CA2404735C - Dispositif de distribution de petites doses de liquide tres precises - Google Patents

Dispositif de distribution de petites doses de liquide tres precises Download PDF

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Publication number
CA2404735C
CA2404735C CA002404735A CA2404735A CA2404735C CA 2404735 C CA2404735 C CA 2404735C CA 002404735 A CA002404735 A CA 002404735A CA 2404735 A CA2404735 A CA 2404735A CA 2404735 C CA2404735 C CA 2404735C
Authority
CA
Canada
Prior art keywords
liquid
duct
capillary
supply
gas supply
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002404735A
Other languages
English (en)
Other versions
CA2404735A1 (fr
Inventor
Philippe Renaud
Alain Donzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parabol Technologies SA
Original Assignee
Parabol Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parabol Technologies SA filed Critical Parabol Technologies SA
Publication of CA2404735A1 publication Critical patent/CA2404735A1/fr
Application granted granted Critical
Publication of CA2404735C publication Critical patent/CA2404735C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Transplanting Machines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un dispositif de distribution de petites doses très précises d'au moins un liquide, ce dispositif comprenant une réserve de liquide (L), une réserve de gaz (G) agencée pour fournir de manière sélective une certaine pression de gaz, ainsi qu'un conduit capillaire (20) conçu pour être rempli du liquide à distribuer et pour éjecter ce liquide. Ce dispositif possède une structure de remplissage dans laquelle le liquide provenant de la réserve de liquide entre en contact avec une extrémité (20a) du conduit capillaire, afin de remplir ce conduit de liquide, ainsi qu'une structure de séparation et d'éjection de liquide dans laquelle le liquide restant dans la réserve de liquide est séparé du liquide remplissant le conduit capillaire, de manière à former une quantité distincte (V) de liquide remplissant le conduit capillaire (20) et n'étant pas en contact avec le liquide restant de la réserve de liquide. Le conduit capillaire, rempli de cette quantité distincte (V) de liquide possède alors une extrémité qui est en contact avec la réserve de gaz et une autre extrémité en contact avec l'atmosphère. La quantité distincte de liquide (V) formant une dose exacte de liquide à distribuer peut être éjectée de la seconde extrémité (20b) du conduit capillaire, par application d'une pression de gaz.
CA002404735A 2000-04-03 2001-04-03 Dispositif de distribution de petites doses de liquide tres precises Expired - Fee Related CA2404735C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54185400A 2000-04-03 2000-04-03
US09/541,854 2000-04-03
PCT/IB2001/000556 WO2001074490A2 (fr) 2000-04-03 2001-04-03 Dispositif de distribution de petites doses de liquide tres precises

Publications (2)

Publication Number Publication Date
CA2404735A1 CA2404735A1 (fr) 2001-10-11
CA2404735C true CA2404735C (fr) 2009-02-24

Family

ID=24161362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002404735A Expired - Fee Related CA2404735C (fr) 2000-04-03 2001-04-03 Dispositif de distribution de petites doses de liquide tres precises

Country Status (9)

Country Link
US (1) US7229594B2 (fr)
EP (1) EP1274508B1 (fr)
JP (1) JP2004518106A (fr)
AT (1) ATE380071T1 (fr)
AU (1) AU4270401A (fr)
CA (1) CA2404735C (fr)
DE (1) DE60131735T2 (fr)
ES (1) ES2296735T3 (fr)
WO (1) WO2001074490A2 (fr)

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WO2003072255A1 (fr) 2002-02-23 2003-09-04 Nanostream, Inc. Diviseurs micro-hydrauliques multiples
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Also Published As

Publication number Publication date
JP2004518106A (ja) 2004-06-17
US7229594B2 (en) 2007-06-12
DE60131735D1 (de) 2008-01-17
ES2296735T3 (es) 2008-05-01
WO2001074490A3 (fr) 2002-04-11
EP1274508B1 (fr) 2007-12-05
EP1274508A2 (fr) 2003-01-15
WO2001074490A2 (fr) 2001-10-11
CA2404735A1 (fr) 2001-10-11
AU4270401A (en) 2001-10-15
ATE380071T1 (de) 2007-12-15
US20030099577A1 (en) 2003-05-29
DE60131735T2 (de) 2008-11-06

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