CA2443057A1 - Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors - Google Patents
Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors Download PDFInfo
- Publication number
- CA2443057A1 CA2443057A1 CA002443057A CA2443057A CA2443057A1 CA 2443057 A1 CA2443057 A1 CA 2443057A1 CA 002443057 A CA002443057 A CA 002443057A CA 2443057 A CA2443057 A CA 2443057A CA 2443057 A1 CA2443057 A1 CA 2443057A1
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- CA
- Canada
- Prior art keywords
- compound
- guanidine
- hydrogen
- bromo
- receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB0108631.3 | 2001-04-05 | ||
| GBGB0108631.3A GB0108631D0 (en) | 2001-04-05 | 2001-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| PCT/GB2002/001593 WO2002081430A2 (en) | 2001-04-05 | 2002-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
Publications (1)
| Publication Number | Publication Date |
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| CA2443057A1 true CA2443057A1 (en) | 2002-10-17 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| CA002443057A Abandoned CA2443057A1 (en) | 2001-04-05 | 2002-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| CA002443099A Abandoned CA2443099A1 (en) | 2001-04-05 | 2002-04-05 | Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors |
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| Application Number | Title | Priority Date | Filing Date |
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| CA002443099A Abandoned CA2443099A1 (en) | 2001-04-05 | 2002-04-05 | Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors |
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| US (2) | US20040106682A1 (https=) |
| EP (2) | EP1383740A2 (https=) |
| JP (2) | JP2004531510A (https=) |
| KR (2) | KR20030088056A (https=) |
| BR (2) | BR0208657A (https=) |
| CA (2) | CA2443057A1 (https=) |
| GB (1) | GB0108631D0 (https=) |
| IL (2) | IL158247A0 (https=) |
| MX (2) | MXPA03008972A (https=) |
| WO (2) | WO2002080896A1 (https=) |
| ZA (1) | ZA200307453B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| GB0119172D0 (en) * | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
| DE602004025758D1 (de) | 2003-01-23 | 2010-04-15 | Kuraray Co | Polyvinylacetal und dessen Verwendung |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| GB0624987D0 (en) * | 2006-12-14 | 2007-01-24 | Acure Pharma Ab | Novel aminoguanidines as melanocortin receptor ligands |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2045250A1 (en) * | 2007-09-26 | 2009-04-08 | Action Pharma A/S | Ring-substituted phenyl pyrrole aminoguanidine derivatives |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| JP5514831B2 (ja) | 2008-11-17 | 2014-06-04 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病の治療のための置換二環式アミン |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| CA2768577A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2563764B1 (en) | 2010-04-26 | 2015-02-25 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
| US9365539B2 (en) | 2010-05-11 | 2016-06-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| US9006268B2 (en) | 2010-06-11 | 2015-04-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| BR112013021236B1 (pt) | 2011-02-25 | 2021-05-25 | Merck Sharp & Dohme Corp | composto derivado de benzimidazol, e, composição |
| US9527875B2 (en) | 2012-08-02 | 2016-12-27 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| SI3004138T1 (sl) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Limited | Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| ES2812800T3 (es) * | 2014-07-02 | 2021-03-18 | Inflectis Bioscience | Nuevos usos terapéuticos de derivados de la bencilidenguanidina para el tratamiento de proteopatías |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| US20180230105A1 (en) | 2017-01-13 | 2018-08-16 | Regents Of The University Of Minnesota | Therapeutic compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2584784A (en) * | 1949-05-21 | 1952-02-05 | Du Pont | Salts of 1-salicylalaminoguanidine |
| DE1165013B (de) * | 1960-08-09 | 1964-03-12 | Vismara Francesco Spa | Verfahren zur Herstellung von Guanylhydrazonen |
| GB1223491A (en) * | 1967-10-13 | 1971-02-24 | American Home Prod | Guanidines |
| US3592935A (en) * | 1969-12-11 | 1971-07-13 | Sandoz Ag | Substituted benzylidene hydrazines as anti-inflammatory agents |
| US3982020A (en) * | 1970-03-17 | 1976-09-21 | Sandoz, Inc. | Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation |
| US4060640A (en) * | 1970-04-29 | 1977-11-29 | Shell Oil Company | Therapeutic agents |
| US3816531A (en) * | 1970-07-01 | 1974-06-11 | American Home Prod | (2,6-disubstituted benzylidene)amino guanidines and related compounds |
| US3896232A (en) * | 1973-01-11 | 1975-07-22 | Sandoz Ag | Substituted benzylidene hydrazines as anti-migraine syndrome agents |
| US3941825A (en) * | 1973-07-27 | 1976-03-02 | American Cyanamid Company | Substituted aminobenzylideneamino guanidine compounds |
| US4006250A (en) * | 1975-08-25 | 1977-02-01 | American Home Products Corporation | Systemic treatment of psoriasis |
| JPH06510760A (ja) * | 1991-08-27 | 1994-12-01 | ジ・アップジョン・カンパニー | 代謝障害および代謝の治療法 |
| US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| SE9604348D0 (sv) * | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| WO2001013921A1 (en) * | 1999-08-23 | 2001-03-01 | Ockert David M | Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms |
| AU7802700A (en) * | 1999-10-06 | 2001-05-10 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
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2001
- 2001-04-05 GB GBGB0108631.3A patent/GB0108631D0/en not_active Ceased
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2002
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- 2002-04-05 KR KR10-2003-7012903A patent/KR20030088056A/ko not_active Withdrawn
- 2002-04-05 JP JP2002578935A patent/JP2004531510A/ja not_active Withdrawn
- 2002-04-05 CA CA002443057A patent/CA2443057A1/en not_active Abandoned
- 2002-04-05 KR KR10-2003-7012904A patent/KR20030092045A/ko not_active Withdrawn
- 2002-04-05 MX MXPA03008972A patent/MXPA03008972A/es unknown
- 2002-04-05 BR BR0208657-3A patent/BR0208657A/pt not_active Application Discontinuation
- 2002-04-05 IL IL15824802A patent/IL158248A0/xx unknown
- 2002-04-05 EP EP02707026A patent/EP1383740A2/en not_active Withdrawn
- 2002-04-05 WO PCT/GB2002/001589 patent/WO2002080896A1/en not_active Ceased
- 2002-04-05 CA CA002443099A patent/CA2443099A1/en not_active Abandoned
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- 2002-04-05 MX MXPA03008973A patent/MXPA03008973A/es unknown
- 2002-04-05 EP EP02707025A patent/EP1372625A1/en not_active Withdrawn
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- 2002-04-05 BR BR0208658-1A patent/BR0208658A/pt not_active Application Discontinuation
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2003
- 2003-09-25 ZA ZA200307453A patent/ZA200307453B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200307453B (en) | 2004-09-27 |
| JP2004531516A (ja) | 2004-10-14 |
| MXPA03008973A (es) | 2004-02-12 |
| EP1372625A1 (en) | 2004-01-02 |
| JP2004531510A (ja) | 2004-10-14 |
| IL158248A0 (en) | 2004-05-12 |
| IL158247A0 (en) | 2004-05-12 |
| CA2443099A1 (en) | 2002-10-17 |
| US20040106682A1 (en) | 2004-06-03 |
| BR0208657A (pt) | 2004-03-02 |
| KR20030092045A (ko) | 2003-12-03 |
| US20040106683A1 (en) | 2004-06-03 |
| KR20030088056A (ko) | 2003-11-15 |
| WO2002081430A2 (en) | 2002-10-17 |
| EP1383740A2 (en) | 2004-01-28 |
| GB0108631D0 (en) | 2001-05-30 |
| WO2002081430A3 (en) | 2003-08-14 |
| WO2002080896A1 (en) | 2002-10-17 |
| MXPA03008972A (es) | 2004-02-12 |
| BR0208658A (pt) | 2004-03-02 |
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