CA2458958A1 - Method and apparatus for dispensing inhalator medicament - Google Patents
Method and apparatus for dispensing inhalator medicament Download PDFInfo
- Publication number
- CA2458958A1 CA2458958A1 CA002458958A CA2458958A CA2458958A1 CA 2458958 A1 CA2458958 A1 CA 2458958A1 CA 002458958 A CA002458958 A CA 002458958A CA 2458958 A CA2458958 A CA 2458958A CA 2458958 A1 CA2458958 A1 CA 2458958A1
- Authority
- CA
- Canada
- Prior art keywords
- medicament
- blister pack
- blisters
- medicaments
- delivering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Applications Claiming Priority (5)
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| US34454401P | 2001-10-19 | 2001-10-19 | |
| US60/344,544 | 2001-10-19 | ||
| US10/267,013 US7931022B2 (en) | 2001-10-19 | 2002-10-08 | Method and apparatus for dispensing inhalator medicament |
| US10/267,013 | 2002-10-08 | ||
| PCT/US2002/032387 WO2003035137A2 (en) | 2001-10-19 | 2002-10-10 | Method and apparatus for dispensing inhalator medicament |
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| CA2458958A1 true CA2458958A1 (en) | 2003-05-01 |
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Country Status (5)
| Country | Link |
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| US (4) | US7931022B2 (de) |
| EP (1) | EP1439878A2 (de) |
| JP (1) | JP2005506880A (de) |
| CA (1) | CA2458958A1 (de) |
| WO (1) | WO2003035137A2 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241611T3 (es) * | 1999-06-05 | 2005-11-01 | Innovata Biomed Limited | Sisstema de suministro de medicamentos. |
| GB9920839D0 (en) * | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
| GB9928265D0 (en) * | 1999-12-01 | 2000-01-26 | Innovata Biomed Ltd | Inhaler |
| JP5154732B2 (ja) * | 2001-02-06 | 2013-02-27 | イノバータ・バイオメッド・リミテッド | 薬剤 |
| GB0128148D0 (en) * | 2001-11-23 | 2002-01-16 | Innovata Biomed Ltd | Assembly |
| GB0217199D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
| EP1467790A1 (de) * | 2002-01-25 | 2004-10-20 | Glaxo Group Limited | Arzneimittelspender |
| GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| US20050147566A1 (en) * | 2002-03-12 | 2005-07-07 | Scott Fleming | Site specific delivery of co-administered drugs via inhalation |
| GB0217198D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
| SE526509C2 (sv) * | 2003-06-19 | 2005-09-27 | Microdrug Ag | Kombinerade doser av formoterol och budesonid separerade på en gemensam dosbädd |
| SE527069C2 (sv) * | 2003-06-19 | 2005-12-13 | Mederio Ag | Förfarande och anordning för administrering av läkemedelspulver |
| SE527200C2 (sv) * | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av formaterol och fluticason |
| GB0315509D0 (en) | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
| WO2005013963A1 (en) * | 2003-08-06 | 2005-02-17 | Galephar M/F | Advantageous combinations for inhalation of nacystelyn and bronchodilators |
| US20070221218A1 (en) * | 2003-10-27 | 2007-09-27 | Warden Jeffrey A | Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods |
| JP2007526796A (ja) * | 2003-12-15 | 2007-09-20 | アレックザ ファーマシューティカルズ， インコーポレイテッド | 薬剤エアロゾル吸入による突出痛の治療 |
| JP4601627B2 (ja) * | 2004-01-16 | 2010-12-22 | バイオデル， インコーポレイテッド | 舌下薬物送達デバイス |
| SE528121C2 (sv) * | 2004-03-29 | 2006-09-05 | Mederio Ag | Preparering av torrpulver för på förhand uppmätt DPI |
| US20090317477A1 (en) * | 2004-03-31 | 2009-12-24 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis |
| US20050227927A1 (en) * | 2004-03-31 | 2005-10-13 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis |
| EP1744800B1 (de) * | 2004-04-21 | 2016-06-22 | Innovata Biomed Limited | Inhalator |
| GB0409197D0 (en) | 2004-04-24 | 2004-05-26 | Innovata Biomed Ltd | Device |
| WO2006031712A2 (en) | 2004-09-13 | 2006-03-23 | Oriel Therapeutics, Inc. | Tubular dry powder drug containment systems, associated inhalers and methods |
| WO2006113309A1 (en) * | 2005-04-15 | 2006-10-26 | Dr. Reddy's Laboratories Ltd. | Lacidipine particles |
| US20080216825A1 (en) * | 2005-08-08 | 2008-09-11 | Dilraj Singh | Insulated Cansister for Metered Dose Inhalers |
| US8360057B2 (en) * | 2006-03-10 | 2013-01-29 | Dose One, Llc | Medication inhaler for dispensing multiple capsules |
| GR1005668B (el) | 2006-05-09 | 2007-10-02 | Συσκευη εισπνοων ξηρης σκονης για την ταυτοχρονη χορηγηση περισσοτερων απο μιας φαρμακευτικων ουσιων | |
| US20090250058A1 (en) * | 2006-07-14 | 2009-10-08 | Astrazeneca Ab | Inhalation System and Delivery Device for the Administration of a Drug in the Form of Dry Powder |
| US20080063722A1 (en) * | 2006-09-08 | 2008-03-13 | Advanced Inhalation Research, Inc. | Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI) |
| WO2009050726A2 (en) * | 2007-05-28 | 2009-04-23 | Panacea Biotec Limited | Compositions and methods for improved delivery of bupropion |
| WO2009079078A1 (en) | 2007-12-14 | 2009-06-25 | Labogroup S.A.S. | Delivering aerosolizable food products |
| EP2082760A1 (de) * | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International Gmbh | Inhalator |
| CA2732840C (en) | 2008-09-26 | 2016-07-05 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and related devices and methods |
| WO2010036355A2 (en) * | 2008-09-26 | 2010-04-01 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially biased piercers and related methods |
| CN102159270B (zh) | 2008-09-26 | 2014-07-02 | 奥里尔治疗公司 | 一种带有具有气道盘沟槽的气道盘的吸入器和相关的气道盘和方法 |
| US9050427B2 (en) * | 2008-09-30 | 2015-06-09 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
| US20100081954A1 (en) * | 2008-09-30 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and system to control pH in pulmonary tissue of a subject |
| ES2561899T3 (es) * | 2008-10-01 | 2016-03-01 | Oriel Therapeutics, Inc. | Inhaladores de polvo seco con mecanismos de perforación giratorios y dispositivos y métodos relacionados |
| JP5801997B2 (ja) * | 2009-07-07 | 2015-10-28 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器 |
| WO2011085022A1 (en) | 2010-01-05 | 2011-07-14 | Microdose Therapeutx, Inc. | Inhalation device and method |
| US8490795B2 (en) | 2010-02-01 | 2013-07-23 | Mallinckrodt Llc | Container and method for facilitating disposal of unused pharmaceutical product |
| US9046403B2 (en) * | 2010-02-01 | 2015-06-02 | Mallinckrodt Llc | Systems and methods for managing use of a medicament |
| USD641076S1 (en) | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
| USD635246S1 (en) | 2010-03-26 | 2011-03-29 | Oriel Therapeutics, Inc. | Dose disk for dry powder inhalers |
| US9427533B2 (en) * | 2010-11-29 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Medicated module for an inhaler |
| EP2645972A1 (de) * | 2010-11-29 | 2013-10-09 | Sanofi-Aventis Deutschland GmbH | Ophtalmische arzneimittelverabreichungsvorrichtung mit medizinischem modul |
| EP2556832B1 (de) * | 2011-08-12 | 2017-07-19 | Universitätsklinikum Freiburg | Uridin und Uridinanaloga zur Behandlung von Chronischer obstruktiver Lungenerkrankung |
| WO2013114371A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Dry powder formulations of dnase i |
| CN104208688A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 糠酸莫米松、肾上腺素β2-受体激动剂分别包装并在一个吸入装置同时使用的药物组合物 |
| CN104208690A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 环索奈德、肾上腺素β2-受体激动剂分别包装并在一个吸入装置同时使用的药物组合物 |
| CN104208689A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 布地奈德、肾上腺素β2-受体激动剂分别包装并在一个吸入装置同时使用的药物组合物 |
| CN104208686A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 氟替卡松、肾上腺素β2-受体激动剂分别包装并在一个吸入装置同时使用的药物组合物 |
| CN104208687A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 不同活性成分分别包装并在一个吸入装置同时使用的干粉吸入药物组合物 |
| US20170304459A1 (en) | 2014-10-10 | 2017-10-26 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
| FR3032353B1 (fr) * | 2015-02-06 | 2017-03-10 | Jacques Seguin | Composition pharmaceutique et dispositif pour le traitement de la douleur |
| AU2016247973A1 (en) | 2015-04-15 | 2017-11-16 | Philip Morris Products S.A. | Dry powder inhalers with partial dosage delivery |
| CA3022449A1 (en) * | 2016-07-07 | 2018-01-11 | Philip Morris Products S.A. | Nicotine inhaler system |
| CN109821118A (zh) * | 2017-11-23 | 2019-05-31 | 正大天晴药业集团股份有限公司 | 新型肺部药物输送系统 |
| DE102018108958A1 (de) * | 2018-04-16 | 2019-10-17 | Emphasys Importadora Exportadora E Distribuidora Ltda. | Trockenpulverinhalator |
| US20200324064A1 (en) * | 2019-04-10 | 2020-10-15 | Cai Gu Huang | Inhalation Device for Administering Powdered Pharmaceutical Composition |
| EP4061457A1 (de) * | 2020-06-15 | 2022-09-28 | Norton (Waterford) Limited | Blisterpackung und inhalator damit |
| CA3227858A1 (en) | 2021-09-29 | 2023-04-06 | Norton (Waterford) Limited | Dry powder medicament inhaler |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL58649A (en) * | 1978-11-10 | 1982-04-30 | Beecham Group Ltd | Pharmaceutical dispensing container |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| IE56059B1 (en) * | 1982-10-08 | 1991-04-10 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| US4738817A (en) * | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
| GR861995B (en) * | 1985-07-30 | 1986-11-04 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| US5270305A (en) * | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
| US5002048A (en) * | 1989-12-12 | 1991-03-26 | Makiej Jr Walter J | Inhalation device utilizing two or more aerosol containers |
| US6536427B2 (en) * | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
| SE9002895D0 (sv) * | 1990-09-12 | 1990-09-12 | Astra Ab | Inhalation devices for dispensing powders i |
| US5874063A (en) * | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
| IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
| AU673660C (en) * | 1991-12-18 | 2002-07-25 | Astrazeneca Ab | New combination of formoterol and budesonide |
| GB2264237A (en) | 1992-02-05 | 1993-08-25 | Robert Edward Newell | An inhaler |
| GB9203761D0 (en) * | 1992-02-21 | 1992-04-08 | Innovata Biomed Ltd | Inhaler |
| GB2270293A (en) * | 1992-09-05 | 1994-03-09 | Medix Ltd | Drug dispensing system |
| JP3194956B2 (ja) * | 1992-09-11 | 2001-08-06 | グラクソ、グループ、リミテッド | 吸入装置 |
| SE9203743D0 (sv) * | 1992-12-11 | 1992-12-11 | Astra Ab | Efficient use |
| US6250300B1 (en) * | 1992-12-11 | 2001-06-26 | Ab Astra | System for dispensing pharmaceutically active compounds |
| US5368187A (en) * | 1993-01-19 | 1994-11-29 | Poncetta; Stanley | Method and apparatus for dispensing materials from blister packages |
| US5349947A (en) * | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
| DE4400084C2 (de) | 1994-01-04 | 2001-08-02 | Softec Gmbh & Co Kg | Vorrichtung zum Verabreichen von Medikamenten in fester in einem Luftstrom fein verteilter Form |
| US5415162A (en) * | 1994-01-18 | 1995-05-16 | Glaxo Inc. | Multi-dose dry powder inhalation device |
| GB9404945D0 (en) * | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
| US5983956A (en) * | 1994-10-03 | 1999-11-16 | Astra Aktiebolag | Formulation for inhalation |
| US5980949A (en) * | 1994-10-03 | 1999-11-09 | Astra Aktiebolag | Formulation for inhalation |
| SE9501384D0 (sv) * | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
| US5826571A (en) | 1995-06-08 | 1998-10-27 | Innovative Devices, Llc | Device for use with metered dose inhalers (MDIS) |
| DE19523516C1 (de) | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
| US6209538B1 (en) | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| EA001016B1 (ru) * | 1996-01-03 | 2000-08-28 | Глаксо Груп Лимитед | Ингаляционное устройство |
| SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| SE9700133D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| SE9700424D0 (sv) | 1997-02-07 | 1997-02-07 | Astra Ab | Powder inhaler |
| SE9700423D0 (sv) | 1997-02-07 | 1997-02-07 | Astra Ab | Disposable inhaler |
| CN100548277C (zh) | 1997-03-20 | 2009-10-14 | 先灵公司 | 粉末附聚物的制备方法 |
| US5830490A (en) * | 1997-04-04 | 1998-11-03 | Weinstein; Robert E. | Method and device for organizing and coordinating the combined use of topical aerosols and oral medications for the treatment of disorders |
| US6564945B1 (en) * | 1997-07-14 | 2003-05-20 | Robert E. Weinstein | Medication assemblage for use in sinusitis treatment regimens |
| US6270796B1 (en) * | 1997-10-29 | 2001-08-07 | Robert E. Weinstein | Antihistamine/decongestant regimens for treating rhinitis |
| SE9800897D0 (sv) * | 1998-03-17 | 1998-03-17 | Astra Ab | Inhalation device |
| PL346271A1 (en) * | 1998-08-26 | 2002-01-28 | Smithkline Beecham Corp | Therapies for treating pulmonary diseases |
| US6234167B1 (en) * | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
| GB9902493D0 (en) * | 1999-02-05 | 1999-03-24 | Glaxo Group Ltd | Inhalation device |
| GB9902689D0 (en) * | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
| GB9903759D0 (en) | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
| FI107126B (fi) * | 1999-04-23 | 2001-06-15 | Orion Yhtymae Oyj | Jauheinhalaattori yhdistelmälääkkeelle |
| SE516826C2 (sv) * | 1999-06-18 | 2002-03-05 | Shl Medical Ab | Anordning i en inhalator med organ för aktivering och avaktivering av en kanister som svar på ett luftflöde |
| GB9920839D0 (en) * | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
| US6880555B1 (en) * | 1999-10-12 | 2005-04-19 | Shl Medical Ab | Inhaler |
| GB9924415D0 (en) * | 1999-10-16 | 1999-12-15 | Glaxo Group Ltd | Medicament pack |
| GB9928265D0 (en) | 1999-12-01 | 2000-01-26 | Innovata Biomed Ltd | Inhaler |
| FI20000810A0 (fi) * | 2000-04-06 | 2000-04-06 | Orion Yhtymae Oyj | Jauheinhalaattori |
| WO2001078735A1 (en) | 2000-04-13 | 2001-10-25 | Innovata Biomed Limited | Medicaments for treating respiratory disorders comprising formoterol and fluticasone |
| GB0009591D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medical combinations |
| CA2409093C (en) * | 2000-05-16 | 2009-07-21 | Regents Of The University Of Minnesota | High mass throughput particle generation using multiple nozzle spraying |
| GB0015034D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Inhalation device |
| US6543443B1 (en) * | 2000-07-12 | 2003-04-08 | Aerogen, Inc. | Methods and devices for nebulizing fluids |
| US20020066691A1 (en) * | 2000-12-04 | 2002-06-06 | Varon Steven C. | Therapy pack |
| US6630743B2 (en) * | 2001-02-27 | 2003-10-07 | International Business Machines Corporation | Copper plated PTH barrels and methods for fabricating |
| US6667344B2 (en) * | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| US6651816B2 (en) * | 2001-05-04 | 2003-11-25 | Robert E. Weinstein | Antihistamine/decongestant regimens for treating rhinitis |
| GB0122031D0 (en) | 2001-09-12 | 2001-10-31 | Pfizer Ltd | Use of pde4 inhibitors in a dry powder inhaler |
| CA2460904C (en) * | 2001-09-19 | 2011-03-22 | Advent Pharmaceuticals Pty Ltd | An inhaler for delivering metered doses of powdered medicament |
| TW518802B (en) * | 2001-10-03 | 2003-01-21 | Accton Technology Corp | Broadband circularly polarized panel antenna |
| GR1004350B (el) * | 2002-03-29 | 2003-09-26 | Συσκευη εισπνοων ξηρης σκονης | |
| US6889690B2 (en) * | 2002-05-10 | 2005-05-10 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages |
| SI1386630T1 (sl) | 2002-07-31 | 2006-10-31 | Chiesi Farma Spa | Inhalator za prasek |
| CA2506866A1 (en) | 2002-11-20 | 2004-06-03 | Sun Pharmaceutical Industries Limited | Dry powder inhaler |
-
2002
- 2002-10-08 US US10/267,013 patent/US7931022B2/en active Active
- 2002-10-10 JP JP2003537699A patent/JP2005506880A/ja not_active Withdrawn
- 2002-10-10 CA CA002458958A patent/CA2458958A1/en not_active Abandoned
- 2002-10-10 EP EP02802130A patent/EP1439878A2/de not_active Withdrawn
- 2002-10-10 WO PCT/US2002/032387 patent/WO2003035137A2/en active Application Filing
-
2006
- 2006-07-26 US US11/494,793 patent/US20070181124A1/en not_active Abandoned
- 2006-07-26 US US11/494,769 patent/US20070017513A1/en not_active Abandoned
- 2006-07-26 US US11/494,764 patent/US20070044795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003035137A3 (en) | 2003-12-24 |
| US20070181124A1 (en) | 2007-08-09 |
| US20030075172A1 (en) | 2003-04-24 |
| US7931022B2 (en) | 2011-04-26 |
| WO2003035137A2 (en) | 2003-05-01 |
| JP2005506880A (ja) | 2005-03-10 |
| EP1439878A2 (de) | 2004-07-28 |
| US20070017513A1 (en) | 2007-01-25 |
| US20070044795A1 (en) | 2007-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |