CA2471620A1 - Pyrrolidone carboxamides - Google Patents
Pyrrolidone carboxamides Download PDFInfo
- Publication number
- CA2471620A1 CA2471620A1 CA002471620A CA2471620A CA2471620A1 CA 2471620 A1 CA2471620 A1 CA 2471620A1 CA 002471620 A CA002471620 A CA 002471620A CA 2471620 A CA2471620 A CA 2471620A CA 2471620 A1 CA2471620 A1 CA 2471620A1
- Authority
- CA
- Canada
- Prior art keywords
- rac
- phenyl
- carboxamide
- oxopyrrolidine
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH23812001 | 2001-12-31 | ||
| CH2381/01 | 2001-12-31 | ||
| CHPCT/CH02/00429 | 2002-08-05 | ||
| CH0200429 | 2002-08-05 | ||
| PCT/CH2002/000725 WO2003059905A1 (de) | 2001-12-31 | 2002-12-27 | Pyrrolidon-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2471620A1 true CA2471620A1 (en) | 2003-07-24 |
Family
ID=25705687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002471620A Abandoned CA2471620A1 (en) | 2001-12-31 | 2002-12-27 | Pyrrolidone carboxamides |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1463724A1 (ja) |
| JP (1) | JP2005521651A (ja) |
| KR (1) | KR20040072697A (ja) |
| CN (1) | CN100534990C (ja) |
| AU (1) | AU2002350366A1 (ja) |
| CA (1) | CA2471620A1 (ja) |
| MX (1) | MXPA04006458A (ja) |
| WO (1) | WO2003059905A1 (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319151D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| ES2386365T3 (es) | 2005-01-05 | 2012-08-17 | Abbott Laboratories | Derivados de adamantilo como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20090264650A1 (en) * | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| US20090036492A1 (en) * | 2005-08-09 | 2009-02-05 | Akihiro Furukawa | Novel Cercosporamide Derivative |
| JP4726243B2 (ja) * | 2005-08-09 | 2011-07-20 | 第一三共株式会社 | 新規セルコスポラミド誘導体 |
| US7435833B2 (en) * | 2006-04-07 | 2008-10-14 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| GB0815781D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| WO2011035332A1 (en) * | 2009-09-21 | 2011-03-24 | Chemocentryx, Inc. | Pyrrolidinone carboxamide derivatives as chemerin-r ( chemr23 ) modulators |
| CN102827056B (zh) * | 2012-09-03 | 2014-07-23 | 华东理工大学 | N-芳基取代吡咯烷酮衍生物及其用途 |
| SG11201606619UA (en) * | 2014-04-04 | 2016-09-29 | Sanofi Sa | Substituted indanone compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
| US10968176B2 (en) | 2014-09-14 | 2021-04-06 | Nanosynthons Llc | Pyrrolidone derivatives, oligomers and polymers |
| WO2016040962A1 (en) * | 2014-09-14 | 2016-03-17 | Nanosynthons Llc | Pyrrolidone derivatives, oligomers and polymers |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB856452A (en) * | 1957-06-27 | 1960-12-14 | Bayer Ag | Protective agents against textile pests, mould and bacteria |
| US5281612A (en) * | 1982-09-09 | 1994-01-25 | Warner-Lambert Company | Naphthyridine antibacterial agents |
| ES2087097T3 (es) * | 1989-04-19 | 1996-07-16 | Otsuka Pharma Co Ltd | Derivados de acidos fenilcarboxilicos que contienen un heterociclo. |
| US6387932B1 (en) * | 1999-06-25 | 2002-05-14 | Merck & Co., Inc. | Somatostatin agonists |
| AU6000900A (en) * | 1999-07-23 | 2001-02-13 | Astrazeneca Uk Limited | Carbazole derivatives and their use as neuropeptide y5 receptor ligands |
| GB0010757D0 (en) * | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
-
2002
- 2002-12-27 WO PCT/CH2002/000725 patent/WO2003059905A1/de active Application Filing
- 2002-12-27 AU AU2002350366A patent/AU2002350366A1/en not_active Abandoned
- 2002-12-27 EP EP02785006A patent/EP1463724A1/de not_active Withdrawn
- 2002-12-27 KR KR10-2004-7010431A patent/KR20040072697A/ko not_active Application Discontinuation
- 2002-12-27 CN CNB028265483A patent/CN100534990C/zh not_active Expired - Fee Related
- 2002-12-27 JP JP2003560008A patent/JP2005521651A/ja active Pending
- 2002-12-27 CA CA002471620A patent/CA2471620A1/en not_active Abandoned
- 2002-12-27 MX MXPA04006458A patent/MXPA04006458A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN100534990C (zh) | 2009-09-02 |
| MXPA04006458A (es) | 2004-10-04 |
| KR20040072697A (ko) | 2004-08-18 |
| JP2005521651A (ja) | 2005-07-21 |
| WO2003059905A1 (de) | 2003-07-24 |
| CN1610678A (zh) | 2005-04-27 |
| EP1463724A1 (de) | 2004-10-06 |
| AU2002350366A1 (en) | 2003-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2471620A1 (en) | Pyrrolidone carboxamides | |
| JP3108719B2 (ja) | 新規なｎ−アルキレンピペリジノ化合物及びそのエナンチオマー；これらを合成する方法及びこれらを含む医薬品組成物 | |
| AU2008206759B2 (en) | Nicotinic acetylcholine receptor modulators | |
| CN100383118C (zh) | 4-吡咯烷基-苯基-苄基醚衍生物 | |
| RO121597B1 (ro) | Derivati de 2-oxo-1-pirolidina, compozitii farmaceutice si utilizarea lor | |
| CA2218548A1 (en) | Xanthines and their therapeutic use | |
| JP2007510702A (ja) | 代謝性疾患の処置に有用な１１−β−ＨＳＤ１阻害剤としてのＮ−アシル化−３−（ベンゾイル）−ピロリジン | |
| CA2491835A1 (en) | Mch1r antagonists | |
| JP2013508434A (ja) | ポジティブアロステリックモジュレータ（ｐａｍ） | |
| WO2004022528A2 (en) | Arylglycine derivatives and their use as glycine transport inhibitors | |
| JP2003506437A (ja) | 苦痛状態の治療のためのｎｍｄａ−レセプターアンタゴニストとして有効な置換された１，５−ジヒドロピロール−２−オン誘導体 | |
| HU225111B1 (en) | Aminomethylindans, -benzofuranes and-benzothiophenes and pharmaceutical compositions containing them | |
| KR20000005505A (ko) | 피페리딘 및 피롤리딘 | |
| CN112513032B (zh) | 作为trk受体的调节剂的4-取代的苯基-1,3,5-三嗪衍生物 | |
| EP0299493B1 (en) | N-[(2-Oxopyrrolidin-1-yl)-acetyl]piperazine derivatives and drug for senile dementia | |
| CA2306477A1 (en) | Azaring-ether derivatives and their use as nicotinic ach receptor modulators | |
| US7067549B2 (en) | Pyrrolidone carboxamides | |
| FR2908766A1 (fr) | Derives de pyrrole,leur preparation et leur utilisation en therapeutique. | |
| US6395905B1 (en) | Tetrahydroindazole derivatives as ligands for GABA-A α 5 receptors | |
| RU2378270C2 (ru) | Бензилокси-производные в качестве ингибиторов моноаминоксидазы b | |
| RU2296757C2 (ru) | Производные хиназолина | |
| FR2911136A1 (fr) | Derives de n-(4-cyano-1h-pyrazol-3-yl)methylamine substitues leur preparation et leur application en therapeutique. | |
| TWI589571B (zh) | 乙炔基衍生物 | |
| FR2676227A1 (fr) | Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino. | |
| FR2676225A1 (fr) | Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |