CA2468649C - Adenosine a2a receptor antagonists - Google Patents
Adenosine a2a receptor antagonists Download PDFInfo
- Publication number
- CA2468649C CA2468649C CA002468649A CA2468649A CA2468649C CA 2468649 C CA2468649 C CA 2468649C CA 002468649 A CA002468649 A CA 002468649A CA 2468649 A CA2468649 A CA 2468649A CA 2468649 C CA2468649 C CA 2468649C
- Authority
- CA
- Canada
- Prior art keywords
- disease
- group
- alkyl
- alkoxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33434201P | 2001-11-30 | 2001-11-30 | |
US60/334,342 | 2001-11-30 | ||
PCT/US2002/037710 WO2003048165A1 (en) | 2001-11-30 | 2002-11-26 | ADENOSINE A2a RECEPTOR ANTAGONISTS |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2468649A1 CA2468649A1 (en) | 2003-06-12 |
CA2468649C true CA2468649C (en) | 2009-03-10 |
Family
ID=23306779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002468649A Expired - Fee Related CA2468649C (en) | 2001-11-30 | 2002-11-26 | Adenosine a2a receptor antagonists |
Country Status (19)
Country | Link |
---|---|
US (1) | US6916811B2 (ro) |
EP (1) | EP1448565B1 (ro) |
JP (2) | JP4284182B2 (ro) |
KR (1) | KR20050044593A (ro) |
CN (1) | CN1692116A (ro) |
AR (1) | AR037680A1 (ro) |
AT (1) | ATE453647T1 (ro) |
AU (1) | AU2002346503A1 (ro) |
CA (1) | CA2468649C (ro) |
DE (1) | DE60234951D1 (ro) |
ES (1) | ES2336435T3 (ro) |
HK (1) | HK1063780A1 (ro) |
HU (1) | HUP0402018A3 (ro) |
IL (1) | IL161716A0 (ro) |
MX (1) | MXPA04005209A (ro) |
PE (1) | PE20030665A1 (ro) |
TW (1) | TW200306837A (ro) |
WO (1) | WO2003048165A1 (ro) |
ZA (1) | ZA200404161B (ro) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK287748B6 (sk) * | 2000-05-26 | 2011-08-04 | Schering Corporation | Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
US6964288B2 (en) * | 2001-07-06 | 2005-11-15 | Ksaria Corporation | Apparatus and method for automated preparation of an optical fiber |
PE20030477A1 (es) | 2001-10-15 | 2003-06-06 | Schering Corp | ANTAGONISTAS DEL RECEPTOR DE ADENOSINA A2a |
JP2005527635A (ja) * | 2002-05-30 | 2005-09-15 | キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド | 三環ピラゾロトリアゾロピリミジン環構造を有する薬学的に活性な化合物及び使用方法 |
JP2006514697A (ja) | 2002-12-19 | 2006-05-11 | シェーリング コーポレイション | アデノシンA2aレセプターアンタゴニストの使用 |
EP1678168B1 (en) * | 2003-10-24 | 2012-07-11 | Exelixis, Inc. | P70s6 kinase modulators and method of use |
EP1678182B1 (en) * | 2003-10-28 | 2007-02-07 | Schering Corporation | Process for preparing substituted 5-amino-pyrazolo- [4,3-e]-1,2,4-triazolo [1,5-c]pyrimidines |
CA2550071A1 (en) * | 2003-12-19 | 2005-07-07 | Schering Corporation | Pharmaceutical compositions |
ATE556712T1 (de) * | 2005-06-07 | 2012-05-15 | Kyowa Hakko Kirin Co Ltd | A2a antagonisten zur behandlung von motorischen störungen |
ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
US7691869B2 (en) | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
EP2224929B1 (en) | 2007-12-17 | 2016-05-04 | Janssen Pharmaceutica, N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
PT2320911E (pt) | 2008-08-01 | 2014-11-11 | Eye Therapies Llc | Composições de vasoconstrição e métodos de utilização |
US20100203165A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
TW201036614A (en) | 2008-12-30 | 2010-10-16 | Arqule Inc | Substituted 1H-pyrazolo[3,4-d]pyrimidine-6-amine compounds |
AU2010232727A1 (en) | 2009-03-31 | 2011-10-20 | Arqule, Inc. | Substituted heterocyclic compounds |
US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
CA2782872A1 (en) * | 2009-12-17 | 2011-06-23 | Alpha Synergy Development, Inc. | Compositions and methods for ophthalmic delivery of nasal decongestants |
US8445526B2 (en) | 2011-02-03 | 2013-05-21 | Glaucoma & Nasal Therapies Llc | Compositions and methods for treatment of glaucoma |
US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
CN110742893B (zh) * | 2018-07-23 | 2024-04-05 | 百济神州(北京)生物科技有限公司 | A2a受体拮抗剂治疗癌症的方法 |
CA3120862C (en) | 2018-11-30 | 2024-05-07 | Merck Sharp & Dohme Corp. | 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
DE102019116986A1 (de) | 2019-06-24 | 2020-12-24 | Helmholtz-Zentrum Dresden-Rossendorf E. V. | Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate |
JP2022540583A (ja) * | 2019-07-17 | 2022-09-16 | テオン セラピューティクス,インク. | アデノシンa2a受容体アンタゴニスト及びその使用 |
CN112028891B (zh) | 2019-07-30 | 2022-07-05 | 厦门宝太生物科技股份有限公司 | 腺苷受体拮抗剂 |
CN112592354B (zh) | 2019-07-30 | 2022-05-27 | 厦门宝太生物科技股份有限公司 | 一种异噁唑并嘧啶类杂环化合物的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
ATE208199T1 (de) * | 1993-07-27 | 2001-11-15 | Kyowa Hakko Kogyo Kk | Arzneimittel gegen parkinsonsche krankheit |
IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
US6921825B2 (en) * | 1998-09-16 | 2005-07-26 | King Pharmaceuticuals Research & Development, Inc. | Adenosine A3 receptor modulators |
US6448253B1 (en) * | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
SK287748B6 (sk) * | 2000-05-26 | 2011-08-04 | Schering Corporation | Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
JP2005527635A (ja) * | 2002-05-30 | 2005-09-15 | キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド | 三環ピラゾロトリアゾロピリミジン環構造を有する薬学的に活性な化合物及び使用方法 |
CN100503609C (zh) * | 2003-04-23 | 2009-06-24 | 先灵公司 | 2-炔基-及2-链烯基-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]-嘧啶腺苷A2a受体拮抗剂 |
-
2002
- 2002-11-26 WO PCT/US2002/037710 patent/WO2003048165A1/en active Application Filing
- 2002-11-26 JP JP2003549355A patent/JP4284182B2/ja not_active Expired - Fee Related
- 2002-11-26 EP EP02784568A patent/EP1448565B1/en not_active Expired - Lifetime
- 2002-11-26 CA CA002468649A patent/CA2468649C/en not_active Expired - Fee Related
- 2002-11-26 DE DE60234951T patent/DE60234951D1/de not_active Expired - Lifetime
- 2002-11-26 US US10/304,931 patent/US6916811B2/en not_active Expired - Lifetime
- 2002-11-26 HU HU0402018A patent/HUP0402018A3/hu unknown
- 2002-11-26 AT AT02784568T patent/ATE453647T1/de not_active IP Right Cessation
- 2002-11-26 AU AU2002346503A patent/AU2002346503A1/en not_active Abandoned
- 2002-11-26 CN CNA02823782XA patent/CN1692116A/zh active Pending
- 2002-11-26 IL IL16171602A patent/IL161716A0/xx unknown
- 2002-11-26 MX MXPA04005209A patent/MXPA04005209A/es active IP Right Grant
- 2002-11-26 KR KR1020047007876A patent/KR20050044593A/ko not_active Application Discontinuation
- 2002-11-26 ES ES02784568T patent/ES2336435T3/es not_active Expired - Lifetime
- 2002-11-27 AR ARP020104561A patent/AR037680A1/es unknown
- 2002-11-27 TW TW091134471A patent/TW200306837A/zh unknown
- 2002-11-27 PE PE2002001143A patent/PE20030665A1/es not_active Application Discontinuation
-
2004
- 2004-05-27 ZA ZA200404161A patent/ZA200404161B/en unknown
- 2004-08-28 HK HK04106478.4A patent/HK1063780A1/xx not_active IP Right Cessation
-
2008
- 2008-06-04 JP JP2008147306A patent/JP2008260776A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2468649A1 (en) | 2003-06-12 |
JP4284182B2 (ja) | 2009-06-24 |
JP2005511699A (ja) | 2005-04-28 |
ATE453647T1 (de) | 2010-01-15 |
AR037680A1 (es) | 2004-12-01 |
US6916811B2 (en) | 2005-07-12 |
JP2008260776A (ja) | 2008-10-30 |
PE20030665A1 (es) | 2003-08-08 |
ZA200404161B (en) | 2005-11-30 |
EP1448565A1 (en) | 2004-08-25 |
DE60234951D1 (de) | 2010-02-11 |
US20030212059A1 (en) | 2003-11-13 |
WO2003048165A1 (en) | 2003-06-12 |
MXPA04005209A (es) | 2004-08-19 |
EP1448565B1 (en) | 2009-12-30 |
IL161716A0 (en) | 2004-09-27 |
TW200306837A (en) | 2003-12-01 |
ES2336435T3 (es) | 2010-04-13 |
HUP0402018A2 (hu) | 2005-02-28 |
AU2002346503A1 (en) | 2003-06-17 |
HUP0402018A3 (en) | 2008-06-30 |
KR20050044593A (ko) | 2005-05-12 |
CN1692116A (zh) | 2005-11-02 |
HK1063780A1 (en) | 2005-01-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20131126 |