CA2412764C - Stimulation of cellular regeneration and differentiation in the inner ear - Google Patents
Stimulation of cellular regeneration and differentiation in the inner ear Download PDFInfo
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- CA2412764C CA2412764C CA2412764A CA2412764A CA2412764C CA 2412764 C CA2412764 C CA 2412764C CA 2412764 A CA2412764 A CA 2412764A CA 2412764 A CA2412764 A CA 2412764A CA 2412764 C CA2412764 C CA 2412764C
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- inner ear
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- 229950004616 tribromoethanol Drugs 0.000 description 1
- 108010080629 tryptophan-leucine Proteins 0.000 description 1
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- 229910052721 tungsten Inorganic materials 0.000 description 1
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- 108010078580 tyrosylleucine Proteins 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Analytical Chemistry (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61409900A | 2000-07-11 | 2000-07-11 | |
| US09/614,099 | 2000-07-11 | ||
| PCT/US2001/021793 WO2002004605A2 (en) | 2000-07-11 | 2001-07-10 | Stimulation of cellular regeneration and differentiation in the inner ear |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2412764A1 CA2412764A1 (en) | 2002-01-17 |
| CA2412764C true CA2412764C (en) | 2014-06-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2412764A Expired - Lifetime CA2412764C (en) | 2000-07-11 | 2001-07-10 | Stimulation of cellular regeneration and differentiation in the inner ear |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1307542A2 (enExample) |
| JP (1) | JP2004502785A (enExample) |
| KR (1) | KR100896489B1 (enExample) |
| CN (1) | CN1441841B (enExample) |
| AU (2) | AU2001288219C1 (enExample) |
| CA (1) | CA2412764C (enExample) |
| WO (1) | WO2002004605A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745209B2 (en) | 2005-07-26 | 2010-06-29 | Corning Incorporated | Multilayered cell culture apparatus |
| CA2669693C (en) | 2006-11-15 | 2018-06-12 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| US20080176318A1 (en) | 2006-12-07 | 2008-07-24 | Wilson John R | Highly efficient devices and methods for culturing cells |
| DE102010007281A1 (de) * | 2010-02-08 | 2011-08-11 | EMC microcollections GmbH, 72070 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
| AU2012289865A1 (en) * | 2011-08-03 | 2014-02-20 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide compounds for treating hearing and balance disorders |
| EP2802657B1 (en) | 2012-01-12 | 2018-05-02 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
| AU2013312358B2 (en) | 2012-09-07 | 2018-08-09 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| CN109219439B (zh) * | 2016-01-29 | 2022-09-20 | 马萨诸塞眼科耳科诊所 | 内耳支持细胞的扩增和分化及其使用方法 |
| CN114736924B (zh) * | 2021-01-07 | 2024-11-22 | 中国科学院脑科学与智能技术卓越创新中心 | 异位联合过表达Atoh1和Ikzf2再生耳蜗外毛细胞及其应用 |
| JP7760144B2 (ja) * | 2021-04-21 | 2025-10-27 | 学校法人順天堂 | 内耳細胞の製造法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593290B1 (en) * | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
| WO2000023084A1 (en) * | 1998-10-21 | 2000-04-27 | Jonathan Kil | Methods for stimulating the regeneration of inner ear cells |
| DE19807426A1 (de) * | 1998-02-23 | 1999-10-14 | Otogene Biotechnologische Fors | Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs |
-
2001
- 2001-07-10 CA CA2412764A patent/CA2412764C/en not_active Expired - Lifetime
- 2001-07-10 WO PCT/US2001/021793 patent/WO2002004605A2/en not_active Ceased
- 2001-07-10 KR KR1020037000388A patent/KR100896489B1/ko not_active Expired - Fee Related
- 2001-07-10 JP JP2002509459A patent/JP2004502785A/ja active Pending
- 2001-07-10 AU AU2001288219A patent/AU2001288219C1/en not_active Ceased
- 2001-07-10 CN CN018126065A patent/CN1441841B/zh not_active Expired - Lifetime
- 2001-07-10 EP EP01967939A patent/EP1307542A2/en not_active Withdrawn
- 2001-07-10 AU AU8821901A patent/AU8821901A/xx active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030046386A (ko) | 2003-06-12 |
| AU2001288219C1 (en) | 2009-12-03 |
| AU2001288219B9 (en) | 2009-11-19 |
| KR100896489B1 (ko) | 2009-05-08 |
| WO2002004605A2 (en) | 2002-01-17 |
| EP1307542A2 (en) | 2003-05-07 |
| CA2412764A1 (en) | 2002-01-17 |
| CN1441841A (zh) | 2003-09-10 |
| AU8821901A (en) | 2002-01-21 |
| AU2001288219B2 (en) | 2006-11-23 |
| JP2004502785A (ja) | 2004-01-29 |
| WO2002004605A3 (en) | 2003-02-27 |
| CN1441841B (zh) | 2013-03-20 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20210712 |