WO2002060565A8 - Automated in-process isotope and mass spectrometry - Google Patents

Automated in-process isotope and mass spectrometry

Info

Publication number
WO2002060565A8
WO2002060565A8 PCT/US2001/046539 US0146539W WO02060565A8 WO 2002060565 A8 WO2002060565 A8 WO 2002060565A8 US 0146539 W US0146539 W US 0146539W WO 02060565 A8 WO02060565 A8 WO 02060565A8
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometer
automated
specie
equilibration
elemental
Prior art date
Application number
PCT/US2001/046539
Other languages
French (fr)
Other versions
WO2002060565A1 (en
Inventor
Howard M Kingston
Original Assignee
Howard M Kingston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howard M Kingston filed Critical Howard M Kingston
Priority to CA002434094A priority Critical patent/CA2434094A1/en
Priority to EP01996118A priority patent/EP1355728A4/en
Priority to JP2002560754A priority patent/JP2004526952A/en
Priority to KR10-2003-7009937A priority patent/KR20030079968A/en
Publication of WO2002060565A1 publication Critical patent/WO2002060565A1/en
Publication of WO2002060565A8 publication Critical patent/WO2002060565A8/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D59/00—Separation of different isotopes of the same chemical element
    • B01D59/44—Separation by mass spectrography
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/0004—Use of compounding ingredients, the chemical constitution of which is unknown, broadly defined, or irrelevant
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0009—Calibration of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A method and associated apparatus for in-process automated analysis employing a modified form of isotope dilution mass spectrometry is disclosed. It involves elemental and speciation threshold measurement that is optimised for quality assurance at and is capable of functioning at and near quantitative instrumental detection limits. The system is automated and may be employed in an unattended operation for identification and quantification of elemental or specie contaminants. In a preferred aspect of the method, a sample(2) is subjected to equilibration with at least one spiked stable isotope element or specie (38) after which it is subjected to ionization in an atmospheric ion generator (32) and processed by a mass spectrometer with the output of the mass spectrometer being processed by a microprocessor which through a controller(20), coordinates operation of sample and spike delivery and equilibration as well as, the operation of the atmospheric ion generator and mass spectrometer (36). The method may in the alternative be employed qualitatively.
PCT/US2001/046539 2001-01-29 2001-12-05 Automated in-process isotope and mass spectrometry WO2002060565A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002434094A CA2434094A1 (en) 2001-01-29 2001-12-05 Automated in-process isotope and mass spectrometry
EP01996118A EP1355728A4 (en) 2001-01-29 2001-12-05 Automated in-process isotope and mass spectrometry
JP2002560754A JP2004526952A (en) 2001-01-29 2001-12-05 Isotope and mass analysis by automated in-process
KR10-2003-7009937A KR20030079968A (en) 2001-01-29 2001-12-05 Automated in-process isotope and mass spectrometry

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26474801P 2001-01-29 2001-01-29
US60/264,748 2001-01-29

Publications (2)

Publication Number Publication Date
WO2002060565A1 WO2002060565A1 (en) 2002-08-08
WO2002060565A8 true WO2002060565A8 (en) 2002-10-03

Family

ID=23007429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046539 WO2002060565A1 (en) 2001-01-29 2001-12-05 Automated in-process isotope and mass spectrometry

Country Status (6)

Country Link
EP (1) EP1355728A4 (en)
JP (1) JP2004526952A (en)
KR (1) KR20030079968A (en)
CN (1) CN100408151C (en)
CA (1) CA2434094A1 (en)
WO (1) WO2002060565A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0218946D0 (en) 2002-08-14 2002-09-25 Thermo Electron Corp Diluting a sample
US7309608B2 (en) * 2003-09-30 2007-12-18 Hoa Duc Nguyen Method of analysis of aldehyde and ketone by mass spectrometry
KR100795875B1 (en) * 2005-02-22 2008-01-21 한국원자력연구원 High Resolution Atom Trap-Mass Spectrometry
DK2108111T3 (en) * 2006-12-07 2019-07-15 Definitek Inc SOLID PHASE AND CATALYST ACTIVATED AUTOMATED ISOTOP IMPROVEMENT AND SPECIFIED ISOTOP IMPROVEMENT PASS SPECTROMETRY
KR101068996B1 (en) * 2008-09-18 2011-09-30 한국표준과학연구원 A method for verification of animal age based on stable isotopic ratio measurement
KR101107407B1 (en) * 2010-06-24 2012-01-19 장명석 Drain trap
CN102608227B (en) * 2012-02-23 2014-08-20 西安交通大学 Singlechip valve control system of two-dimensional coupling analysis meter of cell chromatograph and liquid phase mass spectrum
GB201204723D0 (en) * 2012-03-19 2012-05-02 Micromass Ltd Improved time of flight quantitation using alternative characteristic ions
CN104006993B (en) * 2014-05-26 2016-08-24 中国兵器工业集团第五三研究所 The test sample preparation method of sulfur content in ID-ICP-MS method fuel oil
CN107064361B (en) 2014-12-31 2020-03-27 同方威视技术股份有限公司 Detection apparatus and detection method
CN104576289B (en) * 2014-12-31 2017-08-25 聚光科技(杭州)股份有限公司 A kind of icp mses of adjustable vacuum pressure
GB2551127B (en) * 2016-06-06 2020-01-08 Thermo Fisher Scient Bremen Gmbh Apparatus and method for static gas mass spectrometry
CN108760799A (en) * 2018-03-23 2018-11-06 北京农业质量标准与检测技术研究中心 A kind of Stable isotope ratio assay method carrying out sample dynamic dilution based on Thermal Conductivity signal
CN112912736B (en) * 2018-10-25 2024-05-07 株式会社日立高新技术 Automatic analysis device
EP4075116A4 (en) 2020-04-08 2023-06-07 BL Tec K.K. Flow analysis device and flow analysis method
WO2021205953A1 (en) * 2020-04-08 2021-10-14 ビーエルテック株式会社 Flow analysis device and flow analysis method
CN116264105B (en) * 2022-06-16 2023-10-03 中国科学院大气物理研究所 Algorithm suitable for coupling isotope chemical fractionation and atmospheric chemical transmission mode
CN116087374B (en) * 2023-04-11 2023-06-27 农业农村部环境保护科研监测所 Detection method for trace bisphenol compounds in agricultural products
CN117538406B (en) * 2023-11-17 2024-07-19 中国地质大学（武汉） Isotope analysis and correction method for laser micro-region based on isotope mixing model correction

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3796879A (en) * 1972-03-24 1974-03-12 Searle & Co Automated multiple sample processing for well type radioactivity counters
CN87212873U (en) * 1987-11-19 1988-07-27 北京信通电脑技术公司 Ion mass-spectrometer
US5414259A (en) * 1994-01-05 1995-05-09 Duquesne University Of The Holy Ghost Method of speciated isotope dilution mass spectrometry
JP2002514302A (en) * 1997-03-14 2002-05-14 ジョージワシントン大学 医学、健康科学部 A continuous isotope monitoring system that tracks fluorine-based chemical reactions
JPH1197321A (en) * 1997-09-18 1999-04-09 Toshiba Corp Method for identifying contamination source
US6790673B1 (en) * 1998-01-29 2004-09-14 Duquesne University Of The Holy Ghost Speciated isotope dilution mass spectrometry of reactive species and related methods
US6258605B1 (en) * 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US6410914B1 (en) * 1999-03-05 2002-06-25 Bruker Daltonics Inc. Ionization chamber for atmospheric pressure ionization mass spectrometry
GB2349270B (en) * 1999-04-15 2002-02-13 Hitachi Ltd Mass analysis apparatus and method for mass analysis

Also Published As

Publication number Publication date
WO2002060565A1 (en) 2002-08-08
CA2434094A1 (en) 2002-08-08
CN100408151C (en) 2008-08-06
JP2004526952A (en) 2004-09-02
EP1355728A2 (en) 2003-10-29
CN1575195A (en) 2005-02-02
EP1355728A4 (en) 2005-01-12
KR20030079968A (en) 2003-10-10

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