CA2467773C - Acyloxymethyl esters of c4-16 n-alkane-dicarboxylic acids for the treatment of acne and other related skin disorders - Google Patents

Acyloxymethyl esters of c4-16 n-alkane-dicarboxylic acids for the treatment of acne and other related skin disorders Download PDF

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Publication number
CA2467773C
CA2467773C CA2467773A CA2467773A CA2467773C CA 2467773 C CA2467773 C CA 2467773C CA 2467773 A CA2467773 A CA 2467773A CA 2467773 A CA2467773 A CA 2467773A CA 2467773 C CA2467773 C CA 2467773C
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CA
Canada
Prior art keywords
group
bis
methyl
ethyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2467773A
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English (en)
French (fr)
Other versions
CA2467773A1 (en
Inventor
Jo Klaveness
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drug Discovery Laboratory AS
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Drug Discovery Laboratory AS
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Filing date
Publication date
Application filed by Drug Discovery Laboratory AS filed Critical Drug Discovery Laboratory AS
Publication of CA2467773A1 publication Critical patent/CA2467773A1/en
Application granted granted Critical
Publication of CA2467773C publication Critical patent/CA2467773C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/50—Sebacic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/44—Adipic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/48—Azelaic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Tires In General (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2467773A 2001-11-22 2002-11-22 Acyloxymethyl esters of c4-16 n-alkane-dicarboxylic acids for the treatment of acne and other related skin disorders Expired - Fee Related CA2467773C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0128052.8 2001-11-22
GBGB0128052.8A GB0128052D0 (en) 2001-11-22 2001-11-22 Compounds
PCT/GB2002/005305 WO2003045893A1 (en) 2001-11-22 2002-11-22 Double esters

Publications (2)

Publication Number Publication Date
CA2467773A1 CA2467773A1 (en) 2003-06-05
CA2467773C true CA2467773C (en) 2011-08-16

Family

ID=9926289

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2467773A Expired - Fee Related CA2467773C (en) 2001-11-22 2002-11-22 Acyloxymethyl esters of c4-16 n-alkane-dicarboxylic acids for the treatment of acne and other related skin disorders

Country Status (15)

Country Link
US (1) US7629383B2 (enExample)
EP (1) EP1448508B1 (enExample)
JP (1) JP4426298B2 (enExample)
KR (1) KR20040071138A (enExample)
CN (1) CN100516018C (enExample)
AT (1) ATE443695T1 (enExample)
AU (1) AU2002343086C1 (enExample)
CA (1) CA2467773C (enExample)
DE (1) DE60233819D1 (enExample)
GB (1) GB0128052D0 (enExample)
HU (1) HUP0402122A2 (enExample)
MX (1) MXPA04004763A (enExample)
NO (1) NO20042603L (enExample)
RU (1) RU2350599C2 (enExample)
WO (1) WO2003045893A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
DE102006004804A1 (de) * 2006-01-23 2007-07-26 Intendis Gmbh Verwendung von Alkandicarbonsäuren und Retinoiden zur Behandlung entzündlicher Hauterkrankungen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462934A (en) 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
GB8310080D0 (en) * 1983-04-14 1983-05-18 Interox Chemicals Ltd Bleach composition
DE3465334D1 (en) 1983-04-14 1987-09-17 Interox Chemicals Ltd Peroxygen compounds
ATE74359T1 (de) * 1987-01-27 1992-04-15 Pfizer 6-beta(substituierte)-(s)hydroxymethylpenicillans|ure und deren derivate.
LU86918A1 (fr) * 1987-06-12 1989-03-08 Oreal Nouveaux diesters de l'acide azelaique,leur procede de preparation,les compositions topiques les contenant et leur utilisation dans le traitement de l'acne
EP0577659B1 (en) 1991-03-28 1996-01-17 Nycomed Imaging As Cross-linking agent
CZ284844B6 (cs) 1992-03-06 1999-03-17 Nycomed Imaging A/S Kontrastní prostředek a způsob jeho výroby
GB9504948D0 (en) * 1995-03-10 1995-04-26 Norwegian Radium Hospital Rese Compounds
JP4029440B2 (ja) 1997-07-09 2008-01-09 大日本インキ化学工業株式会社 側鎖型ラジカル重合性化合物及びそれを用いた液晶デバイス

Also Published As

Publication number Publication date
NO20042603L (no) 2004-06-21
DE60233819D1 (de) 2009-11-05
RU2350599C2 (ru) 2009-03-27
AU2002343086B2 (en) 2008-01-03
CN100516018C (zh) 2009-07-22
JP2005510556A (ja) 2005-04-21
MXPA04004763A (es) 2004-07-30
GB0128052D0 (en) 2002-01-16
AU2002343086C1 (en) 2008-06-26
CA2467773A1 (en) 2003-06-05
US20050203181A1 (en) 2005-09-15
WO2003045893A1 (en) 2003-06-05
HUP0402122A2 (hu) 2005-02-28
AU2002343086A1 (en) 2003-06-10
JP4426298B2 (ja) 2010-03-03
US7629383B2 (en) 2009-12-08
KR20040071138A (ko) 2004-08-11
EP1448508A1 (en) 2004-08-25
RU2004118713A (ru) 2005-03-27
ATE443695T1 (de) 2009-10-15
EP1448508B1 (en) 2009-09-23
CN1589254A (zh) 2005-03-02

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