CA2451314A1 - Systeme de distribution de gouttelettes - Google Patents
Systeme de distribution de gouttelettes Download PDFInfo
- Publication number
- CA2451314A1 CA2451314A1 CA002451314A CA2451314A CA2451314A1 CA 2451314 A1 CA2451314 A1 CA 2451314A1 CA 002451314 A CA002451314 A CA 002451314A CA 2451314 A CA2451314 A CA 2451314A CA 2451314 A1 CA2451314 A1 CA 2451314A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- tip
- droplet
- dispensing system
- pin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000203 droplet dispensing Methods 0.000 title claims abstract description 56
- 238000011049 filling Methods 0.000 claims abstract description 81
- 239000012530 fluid Substances 0.000 claims abstract description 34
- 239000007788 liquid Substances 0.000 claims description 92
- 238000004891 communication Methods 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 230000015572 biosynthetic process Effects 0.000 claims description 13
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 10
- 230000003213 activating effect Effects 0.000 claims description 10
- 238000011068 loading method Methods 0.000 claims description 10
- 229910052710 silicon Inorganic materials 0.000 claims description 10
- 239000010703 silicon Substances 0.000 claims description 10
- 230000004913 activation Effects 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 160
- 239000000758 substrate Substances 0.000 description 12
- 238000007639 printing Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 5
- 238000011109 contamination Methods 0.000 description 5
- 238000000206 photolithography Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 238000003491 array Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
- B01L3/0255—Drop counters; Drop formers using pins characterized by the form or material of the pin tip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
L'invention concerne une aiguille à distribuer des gouttelettes (13) comprenant une buse de sortie de gouttelette (25), un conduit de remplissage (20), un réservoir de fluide (21) et un actionneur (24) destiné à éjecter des gouttelettes sur demande. L'aiguille (13) est montée sur un support comprenant un circuit de commande afin de former un système de distribution.
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29951501P | 2001-06-20 | 2001-06-20 | |
| US60/299,515 | 2001-06-20 | ||
| US32504001P | 2001-09-25 | 2001-09-25 | |
| US60/325,040 | 2001-09-25 | ||
| US10/027,171 | 2001-12-21 | ||
| US10/028,852 | 2001-12-21 | ||
| US10/027,516 | 2001-12-21 | ||
| US10/027,484 | 2001-12-21 | ||
| US10/027,171 US7041257B2 (en) | 2001-09-25 | 2001-12-21 | Microfabricated two-pin liquid sample dispensing system |
| US10/027,484 US20030015425A1 (en) | 2001-06-20 | 2001-12-21 | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| US10/027,922 US20030077570A1 (en) | 2001-09-20 | 2001-12-21 | Small molecule substrate based enzyme activity assays |
| US10/028,852 US7179423B2 (en) | 2001-06-20 | 2001-12-21 | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| US10/020,108 | 2001-12-21 | ||
| US10/029,108 US6808683B2 (en) | 2001-09-25 | 2001-12-21 | Droplet dispensing system |
| US10/027,922 | 2001-12-21 | ||
| US10/027,516 US20020197733A1 (en) | 2001-06-20 | 2001-12-21 | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| PCT/US2002/019826 WO2003004275A1 (fr) | 2001-06-20 | 2002-06-20 | Systeme de distribution de gouttelettes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2451314A1 true CA2451314A1 (fr) | 2003-01-16 |
Family
ID=27574129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002451314A Abandoned CA2451314A1 (fr) | 2001-06-20 | 2002-06-20 | Systeme de distribution de gouttelettes |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1406765A4 (fr) |
| JP (2) | JP4166690B2 (fr) |
| CA (1) | CA2451314A1 (fr) |
| WO (1) | WO2003004275A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006058439A1 (fr) * | 2004-12-02 | 2006-06-08 | The Governors Of The University Of Alberta | Appareils et procédés de dépôt de gouttelettes de liquide |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG129284A1 (en) * | 2004-04-19 | 2007-02-26 | Nyang Polytechnic | Waterjet micromachined microspotting pins |
| JP2007535681A (ja) | 2004-04-30 | 2007-12-06 | バイオフォース・ナノサイエンシィズ・インコーポレーテッド | 物質を表面上に堆積させるための方法と装置 |
| WO2005115619A1 (fr) * | 2004-05-28 | 2005-12-08 | Tops-Pin Aps | Aiguille de microdepot pour production de biopuces |
| EP1895308A1 (fr) * | 2006-09-01 | 2008-03-05 | Agilent Technologies, Inc. | Couplage fluidique à base de gouttelettes |
| KR101309471B1 (ko) | 2010-06-28 | 2013-09-23 | 삼성전기주식회사 | 미세 토출 장치 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4877745A (en) * | 1986-11-17 | 1989-10-31 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
| US5658802A (en) * | 1995-09-07 | 1997-08-19 | Microfab Technologies, Inc. | Method and apparatus for making miniaturized diagnostic arrays |
| US6183067B1 (en) * | 1997-01-21 | 2001-02-06 | Agilent Technologies | Inkjet printhead and fabrication method for integrating an actuator and firing chamber |
| US6028189A (en) * | 1997-03-20 | 2000-02-22 | University Of Washington | Solvent for oligonucleotide synthesis and methods of use |
| US6232129B1 (en) * | 1999-02-03 | 2001-05-15 | Peter Wiktor | Piezoelectric pipetting device |
| US6242266B1 (en) * | 1999-04-30 | 2001-06-05 | Agilent Technologies Inc. | Preparation of biopolymer arrays |
-
2002
- 2002-06-20 WO PCT/US2002/019826 patent/WO2003004275A1/fr active Application Filing
- 2002-06-20 EP EP02744538A patent/EP1406765A4/fr not_active Withdrawn
- 2002-06-20 CA CA002451314A patent/CA2451314A1/fr not_active Abandoned
- 2002-06-20 JP JP2003510266A patent/JP4166690B2/ja not_active Expired - Fee Related
-
2008
- 2008-05-22 JP JP2008134614A patent/JP2008249720A/ja not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006058439A1 (fr) * | 2004-12-02 | 2006-06-08 | The Governors Of The University Of Alberta | Appareils et procédés de dépôt de gouttelettes de liquide |
| US8202494B2 (en) | 2004-12-02 | 2012-06-19 | The Governors Of The University Of Alberta | Apparatus and methods for liquid droplet deposition |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003004275A9 (fr) | 2004-01-29 |
| JP2004534229A (ja) | 2004-11-11 |
| WO2003004275A1 (fr) | 2003-01-16 |
| JP4166690B2 (ja) | 2008-10-15 |
| JP2008249720A (ja) | 2008-10-16 |
| EP1406765A1 (fr) | 2004-04-14 |
| EP1406765A4 (fr) | 2004-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |