CA2471891A1 - Methods of inducing or enhancing connective tissue repair - Google Patents

Methods of inducing or enhancing connective tissue repair Download PDF

Info

Publication number
CA2471891A1
CA2471891A1 CA002471891A CA2471891A CA2471891A1 CA 2471891 A1 CA2471891 A1 CA 2471891A1 CA 002471891 A CA002471891 A CA 002471891A CA 2471891 A CA2471891 A CA 2471891A CA 2471891 A1 CA2471891 A1 CA 2471891A1
Authority
CA
Canada
Prior art keywords
smad
cell
protein
variant
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002471891A
Other languages
English (en)
French (fr)
Inventor
Dan Gazit
Gadi Pelled
Gadi Turgeman
Andrea Hoffmann
Peter Eberle
Gerhard Gross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2471891A1 publication Critical patent/CA2471891A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002471891A 2001-12-27 2002-12-26 Methods of inducing or enhancing connective tissue repair Abandoned CA2471891A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34237501P 2001-12-27 2001-12-27
US60/342,375 2001-12-27
PCT/IL2002/001041 WO2003059932A2 (en) 2001-12-27 2002-12-26 Methods of inducing or enhancing connective tissue repair

Publications (1)

Publication Number Publication Date
CA2471891A1 true CA2471891A1 (en) 2003-07-24

Family

ID=23341566

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002471891A Abandoned CA2471891A1 (en) 2001-12-27 2002-12-26 Methods of inducing or enhancing connective tissue repair

Country Status (7)

Country Link
US (1) US20030228292A1 (https=)
EP (1) EP1467624A4 (https=)
JP (1) JP2005526015A (https=)
AU (1) AU2002366974A1 (https=)
CA (1) CA2471891A1 (https=)
IL (1) IL162736A0 (https=)
WO (1) WO2003059932A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6755863B2 (en) * 1999-10-08 2004-06-29 Bret A. Ferree Rotator cuff repair using engineered tissues
US7435260B2 (en) 1999-08-13 2008-10-14 Ferree Bret A Use of morphogenetic proteins to treat human disc disease
WO2005077403A1 (en) * 2004-02-04 2005-08-25 Stryker Corporation Therapeutic methods using smads
US7520888B2 (en) 2006-02-14 2009-04-21 Warsaw Orthopedic, Inc. Treatment of the vertebral column
US8016859B2 (en) 2006-02-17 2011-09-13 Medtronic, Inc. Dynamic treatment system and method of use
WO2007122823A1 (ja) * 2006-04-20 2007-11-01 Jichi Medical University ベクター産生型腫瘍標的細胞
US20100172886A1 (en) 2006-11-28 2010-07-08 University Of Southern California Method for Promoting Wound Healing
GB0820492D0 (en) 2008-11-07 2008-12-17 Sportcell Cell compositions and uses thereof
US20220039450A1 (en) * 2018-09-25 2022-02-10 Societe Des Produits Nestle S.A. Synthetic nutritional compositions tailored for infants of specific ages, and nutritional systems comprising them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
JPH10117782A (ja) * 1996-10-25 1998-05-12 Otsuka Pharmaceut Co Ltd ヒトＭａｄ関連蛋白遺伝子
AU749465B2 (en) * 1997-06-13 2002-06-27 Japanese Foundation For Cancer Research Smad6 and uses thereof
EP0950414A1 (en) * 1998-04-08 1999-10-20 Boehringer Mannheim Gmbh Use of a combination of an osteoinductive protein and a dorsalizing factor for cartilage induction
US6277636B1 (en) * 2000-09-14 2001-08-21 Isis Pharmaceuticals, Inc. Antisense inhibition of MADH6 expression

Also Published As

Publication number Publication date
WO2003059932A2 (en) 2003-07-24
EP1467624A4 (en) 2006-07-26
AU2002366974A1 (en) 2003-07-30
JP2005526015A (ja) 2005-09-02
AU2002366974A8 (en) 2003-07-30
EP1467624A2 (en) 2004-10-20
WO2003059932A3 (en) 2004-01-29
IL162736A0 (en) 2005-11-20
US20030228292A1 (en) 2003-12-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued