CA2464924A1 - Derives de carboxamide heteroaromatique destines au traitement des inflammations - Google Patents

Derives de carboxamide heteroaromatique destines au traitement des inflammations Download PDF

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Publication number
CA2464924A1
CA2464924A1 CA002464924A CA2464924A CA2464924A1 CA 2464924 A1 CA2464924 A1 CA 2464924A1 CA 002464924 A CA002464924 A CA 002464924A CA 2464924 A CA2464924 A CA 2464924A CA 2464924 A1 CA2464924 A1 CA 2464924A1
Authority
CA
Canada
Prior art keywords
carboxamide
amino
group
substituted
thiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002464924A
Other languages
English (en)
Inventor
Matthew Graneto
Cathleen E. Hanau
Thao D. Perry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2464924A1 publication Critical patent/CA2464924A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

La présente invention concerne des dérivés de carboxamide héréroaromatique, des compositions comprenant ces dérivés, des intermédiaires, des techniques de fabrication de ces dérivés de carboxamide héréroaromatique et des techniques de traitement du cancer, des inflammations et des pathologies associées aux inflammations, telles que l'arthrite.
CA002464924A 2001-10-30 2002-10-30 Derives de carboxamide heteroaromatique destines au traitement des inflammations Abandoned CA2464924A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34081601P 2001-10-30 2001-10-30
US60/340,816 2001-10-30
PCT/US2002/034801 WO2003037886A2 (fr) 2001-10-30 2002-10-30 Derives de carboxamide heteroaromatique destines au traitement des inflammations

Publications (1)

Publication Number Publication Date
CA2464924A1 true CA2464924A1 (fr) 2003-05-08

Family

ID=23335051

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002464924A Abandoned CA2464924A1 (fr) 2001-10-30 2002-10-30 Derives de carboxamide heteroaromatique destines au traitement des inflammations

Country Status (7)

Country Link
EP (1) EP1444010A2 (fr)
JP (1) JP2005509645A (fr)
AU (1) AU2002356871A1 (fr)
BR (1) BR0213734A (fr)
CA (1) CA2464924A1 (fr)
MX (1) MXPA04004064A (fr)
WO (1) WO2003037886A2 (fr)

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PE20060748A1 (es) 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
MX2007012116A (es) 2005-03-29 2008-04-08 Icos Corp Derivados de heteroaril urea utiles para inhibir chk1.
GB0507200D0 (en) * 2005-04-08 2005-05-18 Smithkline Beecham Corp Chemical compounds
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
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CA2637335A1 (fr) 2006-01-23 2007-08-02 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides utiles en tant qu'inhibiteurs de proteines kinases
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MX2008013584A (es) 2006-04-26 2009-03-23 Genentech Inc Compuestos farmaceuticos.
US8853244B2 (en) 2006-05-23 2014-10-07 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
CN101495474A (zh) 2006-05-23 2009-07-29 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的噻吩-甲酰胺类
CA2653654A1 (fr) 2006-06-06 2007-12-21 Boehringer Ingelheim International Gmbh Composes amide de l'acide 3-amino-thieno[2,3-b]pyridine-2-carboxylique substitues, procedes de preparation et leurs utilisations
WO2008020622A1 (fr) * 2006-08-17 2008-02-21 Kyorin Pharmaceutical Co., Ltd. NOUVEAU COMPOSÉ DE THIÉNO[2,3-d]PYRIMIDINE
PE20081679A1 (es) 2006-12-07 2008-12-18 Hoffmann La Roche Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US7893059B2 (en) 2007-09-24 2011-02-22 Genentech, Inc. Thiazolopyrimidine PI3K inhibitor compounds and methods of use
WO2009085983A1 (fr) 2007-12-19 2009-07-09 Genentech, Inc. 5-anilinoimidazopyridines et procédés d'utilisation
WO2009082687A1 (fr) 2007-12-21 2009-07-02 Genentech, Inc. Azaindolizines et procédés d'utilisation
BRPI1008749B8 (pt) 2009-02-05 2021-05-25 Immunogen Inc compostos derivados de benzodiazepina, seus conjugados, composição farmacêutica, seu uso e seus processos de preparação
WO2010102968A1 (fr) 2009-03-10 2010-09-16 Glaxo Group Limited Dérivés d'indole comme inhibiteurs de ikk2
CA2753285A1 (fr) 2009-03-12 2010-09-16 Genentech, Inc. Combinaisons de composes inhibiteurs de phosphoinositide 3-kinase et d'agents chimiotherapeutiques pour le traitement de tumeurs malignes hematopoietiques
JP2012524066A (ja) * 2009-04-16 2012-10-11 テリック，インコーポレイテッド チューブリン重合阻害剤としての置換４−アミノ−５−ベンゾイル−２−（フェニルアミノ）チオフェン−３−カルボニトリルおよび置換４−アミノ−５−ベンゾイル−２−（フェニルアミノ）チオフェン−３−カルボキサミド
BR112012006802A2 (pt) 2009-09-28 2020-08-18 F.Hoffmann-La Roche Ag composto, composição farmacêutica, método para tratar câncer, usos de um composto, kit e invenção
WO2011049625A1 (fr) 2009-10-20 2011-04-28 Mansour Samadpour Procédé de criblage d'aflatoxine dans des produits
JP5889795B2 (ja) 2009-11-05 2016-03-22 ライゼン・ファーマシューティカルズ・エスアー 新規キナーゼモジュレーター
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PT2705029T (pt) 2011-05-04 2019-02-01 Rhizen Pharmaceuticals S A Novos compostos como moduladores de proteína quinases
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HUE034591T2 (en) 2012-07-04 2018-02-28 Rhizen Pharmaceuticals S A Selective PI3K delta inhibitors
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WO2014134483A2 (fr) 2013-02-28 2014-09-04 Immunogen, Inc. Conjugués comprenant des agents de liaison cellulaire (cba) et des agents cytotoxiques
US9901647B2 (en) 2013-02-28 2018-02-27 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
WO2014194030A2 (fr) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugués comprenant des agents de liaison cellulaire et des agents cytotoxiques
AR104068A1 (es) 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
EP3507305A1 (fr) 2016-09-02 2019-07-10 Dana-Farber Cancer Institute, Inc. Composition et méthodes de traitement des déreglements des lymphocytes b
WO2018204775A1 (fr) 2017-05-05 2018-11-08 Hepanova, Inc. Composés amino-aryl-benzamide et leurs procédés d'utilisation

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Also Published As

Publication number Publication date
EP1444010A2 (fr) 2004-08-11
AU2002356871A1 (en) 2003-05-12
MXPA04004064A (es) 2004-09-06
BR0213734A (pt) 2004-10-19
WO2003037886A2 (fr) 2003-05-08
JP2005509645A (ja) 2005-04-14
WO2003037886A3 (fr) 2003-12-24

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EEER Examination request
FZDE Dead