CA2466928A1 - Treatment of neurodegenerative and cardiovascular disorders - Google Patents

Treatment of neurodegenerative and cardiovascular disorders Download PDF

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Publication number
CA2466928A1
CA2466928A1 CA002466928A CA2466928A CA2466928A1 CA 2466928 A1 CA2466928 A1 CA 2466928A1 CA 002466928 A CA002466928 A CA 002466928A CA 2466928 A CA2466928 A CA 2466928A CA 2466928 A1 CA2466928 A1 CA 2466928A1
Authority
CA
Canada
Prior art keywords
independently
optionally substituted
nr4r5
aryl
neurodegenerative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002466928A
Other languages
English (en)
French (fr)
Inventor
Yansheng Du
Martin R. Farlow
Ruyu Du
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2466928A1 publication Critical patent/CA2466928A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002466928A 2001-12-10 2002-12-10 Treatment of neurodegenerative and cardiovascular disorders Abandoned CA2466928A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33921501P 2001-12-10 2001-12-10
US60/339,215 2001-12-10
PCT/US2002/039458 WO2003053425A1 (en) 2001-12-10 2002-12-10 Treatment of neurodegenerative and cardiovascular disorders

Publications (1)

Publication Number Publication Date
CA2466928A1 true CA2466928A1 (en) 2003-07-03

Family

ID=23328006

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002466928A Abandoned CA2466928A1 (en) 2001-12-10 2002-12-10 Treatment of neurodegenerative and cardiovascular disorders

Country Status (9)

Country Link
US (2) US20030139458A1 (zh)
EP (1) EP1461025B1 (zh)
JP (1) JP4511183B2 (zh)
CN (1) CN100358515C (zh)
AT (1) ATE517617T1 (zh)
AU (1) AU2002351341A1 (zh)
CA (1) CA2466928A1 (zh)
TW (1) TWI335220B (zh)
WO (1) WO2003053425A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070208087A1 (en) 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
ES2473581T3 (es) 2002-05-31 2014-07-07 Proteotech Inc. Compuestos, composiciones y métodos para el tratamiento de amiloidosis y sinucleinopat�as tales como la enfermedad de Alzheimer, la diabetes de tipo 2 y la enfermedad de Parkinson
US20040167217A1 (en) * 2003-02-26 2004-08-26 Giovanni Scapagnini Neuroprotective effects of polyphenolic compounds
US20090227673A1 (en) * 2006-01-13 2009-09-10 Bao Ting Zhu Method and Composition for the Treatment of Parkinson's Disease
EP2125712B1 (en) * 2006-12-04 2014-07-23 Novotyr Therapeutics Ltd. Novel protein kinase modulators and therapeutic uses thereof
US8637575B2 (en) 2008-06-05 2014-01-28 Novotyr Therapeutics Ltd. Modulators of protein kinase signaling
CN101941907B (zh) * 2010-05-28 2015-04-01 毛腾淑 4-叔丁基苄基-3,4-二羟基肉桂酸酯及其用途和制备方法
EP2629766B1 (en) * 2010-10-18 2017-02-22 Chemigen Combination therapy
WO2012068038A2 (en) * 2010-11-15 2012-05-24 Chemigen Caffeic acid derivatives and their use in improving neuronal cell viability
US9770454B2 (en) 2013-07-14 2017-09-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. IGF-1R signaling pathway inhibitors useful in the treatment of neurodegenerative diseases
EP3253733B1 (en) 2015-02-05 2020-04-29 TyrNovo Ltd. Combinations of irs/stat3 dual modulators and anti-cancer agents for treating cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721398A1 (de) * 1976-05-19 1977-12-01 Ciba Geigy Ag Alkylphenol-stabilisatoren
JPS62294634A (ja) * 1986-04-11 1987-12-22 ワ−ナ−−ランバ−ト・コンパニ− ジアリ−ルアルカノイドおよびその製法
US4959503A (en) * 1986-04-11 1990-09-25 Warner-Lambert Company Diarylalkanoids having activity as lipoxygenase inhibitors
JPH0678286B2 (ja) * 1988-03-18 1994-10-05 三井東圧化学株式会社 ジヒドロカフェイン酸誘導体およびそれを有効成分として含有する治療剤
DE3920616A1 (de) * 1989-06-23 1991-01-03 Boehringer Mannheim Gmbh Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate
DE4126662A1 (de) * 1991-08-13 1993-02-18 Boehringer Mannheim Gmbh Neue 3,5-di-tert.butyl-4-hydroxyphenyl-derivate, verfahren zu ihrer herstellung und arzneimittel
WO1997023202A1 (en) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Subtype-selective nmda receptor ligands and the use thereof
CN1132577C (zh) * 1996-09-05 2003-12-31 研究发展基金会 用咖啡酸苯乙酯抑制核转录因子NF－kB
TW466115B (en) * 1996-12-10 2001-12-01 American Home Prod Pharmaceutical composition of antioxidant from equilenin
IL131410A0 (en) * 1997-02-15 2001-01-28 Proscript Inc Pharmaceutical compositions for treating infarcts through inhibition of nf-kappab
GB9801398D0 (en) * 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
CN1212861C (zh) * 1999-09-17 2005-08-03 第一三得利制药株式会社 以NF－κB抑制剂为有效成分的心肌炎、扩张型心肌病和心衰的预防或治疗药

Also Published As

Publication number Publication date
US20100160433A1 (en) 2010-06-24
JP2005513100A (ja) 2005-05-12
US8575215B2 (en) 2013-11-05
CN100358515C (zh) 2008-01-02
TWI335220B (en) 2011-01-01
JP4511183B2 (ja) 2010-07-28
WO2003053425A1 (en) 2003-07-03
CN1589137A (zh) 2005-03-02
US20030139458A1 (en) 2003-07-24
EP1461025B1 (en) 2011-07-27
ATE517617T1 (de) 2011-08-15
EP1461025A1 (en) 2004-09-29
TW200301100A (en) 2003-07-01
EP1461025A4 (en) 2009-07-29
AU2002351341A1 (en) 2003-07-09

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Legal Events

Date Code Title Description
FZDE Discontinued