CA2416976C - Treatment of estrogen receptor positive carcinoma with a rapamycin and an antiestrogen - Google Patents
Treatment of estrogen receptor positive carcinoma with a rapamycin and an antiestrogen Download PDFInfo
- Publication number
- CA2416976C CA2416976C CA002416976A CA2416976A CA2416976C CA 2416976 C CA2416976 C CA 2416976C CA 002416976 A CA002416976 A CA 002416976A CA 2416976 A CA2416976 A CA 2416976A CA 2416976 C CA2416976 C CA 2416976C
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- Prior art keywords
- rapamycin
- carbon atoms
- antiestrogen
- hydroxy
- pharmaceutically acceptable
- Prior art date
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
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| US22432600P | 2000-08-11 | 2000-08-11 | |
| US60/224,326 | 2000-08-11 | ||
| PCT/US2001/024615 WO2002013802A2 (en) | 2000-08-11 | 2001-08-06 | Method of treating estrogen receptor positive carcinoma |
Publications (2)
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| CA2416976A1 CA2416976A1 (en) | 2002-02-21 |
| CA2416976C true CA2416976C (en) | 2008-05-20 |
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| CA002416976A Expired - Fee Related CA2416976C (en) | 2000-08-11 | 2001-08-06 | Treatment of estrogen receptor positive carcinoma with a rapamycin and an antiestrogen |
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| US (1) | US6511986B2 (OSRAM) |
| EP (1) | EP1318837B1 (OSRAM) |
| JP (1) | JP2004507465A (OSRAM) |
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| AT (1) | ATE278421T1 (OSRAM) |
| AU (1) | AU2001283139A1 (OSRAM) |
| CA (1) | CA2416976C (OSRAM) |
| DE (1) | DE60106281T2 (OSRAM) |
| DK (1) | DK1318837T3 (OSRAM) |
| ES (1) | ES2228932T3 (OSRAM) |
| MX (1) | MXPA03001245A (OSRAM) |
| PT (1) | PT1318837E (OSRAM) |
| WO (1) | WO2002013802A2 (OSRAM) |
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| US20030215445A1 (en) * | 1997-05-23 | 2003-11-20 | Ginette Serrero | Methods and compositions for inhibiting the growth of hematopoietic malignant cells |
| US6720159B1 (en) * | 1997-12-16 | 2004-04-13 | A&G Pharmaceutical, Inc. | 88KDA tumorigenic growth factor and antagonists |
| US20100111928A1 (en) * | 1997-05-23 | 2010-05-06 | A & G Pharmaceutical, Inc. | Methods and kits for diagnosis tumorgenicity |
| US7091047B2 (en) * | 1997-05-23 | 2006-08-15 | A&G Pharmaceutical, Inc. | Methods and kits for diagnosing tumorigenicity |
| US8512960B2 (en) * | 1997-05-23 | 2013-08-20 | A&G Pharmaceutical, Inc. | 88kDa tumorigenic growth factor and antagonists |
| US6309826B1 (en) * | 1997-05-23 | 2001-10-30 | Ginette Serrero | 88kDa tumorigenic growth factor and antagonists |
| US6881548B2 (en) * | 1997-05-23 | 2005-04-19 | A&G Pharmaceutical, Inc. | Methods and kits for diagnosing tumorigenicity and determining resistance to the antineoplastic effects of antiestrogen therapy |
| US7617145B1 (en) * | 2000-10-24 | 2009-11-10 | Worldwide Farm Equipment Auctions.Com Ltd. | Adaptive bidding increments in an online auction system |
| TWI286074B (en) | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
| AU2011226833B9 (en) * | 2001-02-19 | 2014-07-03 | Novartis Ag | Cancer treatment |
| EP2762140B1 (en) * | 2001-02-19 | 2017-03-22 | Novartis AG | Treatment of solid brain tumours with a rapamycin derivative |
| AU2016206379B2 (en) * | 2001-02-19 | 2017-09-14 | Novartis Ag | Cancer Treatment |
| EP1389209B1 (en) * | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| CN1954807A (zh) * | 2001-07-09 | 2007-05-02 | 佐纳根有限公司 | 富含反式克罗米酚的克罗米酚组合物 |
| UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
| WO2003064383A2 (en) | 2002-02-01 | 2003-08-07 | Ariad Gene Therapeutics, Inc. | Phosphorus-containing compounds & uses thereof |
| US7910594B2 (en) * | 2002-05-15 | 2011-03-22 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| US7411045B2 (en) * | 2002-11-19 | 2008-08-12 | A&G Pharmaceutical, Inc. | Autocrine growth factor receptor antibodies and methods |
| AR042942A1 (es) | 2003-01-27 | 2005-07-06 | Endocyte Inc | Conjugados de administracion de drogas de union de receptores de vitaminas |
| JP4488903B2 (ja) * | 2003-02-26 | 2010-06-23 | エイアンドジー ファーマスーティカル インコーポレイテッド | Ｂ細胞の増殖を増加させる方法 |
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| PT1615640E (pt) * | 2003-04-22 | 2007-04-30 | Wyeth Corp | Combinações antineoplásticas |
| EP1644038A2 (en) * | 2003-06-23 | 2006-04-12 | A & G Pharmaceuticals, Inc. | Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis |
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-
2001
- 2001-08-06 PT PT01961914T patent/PT1318837E/pt unknown
- 2001-08-06 JP JP2002518948A patent/JP2004507465A/ja not_active Withdrawn
- 2001-08-06 CN CNB018137539A patent/CN100448487C/zh not_active Expired - Fee Related
- 2001-08-06 AT AT01961914T patent/ATE278421T1/de not_active IP Right Cessation
- 2001-08-06 US US09/923,217 patent/US6511986B2/en not_active Expired - Fee Related
- 2001-08-06 CA CA002416976A patent/CA2416976C/en not_active Expired - Fee Related
- 2001-08-06 DE DE60106281T patent/DE60106281T2/de not_active Expired - Fee Related
- 2001-08-06 WO PCT/US2001/024615 patent/WO2002013802A2/en not_active Ceased
- 2001-08-06 AU AU2001283139A patent/AU2001283139A1/en not_active Abandoned
- 2001-08-06 EP EP01961914A patent/EP1318837B1/en not_active Expired - Lifetime
- 2001-08-06 ES ES01961914T patent/ES2228932T3/es not_active Expired - Lifetime
- 2001-08-06 DK DK01961914T patent/DK1318837T3/da active
- 2001-08-06 MX MXPA03001245A patent/MXPA03001245A/es active IP Right Grant
- 2001-08-10 AR ARP010103839A patent/AR033555A1/es unknown
Also Published As
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| EP1318837A2 (en) | 2003-06-18 |
| PT1318837E (pt) | 2004-12-31 |
| ATE278421T1 (de) | 2004-10-15 |
| DE60106281T2 (de) | 2005-02-24 |
| CN1446106A (zh) | 2003-10-01 |
| HK1056687A1 (en) | 2004-02-27 |
| US6511986B2 (en) | 2003-01-28 |
| AU2001283139A1 (en) | 2002-02-25 |
| US20020045638A1 (en) | 2002-04-18 |
| DK1318837T3 (da) | 2005-01-10 |
| CN100448487C (zh) | 2009-01-07 |
| EP1318837B1 (en) | 2004-10-06 |
| WO2002013802A3 (en) | 2003-03-27 |
| WO2002013802A2 (en) | 2002-02-21 |
| JP2004507465A (ja) | 2004-03-11 |
| MXPA03001245A (es) | 2003-05-27 |
| CA2416976A1 (en) | 2002-02-21 |
| DE60106281D1 (de) | 2004-11-11 |
| AR033555A1 (es) | 2003-12-26 |
| ES2228932T3 (es) | 2005-04-16 |
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