CA2437639C - Long term drug delivery devices with polyurethane based polymers and their manufacture - Google Patents
Long term drug delivery devices with polyurethane based polymers and their manufacture Download PDFInfo
- Publication number
- CA2437639C CA2437639C CA2437639A CA2437639A CA2437639C CA 2437639 C CA2437639 C CA 2437639C CA 2437639 A CA2437639 A CA 2437639A CA 2437639 A CA2437639 A CA 2437639A CA 2437639 C CA2437639 C CA 2437639C
- Authority
- CA
- Canada
- Prior art keywords
- polyurethane
- based polymer
- drug delivery
- active ingredients
- delivery device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920002635 polyurethane Polymers 0.000 title claims abstract description 83
- 239000004814 polyurethane Substances 0.000 title claims abstract description 83
- 229920000642 polymer Polymers 0.000 title claims abstract description 62
- 238000012377 drug delivery Methods 0.000 title claims abstract description 55
- 238000004519 manufacturing process Methods 0.000 title description 13
- 230000007774 longterm Effects 0.000 title description 3
- 229940079593 drug Drugs 0.000 claims abstract description 35
- 239000003814 drug Substances 0.000 claims abstract description 35
- 239000004480 active ingredient Substances 0.000 claims abstract description 23
- 230000000144 pharmacologic effect Effects 0.000 claims abstract description 6
- 230000009885 systemic effect Effects 0.000 claims abstract description 6
- 239000003937 drug carrier Substances 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 32
- 238000009472 formulation Methods 0.000 claims description 22
- 238000009792 diffusion process Methods 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 7
- 230000001143 conditioned effect Effects 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 230000003444 anaesthetic effect Effects 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 230000001773 anti-convulsant effect Effects 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims description 2
- 230000000648 anti-parkinson Effects 0.000 claims description 2
- 230000002921 anti-spasmodic effect Effects 0.000 claims description 2
- 239000001961 anticonvulsive agent Substances 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000000939 antiparkinson agent Substances 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 239000000812 cholinergic antagonist Substances 0.000 claims description 2
- 125000003010 ionic group Chemical group 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 239000003158 myorelaxant agent Substances 0.000 claims description 2
- 230000003236 psychic effect Effects 0.000 claims description 2
- 239000003204 tranquilizing agent Substances 0.000 claims description 2
- 230000002936 tranquilizing effect Effects 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims 2
- 229960003965 antiepileptics Drugs 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 229940125725 tranquilizer Drugs 0.000 claims 1
- 239000007943 implant Substances 0.000 abstract description 22
- 238000000034 method Methods 0.000 abstract description 22
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 229920001187 thermosetting polymer Polymers 0.000 description 29
- 230000003750 conditioning effect Effects 0.000 description 28
- 230000037452 priming Effects 0.000 description 28
- 238000007789 sealing Methods 0.000 description 23
- 230000008569 process Effects 0.000 description 20
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 18
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 13
- 239000002609 medium Substances 0.000 description 13
- 239000008188 pellet Substances 0.000 description 13
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 13
- 230000002209 hydrophobic effect Effects 0.000 description 12
- 239000000969 carrier Substances 0.000 description 11
- 238000004528 spin coating Methods 0.000 description 10
- 238000010107 reaction injection moulding Methods 0.000 description 9
- 239000004970 Chain extender Substances 0.000 description 8
- 238000001125 extrusion Methods 0.000 description 8
- 229920005862 polyol Polymers 0.000 description 7
- 150000003077 polyols Chemical class 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 238000010828 elution Methods 0.000 description 5
- HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 description 5
- 238000001746 injection moulding Methods 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 125000005442 diisocyanate group Chemical group 0.000 description 4
- 229960002193 histrelin Drugs 0.000 description 4
- 108700020746 histrelin Proteins 0.000 description 4
- 230000000977 initiatory effect Effects 0.000 description 4
- 239000012948 isocyanate Substances 0.000 description 4
- 150000002513 isocyanates Chemical class 0.000 description 4
- -1 muscle contractants Substances 0.000 description 4
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 4
- 229960003086 naltrexone Drugs 0.000 description 4
- 239000004971 Cross linker Substances 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 238000000748 compression moulding Methods 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 239000003999 initiator Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 125000005373 siloxane group Chemical group [SiH2](O*)* 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000000150 Sympathomimetic Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 230000002141 anti-parasite Effects 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 229940033495 antimalarials Drugs 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 229960003911 histrelin acetate Drugs 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Nanotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Mechanical Engineering (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2437639A CA2437639C (en) | 2003-08-11 | 2003-08-18 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US10/915,625 US7842303B2 (en) | 2003-08-11 | 2004-08-10 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| HK06113056.8A HK1091145B (en) | 2003-08-11 | 2004-08-11 | Manufacture of long term drug delivery devices with polyurethane based polymers |
| PL04769233T PL1660034T3 (pl) | 2003-08-11 | 2004-08-11 | Sposób wytwarzania urządzeń do przedłużonego uwalniania leków, wytworzonych z polimerów opartych na poliuretanie |
| EP04769233A EP1660034B1 (en) | 2003-08-11 | 2004-08-11 | Manufacture of long term drug delivery devices with polyurethane based polymers |
| AU2004262999A AU2004262999B2 (en) | 2003-08-11 | 2004-08-11 | Manufacture of long term drug delivery devices with polyurethane based polymers |
| CN2004800293420A CN1863504B (zh) | 2003-08-11 | 2004-08-11 | 用基于聚氨酯的聚合物制造长效药物递送装置 |
| SI200431052T SI1660034T1 (sl) | 2003-08-11 | 2004-08-11 | Proizvodnja naprave za podaljĺ ano sproĺ äśanje zdravil s polimeri na bazi poliuretana |
| CN201110053656.6A CN102133174B (zh) | 2003-08-11 | 2004-08-11 | 用基于聚氨酯的聚合物制造长效药物递送装置 |
| DE602004019224T DE602004019224D1 (de) | 2003-08-11 | 2004-08-11 | Herstellung von langzeit-arzneimittelabgabevorrichtungen mit polymeren auf polyurethanbasis |
| DK04769233T DK1660034T3 (da) | 2003-08-11 | 2004-08-11 | Fremstilling af langtidsafgivende medikamentindretninger af polyurethanbaserede polymerer |
| PT04769233T PT1660034E (pt) | 2003-08-11 | 2004-08-11 | Manufactura de aparelhos de administração de medicamento a longo termo com polímeros à base de poliuretano |
| HR20090209T HRP20090209T1 (hr) | 2003-08-11 | 2004-08-11 | Proizvodnja uređaja za dugotrajno oslobađanje lijeka sa polimerima na bazi poliuretana |
| AT04769233T ATE421316T1 (de) | 2003-08-11 | 2004-08-11 | Herstellung von langzeit- arzneimittelabgabevorrichtungen mit polymeren auf polyurethanbasis |
| JP2006523081A JP5060128B2 (ja) | 2003-08-11 | 2004-08-11 | ポリウレタンを基とするポリマーを用いた長期薬物輸送装置の製造 |
| PCT/IB2004/002823 WO2005013936A2 (en) | 2003-08-11 | 2004-08-11 | Manufacture of long term drug delivery devices with polyurethane based polymers |
| EP08010973A EP1982695A3 (en) | 2003-08-11 | 2004-08-11 | Manufacture of long term drug delivery devices with polyurethane |
| EP14172031.8A EP2805709A1 (en) | 2003-08-11 | 2004-08-11 | Manufacture of long term drug delivery devices with polyurethane |
| MXPA06001612A MXPA06001612A (es) | 2003-08-11 | 2004-08-11 | Manufactura de dispositivos de administracion de farmacos de largo plazo, con polimeros basados en poliuretano. |
| ES04769233T ES2320556T3 (es) | 2003-08-11 | 2004-08-11 | Fabricacion de dispositivos de suministro de farmaco a largo plazo con polimeros basados en poliuretano. |
| AU2009202942A AU2009202942B2 (en) | 2003-08-11 | 2009-07-22 | Manufacture of long term drug delivery devices with polyurethane based polymers |
| US12/873,130 US8357389B2 (en) | 2003-08-11 | 2010-08-31 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US12/907,717 US8343528B2 (en) | 2003-08-11 | 2010-10-19 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| AU2010251786A AU2010251786B2 (en) | 2003-08-11 | 2010-12-14 | Manufacture of long term drug delivery devices with polyurethane based polymers |
| JP2011031294A JP5368497B2 (ja) | 2003-08-11 | 2011-02-16 | ポリウレタンを基とするポリマーを用いた長期薬物輸送装置の製造 |
| HK12100714.1A HK1160378B (en) | 2003-08-11 | 2012-01-20 | Manufacture of long term drug delivery devices with polyurethane based polymers |
| JP2012219869A JP2013049678A (ja) | 2003-08-11 | 2012-10-01 | ポリウレタン系ポリマーを用いた長期薬物輸送装置の製造 |
| US13/693,659 US8529936B2 (en) | 2003-08-11 | 2012-12-04 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US13/952,327 US8658195B2 (en) | 2003-08-11 | 2013-07-26 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US14/159,119 US20140135684A1 (en) | 2003-08-11 | 2014-01-20 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| JP2014164312A JP2014237699A (ja) | 2003-08-11 | 2014-08-12 | ポリウレタン系ポリマーを用いた長期薬物輸送装置の製造 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49413203P | 2003-08-11 | 2003-08-11 | |
| US60/494,132 | 2003-08-11 | ||
| CA2437639A CA2437639C (en) | 2003-08-11 | 2003-08-18 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
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| WO (1) | WO2005013936A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090208540A1 (en) * | 2003-08-11 | 2009-08-20 | Indevus Pharmaceuticals, Inc. | Implantable device for the delivery of naltrexone and methods of use thereof |
| CA2437639C (en) * | 2003-08-11 | 2016-07-05 | Valera Pharmaceuticals, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US7858110B2 (en) | 2003-08-11 | 2010-12-28 | Endo Pharmaceuticals Solutions, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| EP1773293B1 (en) * | 2004-06-17 | 2015-04-15 | Endo Pharmaceuticals Solutions Inc. | Compositions and methods for treating central precocious puberty |
| CN101193626A (zh) * | 2005-03-11 | 2008-06-04 | 益德威士医药股份有限公司 | 奥曲肽的受控释放制剂 |
| US7759312B2 (en) * | 2005-03-11 | 2010-07-20 | Endo Pharmaceuticals Solutions Inc. | Delivery of dry formulations of octreotide |
| US8211060B2 (en) * | 2005-05-10 | 2012-07-03 | Palyon Medical (Bvi) Limited | Reduced size implantable pump |
| US8114055B2 (en) | 2005-05-10 | 2012-02-14 | Palyon Medical (Bvi) Limited | Implantable pump with infinitely variable resistor |
| US8915893B2 (en) | 2005-05-10 | 2014-12-23 | Palyon Medical (Bvi) Limited | Variable flow infusion pump system |
| US7637892B2 (en) | 2005-05-10 | 2009-12-29 | Palyon Medical (Bvi) Limited | Variable flow infusion pump system |
| NZ580803A (en) * | 2007-04-27 | 2012-03-30 | Endo Pharmaceuticals Solutions | Implant device release agents and methods of using same |
| US8303536B2 (en) * | 2007-08-30 | 2012-11-06 | Sunstorm Research Corp. | Implantable delivery device |
| US9775882B2 (en) * | 2007-09-20 | 2017-10-03 | Medtronic, Inc. | Medical devices and methods including polymers having biologically active agents therein |
| ME01026B (me) | 2007-11-16 | 2012-10-20 | Univ Rockefeller | Antitijela specifična za protofibrilni oblik beta-amiloid proteina |
| JP5622725B2 (ja) * | 2008-06-25 | 2014-11-12 | エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド．Ｅｎｄｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｓｏｌｕｔｉｏｎｓｉｎｃ． | エキセナチド及び他のポリペプチド類の持続的送達 |
| KR20110025974A (ko) * | 2008-06-25 | 2011-03-14 | 엔도 파마슈티컬즈, 솔루션스 아이엔씨. | 이형제를 함유하는 옥트레오티드 이식물 |
| RU2510266C2 (ru) * | 2008-09-30 | 2014-03-27 | Эндо Фармасьютикалз Солюшнз Инк. | Имплантируемое устройство для доставки рисперидона и способы его применения |
| JP2012504144A (ja) * | 2008-09-30 | 2012-02-16 | エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． | オクトレオチド送達用埋め込み可能型装置およびその使用方法 |
| JP2012504139A (ja) * | 2008-09-30 | 2012-02-16 | エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． | ヒストレリン送達用埋め込み可能型装置およびその使用方法 |
| US20110097380A1 (en) * | 2009-10-28 | 2011-04-28 | Warsaw Orthopedic, Inc. | Clonidine formulations having antimicrobial properties |
| WO2011139594A2 (en) | 2010-04-27 | 2011-11-10 | Medtronic, Inc. | Artificial bursa for intra-articular drug delivery |
| WO2012012162A2 (en) * | 2010-06-30 | 2012-01-26 | Surmodics Pharmaceuticals, Inc. | Core-sheath implant device having an inner core lobe |
| US20190263888A1 (en) | 2010-10-19 | 2019-08-29 | Op-T Llc | Therapeutic peptides and methods for treating autoimmune related disease |
| CN103889434B (zh) | 2011-06-21 | 2017-02-15 | Bvw控股公司 | 含有乳香酸的医疗装置 |
| MX357598B (es) * | 2011-07-20 | 2018-07-16 | F Kiser Patrick | Dispositivos intravaginales para administración de fármaco. |
| EP2770981B1 (en) | 2011-10-24 | 2017-05-24 | Braeburn Pharmaceuticals, Inc. | Implantable tizanidine compositions and methods of treatment thereof |
| EP2771320B1 (en) | 2011-10-24 | 2016-06-22 | Endo Pharmaceuticals Inc. | Cyclohexylamines |
| US8568360B2 (en) | 2011-12-28 | 2013-10-29 | Palyon Medical (Bvi) Limited | Programmable implantable pump design |
| SG11201507294WA (en) | 2013-03-15 | 2015-10-29 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| JP6616772B2 (ja) | 2013-12-16 | 2019-12-04 | アサナ・バイオサイエンシズ，リミテッド・ライアビリティ・カンパニー | Ｐ２ｘ３および／またはｐ２ｘ２／３化合物ならびに方法 |
| WO2016172704A1 (en) | 2015-04-23 | 2016-10-27 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| EP3316891B1 (en) | 2015-07-01 | 2019-10-16 | Region Nordjylland, Aalborg Universitetshospital | Treatment of otitis media with retroauricular injection of an anti-inflammatory drug |
| US10729771B2 (en) | 2016-02-10 | 2020-08-04 | Rutgers, The State University Of New Jersey | Anti-LAM and anti-PIM6/LAM monoclonal antibodies for diagnosis and treatment of Mycobacterium tuberculosis infections |
| ITUA20162094A1 (it) * | 2016-03-29 | 2017-09-29 | Cid S P A | Perfezionamenti negli stent per il rilascio di principi attivi |
| US10981976B2 (en) | 2016-08-31 | 2021-04-20 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof |
| CN116854693A (zh) | 2016-09-30 | 2023-10-10 | 阿沙纳生物科学公司 | P2x3和/或p2x2/3化合物及方法 |
| ES3031007T3 (en) * | 2017-11-10 | 2025-07-03 | Op T Llc | Peptide for preventing, modulating and/or reducing cardiovascular disease |
| CA3112938C (en) | 2018-10-15 | 2023-08-15 | Chong Kun Dang Pharmaceutical Corp. | Injectable long-acting naltrexone microparticle compositions |
| CR20210475A (es) | 2019-02-19 | 2021-10-18 | Particle Sciences Inc | Dispositivos de administración de fármacos compartimentados |
| US11793854B2 (en) | 2019-03-21 | 2023-10-24 | Op-T Llc | Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction |
| EP4041189B1 (en) | 2019-10-07 | 2025-09-17 | Oak Crest Institute of Science | Orally implantable drug delivery device |
| AU2020391230A1 (en) | 2019-11-27 | 2022-06-09 | Oak Crest Institute Of Science | Sustained release drug delivery device |
| US12048734B2 (en) | 2020-04-17 | 2024-07-30 | Op-T Llc | Bioactive peptides and methods of use thereof |
| CN112169138A (zh) * | 2020-10-30 | 2021-01-05 | 苏州伟康医疗器械有限公司 | 导尿管的堵头粘结工艺、导尿管 |
| US11820890B2 (en) | 2021-04-01 | 2023-11-21 | Stratasys Inc | Pulverulent thermoplastic polymer blends |
| EP4448543A1 (en) | 2022-01-06 | 2024-10-23 | Oak Crest Institute of Science | Subdermal implant for sustained drug delivery |
| CN114715483B (zh) * | 2022-05-04 | 2023-09-26 | 展一智能科技(东台)有限公司 | 下封堵操作机构及包装箱整理机 |
| CN121038778A (zh) | 2023-04-19 | 2025-11-28 | 橡冠科学研究院 | 阴道药物递送装置 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993073A (en) * | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3975350A (en) * | 1972-08-02 | 1976-08-17 | Princeton Polymer Laboratories, Incorporated | Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles |
| US4136145A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
| US4207890A (en) * | 1977-01-04 | 1980-06-17 | Mcneilab, Inc. | Drug-dispensing device and method |
| US4131604A (en) * | 1977-11-23 | 1978-12-26 | Thermo Electron Corporation | Polyurethane elastomer for heart assist devices |
| US4207809A (en) | 1978-03-20 | 1980-06-17 | Restaurant Technology, Inc. | Dual reservoir coffee urn |
| US4386039A (en) * | 1980-02-11 | 1983-05-31 | Thermo Electron Corporation | Process for forming an optically clear polyurethane lens or cornea |
| US4523005A (en) * | 1981-10-30 | 1985-06-11 | Thermedics, Inc. | Extrudable polyurethane for prosthetic devices prepared from a diisocyanate, a polytetramethylene ether polyol, and 1,4-butane diol |
| US4469671A (en) * | 1983-02-22 | 1984-09-04 | Eli Lilly And Company | Contraceptive device |
| US4751133A (en) * | 1984-11-13 | 1988-06-14 | Thermedics, Inc. | Medical patches and processes for producing same |
| US4720384A (en) * | 1985-05-03 | 1988-01-19 | E. I. Du Pont De Nemours And Company | Manufacture of hollow fine tubular drug delivery systems |
| US4673565A (en) | 1985-05-03 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Pharmaceutical compositions containing hollow fine tubular drug delivery systems |
| JPS62223112A (ja) | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 歯周病治療剤 |
| US4743673A (en) * | 1986-12-19 | 1988-05-10 | Tyndale Plains-Hunter, Ltd. | Hydrophilic carboxy polyurethanes |
| US5035891A (en) * | 1987-10-05 | 1991-07-30 | Syntex (U.S.A.) Inc. | Controlled release subcutaneous implant |
| US5207705A (en) * | 1988-12-08 | 1993-05-04 | Brigham And Women's Hospital | Prosthesis of foam polyurethane and collagen and uses thereof |
| US5254662A (en) * | 1990-09-12 | 1993-10-19 | Polymedia Industries, Inc. | Biostable polyurethane products |
| US5266325A (en) * | 1990-09-28 | 1993-11-30 | Hydro Med Science Division Of National Patent Development Corp. | Preparation of homogeneous hydrogel copolymers |
| AU651654B2 (en) * | 1992-01-14 | 1994-07-28 | Endo Pharmaceuticals Solutions Inc. | Manufacture of water-swellable hydrophilic articles and drug delivery devices |
| JP2530079B2 (ja) * | 1992-02-05 | 1996-09-04 | ナショナル・パテント・ディベロプメント・コーポレーション | 水分膨潤性親水性製品及び薬物放出装置の製造 |
| DK0637323T3 (da) * | 1992-04-24 | 1999-05-25 | Polymer Technology Group Inc | Copolymerer og ikke-porøs, semipermeabel membran deraf og dens anvendelse til permeering af molekyler med et forudbestemt m |
| US5629008A (en) | 1992-06-02 | 1997-05-13 | C.R. Bard, Inc. | Method and device for long-term delivery of drugs |
| US5354835A (en) * | 1993-07-23 | 1994-10-11 | Saudi Basic Industries Corporation | Desalination process |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| CA2212165A1 (en) * | 1995-02-10 | 1996-08-15 | Matthew A. Bergan | Method and device for administering analgesics |
| US5789411A (en) | 1995-09-11 | 1998-08-04 | Lance L. Gooberman P. C. | Improvements to rapid opioid detoxification |
| PL189289B1 (pl) * | 1996-02-02 | 2005-07-29 | Alza Corp | Sposób przygotowania implantowanego układu do dostarczania substancji aktywnej |
| FR2752380B1 (fr) * | 1996-08-14 | 1998-10-30 | Dow Corning Sa | Procede de fabrication d'un dispositif a liberation controlee |
| AUPO251096A0 (en) * | 1996-09-23 | 1996-10-17 | Cardiac Crc Nominees Pty Limited | Polysiloxane-containing polyurethane elastomeric compositions |
| US7728049B2 (en) * | 1996-10-08 | 2010-06-01 | Zamore Alan M | Irradiation conversion of thermoplastic to thermoset polymers |
| US20010006677A1 (en) | 1996-10-29 | 2001-07-05 | Mcginity James W. | Effervescence polymeric film drug delivery system |
| MY125849A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
| US5880571A (en) | 1997-09-11 | 1999-03-09 | Sundstrand Corporation | Method of and system for controlling a variable speed induction motor |
| KR100576583B1 (ko) * | 1997-12-22 | 2006-05-04 | 알자 코포레이션 | 서방성 약물 송달 장치용 속도 조절막 |
| KR100568917B1 (ko) * | 1997-12-30 | 2006-04-07 | 알자 코포레이션 | 멤브레인 플러그를 갖는 익제 전달장치 |
| US20020034534A1 (en) | 1999-12-16 | 2002-03-21 | Barr Deborah P. | System and method for delivering a therapeutic agent over an extended period of time in conjuction with a receptor loading dose of the therapeutic agent |
| US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
| WO2001074555A1 (en) * | 2000-03-31 | 2001-10-11 | Holy Norman L | Compostable, degradable plastic compositions and articles thereof |
| AU8734901A (en) | 2000-09-01 | 2002-03-13 | Palmaya Pty Ltd | Slow release pharmaceutical preparation and method of administering same |
| US6887270B2 (en) | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
| CN100586398C (zh) | 2002-05-23 | 2010-02-03 | 活性移植公司 | 植入体 |
| CA2437639C (en) * | 2003-08-11 | 2016-07-05 | Valera Pharmaceuticals, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US20090208540A1 (en) * | 2003-08-11 | 2009-08-20 | Indevus Pharmaceuticals, Inc. | Implantable device for the delivery of naltrexone and methods of use thereof |
| US7858110B2 (en) * | 2003-08-11 | 2010-12-28 | Endo Pharmaceuticals Solutions, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| EP2594259A1 (en) | 2004-08-04 | 2013-05-22 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
| CN101193626A (zh) | 2005-03-11 | 2008-06-04 | 益德威士医药股份有限公司 | 奥曲肽的受控释放制剂 |
| US20080004260A1 (en) | 2006-06-29 | 2008-01-03 | Transcept Pharmaceuticals, Inc. | Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions |
| WO2008062009A1 (en) | 2006-11-22 | 2008-05-29 | N.V. Organon | Delivery system for risperidone |
| EP2500015A1 (en) | 2006-12-05 | 2012-09-19 | Landec Corporation | Delivery of drugs |
| KR20110025974A (ko) | 2008-06-25 | 2011-03-14 | 엔도 파마슈티컬즈, 솔루션스 아이엔씨. | 이형제를 함유하는 옥트레오티드 이식물 |
| RU2510266C2 (ru) | 2008-09-30 | 2014-03-27 | Эндо Фармасьютикалз Солюшнз Инк. | Имплантируемое устройство для доставки рисперидона и способы его применения |
| JP2012504144A (ja) | 2008-09-30 | 2012-02-16 | エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． | オクトレオチド送達用埋め込み可能型装置およびその使用方法 |
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2003
- 2003-08-18 CA CA2437639A patent/CA2437639C/en not_active Expired - Fee Related
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2004
- 2004-08-10 US US10/915,625 patent/US7842303B2/en not_active Expired - Fee Related
- 2004-08-11 SI SI200431052T patent/SI1660034T1/sl unknown
- 2004-08-11 AU AU2004262999A patent/AU2004262999B2/en not_active Ceased
- 2004-08-11 HR HR20090209T patent/HRP20090209T1/xx unknown
- 2004-08-11 EP EP14172031.8A patent/EP2805709A1/en not_active Withdrawn
- 2004-08-11 CN CN201110053656.6A patent/CN102133174B/zh not_active Expired - Fee Related
- 2004-08-11 CN CN2004800293420A patent/CN1863504B/zh not_active Expired - Fee Related
- 2004-08-11 ES ES04769233T patent/ES2320556T3/es not_active Expired - Lifetime
- 2004-08-11 WO PCT/IB2004/002823 patent/WO2005013936A2/en not_active Ceased
- 2004-08-11 PL PL04769233T patent/PL1660034T3/pl unknown
- 2004-08-11 JP JP2006523081A patent/JP5060128B2/ja not_active Expired - Fee Related
- 2004-08-11 EP EP04769233A patent/EP1660034B1/en not_active Expired - Lifetime
- 2004-08-11 DK DK04769233T patent/DK1660034T3/da active
- 2004-08-11 MX MXPA06001612A patent/MXPA06001612A/es active IP Right Grant
- 2004-08-11 EP EP08010973A patent/EP1982695A3/en not_active Ceased
- 2004-08-11 DE DE602004019224T patent/DE602004019224D1/de not_active Expired - Lifetime
- 2004-08-11 PT PT04769233T patent/PT1660034E/pt unknown
- 2004-08-11 AT AT04769233T patent/ATE421316T1/de active
-
2009
- 2009-07-22 AU AU2009202942A patent/AU2009202942B2/en not_active Ceased
-
2010
- 2010-08-31 US US12/873,130 patent/US8357389B2/en not_active Expired - Fee Related
- 2010-10-19 US US12/907,717 patent/US8343528B2/en not_active Expired - Fee Related
- 2010-12-14 AU AU2010251786A patent/AU2010251786B2/en not_active Ceased
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2011
- 2011-02-16 JP JP2011031294A patent/JP5368497B2/ja not_active Expired - Fee Related
-
2012
- 2012-10-01 JP JP2012219869A patent/JP2013049678A/ja active Pending
- 2012-12-04 US US13/693,659 patent/US8529936B2/en not_active Expired - Fee Related
-
2013
- 2013-07-26 US US13/952,327 patent/US8658195B2/en not_active Expired - Fee Related
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2014
- 2014-01-20 US US14/159,119 patent/US20140135684A1/en not_active Abandoned
- 2014-08-12 JP JP2014164312A patent/JP2014237699A/ja active Pending
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