CA2412600C - Immunostimulants puissants provenant de microalgues - Google Patents

Immunostimulants puissants provenant de microalgues Download PDF

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Publication number
CA2412600C
CA2412600C CA2412600A CA2412600A CA2412600C CA 2412600 C CA2412600 C CA 2412600C CA 2412600 A CA2412600 A CA 2412600A CA 2412600 A CA2412600 A CA 2412600A CA 2412600 C CA2412600 C CA 2412600C
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CA
Canada
Prior art keywords
ethanol
preparation
extraction
immunostimulatory
microalgae
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA2412600A
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English (en)
Other versions
CA2412600A1 (fr
Inventor
David Stanley Pasco
Nirmal Pugh
Samir Ross
Mahmoud Elsohly
Hala Elsohly
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University of Mississippi
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University of Mississippi
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Publication date
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Publication of CA2412600A1 publication Critical patent/CA2412600A1/fr
Application granted granted Critical
Publication of CA2412600C publication Critical patent/CA2412600C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des polysaccharides immunostimulateurs qui sont de préférence extraits de microalgues de qualité alimentaire au moyen d'un processus d'extraction avec de l'éthanol aqueux. Les préparations résultantes présentent une activité immunostimulante extrêmement puissante. L'extraction préférée de ces polysaccharides immunostimulateurs dépend de la concentration d'éthanol utilisée et de la température d'extraction. Les conditions les plus efficientes sont une concentration de 50 % d'éthanol et une température comprise entre 60· et 70 ·C. Les préparations de polysaccharides isolés sont potentiellement utiles en tant que préparation médicinale ou pharmaceutique destinée à améliorer la fonction immunitaire.
CA2412600A 2000-07-10 2001-07-10 Immunostimulants puissants provenant de microalgues Expired - Lifetime CA2412600C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21700100P 2000-07-10 2000-07-10
US60/217,001 2000-07-10
PCT/US2001/021770 WO2002004000A1 (fr) 2000-07-10 2001-07-10 Immunostimulants puissants provenant de microalgues

Publications (2)

Publication Number Publication Date
CA2412600A1 CA2412600A1 (fr) 2002-01-17
CA2412600C true CA2412600C (fr) 2011-09-27

Family

ID=22809278

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2412600A Expired - Lifetime CA2412600C (fr) 2000-07-10 2001-07-10 Immunostimulants puissants provenant de microalgues

Country Status (20)

Country Link
US (2) US7205284B2 (fr)
EP (1) EP1301191B1 (fr)
JP (1) JP2004502737A (fr)
KR (1) KR100831408B1 (fr)
CN (2) CN1823848A (fr)
AT (1) ATE311892T1 (fr)
AU (2) AU7333001A (fr)
BR (1) BR0112424A (fr)
CA (1) CA2412600C (fr)
DE (1) DE60115654T2 (fr)
DK (1) DK1301191T3 (fr)
EA (1) EA006318B1 (fr)
ES (1) ES2254451T3 (fr)
IL (2) IL153503A0 (fr)
MX (1) MXPA03000220A (fr)
NO (1) NO329221B1 (fr)
NZ (1) NZ523695A (fr)
PL (1) PL203814B1 (fr)
WO (1) WO2002004000A1 (fr)
ZA (1) ZA200301050B (fr)

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JP2004505925A (ja) 2000-08-10 2004-02-26 オーシャン、ニュートリッション、カナダ、リミテッド 免疫調節特性を示すクロレラ調製物
US6814961B1 (en) 2001-05-14 2004-11-09 Gitte S. Jensen Method for enhancing stem cell trafficking
EP1478648B1 (fr) 2002-02-01 2014-04-30 ARIAD Pharmaceuticals, Inc. Composes contenant du phosphore et utilisations associees
FR2850277B1 (fr) * 2003-01-24 2005-04-08 Lanatech Composition comprenant un extrait d'aphanizomenon flos-aquae, son utilisation et sa preparation
NO320429B1 (no) * 2003-06-03 2005-12-05 Sinvent As Farmasoytisk blanding for forokning av motstanden mot sykdommer forarsaket av patogene mikroorganismer og anvendelse av glukan for fremstilling av en farmasoytisk blanding.
EP1778260A4 (fr) * 2004-07-30 2012-04-25 Univ Mississippi Extraits immunostimulateurs puissants a partir de micro-algues
AU2006261852B2 (en) 2005-06-24 2012-07-19 Desert Lake Technologies Purified component of blue-green algae and method of use
ES2582197T3 (es) * 2006-06-27 2016-09-09 Nutratec S.R.L. Extractos de Aphanizomenon flos-aquae (AFA de Klamath), compuestos activos y sus usos
WO2008031092A2 (fr) * 2006-09-08 2008-03-13 University Of Mississippi puissants immunostimulants d'extraits de micro-algues
US20110104189A1 (en) * 2008-05-06 2011-05-05 Ocean Nutrition Canada Limited Compositions obtained from chlorella extract having immunomodulating properties
MX2012011558A (es) 2010-04-06 2013-02-21 Heliae Dev Llc Metodos y sistemas para producir biocombustible.
US8475660B2 (en) 2010-04-06 2013-07-02 Heliae Development, Llc Extraction of polar lipids by a two solvent method
US8211309B2 (en) 2010-04-06 2012-07-03 Heliae Development, Llc Extraction of proteins by a two solvent method
US8273248B1 (en) 2010-04-06 2012-09-25 Heliae Development, Llc Extraction of neutral lipids by a two solvent method
US8313648B2 (en) 2010-04-06 2012-11-20 Heliae Development, Llc Methods of and systems for producing biofuels from algal oil
US8211308B2 (en) 2010-04-06 2012-07-03 Heliae Development, Llc Extraction of polar lipids by a two solvent method
US8115022B2 (en) 2010-04-06 2012-02-14 Heliae Development, Llc Methods of producing biofuels, chlorophylls and carotenoids
US8308951B1 (en) 2010-04-06 2012-11-13 Heliae Development, Llc Extraction of proteins by a two solvent method
US8202425B2 (en) 2010-04-06 2012-06-19 Heliae Development, Llc Extraction of neutral lipids by a two solvent method
WO2013075116A2 (fr) 2011-11-17 2013-05-23 Heliae Development, Llc Compositions riches en oméga 7 et procédés d'isolement d'acides gras oméga 7
US9217119B2 (en) 2011-11-28 2015-12-22 Southwest Research Institute Extraction of lipids from living cells utilizing liquid CO2
GB201208325D0 (en) * 2012-05-11 2012-06-27 Glycomar Ltd Saccharides
CN103463141A (zh) * 2013-09-22 2013-12-25 汤永强 一种小球藻喷剂
KR20150102308A (ko) 2014-02-28 2015-09-07 주식회사 코아로직 키터치 인지 가능한 터치패널
EP3034612A1 (fr) 2014-12-16 2016-06-22 Greenaltech, S.L. Procédés de production de chitine et de chitosane
JP6788882B2 (ja) * 2016-08-09 2020-11-25 イマジン・グローバル・ケア株式会社 自然免疫活性化作用を有する多糖類及び該多糖類を含有する自然免疫活性化剤又は飲食品
CN109952107A (zh) * 2016-09-14 2019-06-28 Ｔｅｓ控股股份有限公司 Lin28a激活剂及其使用
CN107625783A (zh) * 2017-08-09 2018-01-26 天津科技大学 硫酸酯化小球藻、螺旋藻复合多糖在免疫调节领域的应用
EP3676367B1 (fr) 2017-08-30 2023-06-07 Far East Bio-Tec Co., Ltd. Extraits de cyanobactéries, leurs procédés de préparation et leurs utilisations
CA3152782A1 (fr) 2019-09-06 2021-03-11 BeautyPaste LLC Dentifrice ameliore et kits
CN110742900B (zh) * 2019-11-22 2022-06-14 湘潭大学 一种具有免疫调节活性的小球藻胞外多糖复合物及其制备方法和应用
CN111205376B (zh) * 2020-01-07 2021-11-02 华侨大学 一种疣荔枝螺多糖的制备方法及其应用
FR3121351B1 (fr) 2021-03-30 2024-03-08 Axeen Pharma Composition à base de spiruline et ses utilisations pour le renforcement de l’immunité
CN114195907B (zh) * 2021-10-20 2022-10-21 中国科学院南海海洋研究所 一种低分子量螺旋藻多糖及其制备方法和应用
CN114544527B (zh) * 2022-01-26 2023-05-02 浙江夸克生物科技有限公司 一种涎液化糖链抗原kl-6测定试剂盒及其制备方法
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Also Published As

Publication number Publication date
US7205284B2 (en) 2007-04-17
CN1823848A (zh) 2006-08-30
AU7333001A (en) 2002-01-21
ES2254451T3 (es) 2006-06-16
ATE311892T1 (de) 2005-12-15
AU2001273330C1 (en) 2006-01-12
EA200300123A1 (ru) 2004-02-26
AU2001273330B2 (en) 2005-07-28
US20070059317A1 (en) 2007-03-15
EP1301191B1 (fr) 2005-12-07
CA2412600A1 (fr) 2002-01-17
KR100831408B1 (ko) 2008-05-21
MXPA03000220A (es) 2003-10-15
DK1301191T3 (da) 2006-05-22
ZA200301050B (en) 2004-05-06
KR20030069974A (ko) 2003-08-27
NO329221B1 (no) 2010-09-13
PL203814B1 (pl) 2009-11-30
WO2002004000A1 (fr) 2002-01-17
JP2004502737A (ja) 2004-01-29
EP1301191A4 (fr) 2004-02-25
NZ523695A (en) 2004-07-30
EA006318B1 (ru) 2005-10-27
CN1447695A (zh) 2003-10-08
DE60115654T2 (de) 2006-09-07
BR0112424A (pt) 2003-07-01
US20070264271A1 (en) 2007-11-15
CN1278691C (zh) 2006-10-11
DE60115654D1 (de) 2006-01-12
PL359269A1 (en) 2004-08-23
NO20026130D0 (no) 2002-12-19
NO20026130L (no) 2003-03-10
IL153503A (en) 2008-11-26
EP1301191A1 (fr) 2003-04-16
IL153503A0 (en) 2003-07-06

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