990-01-05 | Banyu Pharmaceut Co Ltd | Ｌ‐ドーパ誘導体 |
| US5047536A (en) * | 1989-03-17 | 1991-09-10 | Purdue Research Foundation | Hexahydrobenzo(A)phenanthridine compounds |
| IE912999A1 (en) | 1990-09-07 | 1992-03-11 | Abbott Lab | Phenanthridine compounds |
| DE69334206D1 (de) * | 1992-05-26 | 2008-04-03 | Purdue Research Foundation | Substituierte hexahydrobenzo(a) phenanthridine |
| ATE233765T1 (de) | 1993-04-06 | 2003-03-15 | Abbott Lab | Tetracyclische verbindungen als dopamin-agonisten |
| WO1996002513A1 (en) | 1994-07-15 | 1996-02-01 | Purdue Research Foundation | Optically active isomers of dihydrexidine and its substituted analogs |
| WO1997006799A1 (en) * | 1995-08-18 | 1997-02-27 | Purdue Research Foundation | Novel fused isoquinolines as dopamine receptor ligands |
-
2003
- 2003-02-14 DE DE60323339T patent/DE60323339D1/de not_active Expired - Fee Related
- 2003-02-14 AU AU2003217430A patent/AU2003217430B2/en not_active Ceased
- 2003-02-14 CA CA002476115A patent/CA2476115A1/en not_active Abandoned
- 2003-02-14 JP JP2003569201A patent/JP2005526728A/ja active Pending
- 2003-02-14 ES ES03713475T patent/ES2314189T3/es not_active Expired - Lifetime
- 2003-02-14 EP EP03713475A patent/EP1480647B1/en not_active Expired - Lifetime
- 2003-02-14 US US10/503,796 patent/US7220754B2/en not_active Expired - Fee Related
- 2003-02-14 AT AT03713475T patent/ATE406896T1/de not_active IP Right Cessation
- 2003-02-14 DK DK03713475T patent/DK1480647T3/da active
- 2003-02-14 WO PCT/US2003/004592 patent/WO2003070245A1/en not_active Ceased
-
2004
- 2004-08-31 NO NO20043634A patent/NO20043634L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003217430A1 (en) | 2003-09-09 |
| DE60323339D1 (de) | 2008-10-16 |
| WO2003070245A1 (en) | 2003-08-28 |
| US7220754B2 (en) | 2007-05-22 |
| EP1480647B1 (en) | 2008-09-03 |
| US20050096469A1 (en) | 2005-05-05 |
| NO20043634L (no) | 2004-11-11 |
| EP1480647A4 (en) | 2005-07-13 |
| AU2003217430B2 (en) | 2008-10-23 |
| DK1480647T3 (da) | 2009-01-26 |
| JP2005526728A (ja) | 2005-09-08 |
| EP1480647A1 (en) | 2004-12-01 |
| ES2314189T3 (es) | 2009-03-16 |
| ATE406896T1 (de) | 2008-09-15 |
| WO2003070245B1 (en) | 2004-05-27 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |