CA2466338C - New uses for anti-malarial therapeutic agents - Google Patents

New uses for anti-malarial therapeutic agents Download PDF

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Publication number
CA2466338C
CA2466338C CA002466338A CA2466338A CA2466338C CA 2466338 C CA2466338 C CA 2466338C CA 002466338 A CA002466338 A CA 002466338A CA 2466338 A CA2466338 A CA 2466338A CA 2466338 C CA2466338 C CA 2466338C
Authority
CA
Canada
Prior art keywords
use according
hydrogen
lower alkyl
group
malarial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002466338A
Other languages
English (en)
French (fr)
Other versions
CA2466338A1 (en
Inventor
Lauren Charous
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
APT Pharmaceuticals LLC
Original Assignee
APT Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by APT Pharmaceuticals LLC filed Critical APT Pharmaceuticals LLC
Publication of CA2466338A1 publication Critical patent/CA2466338A1/en
Application granted granted Critical
Publication of CA2466338C publication Critical patent/CA2466338C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA002466338A 2001-11-09 2002-11-12 New uses for anti-malarial therapeutic agents Expired - Fee Related CA2466338C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34587201P 2001-11-09 2001-11-09
US60/345,872 2001-11-09
PCT/US2002/036309 WO2003039546A1 (en) 2001-11-09 2002-11-12 New uses for anti-malarial therapeutic agents

Publications (2)

Publication Number Publication Date
CA2466338A1 CA2466338A1 (en) 2003-05-15
CA2466338C true CA2466338C (en) 2010-01-12

Family

ID=23356861

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002466338A Expired - Fee Related CA2466338C (en) 2001-11-09 2002-11-12 New uses for anti-malarial therapeutic agents

Country Status (9)

Country Link
US (1) US20040167162A1 (https=)
EP (1) EP1450803A4 (https=)
JP (1) JP2005512998A (https=)
CN (1) CN1289086C (https=)
AU (1) AU2002363443B2 (https=)
CA (1) CA2466338C (https=)
IL (1) IL161821A0 (https=)
MX (1) MXPA04004393A (https=)
WO (1) WO2003039546A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7084157B2 (en) * 2002-05-17 2006-08-01 Rajeev Raut Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation
BR0318214A (pt) * 2003-03-27 2006-03-21 Council Scient Ind Res análogos de 8-aminoquinolina substituìda no anel, composição anti-malárica, processo para a preparação de análogos de 8-aminoquinolina substituìda no anel, e, uso de análogos de 8-aminoquinolina substituìda no anel
US20070134596A1 (en) * 2005-12-08 2007-06-14 Adrian Lungu Photosensitive printing element having nanoparticles and method for preparing the printing element
RU2008135762A (ru) * 2006-02-16 2010-03-27 Де МакЛин Хоспитал Корпорейшн (US) Способы и композиции для лечения болезни паркинсона
KR101067443B1 (ko) * 2009-06-23 2011-09-27 여오영 하이드록시클로로퀸을 함유하는 치핵 치료를 위한 국소투여용 주사제 조성물
CN103027915A (zh) * 2011-09-29 2013-04-10 中国医学科学院基础医学研究所 氯喹治疗和氯丙嗪预防肺感染和损伤的用途
CN103705516B (zh) * 2013-12-11 2016-01-06 武汉威立得生物医药有限公司 氯喔星在制备治疗或预防流感病毒感染的药物中的应用
KR101828553B1 (ko) * 2016-04-15 2018-02-13 한국화학연구원 신규한 벤조싸이오펜 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물
CA3029012C (en) * 2016-06-28 2024-10-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Hycanthone derivatives and primaquine derivatives intended for use in preventing and/or treating conditions associated with Gammaherpesvirinae
CN111658648A (zh) * 2020-02-03 2020-09-15 中国人民解放军军事科学院军事医学研究院 4-氨基喹啉类化合物在治疗冠状病毒感染方面的应用
US20210244705A1 (en) * 2020-02-07 2021-08-12 Centre For Digestive Diseases Therapeutic compositions, products of manufacture and methods for ameliorating or preventing coronavirus infection
CN114657149B (zh) * 2020-02-16 2023-10-20 北京化工大学 西拉菌素在制备治疗冠状病毒感染性疾病的药物的用途
US11007187B1 (en) * 2020-03-25 2021-05-18 Therapeutica Borealis Oy Medicine for Covid-19 and treatment
US11278602B2 (en) 2020-03-25 2022-03-22 Therapeutica Borealis Oy Medicine for Covid-19 and treatment
WO2021191496A1 (en) * 2020-03-25 2021-09-30 Therapeutica Borealis Oy Medicine for covid-19 and treatment
US11638722B2 (en) 2020-03-25 2023-05-02 Therapeutica Borealis Oy C/O Avance Attorneys Ltd. Medicine for Covid-19 and treatment
WO2021204717A1 (en) * 2020-04-06 2021-10-14 Oxandia Ltd Aminoquinolines for treating coronavirus infections
EP3892275A1 (en) * 2020-04-08 2021-10-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Aerosolization of hcq or its metabolites for the treatment of lung infections
JP2023521563A (ja) * 2020-04-14 2023-05-25 グラニス ファーマシューティカル インコーポレイテッド ヒドロキシクロロキン及び／又はクロロキンを含む経皮及び／又は局所送達システム
KR20230035518A (ko) * 2020-04-21 2023-03-14 노암 코헨 선천적 면역 반응을 생성하기 위한 퀴닌과 그의 용도
WO2021212183A1 (en) * 2020-04-24 2021-10-28 Centre For Digestive Diseases Pty Limited Products of manufacture and methods for treating, ameliorating or preventing microbial infections
EP4142728B1 (en) * 2020-04-27 2025-01-29 Immunologik GmbH 6'-methoxycinchonan-9-ols for the treatment of coronaviral infections
WO2021217574A1 (en) * 2020-04-30 2021-11-04 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Treatment or prevention of coronaviridae infection
CA3192574A1 (en) * 2020-09-14 2022-03-17 Florian Alexis CALVINO Pharmaceutical composition comprising hydroxychloroquine and uses thereof
DE102021000717A1 (de) * 2021-02-12 2022-08-18 Forschungszentrum Jülich GmbH Quinacrin als lnhibitor viraler Cysteinproteasen und/oder Serinproteasen
US20240391876A1 (en) * 2021-08-19 2024-11-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Quinacrine and derivatives thereof for treatment of viral infections
CN115869311A (zh) * 2022-12-30 2023-03-31 湖北工业大学 MefloquineHydrochloride在制备抗腺病毒ADV7药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181725A (en) * 1977-05-02 1980-01-01 The Regents Of The University Of Michigan Method for alleviating psoriasis
US4496549A (en) * 1983-01-17 1985-01-29 American Cyanamid Company Treatment of malaria with antibiotics
US5153202A (en) * 1988-06-30 1992-10-06 Davis Michael H Method of inhibiting the activity of human immuno deficiency virus (HIV) in vivo
US5376359A (en) * 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
US5827681A (en) * 1996-12-20 1998-10-27 University Technology Corporation Rapid detection and drug sensitivity of malaria
JP2002543122A (ja) * 1999-04-30 2002-12-17 エイピーティー ファーマスーティカルズ エルエルスィー 抗マラリア治療剤についての新規使用

Also Published As

Publication number Publication date
EP1450803A4 (en) 2008-09-03
MXPA04004393A (es) 2005-09-12
AU2002363443B2 (en) 2006-02-16
WO2003039546A1 (en) 2003-05-15
IL161821A0 (en) 2005-11-20
CN1612735A (zh) 2005-05-04
HK1075619A1 (en) 2005-12-23
US20040167162A1 (en) 2004-08-26
JP2005512998A (ja) 2005-05-12
EP1450803A1 (en) 2004-09-01
CN1289086C (zh) 2006-12-13
CA2466338A1 (en) 2003-05-15

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MKLA Lapsed

Effective date: 20131113