CA2442881C - Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates - Google Patents
Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates Download PDFInfo
- Publication number
- CA2442881C CA2442881C CA2442881A CA2442881A CA2442881C CA 2442881 C CA2442881 C CA 2442881C CA 2442881 A CA2442881 A CA 2442881A CA 2442881 A CA2442881 A CA 2442881A CA 2442881 C CA2442881 C CA 2442881C
- Authority
- CA
- Canada
- Prior art keywords
- formula
- synthesis
- compound
- process according
- oxoethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211765A FR2844797B1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR02/11765 | 2002-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2442881A1 CA2442881A1 (fr) | 2004-03-24 |
| CA2442881C true CA2442881C (fr) | 2010-06-29 |
Family
ID=29415191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2442881A Expired - Fee Related CA2442881C (fr) | 2002-09-24 | 2003-09-23 | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
Country Status (38)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| ES2275218T3 (es) * | 2003-05-07 | 2007-06-01 | Osteologix A/S | Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos. |
| WO2004098618A2 (en) * | 2003-05-07 | 2004-11-18 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| PL1732575T3 (pl) | 2004-02-26 | 2011-05-31 | Osteologix As | Związki zawierające stron do stosowania w zapobieganiu lub leczeniu stanów nekrotycznych kości |
| CA2571449C (en) | 2004-06-25 | 2015-12-08 | John Nikolaj Hvarre Christensen | Compositions comprising strontium and vitamin d and uses thereof |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
| US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011124992A1 (en) * | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
| CN101812048B (zh) * | 2010-04-06 | 2012-11-14 | 浙江东亚药业有限公司 | 雷尼酸锶及其水合物的合成方法 |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| WO2013113319A1 (en) | 2012-01-31 | 2013-08-08 | Pharmathen S.A. | Process for the preparation of strontium ranelate, intermediate or hydrates thereof |
| ES2505716T3 (es) | 2013-01-21 | 2015-09-04 | Galenicum Health S.L. | Composiciones farmacéuticas que comprenden una sal de ácido |
| GB201310126D0 (en) * | 2013-06-06 | 2013-07-24 | Univ Leicester | Novel pyrrole derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3624304A1 (de) | 1986-07-18 | 1988-01-28 | Bayer Ag | Fungizide verwendung von substituierten thienylaminen |
| GB8715925D0 (en) * | 1987-07-07 | 1987-08-12 | Shell Int Research | Thiapentanamide derivatives |
| FR2651497B1 (fr) | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| DE19528380A1 (de) * | 1995-08-02 | 1997-02-06 | Hoechst Ag | Heterogene Vinylacetat/Ethylen-Dispersion |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| DE19650196A1 (de) * | 1996-12-04 | 1998-06-10 | Bayer Ag | Thienylsulfonylamino(thio)carbonylverbindungen |
| US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
-
2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/sr unknown
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Ceased
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active Expired - Fee Related
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
-
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
-
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180924 |