ATE406896T1 - Monoester und asymmetrisch substituierte diester prodrugs der dopamin-d1-rezeptor-agonisten - Google Patents
Monoester und asymmetrisch substituierte diester prodrugs der dopamin-d1-rezeptor-agonistenInfo
- Publication number
- ATE406896T1 ATE406896T1 AT03713475T AT03713475T ATE406896T1 AT E406896 T1 ATE406896 T1 AT E406896T1 AT 03713475 T AT03713475 T AT 03713475T AT 03713475 T AT03713475 T AT 03713475T AT E406896 T1 ATE406896 T1 AT E406896T1
- Authority
- AT
- Austria
- Prior art keywords
- dopamine
- monoester
- asymmetrically substituted
- receptor agonist
- agonist prodrugs
- Prior art date
Links
- 229940098305 Dopamine D1 receptor agonist Drugs 0.000 title 1
- 239000000510 dopamine 1 receptor stimulating agent Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000005690 diesters Chemical class 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- BGOQGUHWXBGXJW-YOEHRIQHSA-N (6as,12br)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol Chemical compound N1CC2=CC=CC=C2[C@@H]2[C@@H]1CCC1=C2C=C(O)C(O)=C1 BGOQGUHWXBGXJW-YOEHRIQHSA-N 0.000 abstract 1
- REHAKLRYABHSQJ-KDOFPFPSSA-N chembl28338 Chemical compound OC1=C(O)C=C2[C@H]3C(C=C(S4)CCC)=C4CN[C@@H]3CCC2=C1 REHAKLRYABHSQJ-KDOFPFPSSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZQTSNGJHMUKLOM-ZDUSSCGKSA-N dinapsoline Chemical compound C1NCC2=CC=CC3=C2[C@@H]1C1=CC=C(O)C(O)=C1C3 ZQTSNGJHMUKLOM-ZDUSSCGKSA-N 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200478A SE0200478D0 (sv) | 2002-02-15 | 2002-02-15 | Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine D1 receptor agonist A-86929 |
| SE0200474A SE0200474D0 (sv) | 2002-02-17 | 2002-02-17 | Mono-ester and asymmetrically substituted di-ester pro-drugs of the dopamine D1 receptor agonists Dihydrexidine and Dinapsoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE406896T1 true ATE406896T1 (de) | 2008-09-15 |
Family
ID=27759833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03713475T ATE406896T1 (de) | 2002-02-15 | 2003-02-14 | Monoester und asymmetrisch substituierte diester prodrugs der dopamin-d1-rezeptor-agonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7220754B2 (enExample) |
| EP (1) | EP1480647B1 (enExample) |
| JP (1) | JP2005526728A (enExample) |
| AT (1) | ATE406896T1 (enExample) |
| AU (1) | AU2003217430B2 (enExample) |
| CA (1) | CA2476115A1 (enExample) |
| DE (1) | DE60323339D1 (enExample) |
| DK (1) | DK1480647T3 (enExample) |
| ES (1) | ES2314189T3 (enExample) |
| NO (1) | NO20043634L (enExample) |
| WO (1) | WO2003070245A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9046537B2 (en) | 2003-09-22 | 2015-06-02 | Enzo Biochem, Inc. | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain |
| CN1964713A (zh) * | 2003-12-23 | 2007-05-16 | 达法尔摩公司 | 多巴胺－受体结合化合物的共同使用 |
| US9052324B2 (en) | 2004-05-19 | 2015-06-09 | Enzo Biochem, Inc. | Compounds and assays for controlling Wnt activity |
| US8596306B2 (en) * | 2005-10-27 | 2013-12-03 | Synthetic Gas Solutions, Llc | Perfluorocarbon gas insufflation |
| EP2010541A2 (en) * | 2006-02-21 | 2009-01-07 | Purdue Research Foundation | Trans-fused chromenoisoquinolines, synthesis and methods for use |
| WO2010124005A1 (en) | 2009-04-21 | 2010-10-28 | Purdue Research Foundation | Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor |
| CN104981472A (zh) * | 2012-11-08 | 2015-10-14 | 辉瑞大药厂 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340600A (en) * | 1980-05-22 | 1982-07-20 | Smithkline Corporation | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines |
| US4282227A (en) * | 1980-05-22 | 1981-08-04 | Smithkline Corporation | Renal vasodilating 3,4-dihydroxyphenyltetrahydrothienopyridines |
| JPH02138A (ja) * | 1987-09-18 | 1990-01-05 | Banyu Pharmaceut Co Ltd | Ｌ‐ドーパ誘導体 |
| US5047536A (en) * | 1989-03-17 | 1991-09-10 | Purdue Research Foundation | Hexahydrobenzo(A)phenanthridine compounds |
| IE912999A1 (en) | 1990-09-07 | 1992-03-11 | Abbott Lab | Phenanthridine compounds |
| DE69334206D1 (de) * | 1992-05-26 | 2008-04-03 | Purdue Research Foundation | Substituierte hexahydrobenzo(a) phenanthridine |
| ATE233765T1 (de) | 1993-04-06 | 2003-03-15 | Abbott Lab | Tetracyclische verbindungen als dopamin-agonisten |
| WO1996002513A1 (en) | 1994-07-15 | 1996-02-01 | Purdue Research Foundation | Optically active isomers of dihydrexidine and its substituted analogs |
| WO1997006799A1 (en) * | 1995-08-18 | 1997-02-27 | Purdue Research Foundation | Novel fused isoquinolines as dopamine receptor ligands |
-
2003
- 2003-02-14 DE DE60323339T patent/DE60323339D1/de not_active Expired - Fee Related
- 2003-02-14 AU AU2003217430A patent/AU2003217430B2/en not_active Ceased
- 2003-02-14 CA CA002476115A patent/CA2476115A1/en not_active Abandoned
- 2003-02-14 JP JP2003569201A patent/JP2005526728A/ja active Pending
- 2003-02-14 ES ES03713475T patent/ES2314189T3/es not_active Expired - Lifetime
- 2003-02-14 EP EP03713475A patent/EP1480647B1/en not_active Expired - Lifetime
- 2003-02-14 US US10/503,796 patent/US7220754B2/en not_active Expired - Fee Related
- 2003-02-14 AT AT03713475T patent/ATE406896T1/de not_active IP Right Cessation
- 2003-02-14 DK DK03713475T patent/DK1480647T3/da active
- 2003-02-14 WO PCT/US2003/004592 patent/WO2003070245A1/en not_active Ceased
-
2004
- 2004-08-31 NO NO20043634A patent/NO20043634L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003217430A1 (en) | 2003-09-09 |
| DE60323339D1 (de) | 2008-10-16 |
| CA2476115A1 (en) | 2003-08-28 |
| WO2003070245A1 (en) | 2003-08-28 |
| US7220754B2 (en) | 2007-05-22 |
| EP1480647B1 (en) | 2008-09-03 |
| US20050096469A1 (en) | 2005-05-05 |
| NO20043634L (no) | 2004-11-11 |
| EP1480647A4 (en) | 2005-07-13 |
| AU2003217430B2 (en) | 2008-10-23 |
| DK1480647T3 (da) | 2009-01-26 |
| JP2005526728A (ja) | 2005-09-08 |
| EP1480647A1 (en) | 2004-12-01 |
| ES2314189T3 (es) | 2009-03-16 |
| WO2003070245B1 (en) | 2004-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |