JP2004502785A - 内耳における細胞の再生および分化の刺激 - Google Patents

内耳における細胞の再生および分化の刺激 Download PDF

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JP2004502785A
JP2004502785A JP2002509459A JP2002509459A JP2004502785A JP 2004502785 A JP2004502785 A JP 2004502785A JP 2002509459 A JP2002509459 A JP 2002509459A JP 2002509459 A JP2002509459 A JP 2002509459A JP 2004502785 A JP2004502785 A JP 2004502785A
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inner ear
cells
nucleic acid
formation
cell
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JP2004502785A5 (enExample
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キル、ジョナサン
グー、レンデュ
グライガー、コリンヌ
ローベンハイム、フーベルト
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サウンド・ファーマシューティカルズ・インコーポレイテッド
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Analytical Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2002509459A 2000-07-11 2001-07-10 内耳における細胞の再生および分化の刺激 Pending JP2004502785A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61409900A 2000-07-11 2000-07-11
PCT/US2001/021793 WO2002004605A2 (en) 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear

Publications (2)

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JP2004502785A true JP2004502785A (ja) 2004-01-29
JP2004502785A5 JP2004502785A5 (enExample) 2008-09-04

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JP2002509459A Pending JP2004502785A (ja) 2000-07-11 2001-07-10 内耳における細胞の再生および分化の刺激

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EP (1) EP1307542A2 (enExample)
JP (1) JP2004502785A (enExample)
KR (1) KR100896489B1 (enExample)
CN (1) CN1441841B (enExample)
AU (2) AU8821901A (enExample)
CA (1) CA2412764C (enExample)
WO (1) WO2002004605A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013518917A (ja) * 2010-02-08 2013-05-23 イーエムシー マイクロコレクションズ ゲーエムベーハー 感覚器官及び有糸分裂後組織のための再生促進物質としての新規なアミノアルキルオキサゾール及びアミノアルキルチアゾールカルボン酸アミド
JP2022166650A (ja) * 2021-04-21 2022-11-02 学校法人順天堂 内耳細胞の製造法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
JP2010509919A (ja) 2006-11-15 2010-04-02 マサチューセッツ・アイ・アンド・イア・インファーマリー 内耳細胞の生成
CA2671812C (en) 2006-12-07 2015-06-16 Wilson Wolf Manufacturing Corporation Highly efficient gas permeable devices and methods for culturing cells
US20150018404A1 (en) * 2011-08-03 2015-01-15 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide compounds for treating hearing and balance disorders
EP2802657B1 (en) * 2012-01-12 2018-05-02 Quark Pharmaceuticals, Inc. Combination therapy for treating hearing and balance disorders
WO2014039781A1 (en) 2012-09-07 2014-03-13 Massachusetts Eye & Ear Infirmary Treating hearing loss
US11185536B2 (en) 2015-12-04 2021-11-30 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
JP7080173B2 (ja) * 2016-01-29 2022-06-03 マサチューセッツ アイ アンド イヤー インファーマリー 内耳支持細胞の拡大および分化ならびにその使用法
CN114736924B (zh) * 2021-01-07 2024-11-22 中国科学院脑科学与智能技术卓越创新中心 异位联合过表达Atoh1和Ikzf2再生耳蜗外毛细胞及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042088A2 (de) * 1998-02-23 1999-08-26 Otogene Aktiengesellschaft Verfahren zur behandlung von erkrankungen oder störungen des innenohrs
WO2000023084A1 (en) * 1998-10-21 2000-04-27 Jonathan Kil Methods for stimulating the regeneration of inner ear cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593290B1 (en) * 1996-11-01 2003-07-15 Genentech, Inc. Treatment of inner ear hair cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042088A2 (de) * 1998-02-23 1999-08-26 Otogene Aktiengesellschaft Verfahren zur behandlung von erkrankungen oder störungen des innenohrs
WO2000023084A1 (en) * 1998-10-21 2000-04-27 Jonathan Kil Methods for stimulating the regeneration of inner ear cells

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN6011021263; 治療 Ｖｏｌ．７７，　Ｎｏ．５, 1995, ｐ．１６８-１７０ *
JPN6011021265; Ｓｃｉｅｎｃｅ Ｖｏｌ．２５９, 1993, ｐ．１６１６-１６１９ *
JPN6011021266; Ｓｃｉｅｎｃｅ Ｖｏｌ．２５９, 1993, ｐ．１６１９-１６２２ *
JPN6011021269; Ｂｒａｉｎ　Ｒｅｓｅａｒｃｈ Ｖｏｌ．８１３, 1998, ｐ．５７-６６ *
JPN6011021274; Ｉｎｔ．　Ｊ．　Ｄｅｖｌ　Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．１５，　Ｎｏ．４／５, 1997, ｐ．４８７-４９５ *
JPN6011021278; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ Ｖｏｌ．９６, 1999, ｐ．４０８４-４０８８ *
JPN6012015223; Ｊ．　Ｎｅｕｒｏｃｙｔｏｌ． Ｖｏｌ．２８，　Ｎｏ．１０-１１, 1999, ９１３-９２４ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013518917A (ja) * 2010-02-08 2013-05-23 イーエムシー マイクロコレクションズ ゲーエムベーハー 感覚器官及び有糸分裂後組織のための再生促進物質としての新規なアミノアルキルオキサゾール及びアミノアルキルチアゾールカルボン酸アミド
JP2022166650A (ja) * 2021-04-21 2022-11-02 学校法人順天堂 内耳細胞の製造法
JP7760144B2 (ja) 2021-04-21 2025-10-27 学校法人順天堂 内耳細胞の製造法

Also Published As

Publication number Publication date
KR20030046386A (ko) 2003-06-12
CN1441841B (zh) 2013-03-20
AU2001288219B2 (en) 2006-11-23
EP1307542A2 (en) 2003-05-07
AU8821901A (en) 2002-01-21
CA2412764A1 (en) 2002-01-17
KR100896489B1 (ko) 2009-05-08
CN1441841A (zh) 2003-09-10
AU2001288219C1 (en) 2009-12-03
CA2412764C (en) 2014-06-03
WO2002004605A3 (en) 2003-02-27
AU2001288219B9 (en) 2009-11-19
WO2002004605A2 (en) 2002-01-17

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