CA2444257A1 - Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry - Google Patents

Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry Download PDF

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Publication number
CA2444257A1
CA2444257A1 CA002444257A CA2444257A CA2444257A1 CA 2444257 A1 CA2444257 A1 CA 2444257A1 CA 002444257 A CA002444257 A CA 002444257A CA 2444257 A CA2444257 A CA 2444257A CA 2444257 A1 CA2444257 A1 CA 2444257A1
Authority
CA
Canada
Prior art keywords
electrodes
ions
ion
filter
flow path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002444257A
Other languages
English (en)
French (fr)
Inventor
Raanan A. Miller
Erkinjon G. Nazarov
Gary A. Eiceman
Evgeny Krylov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Charles Stark Draper Laboratory Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/123,030 external-priority patent/US6690004B2/en
Application filed by Individual filed Critical Individual
Publication of CA2444257A1 publication Critical patent/CA2444257A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA002444257A 2001-04-17 2002-04-17 Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry Abandoned CA2444257A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US83649501A 2001-04-17 2001-04-17
US09/836,495 2001-04-17
US4097402A 2002-01-07 2002-01-07
US10/040,974 2002-01-07
US10/123,030 US6690004B2 (en) 1999-07-21 2002-04-12 Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US10/123,030 2002-04-12
PCT/US2002/012210 WO2002083276A1 (en) 2001-04-17 2002-04-17 Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry

Publications (1)

Publication Number Publication Date
CA2444257A1 true CA2444257A1 (en) 2002-10-24

Family

ID=27365820

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002444257A Abandoned CA2444257A1 (en) 2001-04-17 2002-04-17 Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry

Country Status (7)

Country Link
EP (1) EP1387724A4 (ja)
JP (1) JP4063676B2 (ja)
CN (1) CN1585666A (ja)
AU (1) AU2002257177B2 (ja)
CA (1) CA2444257A1 (ja)
IL (1) IL158386A0 (ja)
WO (1) WO2002083276A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024201029A1 (en) * 2023-03-31 2024-10-03 The University Of Liverpool Differential mobility spectrometer and analysis method

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005632B2 (en) 2002-04-12 2006-02-28 Sionex Corporation Method and apparatus for control of mobility-based ion species identification
US6690004B2 (en) 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US7098449B1 (en) 1999-07-21 2006-08-29 The Charles Stark Draper Laboratory, Inc. Spectrometer chip assembly
US7129482B2 (en) 1999-07-21 2006-10-31 Sionex Corporation Explosives detection using differential ion mobility spectrometry
US7057168B2 (en) 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US6806463B2 (en) 1999-07-21 2004-10-19 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US7148477B2 (en) 1999-07-21 2006-12-12 Sionex Corporation System for trajectory-based ion species identification
US7091481B2 (en) 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
US6727496B2 (en) 2001-08-14 2004-04-27 Sionex Corporation Pancake spectrometer
US6998608B2 (en) * 2002-02-08 2006-02-14 Ionalytics Corporation FAIMS with non-destructive detection of selectively transmitted ions
US7122794B1 (en) 2002-02-21 2006-10-17 Sionex Corporation Systems and methods for ion mobility control
AU2003298597A1 (en) 2002-10-12 2004-05-25 Sionex Corporation NOx MONITOR USING DIFFERENTIAL MOBILITY SPECTROMETRY
WO2004114347A2 (en) * 2003-06-20 2004-12-29 Brigham Young University Single device for ion mobility and ion trap mass spectrometry
US7223970B2 (en) 2003-09-17 2007-05-29 Sionex Corporation Solid-state gas flow generator and related systems, applications, and methods
US7227134B2 (en) 2003-11-25 2007-06-05 Sionex Corporation Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample
WO2005074584A2 (en) * 2004-02-02 2005-08-18 Sionex Corporation Compact sample analysis systems and related methods using combined chromatography and mobility spectrometry techniques
US6967326B2 (en) * 2004-02-27 2005-11-22 Lucent Technologies Inc. Mass spectrometers on wafer-substrates
US8440968B2 (en) 2005-02-14 2013-05-14 Micromass Uk Limited Ion-mobility analyser
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
JP5219274B2 (ja) * 2005-04-01 2013-06-26 マイクロマス ユーケー リミテッド 質量分析計
WO2006127974A1 (en) * 2005-05-24 2006-11-30 Sionex Corporation Combined mass and differential mobility spectrometry
PL1971855T3 (pl) * 2006-01-10 2018-10-31 Smiths Detection-Watford Limited Urządzenie i sposób selekcji jonów
US8217344B2 (en) * 2007-02-01 2012-07-10 Dh Technologies Development Pte. Ltd. Differential mobility spectrometer pre-filter assembly for a mass spectrometer
CN106885838B (zh) * 2007-02-05 2021-01-12 卓漂仪谱公司 离子迁移谱仪与方法
GB0708391D0 (en) * 2007-05-01 2007-06-06 Smiths Detection Watford Ltd Detection and spectrometers
US7863562B2 (en) * 2007-06-22 2011-01-04 Shimadzu Corporation Method and apparatus for digital differential ion mobility separation
CN101082594B (zh) * 2007-07-06 2010-12-15 清华大学 物质成分测定装置
CN101738417B (zh) * 2009-12-08 2012-09-05 清华大学 基于冷场电子检测生化物质的芯片及检测方法
US8389930B2 (en) * 2010-04-30 2013-03-05 Agilent Technologies, Inc. Input port for mass spectrometers that is adapted for use with ion sources that operate at atmospheric pressure
CN102478545A (zh) * 2010-11-30 2012-05-30 中国科学院大连化学物理研究所 一种平板式差分式离子迁移谱
CN102479664A (zh) * 2010-11-30 2012-05-30 中国科学院大连化学物理研究所 一种平板式离子迁移谱
WO2013080004A1 (en) * 2011-11-29 2013-06-06 Dh Technologies Development Pte. Ltd. Differential mobility spectrometer and methods thereof
CN103163206A (zh) * 2011-12-19 2013-06-19 中国科学院大连化学物理研究所 一种复合电离源差分式离子迁移谱
WO2013098645A2 (en) * 2011-12-28 2013-07-04 Medimass, Ltd. System and method for rapid evaporative ionization of liquid phase samples
CN102636553B (zh) * 2012-03-23 2014-05-28 哈尔滨工业大学（威海） 纸基电喷雾离子迁移谱分析方法
CN102683151B (zh) * 2012-05-15 2015-01-28 中国科学院合肥物质科学研究院 一种选择控制反应离子的化学电离质谱仪
CN102723254B (zh) * 2012-06-20 2015-07-22 清华大学 平板型高场非对称波形离子迁移谱仪的聚焦装置及方法
JP5997650B2 (ja) * 2013-04-15 2016-09-28 株式会社日立ハイテクノロジーズ 分析システム
FI124792B (fi) 2013-06-20 2015-01-30 Helsingin Yliopisto Menetelmä ja laite näytekaasuvirtauksen partikkelien ionisoimiseksi
EP3092484A4 (en) * 2013-12-31 2017-08-23 DH Technologies Development PTE. Ltd. Vacuum dms with high efficiency ion guides
CN106687808B (zh) * 2014-07-07 2019-08-20 纳米技术分析责任有限公司 用于分析时变气流的便携式电子系统
JP6350391B2 (ja) * 2015-05-22 2018-07-04 株式会社島津製作所 放電イオン化検出器
JP6456863B2 (ja) * 2016-03-04 2019-01-23 株式会社日立ハイテクノロジーズ イオン移動度分離部を備える分析装置
JP6926544B2 (ja) * 2016-08-05 2021-08-25 株式会社リコー 洗浄用空気作成装置及び計測システム
CN107357835B (zh) * 2017-06-22 2020-11-03 电子科技大学 一种基于主题模型和遗忘规律的兴趣预测挖掘方法及系统
GB2566326A (en) * 2017-09-11 2019-03-13 Owlstone Inc Ion mobility filter
CN109884157B (zh) * 2017-12-06 2021-06-15 中国科学院大连化学物理研究所 一种新型正负离子快速切换的离子探测器
JP7102733B2 (ja) 2018-01-04 2022-07-20 株式会社リコー イオン検出装置及び電界非対称波形イオン移動度分光分析システム
CN108760637B (zh) * 2018-07-13 2023-11-21 金华职业技术学院 一种研究分子光异构化的装置
CN110596401B (zh) * 2019-09-11 2024-05-14 宁波盘福生物科技有限公司 用于蛋白质检测的高场不对称波形离子淌度装置及方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420424A (en) * 1994-04-29 1995-05-30 Mine Safety Appliances Company Ion mobility spectrometer
US5838003A (en) * 1996-09-27 1998-11-17 Hewlett-Packard Company Ionization chamber and mass spectrometry system containing an asymmetric electrode
US6124592A (en) * 1998-03-18 2000-09-26 Technispan Llc Ion mobility storage trap and method
US6066848A (en) * 1998-06-09 2000-05-23 Combichem, Inc. Parallel fluid electrospray mass spectrometer
EP1102984A1 (en) * 1998-08-05 2001-05-30 National Research Council of Canada Method for separation of isomers and different conformations of ions in gaseous phase
US6495823B1 (en) * 1999-07-21 2002-12-17 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US6815668B2 (en) * 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
AU6363400A (en) * 1999-07-21 2001-02-13 Exatec, Llc. Method of promoting uniform process conditions in pecvd reactor for batch production of glazing panels
US6822224B2 (en) * 2000-03-14 2004-11-23 National Research Council Canada Tandem high field asymmetric waveform ion mobility spectrometry (FAIMS)tandem mass spectrometry

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024201029A1 (en) * 2023-03-31 2024-10-03 The University Of Liverpool Differential mobility spectrometer and analysis method

Also Published As

Publication number Publication date
EP1387724A1 (en) 2004-02-11
JP2004529467A (ja) 2004-09-24
JP4063676B2 (ja) 2008-03-19
CN1585666A (zh) 2005-02-23
IL158386A0 (en) 2004-05-12
AU2002257177B2 (en) 2004-11-25
EP1387724A4 (en) 2006-03-15
WO2002083276A1 (en) 2002-10-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued