CA2457056C - Compositions pharmaceutiques comprenant des conjugues de polysaccharides permettant l'inhibition des metastases ou la prevention de la recurrence des tumeurs malignes - Google Patents

Compositions pharmaceutiques comprenant des conjugues de polysaccharides permettant l'inhibition des metastases ou la prevention de la recurrence des tumeurs malignes Download PDF

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Publication number
CA2457056C
CA2457056C CA002457056A CA2457056A CA2457056C CA 2457056 C CA2457056 C CA 2457056C CA 002457056 A CA002457056 A CA 002457056A CA 2457056 A CA2457056 A CA 2457056A CA 2457056 C CA2457056 C CA 2457056C
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CA
Canada
Prior art keywords
glycyl
glycine
group
polysaccharide
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002457056A
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English (en)
Other versions
CA2457056A1 (fr
Inventor
Takayuki Kawaguchi
Satoshi Okuno
Toshiro Yano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of CA2457056A1 publication Critical patent/CA2457056A1/fr
Application granted granted Critical
Publication of CA2457056C publication Critical patent/CA2457056C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

L'invention concerne une composition pharmaceutique permettant d'inhiber les métastases ou de prévenir la récurrence d'une tumeur maligne. Cette composition comprend en tant que principe actif un dérivé de polysaccharide composé d'un polysaccharide comprenant un groupe carboxyle lié a un composant actif à activité antitumorale par l'intermédiaire d'un acide aminé ou d'un peptide comprenant de 2 à 8 acides aminés identiques ou différents, ou un sel de ce composé. Les principes actifs préférés sont des dérivés de camptothécine.
CA002457056A 2001-08-21 2002-08-16 Compositions pharmaceutiques comprenant des conjugues de polysaccharides permettant l'inhibition des metastases ou la prevention de la recurrence des tumeurs malignes Expired - Fee Related CA2457056C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001-249717 2001-08-21
JP2001249717 2001-08-21
PCT/JP2002/008309 WO2003015826A1 (fr) 2001-08-21 2002-08-16 Compositions pharmaceutiques comprenant des conjugues de polysaccharides permettant l'inhibition des metastases ou la prevention de la recurrence des tumeurs malignes

Publications (2)

Publication Number Publication Date
CA2457056A1 CA2457056A1 (fr) 2003-02-27
CA2457056C true CA2457056C (fr) 2008-07-22

Family

ID=19078678

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002457056A Expired - Fee Related CA2457056C (fr) 2001-08-21 2002-08-16 Compositions pharmaceutiques comprenant des conjugues de polysaccharides permettant l'inhibition des metastases ou la prevention de la recurrence des tumeurs malignes

Country Status (18)

Country Link
EP (1) EP1418947A1 (fr)
KR (1) KR20040027972A (fr)
CN (1) CN100372570C (fr)
AR (1) AR035137A1 (fr)
AU (1) AU2002328093B2 (fr)
BR (1) BR0212036A (fr)
CA (1) CA2457056C (fr)
HU (1) HUP0401351A3 (fr)
IL (1) IL160148A0 (fr)
MX (1) MXPA04001599A (fr)
NO (1) NO20041194L (fr)
NZ (1) NZ530947A (fr)
PL (1) PL368319A1 (fr)
RU (1) RU2275913C2 (fr)
TW (1) TWI313609B (fr)
UA (1) UA75450C2 (fr)
WO (1) WO2003015826A1 (fr)
ZA (1) ZA200400917B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
FR2914305B1 (fr) * 2007-03-29 2009-07-03 Proteins & Peptides Man Dextran fonctionnalise par des amino-acides hydrophobes.
JP5415538B2 (ja) 2008-07-16 2014-02-12 チルドレンズ メディカル センター コーポレーション マイクロチャネルを有する臓器模倣装置ならびにその使用および製造方法
WO2012166903A1 (fr) 2011-06-02 2012-12-06 President And Fellows Of Harvard College Procédés et utilisations associés à des systèmes de culture tissulaire ex vivo
PL221351B1 (pl) 2012-03-14 2016-03-31 Politechnika Warszawska Sposób otrzymywania nanocząstek polisacharydowych
CN115960111A (zh) 2012-10-11 2023-04-14 第一三共株式会社 抗体－药物偶联物
US9872924B2 (en) 2012-10-19 2018-01-23 Daiichi Sankyo Company, Limited Antibody-drug conjugate produced by binding through linker having hydrophilic structure
JP5998289B2 (ja) 2014-01-31 2016-09-28 第一三共株式会社 抗ｈｅｒ２抗体−薬物コンジュゲート
IL297740A (en) 2015-05-04 2022-12-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses
JP6787890B2 (ja) 2015-06-29 2020-11-18 第一三共株式会社 抗体−薬物コンジュゲートの選択的製造方法
JPWO2018110515A1 (ja) 2016-12-12 2019-10-24 第一三共株式会社 抗体−薬物コンジュゲートと免疫チェックポイント阻害剤の組み合わせ
WO2018135501A1 (fr) 2017-01-17 2018-07-26 第一三共株式会社 Anticorps anti-gpr20 et conjugué anticorps-médicament anti-gpr20
TWI794230B (zh) 2017-05-15 2023-03-01 日商第一三共股份有限公司 抗ｃｄｈ６抗體及抗ｃｄｈ６抗體-藥物結合物、以及其製造方法
AU2018327170B2 (en) 2017-08-31 2021-03-11 Daiichi Sankyo Company, Limited Novel method for producing antibody-drug conjugate
KR20200041993A (ko) 2017-08-31 2020-04-22 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 개량 제조 방법
SG11202010496WA (en) 2018-05-18 2020-12-30 Daiichi Sankyo Co Ltd Anti-muc1 antibody-drug conjugate
CN109481691A (zh) * 2018-11-20 2019-03-19 珠海天香苑生物科技发展股份有限公司 吉西他滨-羧甲基多糖共轭物、制备方法及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149867T3 (es) * 1993-02-26 2000-11-16 Drug Delivery System Inst Ltd Derivados de polisacaridos y soportes para farmacos.
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
CA2192725C (fr) * 1995-12-28 2004-04-20 Kenji Tsujihara Derives de la camptothecine
EP0895784B1 (fr) * 1996-04-15 2005-11-23 Asahi Kasei Kabushiki Kaisha Composite de medicaments contenant des derives de taxane ou de steroides
TW527183B (en) * 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
CN1058038C (zh) * 1996-12-31 2000-11-01 中国科学院感光化学研究所 低收缩性光固化涂层材料及其制法和用途
US6835807B1 (en) * 1998-05-22 2004-12-28 Daiichi Pharmaceuticals Co., Ltd. Drug complex and drug delivery system

Also Published As

Publication number Publication date
RU2275913C2 (ru) 2006-05-10
ZA200400917B (en) 2004-08-25
NZ530947A (en) 2006-04-28
KR20040027972A (ko) 2004-04-01
HUP0401351A2 (hu) 2004-12-28
HUP0401351A3 (en) 2011-02-28
CN100372570C (zh) 2008-03-05
CA2457056A1 (fr) 2003-02-27
BR0212036A (pt) 2004-08-17
EP1418947A1 (fr) 2004-05-19
TWI313609B (en) 2009-08-21
PL368319A1 (en) 2005-03-21
RU2004108141A (ru) 2005-04-20
WO2003015826A1 (fr) 2003-02-27
NO20041194L (no) 2004-03-19
AU2002328093B2 (en) 2005-05-05
CN1545423A (zh) 2004-11-10
UA75450C2 (en) 2006-04-17
IL160148A0 (en) 2004-07-25
MXPA04001599A (es) 2004-07-08
AR035137A1 (es) 2004-04-14

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