CA2423296C - N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists - Google Patents

N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists Download PDF

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Publication number
CA2423296C
CA2423296C CA002423296A CA2423296A CA2423296C CA 2423296 C CA2423296 C CA 2423296C CA 002423296 A CA002423296 A CA 002423296A CA 2423296 A CA2423296 A CA 2423296A CA 2423296 C CA2423296 C CA 2423296C
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CA
Canada
Prior art keywords
alkyl
phenyl
substituted
halogen
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002423296A
Other languages
English (en)
French (fr)
Other versions
CA2423296A1 (en
Inventor
Gurdip Bhalay
Trevor John Howe
Darren Mark Le Grand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0024675A external-priority patent/GB0024675D0/en
Priority claimed from GB0120549A external-priority patent/GB0120549D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2423296A1 publication Critical patent/CA2423296A1/en
Application granted granted Critical
Publication of CA2423296C publication Critical patent/CA2423296C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002423296A 2000-10-09 2001-10-08 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists Expired - Fee Related CA2423296C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0024675.1 2000-10-09
GB0024675A GB0024675D0 (en) 2000-10-09 2000-10-09 Organic compounds
GB0120549A GB0120549D0 (en) 2001-08-23 2001-08-23 Organic compounds
GB0120549.1 2001-08-23
PCT/EP2001/011627 WO2002030898A1 (en) 2000-10-09 2001-10-08 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists

Publications (2)

Publication Number Publication Date
CA2423296A1 CA2423296A1 (en) 2002-04-18
CA2423296C true CA2423296C (en) 2009-12-29

Family

ID=26245127

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002423296A Expired - Fee Related CA2423296C (en) 2000-10-09 2001-10-08 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists

Country Status (12)

Country Link
US (1) US7034042B2 (https=)
EP (1) EP1330436B1 (https=)
JP (1) JP4199539B2 (https=)
CN (1) CN1209351C (https=)
AT (1) ATE472533T1 (https=)
AU (1) AU2001295601A1 (https=)
BR (1) BR0114485A (https=)
CA (1) CA2423296C (https=)
DE (1) DE60142484D1 (https=)
ES (1) ES2348290T3 (https=)
PT (1) PT1330436E (https=)
WO (1) WO2002030898A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
EP1505067A4 (en) * 2002-04-25 2006-06-21 Teijin Ltd 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES WITH CCR3 ANTAGONISM
CN101312965B (zh) * 2005-11-24 2011-07-20 卫材R&D管理有限公司 吗啉型肉桂酰胺化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673684A (en) 1984-04-04 1987-06-16 Terumo Corporation Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
JPH0660160B2 (ja) * 1985-12-13 1994-08-10 テルモ株式会社 アミド誘導体およびこれを含有する抗アレルギ−剤
JPS63139124A (ja) 1986-12-01 1988-06-10 Terumo Corp 腎炎治療剤
JPS63179869A (ja) 1987-01-20 1988-07-23 Dainippon Pharmaceut Co Ltd ピペリジン誘導体
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
BR0009338A (pt) 1999-03-26 2001-12-26 Astrazeneca Ab Composto, processo para a preparação do mesmo,composição farmacêutica, processo para apreparação da mesma, uso de um composto, e,método de tratamento de uma doençainflamatória em um paciente sofrendo ou em riscode dita doença
TWI227231B (en) * 2000-07-12 2005-02-01 Novartis Ag 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3

Also Published As

Publication number Publication date
CA2423296A1 (en) 2002-04-18
EP1330436B1 (en) 2010-06-30
PT1330436E (pt) 2010-10-11
WO2002030898A1 (en) 2002-04-18
CN1468222A (zh) 2004-01-14
CN1209351C (zh) 2005-07-06
BR0114485A (pt) 2003-11-18
JP4199539B2 (ja) 2008-12-17
AU2001295601A1 (en) 2002-04-22
EP1330436A1 (en) 2003-07-30
ES2348290T3 (es) 2010-12-02
ATE472533T1 (de) 2010-07-15
JP2004511467A (ja) 2004-04-15
US20040087621A1 (en) 2004-05-06
DE60142484D1 (de) 2010-08-12
US7034042B2 (en) 2006-04-25

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