KR20040071138A - 이중 에스테르류 - Google Patents
이중 에스테르류 Download PDFInfo
- Publication number
- KR20040071138A KR20040071138A KR10-2004-7007220A KR20047007220A KR20040071138A KR 20040071138 A KR20040071138 A KR 20040071138A KR 20047007220 A KR20047007220 A KR 20047007220A KR 20040071138 A KR20040071138 A KR 20040071138A
- Authority
- KR
- South Korea
- Prior art keywords
- bis
- formula
- methyl
- ethyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000002148 esters Chemical class 0.000 title claims abstract description 26
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 125000005042 acyloxymethyl group Chemical group 0.000 claims abstract description 6
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 5
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 57
- -1 methoxy, ethoxy, propyloxy, butoxy, pentoxy Chemical group 0.000 claims description 36
- 239000003814 drug Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 20
- 238000011282 treatment Methods 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 19
- 229920006395 saturated elastomer Polymers 0.000 claims description 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 12
- 208000024891 symptom Diseases 0.000 claims description 10
- 206010000496 acne Diseases 0.000 claims description 9
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- 125000004429 atom Chemical group 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 125000005843 halogen group Chemical group 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 125000005647 linker group Chemical group 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 125000006732 (C1-C15) alkyl group Chemical group 0.000 claims description 4
- 208000035143 Bacterial infection Diseases 0.000 claims description 4
- 206010017533 Fungal infection Diseases 0.000 claims description 4
- 208000031888 Mycoses Diseases 0.000 claims description 4
- 208000036142 Viral infection Diseases 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 208000000069 hyperpigmentation Diseases 0.000 claims description 4
- 230000003810 hyperpigmentation Effects 0.000 claims description 4
- 238000011321 prophylaxis Methods 0.000 claims description 4
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 230000029663 wound healing Effects 0.000 claims description 3
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 2
- 240000009088 Fragaria x ananassa Species 0.000 claims description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 208000009621 actinic keratosis Diseases 0.000 claims description 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 2
- 125000005248 alkyl aryloxy group Chemical group 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 2
- 125000002130 sulfonic acid ester group Chemical group 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 150000003457 sulfones Chemical class 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000003651 hexanedioyl group Chemical group C(CCCCC(=O)*)(=O)* 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 43
- 239000000203 mixture Substances 0.000 description 43
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 35
- 239000000243 solution Substances 0.000 description 24
- 239000002253 acid Substances 0.000 description 23
- 230000015572 biosynthetic process Effects 0.000 description 19
- 239000011541 reaction mixture Substances 0.000 description 18
- 238000003786 synthesis reaction Methods 0.000 description 18
- 229960002255 azelaic acid Drugs 0.000 description 17
- 239000006071 cream Substances 0.000 description 17
- 238000005160 1H NMR spectroscopy Methods 0.000 description 15
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 13
- 238000001704 evaporation Methods 0.000 description 12
- 230000008020 evaporation Effects 0.000 description 12
- 239000000463 material Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 229930040373 Paraformaldehyde Natural products 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 229920002866 paraformaldehyde Polymers 0.000 description 9
- 150000001991 dicarboxylic acids Chemical class 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- TVIDDXQYHWJXFK-UHFFFAOYSA-N dodecanedioic acid Chemical compound OC(=O)CCCCCCCCCCC(O)=O TVIDDXQYHWJXFK-UHFFFAOYSA-N 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 239000003443 antiviral agent Substances 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- GGRHYQCXXYLUTL-UHFFFAOYSA-N chloromethyl 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)OCCl GGRHYQCXXYLUTL-UHFFFAOYSA-N 0.000 description 3
- BOXZXICVMMSYPE-UHFFFAOYSA-N chloromethyl benzoate Chemical compound ClCOC(=O)C1=CC=CC=C1 BOXZXICVMMSYPE-UHFFFAOYSA-N 0.000 description 3
- BDPZFQLKFUONAG-UHFFFAOYSA-N chloromethyl butanoate Chemical compound CCCC(=O)OCCl BDPZFQLKFUONAG-UHFFFAOYSA-N 0.000 description 3
- HNUBMUSOXKDQIN-UHFFFAOYSA-N chloromethyl hexanoate Chemical compound CCCCCC(=O)OCCl HNUBMUSOXKDQIN-UHFFFAOYSA-N 0.000 description 3
- JRCUJOMLYAQHDP-UHFFFAOYSA-N chloromethyl octanoate Chemical compound CCCCCCCC(=O)OCCl JRCUJOMLYAQHDP-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005886 esterification reaction Methods 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- YVRGKFXJZCTTRB-UHFFFAOYSA-N 1-chloroethyl ethyl carbonate Chemical compound CCOC(=O)OC(C)Cl YVRGKFXJZCTTRB-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 150000001535 azelaic acid derivatives Chemical class 0.000 description 2
- ZGMKAGLKMYQEAS-UHFFFAOYSA-N bis(1-ethoxycarbonyloxyethyl) dodecanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)OCC ZGMKAGLKMYQEAS-UHFFFAOYSA-N 0.000 description 2
- KWYYRKXVCJMOEH-UHFFFAOYSA-N bis(1-ethoxycarbonyloxyethyl) nonanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)OCC KWYYRKXVCJMOEH-UHFFFAOYSA-N 0.000 description 2
- VIZVLPZQRVYRKQ-UHFFFAOYSA-N bis(2,2-dimethylpropanoyloxymethyl) dodecanedioate Chemical compound CC(C)(C)C(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)C(C)(C)C VIZVLPZQRVYRKQ-UHFFFAOYSA-N 0.000 description 2
- GLQNWJPLECTESO-UHFFFAOYSA-N bis(2,2-dimethylpropanoyloxymethyl) nonanedioate Chemical compound CC(C)(C)C(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)C(C)(C)C GLQNWJPLECTESO-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- 229960000282 metronidazole Drugs 0.000 description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 238000002428 photodynamic therapy Methods 0.000 description 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 201000004700 rosacea Diseases 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- HQHCYKULIHKCEB-UHFFFAOYSA-N tetradecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCC(O)=O HQHCYKULIHKCEB-UHFFFAOYSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- LWBHHRRTOZQPDM-UHFFFAOYSA-N undecanedioic acid Chemical compound OC(=O)CCCCCCCCCC(O)=O LWBHHRRTOZQPDM-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 1
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 1
- ILBBNQMSDGAAPF-UHFFFAOYSA-N 1-(6-hydroxy-6-methylcyclohexa-2,4-dien-1-yl)propan-1-one Chemical compound CCC(=O)C1C=CC=CC1(C)O ILBBNQMSDGAAPF-UHFFFAOYSA-N 0.000 description 1
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 1
- WMEOLZWYNYCSPY-UHFFFAOYSA-N 11-o-(1-ethoxycarbonyloxyethyl) 1-o-methyl undecanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC WMEOLZWYNYCSPY-UHFFFAOYSA-N 0.000 description 1
- RBCJXYCNUMRYKC-UHFFFAOYSA-N 11-o-(2,2-dimethylpropanoyloxymethyl) 1-o-methyl undecanedioate Chemical compound COC(=O)CCCCCCCCCC(=O)OCOC(=O)C(C)(C)C RBCJXYCNUMRYKC-UHFFFAOYSA-N 0.000 description 1
- QFGCFKJIPBRJGM-UHFFFAOYSA-N 12-[(2-methylpropan-2-yl)oxy]-12-oxododecanoic acid Chemical compound CC(C)(C)OC(=O)CCCCCCCCCCC(O)=O QFGCFKJIPBRJGM-UHFFFAOYSA-N 0.000 description 1
- JRAJFOOHBONEIT-UHFFFAOYSA-N 12-o-(1-ethoxycarbonyloxyethyl) 1-o-methyl dodecanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC JRAJFOOHBONEIT-UHFFFAOYSA-N 0.000 description 1
- YFMCDZHMTTZHJN-UHFFFAOYSA-N 12-o-(2,2-dimethylpropanoyloxymethyl) 1-o-methyl dodecanedioate Chemical compound COC(=O)CCCCCCCCCCC(=O)OCOC(=O)C(C)(C)C YFMCDZHMTTZHJN-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- SEEYHRCMNMPHDG-UHFFFAOYSA-N 2-chloroethyl ethyl carbonate Chemical compound CCOC(=O)OCCCl SEEYHRCMNMPHDG-UHFFFAOYSA-N 0.000 description 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
- UZNLHJCCGYKCIL-UHFFFAOYSA-N 6-ethoxy-6-oxohexanoic acid Chemical class CCOC(=O)CCCCC(O)=O UZNLHJCCGYKCIL-UHFFFAOYSA-N 0.000 description 1
- LKNXZDNCMNTKOF-UHFFFAOYSA-N 6-o-(2,2-dimethylpropanoyloxymethyl) 1-o-methyl hexanedioate Chemical compound COC(=O)CCCCC(=O)OCOC(=O)C(C)(C)C LKNXZDNCMNTKOF-UHFFFAOYSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- KOVPXZDUVJGGFU-UHFFFAOYSA-N 8-methoxy-8-oxooctanoic acid Chemical class COC(=O)CCCCCCC(O)=O KOVPXZDUVJGGFU-UHFFFAOYSA-N 0.000 description 1
- MTRYLAXNDGUFAK-UHFFFAOYSA-N 9-ethoxy-9-oxononanoic acid Chemical class CCOC(=O)CCCCCCCC(O)=O MTRYLAXNDGUFAK-UHFFFAOYSA-N 0.000 description 1
- VVWPSAPZUZXYCM-UHFFFAOYSA-N 9-methoxy-9-oxononanoic acid Chemical class COC(=O)CCCCCCCC(O)=O VVWPSAPZUZXYCM-UHFFFAOYSA-N 0.000 description 1
- YJXXJQBXZYMNIA-UHFFFAOYSA-N 9-o-(1-ethoxycarbonyloxyethyl) 1-o-methyl nonanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC YJXXJQBXZYMNIA-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 102100027211 Albumin Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229930183010 Amphotericin Natural products 0.000 description 1
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 description 1
- BMBXNRCHLGYTFY-UHFFFAOYSA-N CCOC(=O)OC(C)OC(=O)CCCCCC(=O)OC Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCC(=O)OC BMBXNRCHLGYTFY-UHFFFAOYSA-N 0.000 description 1
- VQXMFIAUXZGEMO-UHFFFAOYSA-N CCOC(=O)OC(C)OC(=O)CCCCCCC(=O)OC Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCC(=O)OC VQXMFIAUXZGEMO-UHFFFAOYSA-N 0.000 description 1
- NUBNPXSCXAZMIL-UHFFFAOYSA-N CCOC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC NUBNPXSCXAZMIL-UHFFFAOYSA-N 0.000 description 1
- XQWJVJUULJFOLU-UHFFFAOYSA-N COC(=O)CCCCCC(=O)OCOC(=O)C(C)(C)C Chemical compound COC(=O)CCCCCC(=O)OCOC(=O)C(C)(C)C XQWJVJUULJFOLU-UHFFFAOYSA-N 0.000 description 1
- BHOSROPQCLVBQC-UHFFFAOYSA-N COC(=O)CCCCCCC(=O)OCOC(=O)C(C)(C)C Chemical compound COC(=O)CCCCCCC(=O)OCOC(=O)C(C)(C)C BHOSROPQCLVBQC-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 description 1
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000450599 DNA viruses Species 0.000 description 1
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 description 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229930192392 Mitomycin Natural products 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 description 1
- 241001303601 Rosacea Species 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010040865 Skin hyperpigmentation Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
- IVTVGDXNLFLDRM-HNNXBMFYSA-N Tomudex Chemical compound C=1C=C2NC(C)=NC(=O)C2=CC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)S1 IVTVGDXNLFLDRM-HNNXBMFYSA-N 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical group OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- OGQICQVSFDPSEI-UHFFFAOYSA-N Zorac Chemical compound N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1 OGQICQVSFDPSEI-UHFFFAOYSA-N 0.000 description 1
- 241000222126 [Candida] glabrata Species 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 description 1
- 229960002916 adapalene Drugs 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 229960000250 adipic acid Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 125000005206 alkoxycarbonyloxymethyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229940009444 amphotericin Drugs 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 description 1
- 229960001220 amsacrine Drugs 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 239000003972 antineoplastic antibiotic Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229960003328 benzoyl peroxide Drugs 0.000 description 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 1
- 229940073608 benzyl chloride Drugs 0.000 description 1
- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- OPXHIWDMXZMXEY-UHFFFAOYSA-N bis(1-acetyloxyethyl) decanedioate Chemical compound CC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(C)=O OPXHIWDMXZMXEY-UHFFFAOYSA-N 0.000 description 1
- RALZJKQLRMRUNB-UHFFFAOYSA-N bis(1-acetyloxyethyl) dodecanedioate Chemical compound CC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(C)=O RALZJKQLRMRUNB-UHFFFAOYSA-N 0.000 description 1
- ZVOPZNZCNGWOSH-UHFFFAOYSA-N bis(1-acetyloxyethyl) heptanedioate Chemical compound CC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(C)=O ZVOPZNZCNGWOSH-UHFFFAOYSA-N 0.000 description 1
- LSWXWAIVNBXVGG-UHFFFAOYSA-N bis(1-acetyloxyethyl) hexanedioate Chemical compound CC(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(C)=O LSWXWAIVNBXVGG-UHFFFAOYSA-N 0.000 description 1
- QQVBQUHUJXHTEG-UHFFFAOYSA-N bis(1-acetyloxyethyl) nonanedioate Chemical compound CC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(C)=O QQVBQUHUJXHTEG-UHFFFAOYSA-N 0.000 description 1
- UXZFESUDLICPOG-UHFFFAOYSA-N bis(1-acetyloxyethyl) octanedioate Chemical compound CC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(C)=O UXZFESUDLICPOG-UHFFFAOYSA-N 0.000 description 1
- SOPIEISNILJQIF-UHFFFAOYSA-N bis(1-acetyloxyethyl) undecanedioate Chemical compound CC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(C)=O SOPIEISNILJQIF-UHFFFAOYSA-N 0.000 description 1
- SCSFJZZRWBIKMZ-UHFFFAOYSA-N bis(1-butanoyloxyethyl) decanedioate Chemical compound CCCC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)CCC SCSFJZZRWBIKMZ-UHFFFAOYSA-N 0.000 description 1
- VSJDDYDRLUFEHA-UHFFFAOYSA-N bis(1-butanoyloxyethyl) dodecanedioate Chemical compound CCCC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)CCC VSJDDYDRLUFEHA-UHFFFAOYSA-N 0.000 description 1
- UWQDFAWBGVIJFM-UHFFFAOYSA-N bis(1-butanoyloxyethyl) heptanedioate Chemical compound CCCC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)CCC UWQDFAWBGVIJFM-UHFFFAOYSA-N 0.000 description 1
- NWTGUSJEZOYWTJ-UHFFFAOYSA-N bis(1-butanoyloxyethyl) hexanedioate Chemical compound CCCC(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(=O)CCC NWTGUSJEZOYWTJ-UHFFFAOYSA-N 0.000 description 1
- NFHACVZNHAOSIG-UHFFFAOYSA-N bis(1-butanoyloxyethyl) nonanedioate Chemical compound CCCC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)CCC NFHACVZNHAOSIG-UHFFFAOYSA-N 0.000 description 1
- LTPRKGAMCXNUFS-UHFFFAOYSA-N bis(1-butanoyloxyethyl) octanedioate Chemical compound CCCC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)CCC LTPRKGAMCXNUFS-UHFFFAOYSA-N 0.000 description 1
- JCGWCCLZOJZVJY-UHFFFAOYSA-N bis(1-butanoyloxyethyl) undecanedioate Chemical compound CCCC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)CCC JCGWCCLZOJZVJY-UHFFFAOYSA-N 0.000 description 1
- UOGVRGNCLODPNT-UHFFFAOYSA-N bis(1-ethoxycarbonyloxyethyl) decanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)OCC UOGVRGNCLODPNT-UHFFFAOYSA-N 0.000 description 1
- KKMRGTVJDWUPNE-UHFFFAOYSA-N bis(1-ethoxycarbonyloxyethyl) heptanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)OCC KKMRGTVJDWUPNE-UHFFFAOYSA-N 0.000 description 1
- VEPXHAQQOJFEQM-UHFFFAOYSA-N bis(1-ethoxycarbonyloxyethyl) hexanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(=O)OCC VEPXHAQQOJFEQM-UHFFFAOYSA-N 0.000 description 1
- SERBYSKHDHPOBQ-UHFFFAOYSA-N bis(1-ethoxycarbonyloxyethyl) octanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)OCC SERBYSKHDHPOBQ-UHFFFAOYSA-N 0.000 description 1
- STAAUQPWPKVYHZ-UHFFFAOYSA-N bis(1-ethoxycarbonyloxyethyl) undecanedioate Chemical compound CCOC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)OCC STAAUQPWPKVYHZ-UHFFFAOYSA-N 0.000 description 1
- ISZKAEHTVQGFJL-UHFFFAOYSA-N bis(1-methoxycarbonyloxyethyl) decanedioate Chemical compound COC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)OC ISZKAEHTVQGFJL-UHFFFAOYSA-N 0.000 description 1
- GWUKFJUKWIRIJA-UHFFFAOYSA-N bis(1-methoxycarbonyloxyethyl) dodecanedioate Chemical compound COC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)OC GWUKFJUKWIRIJA-UHFFFAOYSA-N 0.000 description 1
- KXAGDUQKCVMMAF-UHFFFAOYSA-N bis(1-methoxycarbonyloxyethyl) heptanedioate Chemical compound COC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)OC KXAGDUQKCVMMAF-UHFFFAOYSA-N 0.000 description 1
- RLFTUZWNMWZOAF-UHFFFAOYSA-N bis(1-methoxycarbonyloxyethyl) hexanedioate Chemical compound COC(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(=O)OC RLFTUZWNMWZOAF-UHFFFAOYSA-N 0.000 description 1
- GUVCTGDBMYAGLD-UHFFFAOYSA-N bis(1-methoxycarbonyloxyethyl) nonanedioate Chemical compound COC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)OC GUVCTGDBMYAGLD-UHFFFAOYSA-N 0.000 description 1
- SZPMDXDAYKMSIP-UHFFFAOYSA-N bis(1-methoxycarbonyloxyethyl) octanedioate Chemical compound COC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)OC SZPMDXDAYKMSIP-UHFFFAOYSA-N 0.000 description 1
- XRBCSBJZKRYRCP-UHFFFAOYSA-N bis(1-methoxycarbonyloxyethyl) undecanedioate Chemical compound COC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)OC XRBCSBJZKRYRCP-UHFFFAOYSA-N 0.000 description 1
- XCLAKRCREMDPQE-UHFFFAOYSA-N bis(1-octadecanoyloxyethyl) decanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)CCCCCCCCCCCCCCCCC XCLAKRCREMDPQE-UHFFFAOYSA-N 0.000 description 1
- QNQNJVSSDVVCMC-UHFFFAOYSA-N bis(1-octadecanoyloxyethyl) dodecanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)CCCCCCCCCCCCCCCCC QNQNJVSSDVVCMC-UHFFFAOYSA-N 0.000 description 1
- JDRQZNPLZGALAX-UHFFFAOYSA-N bis(1-octadecanoyloxyethyl) heptanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)CCCCCCCCCCCCCCCCC JDRQZNPLZGALAX-UHFFFAOYSA-N 0.000 description 1
- QEVAVGINWMTAHB-UHFFFAOYSA-N bis(1-octadecanoyloxyethyl) hexanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(=O)CCCCCCCCCCCCCCCCC QEVAVGINWMTAHB-UHFFFAOYSA-N 0.000 description 1
- AFRSXVBVNJHWAN-UHFFFAOYSA-N bis(1-octadecanoyloxyethyl) nonanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)CCCCCCCCCCCCCCCCC AFRSXVBVNJHWAN-UHFFFAOYSA-N 0.000 description 1
- HIIXFSRFUFJQGY-UHFFFAOYSA-N bis(1-octadecanoyloxyethyl) octanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)CCCCCCCCCCCCCCCCC HIIXFSRFUFJQGY-UHFFFAOYSA-N 0.000 description 1
- FNGFLVZDGQLUBC-UHFFFAOYSA-N bis(1-octadecanoyloxyethyl) undecanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)CCCCCCCCCCCCCCCCC FNGFLVZDGQLUBC-UHFFFAOYSA-N 0.000 description 1
- JUACLYIUEKVDIG-UHFFFAOYSA-N bis(1-phenylmethoxycarbonyloxyethyl) decanedioate Chemical compound C=1C=CC=CC=1COC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)OCC1=CC=CC=C1 JUACLYIUEKVDIG-UHFFFAOYSA-N 0.000 description 1
- WWXDVRGLWWGLGL-UHFFFAOYSA-N bis(1-phenylmethoxycarbonyloxyethyl) dodecanedioate Chemical compound C=1C=CC=CC=1COC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)OCC1=CC=CC=C1 WWXDVRGLWWGLGL-UHFFFAOYSA-N 0.000 description 1
- IAHPOJPPZUOETA-UHFFFAOYSA-N bis(1-phenylmethoxycarbonyloxyethyl) heptanedioate Chemical compound C=1C=CC=CC=1COC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)OCC1=CC=CC=C1 IAHPOJPPZUOETA-UHFFFAOYSA-N 0.000 description 1
- ULPCJNAMCGQNQZ-UHFFFAOYSA-N bis(1-phenylmethoxycarbonyloxyethyl) nonanedioate Chemical compound C=1C=CC=CC=1COC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)OCC1=CC=CC=C1 ULPCJNAMCGQNQZ-UHFFFAOYSA-N 0.000 description 1
- ZERRTDGTXQDXCH-UHFFFAOYSA-N bis(1-phenylmethoxycarbonyloxyethyl) octanedioate Chemical compound C=1C=CC=CC=1COC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)OCC1=CC=CC=C1 ZERRTDGTXQDXCH-UHFFFAOYSA-N 0.000 description 1
- VXLAQZTUUPSEGS-UHFFFAOYSA-N bis(1-phenylmethoxycarbonyloxyethyl) undecanedioate Chemical compound C=1C=CC=CC=1COC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)OCC1=CC=CC=C1 VXLAQZTUUPSEGS-UHFFFAOYSA-N 0.000 description 1
- XEJPHSFVVNYWSQ-UHFFFAOYSA-N bis(1-propanoyloxyethyl) decanedioate Chemical compound CCC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)CC XEJPHSFVVNYWSQ-UHFFFAOYSA-N 0.000 description 1
- OPFZZLAORDBVMX-UHFFFAOYSA-N bis(1-propanoyloxyethyl) dodecanedioate Chemical compound CCC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)CC OPFZZLAORDBVMX-UHFFFAOYSA-N 0.000 description 1
- CZCHSSPHBGGNPM-UHFFFAOYSA-N bis(1-propanoyloxyethyl) heptanedioate Chemical compound CCC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)CC CZCHSSPHBGGNPM-UHFFFAOYSA-N 0.000 description 1
- PPGDWMDWRGNWOZ-UHFFFAOYSA-N bis(1-propanoyloxyethyl) hexanedioate Chemical compound CCC(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(=O)CC PPGDWMDWRGNWOZ-UHFFFAOYSA-N 0.000 description 1
- LYRBHYYPDPKSRB-UHFFFAOYSA-N bis(1-propanoyloxyethyl) nonanedioate Chemical compound CCC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)CC LYRBHYYPDPKSRB-UHFFFAOYSA-N 0.000 description 1
- QHGNLEIEFRMKAB-UHFFFAOYSA-N bis(1-propanoyloxyethyl) octanedioate Chemical compound CCC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)CC QHGNLEIEFRMKAB-UHFFFAOYSA-N 0.000 description 1
- RJDDMZMOBUXUED-UHFFFAOYSA-N bis(1-propanoyloxyethyl) undecanedioate Chemical compound CCC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)CC RJDDMZMOBUXUED-UHFFFAOYSA-N 0.000 description 1
- UABVXQFBKGKIEC-UHFFFAOYSA-N bis(2,2-dimethylpropanoyloxymethyl) decanedioate Chemical compound CC(C)(C)C(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)C(C)(C)C UABVXQFBKGKIEC-UHFFFAOYSA-N 0.000 description 1
- IBZYNEIWFRWGEE-UHFFFAOYSA-N bis(2,2-dimethylpropanoyloxymethyl) heptanedioate Chemical compound CC(C)(C)C(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)C(C)(C)C IBZYNEIWFRWGEE-UHFFFAOYSA-N 0.000 description 1
- IWWXSUYRZQBTRK-UHFFFAOYSA-N bis(2,2-dimethylpropanoyloxymethyl) hexanedioate Chemical compound CC(C)(C)C(=O)OCOC(=O)CCCCC(=O)OCOC(=O)C(C)(C)C IWWXSUYRZQBTRK-UHFFFAOYSA-N 0.000 description 1
- LPGIISCUQDIEFM-UHFFFAOYSA-N bis(2,2-dimethylpropanoyloxymethyl) octanedioate Chemical compound CC(C)(C)C(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)C(C)(C)C LPGIISCUQDIEFM-UHFFFAOYSA-N 0.000 description 1
- GVXRITCDDHTPIF-UHFFFAOYSA-N bis(acetyloxymethyl) decanedioate Chemical compound CC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(C)=O GVXRITCDDHTPIF-UHFFFAOYSA-N 0.000 description 1
- HJYIKLGXIFERDS-UHFFFAOYSA-N bis(acetyloxymethyl) dodecanedioate Chemical compound CC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(C)=O HJYIKLGXIFERDS-UHFFFAOYSA-N 0.000 description 1
- ONWLTXOIOSMRAZ-UHFFFAOYSA-N bis(acetyloxymethyl) heptanedioate Chemical compound CC(=O)OCOC(=O)CCCCCC(=O)OCOC(C)=O ONWLTXOIOSMRAZ-UHFFFAOYSA-N 0.000 description 1
- QAMNFZVOMMCLIK-UHFFFAOYSA-N bis(acetyloxymethyl) hexanedioate Chemical compound CC(=O)OCOC(=O)CCCCC(=O)OCOC(C)=O QAMNFZVOMMCLIK-UHFFFAOYSA-N 0.000 description 1
- FHMSRJSXZKYXMX-UHFFFAOYSA-N bis(acetyloxymethyl) octanedioate Chemical compound CC(=O)OCOC(=O)CCCCCCC(=O)OCOC(C)=O FHMSRJSXZKYXMX-UHFFFAOYSA-N 0.000 description 1
- RHSIMBKMWPEMOU-UHFFFAOYSA-N bis(acetyloxymethyl) undecanedioate Chemical compound CC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(C)=O RHSIMBKMWPEMOU-UHFFFAOYSA-N 0.000 description 1
- AMCSKILFPWXOST-UHFFFAOYSA-N bis(benzoyloxymethyl) decanedioate Chemical compound C=1C=CC=CC=1C(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)C1=CC=CC=C1 AMCSKILFPWXOST-UHFFFAOYSA-N 0.000 description 1
- GSTVBANTLTXTJW-UHFFFAOYSA-N bis(benzoyloxymethyl) dodecanedioate Chemical compound C=1C=CC=CC=1C(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)C1=CC=CC=C1 GSTVBANTLTXTJW-UHFFFAOYSA-N 0.000 description 1
- TWSDXRPQIONHDX-UHFFFAOYSA-N bis(benzoyloxymethyl) heptanedioate Chemical compound C=1C=CC=CC=1C(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)C1=CC=CC=C1 TWSDXRPQIONHDX-UHFFFAOYSA-N 0.000 description 1
- OXHNCXQZMZQCMM-UHFFFAOYSA-N bis(benzoyloxymethyl) hexanedioate Chemical compound C=1C=CC=CC=1C(=O)OCOC(=O)CCCCC(=O)OCOC(=O)C1=CC=CC=C1 OXHNCXQZMZQCMM-UHFFFAOYSA-N 0.000 description 1
- KOBGCLDFHALTFW-UHFFFAOYSA-N bis(benzoyloxymethyl) nonanedioate Chemical compound C=1C=CC=CC=1C(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)C1=CC=CC=C1 KOBGCLDFHALTFW-UHFFFAOYSA-N 0.000 description 1
- SUBRXTXSULCTGE-UHFFFAOYSA-N bis(benzoyloxymethyl) octanedioate Chemical compound C=1C=CC=CC=1C(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)C1=CC=CC=C1 SUBRXTXSULCTGE-UHFFFAOYSA-N 0.000 description 1
- NTLUYEVRORYSPL-UHFFFAOYSA-N bis(benzoyloxymethyl) undecanedioate Chemical compound C=1C=CC=CC=1C(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)C1=CC=CC=C1 NTLUYEVRORYSPL-UHFFFAOYSA-N 0.000 description 1
- NDUCRNKTPDTSOW-UHFFFAOYSA-N bis(butanoyloxymethyl) decanedioate Chemical compound CCCC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)CCC NDUCRNKTPDTSOW-UHFFFAOYSA-N 0.000 description 1
- QAPQEVUWTCOSMJ-UHFFFAOYSA-N bis(butanoyloxymethyl) dodecanedioate Chemical compound CCCC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)CCC QAPQEVUWTCOSMJ-UHFFFAOYSA-N 0.000 description 1
- YNJPETWBVOZOLH-UHFFFAOYSA-N bis(butanoyloxymethyl) heptanedioate Chemical compound CCCC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)CCC YNJPETWBVOZOLH-UHFFFAOYSA-N 0.000 description 1
- RREJOPWBABDPTG-UHFFFAOYSA-N bis(butanoyloxymethyl) hexanedioate Chemical compound CCCC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)CCC RREJOPWBABDPTG-UHFFFAOYSA-N 0.000 description 1
- ZPVCWNCGHKBKMG-UHFFFAOYSA-N bis(butanoyloxymethyl) octanedioate Chemical compound CCCC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)CCC ZPVCWNCGHKBKMG-UHFFFAOYSA-N 0.000 description 1
- DOJLTHNQCQCSPE-UHFFFAOYSA-N bis(butanoyloxymethyl) undecanedioate Chemical compound CCCC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)CCC DOJLTHNQCQCSPE-UHFFFAOYSA-N 0.000 description 1
- UDIUESJFOYZDDN-UHFFFAOYSA-N bis(ethoxycarbonyloxymethyl) decanedioate Chemical compound CCOC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)OCC UDIUESJFOYZDDN-UHFFFAOYSA-N 0.000 description 1
- QPMUURAZDFOCOI-UHFFFAOYSA-N bis(ethoxycarbonyloxymethyl) dodecanedioate Chemical compound CCOC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)OCC QPMUURAZDFOCOI-UHFFFAOYSA-N 0.000 description 1
- MRQOUJXINWFOQQ-UHFFFAOYSA-N bis(ethoxycarbonyloxymethyl) heptanedioate Chemical compound CCOC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)OCC MRQOUJXINWFOQQ-UHFFFAOYSA-N 0.000 description 1
- ZYTYZEHKWAXPQG-UHFFFAOYSA-N bis(ethoxycarbonyloxymethyl) hexanedioate Chemical compound CCOC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)OCC ZYTYZEHKWAXPQG-UHFFFAOYSA-N 0.000 description 1
- ZTGZHEMWMBALAE-UHFFFAOYSA-N bis(ethoxycarbonyloxymethyl) nonanedioate Chemical compound CCOC(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)OCC ZTGZHEMWMBALAE-UHFFFAOYSA-N 0.000 description 1
- NYKQUSLDVHUBOV-UHFFFAOYSA-N bis(ethoxycarbonyloxymethyl) octanedioate Chemical compound CCOC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)OCC NYKQUSLDVHUBOV-UHFFFAOYSA-N 0.000 description 1
- KDCLBFCOAKAFEY-UHFFFAOYSA-N bis(ethoxycarbonyloxymethyl) undecanedioate Chemical compound CCOC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)OCC KDCLBFCOAKAFEY-UHFFFAOYSA-N 0.000 description 1
- FFAOZZPWKPZCJV-UHFFFAOYSA-N bis(hexanoyloxymethyl) decanedioate Chemical compound CCCCCC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)CCCCC FFAOZZPWKPZCJV-UHFFFAOYSA-N 0.000 description 1
- PIXFLMQPJPPDIL-UHFFFAOYSA-N bis(hexanoyloxymethyl) dodecanedioate Chemical compound CCCCCC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)CCCCC PIXFLMQPJPPDIL-UHFFFAOYSA-N 0.000 description 1
- AXQRQRAOUCBDKH-UHFFFAOYSA-N bis(hexanoyloxymethyl) heptanedioate Chemical compound CCCCCC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)CCCCC AXQRQRAOUCBDKH-UHFFFAOYSA-N 0.000 description 1
- QWQZCEFNFIYDFE-UHFFFAOYSA-N bis(hexanoyloxymethyl) hexanedioate Chemical compound CCCCCC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)CCCCC QWQZCEFNFIYDFE-UHFFFAOYSA-N 0.000 description 1
- VQBKJEPAVHPNFG-UHFFFAOYSA-N bis(hexanoyloxymethyl) nonanedioate Chemical compound CCCCCC(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)CCCCC VQBKJEPAVHPNFG-UHFFFAOYSA-N 0.000 description 1
- RLOWBNXSWPZHSV-UHFFFAOYSA-N bis(hexanoyloxymethyl) octanedioate Chemical compound CCCCCC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)CCCCC RLOWBNXSWPZHSV-UHFFFAOYSA-N 0.000 description 1
- DXSFAFLTSFFPSZ-UHFFFAOYSA-N bis(hexanoyloxymethyl) undecanedioate Chemical compound CCCCCC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)CCCCC DXSFAFLTSFFPSZ-UHFFFAOYSA-N 0.000 description 1
- OLUPFMWYVKVTPF-UHFFFAOYSA-N bis(methoxycarbonyloxymethyl) decanedioate Chemical compound COC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)OC OLUPFMWYVKVTPF-UHFFFAOYSA-N 0.000 description 1
- MAXCLYGVDZLOGR-UHFFFAOYSA-N bis(methoxycarbonyloxymethyl) dodecanedioate Chemical compound COC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)OC MAXCLYGVDZLOGR-UHFFFAOYSA-N 0.000 description 1
- DMVBRIALIOOHGT-UHFFFAOYSA-N bis(methoxycarbonyloxymethyl) heptanedioate Chemical compound COC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)OC DMVBRIALIOOHGT-UHFFFAOYSA-N 0.000 description 1
- YKNYYZRUMMLZAS-UHFFFAOYSA-N bis(methoxycarbonyloxymethyl) hexanedioate Chemical compound COC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)OC YKNYYZRUMMLZAS-UHFFFAOYSA-N 0.000 description 1
- CXUOBEYSLRLTLM-UHFFFAOYSA-N bis(methoxycarbonyloxymethyl) nonanedioate Chemical compound COC(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)OC CXUOBEYSLRLTLM-UHFFFAOYSA-N 0.000 description 1
- BOCXYDPZWCNYDU-UHFFFAOYSA-N bis(methoxycarbonyloxymethyl) octanedioate Chemical compound COC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)OC BOCXYDPZWCNYDU-UHFFFAOYSA-N 0.000 description 1
- DGHAVZAXSIZTHQ-UHFFFAOYSA-N bis(methoxycarbonyloxymethyl) undecanedioate Chemical compound COC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)OC DGHAVZAXSIZTHQ-UHFFFAOYSA-N 0.000 description 1
- CLVICYYERAJNHK-UHFFFAOYSA-N bis(octadecanoyloxymethyl) decanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)CCCCCCCCCCCCCCCCC CLVICYYERAJNHK-UHFFFAOYSA-N 0.000 description 1
- OGTWJLCJDGMARW-UHFFFAOYSA-N bis(octadecanoyloxymethyl) dodecanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)CCCCCCCCCCCCCCCCC OGTWJLCJDGMARW-UHFFFAOYSA-N 0.000 description 1
- QJYJDNZCIAXKRK-UHFFFAOYSA-N bis(octadecanoyloxymethyl) heptanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)CCCCCCCCCCCCCCCCC QJYJDNZCIAXKRK-UHFFFAOYSA-N 0.000 description 1
- QZCUADBRCKDFHJ-UHFFFAOYSA-N bis(octadecanoyloxymethyl) hexanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)CCCCCCCCCCCCCCCCC QZCUADBRCKDFHJ-UHFFFAOYSA-N 0.000 description 1
- BUDHRBODNRRTGD-UHFFFAOYSA-N bis(octadecanoyloxymethyl) nonanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)CCCCCCCCCCCCCCCCC BUDHRBODNRRTGD-UHFFFAOYSA-N 0.000 description 1
- JKNFZWWSHKFNJN-UHFFFAOYSA-N bis(octadecanoyloxymethyl) octanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)CCCCCCCCCCCCCCCCC JKNFZWWSHKFNJN-UHFFFAOYSA-N 0.000 description 1
- XTJXLFOEDDXZTA-UHFFFAOYSA-N bis(octadecanoyloxymethyl) undecanedioate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)CCCCCCCCCCCCCCCCC XTJXLFOEDDXZTA-UHFFFAOYSA-N 0.000 description 1
- DOYXMJAWQKLTAL-UHFFFAOYSA-N bis(octanoyloxymethyl) decanedioate Chemical compound CCCCCCCC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)CCCCCCC DOYXMJAWQKLTAL-UHFFFAOYSA-N 0.000 description 1
- FXHQDWVXTNOPOR-UHFFFAOYSA-N bis(octanoyloxymethyl) dodecanedioate Chemical compound CCCCCCCC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)CCCCCCC FXHQDWVXTNOPOR-UHFFFAOYSA-N 0.000 description 1
- HYDCVZYDTZOMRP-UHFFFAOYSA-N bis(octanoyloxymethyl) heptanedioate Chemical compound CCCCCCCC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)CCCCCCC HYDCVZYDTZOMRP-UHFFFAOYSA-N 0.000 description 1
- HEBIXKONUKIERF-UHFFFAOYSA-N bis(octanoyloxymethyl) hexanedioate Chemical compound CCCCCCCC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)CCCCCCC HEBIXKONUKIERF-UHFFFAOYSA-N 0.000 description 1
- FFXWOWIBGNGUDM-UHFFFAOYSA-N bis(octanoyloxymethyl) nonanedioate Chemical compound CCCCCCCC(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)CCCCCCC FFXWOWIBGNGUDM-UHFFFAOYSA-N 0.000 description 1
- NFUSWJQIDAWTOZ-UHFFFAOYSA-N bis(octanoyloxymethyl) octanedioate Chemical compound CCCCCCCC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)CCCCCCC NFUSWJQIDAWTOZ-UHFFFAOYSA-N 0.000 description 1
- PTTIGCNOGZPKAR-UHFFFAOYSA-N bis(octanoyloxymethyl) undecanedioate Chemical compound CCCCCCCC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)CCCCCCC PTTIGCNOGZPKAR-UHFFFAOYSA-N 0.000 description 1
- ZMUAFZHITMSCLK-UHFFFAOYSA-N bis(phenylmethoxycarbonyloxymethyl) decanedioate Chemical compound C=1C=CC=CC=1COC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)OCC1=CC=CC=C1 ZMUAFZHITMSCLK-UHFFFAOYSA-N 0.000 description 1
- XQRSHDVYRAWMGT-UHFFFAOYSA-N bis(phenylmethoxycarbonyloxymethyl) dodecanedioate Chemical compound C=1C=CC=CC=1COC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)OCC1=CC=CC=C1 XQRSHDVYRAWMGT-UHFFFAOYSA-N 0.000 description 1
- HSOYSXTZFYNNAL-UHFFFAOYSA-N bis(phenylmethoxycarbonyloxymethyl) heptanedioate Chemical compound C=1C=CC=CC=1COC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)OCC1=CC=CC=C1 HSOYSXTZFYNNAL-UHFFFAOYSA-N 0.000 description 1
- VFLLNQFMWHWLNW-UHFFFAOYSA-N bis(phenylmethoxycarbonyloxymethyl) hexanedioate Chemical compound C=1C=CC=CC=1COC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)OCC1=CC=CC=C1 VFLLNQFMWHWLNW-UHFFFAOYSA-N 0.000 description 1
- PHQLTJQCSYBQAG-UHFFFAOYSA-N bis(phenylmethoxycarbonyloxymethyl) nonanedioate Chemical compound C=1C=CC=CC=1COC(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)OCC1=CC=CC=C1 PHQLTJQCSYBQAG-UHFFFAOYSA-N 0.000 description 1
- MXOCDEFRWWBYAX-UHFFFAOYSA-N bis(phenylmethoxycarbonyloxymethyl) octanedioate Chemical compound C=1C=CC=CC=1COC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)OCC1=CC=CC=C1 MXOCDEFRWWBYAX-UHFFFAOYSA-N 0.000 description 1
- CDVBKVBZOQXXQA-UHFFFAOYSA-N bis(propanoyloxymethyl) decanedioate Chemical compound CCC(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)CC CDVBKVBZOQXXQA-UHFFFAOYSA-N 0.000 description 1
- HSNYBOMAXQMWAF-UHFFFAOYSA-N bis(propanoyloxymethyl) dodecanedioate Chemical compound CCC(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)CC HSNYBOMAXQMWAF-UHFFFAOYSA-N 0.000 description 1
- KSRZOLVQQLQBFP-UHFFFAOYSA-N bis(propanoyloxymethyl) heptanedioate Chemical compound CCC(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)CC KSRZOLVQQLQBFP-UHFFFAOYSA-N 0.000 description 1
- VSOMTFJKILFNTP-UHFFFAOYSA-N bis(propanoyloxymethyl) hexanedioate Chemical compound CCC(=O)OCOC(=O)CCCCC(=O)OCOC(=O)CC VSOMTFJKILFNTP-UHFFFAOYSA-N 0.000 description 1
- ZLHBXIYZLRGVAQ-UHFFFAOYSA-N bis(propanoyloxymethyl) nonanedioate Chemical compound CCC(=O)OCOC(=O)CCCCCCCC(=O)OCOC(=O)CC ZLHBXIYZLRGVAQ-UHFFFAOYSA-N 0.000 description 1
- CDCBGKCABJVIOL-UHFFFAOYSA-N bis(propanoyloxymethyl) octanedioate Chemical compound CCC(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)CC CDCBGKCABJVIOL-UHFFFAOYSA-N 0.000 description 1
- RXYIWRXWHDDTGB-UHFFFAOYSA-N bis(propanoyloxymethyl) undecanedioate Chemical compound CCC(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)CC RXYIWRXWHDDTGB-UHFFFAOYSA-N 0.000 description 1
- UZRKJSJGSAOERX-UHFFFAOYSA-N bis[(2,2,2-trifluoroacetyl)oxymethyl] decanedioate Chemical compound FC(F)(F)C(=O)OCOC(=O)CCCCCCCCC(=O)OCOC(=O)C(F)(F)F UZRKJSJGSAOERX-UHFFFAOYSA-N 0.000 description 1
- WOANMTDJBIRXEC-UHFFFAOYSA-N bis[(2,2,2-trifluoroacetyl)oxymethyl] dodecanedioate Chemical compound FC(F)(F)C(=O)OCOC(=O)CCCCCCCCCCC(=O)OCOC(=O)C(F)(F)F WOANMTDJBIRXEC-UHFFFAOYSA-N 0.000 description 1
- YYWXCBJSHHDSTR-UHFFFAOYSA-N bis[(2,2,2-trifluoroacetyl)oxymethyl] heptanedioate Chemical compound FC(F)(F)C(=O)OCOC(=O)CCCCCC(=O)OCOC(=O)C(F)(F)F YYWXCBJSHHDSTR-UHFFFAOYSA-N 0.000 description 1
- DQLRNMBDCZHSJQ-UHFFFAOYSA-N bis[(2,2,2-trifluoroacetyl)oxymethyl] hexanedioate Chemical compound FC(F)(F)C(=O)OCOC(=O)CCCCC(=O)OCOC(=O)C(F)(F)F DQLRNMBDCZHSJQ-UHFFFAOYSA-N 0.000 description 1
- KBNPEDMTANIYTI-UHFFFAOYSA-N bis[(2,2,2-trifluoroacetyl)oxymethyl] octanedioate Chemical compound FC(F)(F)C(=O)OCOC(=O)CCCCCCC(=O)OCOC(=O)C(F)(F)F KBNPEDMTANIYTI-UHFFFAOYSA-N 0.000 description 1
- LFDPSAVUEXGJPT-UHFFFAOYSA-N bis[(2,2,2-trifluoroacetyl)oxymethyl] undecanedioate Chemical compound FC(F)(F)C(=O)OCOC(=O)CCCCCCCCCC(=O)OCOC(=O)C(F)(F)F LFDPSAVUEXGJPT-UHFFFAOYSA-N 0.000 description 1
- NOVQXMVRWNGEEP-UHFFFAOYSA-N bis[(2-phenylacetyl)oxymethyl] decanedioate Chemical compound C(CCCCCCCCC(=O)OCOC(CC1=CC=CC=C1)=O)(=O)OCOC(CC1=CC=CC=C1)=O NOVQXMVRWNGEEP-UHFFFAOYSA-N 0.000 description 1
- CODNHYVNVUKNOY-UHFFFAOYSA-N bis[(2-phenylacetyl)oxymethyl] dodecanedioate Chemical compound C(CCCCCCCCCCC(=O)OCOC(CC1=CC=CC=C1)=O)(=O)OCOC(CC1=CC=CC=C1)=O CODNHYVNVUKNOY-UHFFFAOYSA-N 0.000 description 1
- FGCIZCLIDCNDFY-UHFFFAOYSA-N bis[(2-phenylacetyl)oxymethyl] heptanedioate Chemical compound C(CCCCCC(=O)OCOC(CC1=CC=CC=C1)=O)(=O)OCOC(CC1=CC=CC=C1)=O FGCIZCLIDCNDFY-UHFFFAOYSA-N 0.000 description 1
- YTENINDXWLXMQM-UHFFFAOYSA-N bis[(2-phenylacetyl)oxymethyl] hexanedioate Chemical compound C(CCCCC(=O)OCOC(CC1=CC=CC=C1)=O)(=O)OCOC(CC1=CC=CC=C1)=O YTENINDXWLXMQM-UHFFFAOYSA-N 0.000 description 1
- DMZONVRSQCBTPB-UHFFFAOYSA-N bis[(2-phenylacetyl)oxymethyl] octanedioate Chemical compound C(CCCCCCC(=O)OCOC(CC1=CC=CC=C1)=O)(=O)OCOC(CC1=CC=CC=C1)=O DMZONVRSQCBTPB-UHFFFAOYSA-N 0.000 description 1
- AZGLUCIRDRKPNT-UHFFFAOYSA-N bis[(2-phenylacetyl)oxymethyl] undecanedioate Chemical compound C(CCCCCCCCCC(=O)OCOC(CC1=CC=CC=C1)=O)(=O)OCOC(CC1=CC=CC=C1)=O AZGLUCIRDRKPNT-UHFFFAOYSA-N 0.000 description 1
- YWAACBNDYBVDSE-UHFFFAOYSA-N bis[1-(2,2,2-trifluoroacetyl)oxyethyl] decanedioate Chemical compound FC(F)(F)C(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)C(F)(F)F YWAACBNDYBVDSE-UHFFFAOYSA-N 0.000 description 1
- UJXHYENISMAASW-UHFFFAOYSA-N bis[1-(2,2,2-trifluoroacetyl)oxyethyl] dodecanedioate Chemical compound FC(F)(F)C(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)C(F)(F)F UJXHYENISMAASW-UHFFFAOYSA-N 0.000 description 1
- IKMHQVYEBVKKLC-UHFFFAOYSA-N bis[1-(2,2,2-trifluoroacetyl)oxyethyl] heptanedioate Chemical compound FC(F)(F)C(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)C(F)(F)F IKMHQVYEBVKKLC-UHFFFAOYSA-N 0.000 description 1
- JWXJXEQELZMDAR-UHFFFAOYSA-N bis[1-(2,2,2-trifluoroacetyl)oxyethyl] hexanedioate Chemical compound FC(F)(F)C(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(=O)C(F)(F)F JWXJXEQELZMDAR-UHFFFAOYSA-N 0.000 description 1
- BBXNVWNOIDGCDV-UHFFFAOYSA-N bis[1-(2,2,2-trifluoroacetyl)oxyethyl] nonanedioate Chemical compound FC(F)(F)C(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)C(F)(F)F BBXNVWNOIDGCDV-UHFFFAOYSA-N 0.000 description 1
- BGGFTHFVYBTOLE-UHFFFAOYSA-N bis[1-(2,2,2-trifluoroacetyl)oxyethyl] octanedioate Chemical compound FC(F)(F)C(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)C(F)(F)F BGGFTHFVYBTOLE-UHFFFAOYSA-N 0.000 description 1
- QYMVBPKIJZFEBF-UHFFFAOYSA-N bis[1-(2,2,2-trifluoroacetyl)oxyethyl] undecanedioate Chemical compound FC(F)(F)C(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)C(F)(F)F QYMVBPKIJZFEBF-UHFFFAOYSA-N 0.000 description 1
- TZXXWINSZYPXNV-UHFFFAOYSA-N bis[1-(2-phenylacetyl)oxyethyl] decanedioate Chemical compound C=1C=CC=CC=1CC(=O)OC(C)OC(=O)CCCCCCCCC(=O)OC(C)OC(=O)CC1=CC=CC=C1 TZXXWINSZYPXNV-UHFFFAOYSA-N 0.000 description 1
- ITQKZIMRCGMBJP-UHFFFAOYSA-N bis[1-(2-phenylacetyl)oxyethyl] dodecanedioate Chemical compound C=1C=CC=CC=1CC(=O)OC(C)OC(=O)CCCCCCCCCCC(=O)OC(C)OC(=O)CC1=CC=CC=C1 ITQKZIMRCGMBJP-UHFFFAOYSA-N 0.000 description 1
- MHBNFUXVFGNOQD-UHFFFAOYSA-N bis[1-(2-phenylacetyl)oxyethyl] heptanedioate Chemical compound C=1C=CC=CC=1CC(=O)OC(C)OC(=O)CCCCCC(=O)OC(C)OC(=O)CC1=CC=CC=C1 MHBNFUXVFGNOQD-UHFFFAOYSA-N 0.000 description 1
- KRVFFOFDXXOPBG-UHFFFAOYSA-N bis[1-(2-phenylacetyl)oxyethyl] hexanedioate Chemical compound C=1C=CC=CC=1CC(=O)OC(C)OC(=O)CCCCC(=O)OC(C)OC(=O)CC1=CC=CC=C1 KRVFFOFDXXOPBG-UHFFFAOYSA-N 0.000 description 1
- JTPOSBVNSOVVEI-UHFFFAOYSA-N bis[1-(2-phenylacetyl)oxyethyl] nonanedioate Chemical compound C=1C=CC=CC=1CC(=O)OC(C)OC(=O)CCCCCCCC(=O)OC(C)OC(=O)CC1=CC=CC=C1 JTPOSBVNSOVVEI-UHFFFAOYSA-N 0.000 description 1
- ULZAHTCHAHNAST-UHFFFAOYSA-N bis[1-(2-phenylacetyl)oxyethyl] octanedioate Chemical compound C=1C=CC=CC=1CC(=O)OC(C)OC(=O)CCCCCCC(=O)OC(C)OC(=O)CC1=CC=CC=C1 ULZAHTCHAHNAST-UHFFFAOYSA-N 0.000 description 1
- QBXPPLSBXKOFDA-UHFFFAOYSA-N bis[1-(2-phenylacetyl)oxyethyl] undecanedioate Chemical compound C=1C=CC=CC=1CC(=O)OC(C)OC(=O)CCCCCCCCCC(=O)OC(C)OC(=O)CC1=CC=CC=C1 QBXPPLSBXKOFDA-UHFFFAOYSA-N 0.000 description 1
- SMFPLJXYVHJUNL-UHFFFAOYSA-N bis[2-(2,2-dimethylpropanoyloxy)ethyl] decanedioate Chemical compound CC(C)(C)C(=O)OCCOC(=O)CCCCCCCCC(=O)OCCOC(=O)C(C)(C)C SMFPLJXYVHJUNL-UHFFFAOYSA-N 0.000 description 1
- WJQXCGRVXVZOKW-UHFFFAOYSA-N bis[2-(2,2-dimethylpropanoyloxy)ethyl] dodecanedioate Chemical compound CC(C)(C)C(=O)OCCOC(=O)CCCCCCCCCCC(=O)OCCOC(=O)C(C)(C)C WJQXCGRVXVZOKW-UHFFFAOYSA-N 0.000 description 1
- YRHPJJPZUKBMTA-UHFFFAOYSA-N bis[2-(2,2-dimethylpropanoyloxy)ethyl] heptanedioate Chemical compound CC(C)(C)C(=O)OCCOC(=O)CCCCCC(=O)OCCOC(=O)C(C)(C)C YRHPJJPZUKBMTA-UHFFFAOYSA-N 0.000 description 1
- PUBBCMWEJIXNBR-UHFFFAOYSA-N bis[2-(2,2-dimethylpropanoyloxy)ethyl] hexanedioate Chemical compound CC(C)(C)C(=O)OCCOC(=O)CCCCC(=O)OCCOC(=O)C(C)(C)C PUBBCMWEJIXNBR-UHFFFAOYSA-N 0.000 description 1
- LKNNPLGQVHBMFT-UHFFFAOYSA-N bis[2-(2,2-dimethylpropanoyloxy)ethyl] nonanedioate Chemical compound CC(C)(C)C(=O)OCCOC(=O)CCCCCCCC(=O)OCCOC(=O)C(C)(C)C LKNNPLGQVHBMFT-UHFFFAOYSA-N 0.000 description 1
- VMNKAKFGWYQTFV-UHFFFAOYSA-N bis[2-(2,2-dimethylpropanoyloxy)ethyl] octanedioate Chemical compound CC(C)(C)C(=O)OCCOC(=O)CCCCCCC(=O)OCCOC(=O)C(C)(C)C VMNKAKFGWYQTFV-UHFFFAOYSA-N 0.000 description 1
- RKTZICXYJBGXFG-UHFFFAOYSA-N bis[2-(2,2-dimethylpropanoyloxy)ethyl] undecanedioate Chemical compound CC(C)(C)C(=O)OCCOC(=O)CCCCCCCCCC(=O)OCCOC(=O)C(C)(C)C RKTZICXYJBGXFG-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical class [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000012830 cancer therapeutic Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 208000032343 candida glabrata infection Diseases 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- 229960005243 carmustine Drugs 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 159000000006 cesium salts Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960004630 chlorambucil Drugs 0.000 description 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 229960002436 cladribine Drugs 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940111134 coxibs Drugs 0.000 description 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 229960000684 cytarabine Drugs 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 150000001990 dicarboxylic acid derivatives Chemical class 0.000 description 1
- 125000001142 dicarboxylic acid group Chemical group 0.000 description 1
- 229960002656 didanosine Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 229960001904 epirubicin Drugs 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229940125753 fibrate Drugs 0.000 description 1
- 229960000390 fludarabine Drugs 0.000 description 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229960002963 ganciclovir Drugs 0.000 description 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 229960005277 gemcitabine Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
- 229960002867 griseofulvin Drugs 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 1
- YWGHUJQYGPDNKT-UHFFFAOYSA-N hexanoyl chloride Chemical compound CCCCCC(Cl)=O YWGHUJQYGPDNKT-UHFFFAOYSA-N 0.000 description 1
- OJGRZJILAIHWIY-UHFFFAOYSA-N hexyl 2-chloroacetate Chemical compound CCCCCCOC(=O)CCl OJGRZJILAIHWIY-UHFFFAOYSA-N 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960000908 idarubicin Drugs 0.000 description 1
- 229960001101 ifosfamide Drugs 0.000 description 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 229960001936 indinavir Drugs 0.000 description 1
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001627 lamivudine Drugs 0.000 description 1
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 229960001156 mitoxantrone Drugs 0.000 description 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- UOBSVARXACCLLH-UHFFFAOYSA-N monomethyl adipate Chemical class COC(=O)CCCCC(O)=O UOBSVARXACCLLH-UHFFFAOYSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229960000689 nevirapine Drugs 0.000 description 1
- 239000002353 niosome Substances 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- REEZZSHJLXOIHL-UHFFFAOYSA-N octanoyl chloride Chemical compound CCCCCCCC(Cl)=O REEZZSHJLXOIHL-UHFFFAOYSA-N 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 239000013588 oral product Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 229940127084 other anti-cancer agent Drugs 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229950010765 pivalate Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229960004432 raltitrexed Drugs 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 229960000311 ritonavir Drugs 0.000 description 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 231100000161 signs of toxicity Toxicity 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229960001203 stavudine Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229960000565 tazarotene Drugs 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 229960000303 topotecan Drugs 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- DXNCZXXFRKPEPY-UHFFFAOYSA-N tridecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCC(O)=O DXNCZXXFRKPEPY-UHFFFAOYSA-N 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 229960001028 zanamivir Drugs 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/50—Sebacic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/44—Adipic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/48—Azelaic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Lubricants (AREA)
- Tires In General (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0128052.8 | 2001-11-22 | ||
| GBGB0128052.8A GB0128052D0 (en) | 2001-11-22 | 2001-11-22 | Compounds |
| PCT/GB2002/005305 WO2003045893A1 (en) | 2001-11-22 | 2002-11-22 | Double esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20040071138A true KR20040071138A (ko) | 2004-08-11 |
Family
ID=9926289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2004-7007220A Withdrawn KR20040071138A (ko) | 2001-11-22 | 2002-11-22 | 이중 에스테르류 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7629383B2 (enExample) |
| EP (1) | EP1448508B1 (enExample) |
| JP (1) | JP4426298B2 (enExample) |
| KR (1) | KR20040071138A (enExample) |
| CN (1) | CN100516018C (enExample) |
| AT (1) | ATE443695T1 (enExample) |
| AU (1) | AU2002343086C1 (enExample) |
| CA (1) | CA2467773C (enExample) |
| DE (1) | DE60233819D1 (enExample) |
| GB (1) | GB0128052D0 (enExample) |
| HU (1) | HUP0402122A2 (enExample) |
| MX (1) | MXPA04004763A (enExample) |
| NO (1) | NO20042603L (enExample) |
| RU (1) | RU2350599C2 (enExample) |
| WO (1) | WO2003045893A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| DE102006004804A1 (de) * | 2006-01-23 | 2007-07-26 | Intendis Gmbh | Verwendung von Alkandicarbonsäuren und Retinoiden zur Behandlung entzündlicher Hauterkrankungen |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4462934A (en) | 1983-03-31 | 1984-07-31 | Pfizer Inc. | Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides |
| GB8310080D0 (en) * | 1983-04-14 | 1983-05-18 | Interox Chemicals Ltd | Bleach composition |
| DE3465334D1 (en) | 1983-04-14 | 1987-09-17 | Interox Chemicals Ltd | Peroxygen compounds |
| ATE74359T1 (de) * | 1987-01-27 | 1992-04-15 | Pfizer | 6-beta(substituierte)-(s)hydroxymethylpenicillans|ure und deren derivate. |
| LU86918A1 (fr) * | 1987-06-12 | 1989-03-08 | Oreal | Nouveaux diesters de l'acide azelaique,leur procede de preparation,les compositions topiques les contenant et leur utilisation dans le traitement de l'acne |
| EP0577659B1 (en) | 1991-03-28 | 1996-01-17 | Nycomed Imaging As | Cross-linking agent |
| CZ284844B6 (cs) | 1992-03-06 | 1999-03-17 | Nycomed Imaging A/S | Kontrastní prostředek a způsob jeho výroby |
| GB9504948D0 (en) * | 1995-03-10 | 1995-04-26 | Norwegian Radium Hospital Rese | Compounds |
| JP4029440B2 (ja) | 1997-07-09 | 2008-01-09 | 大日本インキ化学工業株式会社 | 側鎖型ラジカル重合性化合物及びそれを用いた液晶デバイス |
-
2001
- 2001-11-22 GB GBGB0128052.8A patent/GB0128052D0/en not_active Ceased
-
2002
- 2002-11-22 MX MXPA04004763A patent/MXPA04004763A/es unknown
- 2002-11-22 JP JP2003547347A patent/JP4426298B2/ja not_active Expired - Fee Related
- 2002-11-22 EP EP02779748A patent/EP1448508B1/en not_active Expired - Lifetime
- 2002-11-22 WO PCT/GB2002/005305 patent/WO2003045893A1/en not_active Ceased
- 2002-11-22 DE DE60233819T patent/DE60233819D1/de not_active Expired - Lifetime
- 2002-11-22 AU AU2002343086A patent/AU2002343086C1/en not_active Ceased
- 2002-11-22 AT AT02779748T patent/ATE443695T1/de not_active IP Right Cessation
- 2002-11-22 CN CNB028232739A patent/CN100516018C/zh not_active Expired - Fee Related
- 2002-11-22 US US10/496,328 patent/US7629383B2/en not_active Expired - Fee Related
- 2002-11-22 KR KR10-2004-7007220A patent/KR20040071138A/ko not_active Withdrawn
- 2002-11-22 HU HU0402122A patent/HUP0402122A2/hu unknown
- 2002-11-22 CA CA2467773A patent/CA2467773C/en not_active Expired - Fee Related
- 2002-11-22 RU RU2004118713/04A patent/RU2350599C2/ru not_active IP Right Cessation
-
2004
- 2004-06-21 NO NO20042603A patent/NO20042603L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20042603L (no) | 2004-06-21 |
| DE60233819D1 (de) | 2009-11-05 |
| RU2350599C2 (ru) | 2009-03-27 |
| AU2002343086B2 (en) | 2008-01-03 |
| CN100516018C (zh) | 2009-07-22 |
| JP2005510556A (ja) | 2005-04-21 |
| CA2467773C (en) | 2011-08-16 |
| MXPA04004763A (es) | 2004-07-30 |
| GB0128052D0 (en) | 2002-01-16 |
| AU2002343086C1 (en) | 2008-06-26 |
| CA2467773A1 (en) | 2003-06-05 |
| US20050203181A1 (en) | 2005-09-15 |
| WO2003045893A1 (en) | 2003-06-05 |
| HUP0402122A2 (hu) | 2005-02-28 |
| AU2002343086A1 (en) | 2003-06-10 |
| JP4426298B2 (ja) | 2010-03-03 |
| US7629383B2 (en) | 2009-12-08 |
| EP1448508A1 (en) | 2004-08-25 |
| RU2004118713A (ru) | 2005-03-27 |
| ATE443695T1 (de) | 2009-10-15 |
| EP1448508B1 (en) | 2009-09-23 |
| CN1589254A (zh) | 2005-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20240156770A1 (en) | High penetration prodrug compositions of retinoids and retinoid-related compounds | |
| Nudelman et al. | Novel anticancer prodrugs of butyric acid. 2 | |
| TWI316942B (en) | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents | |
| WO2022133544A1 (en) | Cbd cannabinoids and cbd cannabinoid analogues | |
| WO2019113210A1 (en) | Phosphonium-based ionic drug conjugates | |
| EP0308564B1 (fr) | Composition inhibitrice ou destructrice d'au moins un être vivant unicellulaire renfermant un fluorure d'ammononium quaternaire et procédé de préparation de ce sel | |
| FR2598420A1 (fr) | Nouveaux esters retinoiques d'antibiotiques, leur procede de preparation et compositions pharmaceutiques et cosmetiques les contenant | |
| TWI384988B (zh) | 處理中樞神經系統失常用之組成物 | |
| RU2350599C2 (ru) | Двойные сложные эфиры | |
| FR2483232A1 (fr) | Nouveaux agents anti-rhinovirus et leur procede de preparation | |
| IT9021768A1 (it) | Derivato della melatonina ad attivita' terapeutica in dermatologia. | |
| JPH05105627A (ja) | 腸機能性疾患の治療に用いられる新規な医薬組成物と、その調整方法と、治療用医薬の調製方法 | |
| CA3031815A1 (en) | Dermatological formulations of 2-(2-ethoxy-2-oxoethyl)(methyl)amino-2-oxoethyl 5-(tetradecyloxy)furan-2-carboxylate | |
| EP4069370A1 (en) | Phenolic dihydrobenzofurane derivatives, medical and cosmetic preparations containing these derivatives, and use thereof | |
| US7528166B2 (en) | Lignan derivatives | |
| US12195437B2 (en) | Lipophenolic flavonoid derivatives useful to reduce carbonyl and oxidative stresses (COS) | |
| CA2553318A1 (fr) | Derives de pyranone utiles pour le traitement du cancer | |
| US20230109489A1 (en) | Compound and Use Thereof | |
| EP2195323B1 (fr) | Composés polyspiranniques, leur application dans le traitement du paludisme ou de la toxoplasmose et leur procédé de préparation | |
| WO2022155290A1 (en) | Antibiotics with improved drug resistance profile | |
| US20080033031A1 (en) | Antibiotic compounds, compositions and methods of treatment | |
| CA2988593A1 (en) | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof | |
| BE881677A (fr) | Nouveaux derives d'acide penicillanique utile notamment comme antibiotiques et leurs procedes de preparation | |
| WO2003075913A1 (en) | Topical compostions comprising furfuryl derivatives and their use for the treatment of dermatologic disorders | |
| JPH0769881A (ja) | 抗ｈｉｖ剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20040512 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |