CA2461989C - Method for treating multiple myeloma - Google Patents

Method for treating multiple myeloma Download PDF

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Publication number
CA2461989C
CA2461989C CA2461989A CA2461989A CA2461989C CA 2461989 C CA2461989 C CA 2461989C CA 2461989 A CA2461989 A CA 2461989A CA 2461989 A CA2461989 A CA 2461989A CA 2461989 C CA2461989 C CA 2461989C
Authority
CA
Canada
Prior art keywords
antibody
cells
seq
set forth
region set
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2461989A
Other languages
English (en)
French (fr)
Other versions
CA2461989A1 (en
Inventor
Robert Lindsay Raison
Rosanne Dorothy Dunn
Boon Hwa Andre Choo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Haemalogix Pty Ltd
Original Assignee
Immune System Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immune System Therapeutics Ltd filed Critical Immune System Therapeutics Ltd
Publication of CA2461989A1 publication Critical patent/CA2461989A1/en
Application granted granted Critical
Publication of CA2461989C publication Critical patent/CA2461989C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/80Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2461989A 2001-07-06 2002-07-05 Method for treating multiple myeloma Expired - Lifetime CA2461989C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPR6179A AUPR617901A0 (en) 2001-07-06 2001-07-06 Method for treating multiple myeloma
AUPR6179 2001-07-06
PCT/AU2002/000896 WO2003004056A1 (en) 2001-07-06 2002-07-05 Method for treating multiple myeloma

Publications (2)

Publication Number Publication Date
CA2461989A1 CA2461989A1 (en) 2003-01-16
CA2461989C true CA2461989C (en) 2011-11-15

Family

ID=3830143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2461989A Expired - Lifetime CA2461989C (en) 2001-07-06 2002-07-05 Method for treating multiple myeloma

Country Status (13)

Country Link
US (3) US7344715B2 (cg-RX-API-DMAC7.html)
EP (1) EP1414492B1 (cg-RX-API-DMAC7.html)
JP (1) JP4535424B2 (cg-RX-API-DMAC7.html)
CN (1) CN1551783B (cg-RX-API-DMAC7.html)
AU (1) AUPR617901A0 (cg-RX-API-DMAC7.html)
CA (1) CA2461989C (cg-RX-API-DMAC7.html)
DE (1) DE60223688T2 (cg-RX-API-DMAC7.html)
DK (1) DK1414492T3 (cg-RX-API-DMAC7.html)
ES (1) ES2296952T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA04000130A (cg-RX-API-DMAC7.html)
NZ (1) NZ530099A (cg-RX-API-DMAC7.html)
WO (1) WO2003004056A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200400959B (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR617901A0 (en) * 2001-07-06 2001-08-02 Pacmab Pty Ltd Method for treating multiple myeloma
ZA200607426B (en) * 2004-02-27 2007-11-28 Pacmab Ltd Target for B-Cell disorders
AU2005318407B2 (en) * 2004-12-23 2009-11-05 F. Hoffmann-La Roche Ag Detection of a therapeutic antibody in an experimental animal
GB0608444D0 (en) * 2006-04-27 2006-06-07 Binding Site The Ltd Dialysis
AU2009211635B2 (en) 2008-02-08 2014-06-26 National Center For Geriatrics And Gerontology Antibody capable of binding specifically to Abeta-oligomer, and use thereof
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
MX339022B (es) * 2009-04-07 2016-05-05 Immune System Therapeutics Ltd Método para el tratamiento de trastornos inmunes.
US9090679B2 (en) 2009-04-17 2015-07-28 Immunas Pharma, Inc. Antibodies that specifically bind to A beta oligomers and use thereof
US8613924B2 (en) 2009-08-06 2013-12-24 Immunas Pharma, Inc. Antibodies that specifically bind to A beta oligomers and use thereof
WO2011016238A1 (en) 2009-08-06 2011-02-10 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
CN102241773B (zh) * 2010-05-13 2014-05-14 四川大学 抗骨髓瘤细胞多克隆抗体及其制备方法
BR112012033163A2 (pt) 2010-08-17 2016-10-11 Hoffmann La Roche ''anticorpos monoclonais, linhagens celulares, usos de um anticorpo, kit, métodos para detectar um anticorpo, composição de anticorpo e uso de uma composição de anticorpo''
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
HK1220205A1 (zh) 2013-03-15 2017-04-28 Celgene Corporation 修饰的t淋巴细胞
PT3286223T (pt) * 2015-04-23 2024-03-22 HaemaLogiX Ltd Recetores de antigénio quimérico do antigénio do mieloma kappa e suas utilizações
CN109395058A (zh) * 2016-03-13 2019-03-01 曹帅 一种用于治疗骨髓增生、骨癌的药物组合物及其用途
CA3041284A1 (en) 2016-10-20 2018-04-26 Celgene Corporation Cereblon-based heterodimerizable chimeric antigen receptors
AU2019392579A1 (en) * 2018-12-03 2021-06-24 Haemalogix Pty Ltd Method of treatment
BR112022019076A2 (pt) * 2020-03-27 2023-01-10 HaemaLogiX Ltd Composição e método
JP2023085151A (ja) * 2021-12-08 2023-06-20 株式会社八神製作所 体外ホウ素中性子反応を用いた幹細胞の分取方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
AUPR617901A0 (en) * 2001-07-06 2001-08-02 Pacmab Pty Ltd Method for treating multiple myeloma

Also Published As

Publication number Publication date
AU2006202148A1 (en) 2006-06-08
US7838041B2 (en) 2010-11-23
NZ530099A (en) 2006-04-28
EP1414492B1 (en) 2007-11-21
JP4535424B2 (ja) 2010-09-01
WO2003004056A1 (en) 2003-01-16
CN1551783A (zh) 2004-12-01
US7556803B2 (en) 2009-07-07
CA2461989A1 (en) 2003-01-16
US20090263358A1 (en) 2009-10-22
JP2005504018A (ja) 2005-02-10
DE60223688D1 (de) 2008-01-03
ES2296952T3 (es) 2008-05-01
EP1414492A4 (en) 2005-12-21
DE60223688T2 (de) 2008-10-30
CN1551783B (zh) 2010-11-03
US20080199463A1 (en) 2008-08-21
US20040214761A1 (en) 2004-10-28
DK1414492T3 (da) 2008-04-07
US7344715B2 (en) 2008-03-18
ZA200400959B (en) 2005-04-26
AUPR617901A0 (en) 2001-08-02
EP1414492A1 (en) 2004-05-06
MXPA04000130A (es) 2005-06-06

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Effective date: 20220705