CA2434094A1 - Automated in-process isotope and mass spectrometry - Google Patents
Automated in-process isotope and mass spectrometry Download PDFInfo
- Publication number
- CA2434094A1 CA2434094A1 CA002434094A CA2434094A CA2434094A1 CA 2434094 A1 CA2434094 A1 CA 2434094A1 CA 002434094 A CA002434094 A CA 002434094A CA 2434094 A CA2434094 A CA 2434094A CA 2434094 A1 CA2434094 A1 CA 2434094A1
- Authority
- CA
- Canada
- Prior art keywords
- mass spectrometry
- sample
- isotope dilution
- dilution mass
- automated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 157
- 238000004949 mass spectrometry Methods 0.000 title description 7
- 241000894007 species Species 0.000 claims abstract description 106
- 238000004750 isotope dilution mass spectroscopy Methods 0.000 claims abstract description 70
- 238000001514 detection method Methods 0.000 claims abstract description 52
- 239000000356 contaminant Substances 0.000 claims abstract description 25
- 238000004458 analytical method Methods 0.000 claims abstract description 16
- 238000011067 equilibration Methods 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims description 55
- 230000000155 isotopic effect Effects 0.000 claims description 32
- 239000000126 substance Substances 0.000 claims description 20
- 150000002500 ions Chemical class 0.000 claims description 19
- 230000008569 process Effects 0.000 claims description 18
- 238000007385 chemical modification Methods 0.000 claims description 13
- 239000004065 semiconductor Substances 0.000 claims description 13
- 238000012545 processing Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 238000012421 spiking Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 238000004451 qualitative analysis Methods 0.000 claims description 6
- 238000004445 quantitative analysis Methods 0.000 claims description 6
- 238000004094 preconcentration Methods 0.000 claims description 4
- 238000013459 approach Methods 0.000 claims description 3
- 238000004811 liquid chromatography Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims 3
- 238000000132 electrospray ionisation Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 81
- 238000011002 quantification Methods 0.000 abstract description 12
- 238000000275 quality assurance Methods 0.000 abstract description 5
- 239000000523 sample Substances 0.000 description 85
- 239000012530 fluid Substances 0.000 description 39
- 239000003446 ligand Substances 0.000 description 24
- 239000003153 chemical reaction reagent Substances 0.000 description 18
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 17
- 239000010949 copper Substances 0.000 description 13
- 238000011156 evaluation Methods 0.000 description 13
- 239000007789 gas Substances 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- 235000012431 wafers Nutrition 0.000 description 13
- 229910052802 copper Inorganic materials 0.000 description 12
- 230000004044 response Effects 0.000 description 12
- 239000011701 zinc Substances 0.000 description 11
- 238000011088 calibration curve Methods 0.000 description 10
- 238000004140 cleaning Methods 0.000 description 10
- 238000011109 contamination Methods 0.000 description 10
- 238000010790 dilution Methods 0.000 description 10
- 239000012895 dilution Substances 0.000 description 10
- 229910052759 nickel Inorganic materials 0.000 description 10
- 229910052725 zinc Inorganic materials 0.000 description 10
- 238000012544 monitoring process Methods 0.000 description 9
- 238000005457 optimization Methods 0.000 description 9
- 229910052709 silver Inorganic materials 0.000 description 9
- 238000009616 inductively coupled plasma Methods 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 7
- 238000001360 collision-induced dissociation Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 229910052710 silicon Inorganic materials 0.000 description 6
- 239000010703 silicon Substances 0.000 description 6
- 239000010944 silver (metal) Substances 0.000 description 6
- 238000004088 simulation Methods 0.000 description 6
- 230000009466 transformation Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000536 complexating effect Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000005755 formation reaction Methods 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 229910001868 water Inorganic materials 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000003113 dilution method Methods 0.000 description 4
- 238000004401 flow injection analysis Methods 0.000 description 4
- 229910001385 heavy metal Inorganic materials 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- 238000001819 mass spectrum Methods 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000002485 combustion reaction Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000007405 data analysis Methods 0.000 description 3
- 238000013480 data collection Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 239000012088 reference solution Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 239000011573 trace mineral Substances 0.000 description 3
- 238000012929 ultra trace analysis Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 238000000342 Monte Carlo simulation Methods 0.000 description 2
- 229910017974 NH40H Inorganic materials 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- 101000580354 Rhea americana Rheacalcin-2 Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- BFGKITSFLPAWGI-UHFFFAOYSA-N chromium(3+) Chemical compound [Cr+3] BFGKITSFLPAWGI-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 2
- 238000010949 in-process test method Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 229910000000 metal hydroxide Inorganic materials 0.000 description 2
- 150000004692 metal hydroxides Chemical class 0.000 description 2
- 229910052750 molybdenum Inorganic materials 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 125000002524 organometallic group Chemical group 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000003908 quality control method Methods 0.000 description 2
- 238000011158 quantitative evaluation Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000012882 sequential analysis Methods 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 238000000844 transformation Methods 0.000 description 2
- 229910021642 ultra pure water Inorganic materials 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000252506 Characiformes Species 0.000 description 1
- VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical compound [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 101000580353 Rhea americana Rheacalcin-1 Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000004454 trace mineral analysis Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D59/00—Separation of different isotopes of the same chemical element
- B01D59/44—Separation by mass spectrography
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/0004—Use of compounding ingredients, the chemical constitution of which is unknown, broadly defined, or irrelevant
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0009—Calibration of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2300/00—Characterised by the use of unspecified polymers
- C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26474801P | 2001-01-29 | 2001-01-29 | |
| US60/264,748 | 2001-01-29 | ||
| PCT/US2001/046539 WO2002060565A1 (en) | 2001-01-29 | 2001-12-05 | Automated in-process isotope and mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2434094A1 true CA2434094A1 (en) | 2002-08-08 |
Family
ID=23007429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002434094A Abandoned CA2434094A1 (en) | 2001-01-29 | 2001-12-05 | Automated in-process isotope and mass spectrometry |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1355728A4 (enExample) |
| JP (1) | JP2004526952A (enExample) |
| KR (1) | KR20030079968A (enExample) |
| CN (1) | CN100408151C (enExample) |
| CA (1) | CA2434094A1 (enExample) |
| WO (1) | WO2002060565A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107462622A (zh) * | 2016-06-06 | 2017-12-12 | 塞莫费雪科学（不来梅）有限公司 | 用于静态气体质谱分析的设备和方法 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0218946D0 (en) | 2002-08-14 | 2002-09-25 | Thermo Electron Corp | Diluting a sample |
| US7309608B2 (en) * | 2003-09-30 | 2007-12-18 | Hoa Duc Nguyen | Method of analysis of aldehyde and ketone by mass spectrometry |
| KR100795875B1 (ko) * | 2005-02-22 | 2008-01-21 | 한국원자력연구원 | 고분해능 원자포획-질량분석 방법 |
| AU2007349186B2 (en) * | 2006-12-07 | 2014-03-06 | Applied Isotope Technologies, Inc | Solid phase and catalyzed enabled automated isotope dilution and speciated isotope dilution mass spectrometry |
| KR101068996B1 (ko) * | 2008-09-18 | 2011-09-30 | 한국표준과학연구원 | 안정동위원소의 질량비를 이용한 동물의 월령 측정 방법 |
| KR101107407B1 (ko) * | 2010-06-24 | 2012-01-19 | 장명석 | 배수트랩 |
| CN102608227B (zh) * | 2012-02-23 | 2014-08-20 | 西安交通大学 | 细胞色谱与液相质谱二维联用分析仪的单片机阀控系统 |
| GB201204723D0 (en) * | 2012-03-19 | 2012-05-02 | Micromass Ltd | Improved time of flight quantitation using alternative characteristic ions |
| CN104006993B (zh) * | 2014-05-26 | 2016-08-24 | 中国兵器工业集团第五三研究所 | Id-icp-ms法燃油中硫含量的测试样品制备方法 |
| CN104576289B (zh) * | 2014-12-31 | 2017-08-25 | 聚光科技(杭州)股份有限公司 | 一种可调真空压力的电感耦合等离子体质谱仪 |
| CN104517799B (zh) * | 2014-12-31 | 2017-09-15 | 同方威视技术股份有限公司 | 检测设备和检测方法 |
| CN108760799A (zh) * | 2018-03-23 | 2018-11-06 | 北京农业质量标准与检测技术研究中心 | 一种基于热导检测信号进行样品动态稀释的稳定同位素比值测定方法 |
| CN112912736B (zh) * | 2018-10-25 | 2024-05-07 | 株式会社日立高新技术 | 自动分析装置 |
| KR102561527B1 (ko) * | 2020-04-08 | 2023-07-28 | 비엘 텍 케이.케이. | 흐름 분석 장치 및 흐름 분석 방법 |
| CA3196351A1 (en) * | 2020-10-20 | 2022-04-28 | Definitek, Inc. | Quantification of previously undetectable quantities |
| US20240408569A1 (en) * | 2021-09-10 | 2024-12-12 | The European Atomic Energy Community (Euratom), Represented By The European Commission | Embedded product for the transportation, storage and/or handling of lanthanides or actinides and method of manufacturing |
| CN116264105B (zh) * | 2022-06-16 | 2023-10-03 | 中国科学院大气物理研究所 | 一种适用于同位素化学分馏与大气化学传输模式耦合的算法 |
| CN116087374B (zh) * | 2023-04-11 | 2023-06-27 | 农业农村部环境保护科研监测所 | 一种用于农产品中痕量双酚类化合物的检测方法 |
| CN117110381A (zh) * | 2023-08-29 | 2023-11-24 | 中国地质科学院水文地质环境地质研究所 | 一种信号调试装置及方法 |
| CN117538406B (zh) * | 2023-11-17 | 2024-07-19 | 中国地质大学（武汉） | 一种基于同位素混合模型校正的激光微区同位素分析和校正方法 |
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| US3796879A (en) * | 1972-03-24 | 1974-03-12 | Searle & Co | Automated multiple sample processing for well type radioactivity counters |
| CN87212873U (zh) * | 1987-11-19 | 1988-07-27 | 北京信通电脑技术公司 | 离子质谱计 |
| US5414259A (en) * | 1994-01-05 | 1995-05-09 | Duquesne University Of The Holy Ghost | Method of speciated isotope dilution mass spectrometry |
| EP1008167A4 (en) * | 1997-03-14 | 2006-08-23 | Univ George Washington | DEVICE FOR THE CONTINUOUS CONTROL OF THE ISOTOPIC RATIO AFTER FLUORINE CHEMICAL REACTIONS |
| JPH1197321A (ja) * | 1997-09-18 | 1999-04-09 | Toshiba Corp | 汚染源特定方法 |
| US6790673B1 (en) * | 1998-01-29 | 2004-09-14 | Duquesne University Of The Holy Ghost | Speciated isotope dilution mass spectrometry of reactive species and related methods |
| US6258605B1 (en) * | 1999-03-26 | 2001-07-10 | Neo Gen Screening, Inc. | Clinical method for the genetic screening of newborns using tandem mass spectrometry |
| US6410914B1 (en) * | 1999-03-05 | 2002-06-25 | Bruker Daltonics Inc. | Ionization chamber for atmospheric pressure ionization mass spectrometry |
| GB2349270B (en) * | 1999-04-15 | 2002-02-13 | Hitachi Ltd | Mass analysis apparatus and method for mass analysis |
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2001
- 2001-12-05 WO PCT/US2001/046539 patent/WO2002060565A1/en not_active Ceased
- 2001-12-05 EP EP01996118A patent/EP1355728A4/en not_active Withdrawn
- 2001-12-05 CN CNB018223656A patent/CN100408151C/zh not_active Expired - Fee Related
- 2001-12-05 KR KR10-2003-7009937A patent/KR20030079968A/ko not_active Ceased
- 2001-12-05 JP JP2002560754A patent/JP2004526952A/ja active Pending
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107462622A (zh) * | 2016-06-06 | 2017-12-12 | 塞莫费雪科学（不来梅）有限公司 | 用于静态气体质谱分析的设备和方法 |
| CN107462622B (zh) * | 2016-06-06 | 2020-12-08 | 塞莫费雪科学（不来梅）有限公司 | 用于静态气体质谱分析的设备和方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100408151C (zh) | 2008-08-06 |
| EP1355728A4 (en) | 2005-01-12 |
| JP2004526952A (ja) | 2004-09-02 |
| WO2002060565A8 (en) | 2002-10-03 |
| EP1355728A2 (en) | 2003-10-29 |
| CN1575195A (zh) | 2005-02-02 |
| WO2002060565A1 (en) | 2002-08-08 |
| KR20030079968A (ko) | 2003-10-10 |
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