CA2458084A1 - Nouvelle methode de synthese de l'octreotide - Google Patents

Nouvelle methode de synthese de l'octreotide Download PDF

Info

Publication number
CA2458084A1
CA2458084A1 CA002458084A CA2458084A CA2458084A1 CA 2458084 A1 CA2458084 A1 CA 2458084A1 CA 002458084 A CA002458084 A CA 002458084A CA 2458084 A CA2458084 A CA 2458084A CA 2458084 A1 CA2458084 A1 CA 2458084A1
Authority
CA
Canada
Prior art keywords
boc
phe
cys
trt
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002458084A
Other languages
English (en)
Inventor
Alexei Iarov
Ilya Avrutov
Natalie Lazarowych
Stephen Houldsworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DALTON CHEMICAL LABORATORIES Inc
Original Assignee
DALTON CHEMICAL LABORATORIES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DALTON CHEMICAL LABORATORIES Inc filed Critical DALTON CHEMICAL LABORATORIES Inc
Priority to CA002458084A priority Critical patent/CA2458084A1/fr
Priority to PCT/CA2005/000378 priority patent/WO2005087794A1/fr
Publication of CA2458084A1 publication Critical patent/CA2458084A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
CA002458084A 2004-03-12 2004-03-12 Nouvelle methode de synthese de l'octreotide Abandoned CA2458084A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002458084A CA2458084A1 (fr) 2004-03-12 2004-03-12 Nouvelle methode de synthese de l'octreotide
PCT/CA2005/000378 WO2005087794A1 (fr) 2004-03-12 2005-03-14 Procede de synthese d'octreotide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002458084A CA2458084A1 (fr) 2004-03-12 2004-03-12 Nouvelle methode de synthese de l'octreotide

Publications (1)

Publication Number Publication Date
CA2458084A1 true CA2458084A1 (fr) 2005-09-12

Family

ID=34975525

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002458084A Abandoned CA2458084A1 (fr) 2004-03-12 2004-03-12 Nouvelle methode de synthese de l'octreotide

Country Status (2)

Country Link
CA (1) CA2458084A1 (fr)
WO (1) WO2005087794A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013132505A1 (fr) 2012-03-09 2013-09-12 Natco Pharma Limited Procédé amélioré pour la préparation d'octréotide par une synthèse peptidique en phase solution
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010089757A2 (fr) 2008-11-07 2010-08-12 Usv Limited Procédé amélioré de synthèse d'un octapeptide cyclique
CA2748873C (fr) 2009-01-23 2017-09-12 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methodes et compositions basees sur la proteine shiga-toxine de type 2
WO2013046233A2 (fr) 2011-09-30 2013-04-04 Mylan Laboratories Ltd Procédé de préparation d'acétate d'octréotide
US9388212B2 (en) 2013-02-21 2016-07-12 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Solid phase peptide synthesis via side chain attachment
CN102850438B (zh) * 2012-09-19 2014-11-05 上海昂博生物技术有限公司 一种奥曲肽粗品的固相制备方法
JP6382488B2 (ja) * 2013-02-21 2018-08-29 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． 側鎖結合を介する固相ペプチド合成
WO2017175107A1 (fr) * 2016-04-04 2017-10-12 Emcure Pharmaceuticals Limited Procédé de préparation d'acétate d'octréotide
CN117534728A (zh) * 2024-01-10 2024-02-09 哈尔滨吉象隆生物技术有限公司 一种奥曲肽三硫键杂质e的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2144357B1 (es) * 1998-01-29 2000-12-16 Lipotec Sa Procedimiento para la obtencion del analogo de somatostatina octreotide.
US6476186B1 (en) * 2000-05-23 2002-11-05 Institute Of Nuclear Energy Research Process for preparing octreotide and derivatives thereof
AU2003245030A1 (en) * 2002-05-22 2003-12-02 Suresh Beri Novel process for production of the somatostatin analog, octreotide

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013132505A1 (fr) 2012-03-09 2013-09-12 Natco Pharma Limited Procédé amélioré pour la préparation d'octréotide par une synthèse peptidique en phase solution
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products

Also Published As

Publication number Publication date
WO2005087794A1 (fr) 2005-09-22

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Legal Events

Date Code Title Description
FZDE Discontinued