CA2412600C - Immunostimulants puissants provenant de microalgues - Google Patents
Immunostimulants puissants provenant de microalgues Download PDFInfo
- Publication number
- CA2412600C CA2412600C CA2412600A CA2412600A CA2412600C CA 2412600 C CA2412600 C CA 2412600C CA 2412600 A CA2412600 A CA 2412600A CA 2412600 A CA2412600 A CA 2412600A CA 2412600 C CA2412600 C CA 2412600C
- Authority
- CA
- Canada
- Prior art keywords
- ethanol
- preparation
- extraction
- immunostimulatory
- microalgae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Virology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des polysaccharides immunostimulateurs qui sont de préférence extraits de microalgues de qualité alimentaire au moyen d'un processus d'extraction avec de l'éthanol aqueux. Les préparations résultantes présentent une activité immunostimulante extrêmement puissante. L'extraction préférée de ces polysaccharides immunostimulateurs dépend de la concentration d'éthanol utilisée et de la température d'extraction. Les conditions les plus efficientes sont une concentration de 50 % d'éthanol et une température comprise entre 60· et 70 ·C. Les préparations de polysaccharides isolés sont potentiellement utiles en tant que préparation médicinale ou pharmaceutique destinée à améliorer la fonction immunitaire.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21700100P | 2000-07-10 | 2000-07-10 | |
US60/217,001 | 2000-07-10 | ||
PCT/US2001/021770 WO2002004000A1 (fr) | 2000-07-10 | 2001-07-10 | Immunostimulants puissants provenant de microalgues |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2412600A1 CA2412600A1 (fr) | 2002-01-17 |
CA2412600C true CA2412600C (fr) | 2011-09-27 |
Family
ID=22809278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2412600A Expired - Lifetime CA2412600C (fr) | 2000-07-10 | 2001-07-10 | Immunostimulants puissants provenant de microalgues |
Country Status (20)
Country | Link |
---|---|
US (2) | US7205284B2 (fr) |
EP (1) | EP1301191B1 (fr) |
JP (1) | JP2004502737A (fr) |
KR (1) | KR100831408B1 (fr) |
CN (2) | CN1278691C (fr) |
AT (1) | ATE311892T1 (fr) |
AU (2) | AU7333001A (fr) |
BR (1) | BR0112424A (fr) |
CA (1) | CA2412600C (fr) |
DE (1) | DE60115654T2 (fr) |
DK (1) | DK1301191T3 (fr) |
EA (1) | EA006318B1 (fr) |
ES (1) | ES2254451T3 (fr) |
IL (2) | IL153503A0 (fr) |
MX (1) | MXPA03000220A (fr) |
NO (1) | NO329221B1 (fr) |
NZ (1) | NZ523695A (fr) |
PL (1) | PL203814B1 (fr) |
WO (1) | WO2002004000A1 (fr) |
ZA (1) | ZA200301050B (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002011746A2 (fr) | 2000-08-10 | 2002-02-14 | Ocean Nutrition Canada Limited | Préparations à base de chlorelle présentant des propriétés d'immunomodulation |
US6814961B1 (en) | 2001-05-14 | 2004-11-09 | Gitte S. Jensen | Method for enhancing stem cell trafficking |
IL162734A0 (en) | 2002-02-01 | 2005-11-20 | Ariad Gene Therapeutics Inc | Phosphorus-containing compounds & uses thereof |
FR2850277B1 (fr) * | 2003-01-24 | 2005-04-08 | Lanatech | Composition comprenant un extrait d'aphanizomenon flos-aquae, son utilisation et sa preparation |
NO320429B1 (no) * | 2003-06-03 | 2005-12-05 | Sinvent As | Farmasoytisk blanding for forokning av motstanden mot sykdommer forarsaket av patogene mikroorganismer og anvendelse av glukan for fremstilling av en farmasoytisk blanding. |
EP1778260A4 (fr) * | 2004-07-30 | 2012-04-25 | Univ Mississippi | Extraits immunostimulateurs puissants a partir de micro-algues |
WO2007002570A1 (fr) | 2005-06-24 | 2007-01-04 | Desert Lake Technologies | Composant purifie de l'algue bleu-vert et procede d'utilisation |
KR20090048399A (ko) * | 2006-06-27 | 2009-05-13 | 뉴트라테크 에스.알.엘. | 아파니조메논 플로스 아쿠애 추출물 및 이를 포함하는 영양, 미용 및 약제학적 조성물 |
CA2662550A1 (fr) * | 2006-09-08 | 2008-03-13 | University Of Mississippi | Puissants immunostimulants d'extraits de micro-algues |
JP2011522911A (ja) * | 2008-05-06 | 2011-08-04 | オーシャン ニュートリッション カナダ リミテッド | 免疫調節特性を有するクロレラ抽出物から得られる組成物 |
US8115022B2 (en) | 2010-04-06 | 2012-02-14 | Heliae Development, Llc | Methods of producing biofuels, chlorophylls and carotenoids |
US8475660B2 (en) | 2010-04-06 | 2013-07-02 | Heliae Development, Llc | Extraction of polar lipids by a two solvent method |
US8202425B2 (en) | 2010-04-06 | 2012-06-19 | Heliae Development, Llc | Extraction of neutral lipids by a two solvent method |
US8308951B1 (en) | 2010-04-06 | 2012-11-13 | Heliae Development, Llc | Extraction of proteins by a two solvent method |
US8211309B2 (en) | 2010-04-06 | 2012-07-03 | Heliae Development, Llc | Extraction of proteins by a two solvent method |
US8313648B2 (en) | 2010-04-06 | 2012-11-20 | Heliae Development, Llc | Methods of and systems for producing biofuels from algal oil |
US8273248B1 (en) | 2010-04-06 | 2012-09-25 | Heliae Development, Llc | Extraction of neutral lipids by a two solvent method |
US8211308B2 (en) | 2010-04-06 | 2012-07-03 | Heliae Development, Llc | Extraction of polar lipids by a two solvent method |
JP2013523158A (ja) | 2010-04-06 | 2013-06-17 | ヘリアエ デベロップメント、 エルエルシー | 淡水または塩水藻類からのタンパク質の選択的抽出 |
US9200236B2 (en) | 2011-11-17 | 2015-12-01 | Heliae Development, Llc | Omega 7 rich compositions and methods of isolating omega 7 fatty acids |
US9217119B2 (en) | 2011-11-28 | 2015-12-22 | Southwest Research Institute | Extraction of lipids from living cells utilizing liquid CO2 |
GB201208325D0 (en) * | 2012-05-11 | 2012-06-27 | Glycomar Ltd | Saccharides |
CN103463141A (zh) * | 2013-09-22 | 2013-12-25 | 汤永强 | 一种小球藻喷剂 |
KR20150102308A (ko) | 2014-02-28 | 2015-09-07 | 주식회사 코아로직 | 키터치 인지 가능한 터치패널 |
EP3034612A1 (fr) | 2014-12-16 | 2016-06-22 | Greenaltech, S.L. | Procédés de production de chitine et de chitosane |
JP6788882B2 (ja) * | 2016-08-09 | 2020-11-25 | イマジン・グローバル・ケア株式会社 | 自然免疫活性化作用を有する多糖類及び該多糖類を含有する自然免疫活性化剤又は飲食品 |
CN109952107A (zh) * | 2016-09-14 | 2019-06-28 | Tes控股股份有限公司 | Lin28a激活剂及其使用 |
CN107625783A (zh) * | 2017-08-09 | 2018-01-26 | 天津科技大学 | 硫酸酯化小球藻、螺旋藻复合多糖在免疫调节领域的应用 |
KR102353119B1 (ko) | 2017-08-30 | 2022-01-18 | 파 이스트 바이오-테크 코., 엘티디. | 시아노박테리아 추출물, 이의 제조 방법 및 그 용도 |
EP4025181A1 (fr) | 2019-09-06 | 2022-07-13 | Beautypaste LLC | Dentifrice amélioré et kits |
CN110742900B (zh) * | 2019-11-22 | 2022-06-14 | 湘潭大学 | 一种具有免疫调节活性的小球藻胞外多糖复合物及其制备方法和应用 |
CN111205376B (zh) * | 2020-01-07 | 2021-11-02 | 华侨大学 | 一种疣荔枝螺多糖的制备方法及其应用 |
FR3121351B1 (fr) | 2021-03-30 | 2024-03-08 | Axeen Pharma | Composition à base de spiruline et ses utilisations pour le renforcement de l’immunité |
CN114195907B (zh) * | 2021-10-20 | 2022-10-21 | 中国科学院南海海洋研究所 | 一种低分子量螺旋藻多糖及其制备方法和应用 |
CN114544527B (zh) * | 2022-01-26 | 2023-05-02 | 浙江夸克生物科技有限公司 | 一种涎液化糖链抗原kl-6测定试剂盒及其制备方法 |
WO2023192811A1 (fr) * | 2022-03-30 | 2023-10-05 | Om Biome, Inc. | Procédé de renouvellement tissulaire à l'aide d'une formule de base biologiquement respectueuse à base de micro-algues pour inverser la progression d'une maladie et favoriser la régénération tissulaire dans des conditions de lésion de muqueuse et d'inflammation dans la bouche et le tractus gastro-intestinal |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3462412A (en) | 1966-04-20 | 1969-08-19 | Tohoku Yakult Seizo Kk | Process of producing an active substance for stimulating the function of the reticulo-endothelial system |
JPS5896025A (ja) * | 1981-12-02 | 1983-06-07 | Kitasato Inst:The | 新規生理活性物質ch−1およびその製造法 |
HU188311B (en) * | 1982-03-04 | 1986-04-28 | Szendrei,Kalman,Hu | Process for producing biologically active polisaccharide concentrates and pharmaceutical compositions containing them as active agents |
JPS6178729A (ja) * | 1984-09-26 | 1986-04-22 | Nisshin Oil Mills Ltd:The | 免疫賦活化作用成分 |
JPS61167620A (ja) * | 1985-01-19 | 1986-07-29 | Toa Nenryo Kogyo Kk | 多糖類を含んで成る抗癌剤 |
JPS61197525A (ja) * | 1985-02-27 | 1986-09-01 | Nisshin Oil Mills Ltd:The | 抗腫瘍活性をもつ免疫賦活化剤 |
JPS6219528A (ja) * | 1985-07-16 | 1987-01-28 | Kurorera Kogyo Kk | 制癌剤 |
KR900007498B1 (ko) * | 1987-06-18 | 1990-10-11 | 구레하 가가꾸 고교 가부시끼가이샤 | 다당류 및 그것을 활성성분으로 함유하는 항바이러스 약제 |
US5084386A (en) * | 1989-03-31 | 1992-01-28 | Sri International | Production of beta-1,3-glucan in euglena |
JPH06253881A (ja) * | 1993-03-01 | 1994-09-13 | Kurorera Kogyo Kk | 糖タンパク複合体およびその製造方法 |
JP3020387B2 (ja) * | 1993-07-27 | 2000-03-15 | 日石三菱株式会社 | 抗ウイルス物質 |
JPH0937265A (ja) * | 1995-07-18 | 1997-02-07 | Toshiba Corp | 画像復号化装置 |
JPH09176022A (ja) * | 1995-12-26 | 1997-07-08 | Dainippon Ink & Chem Inc | 腫瘍転移抑制剤 |
EA003902B1 (ru) * | 1996-01-26 | 2003-10-30 | Такара Сузо Ко., Лтд. | Индукторы апоптоза, содержащие их противораковые и канцеростатические средства, способ индуцирования апоптоза, полисахариды и способы их получения |
-
2001
- 2001-07-10 PL PL359269A patent/PL203814B1/pl unknown
- 2001-07-10 CN CNB018143164A patent/CN1278691C/zh not_active Expired - Lifetime
- 2001-07-10 US US10/332,323 patent/US7205284B2/en not_active Expired - Lifetime
- 2001-07-10 WO PCT/US2001/021770 patent/WO2002004000A1/fr active IP Right Grant
- 2001-07-10 EA EA200300123A patent/EA006318B1/ru not_active IP Right Cessation
- 2001-07-10 MX MXPA03000220A patent/MXPA03000220A/es active IP Right Grant
- 2001-07-10 NZ NZ523695A patent/NZ523695A/en not_active IP Right Cessation
- 2001-07-10 BR BR0112424-2A patent/BR0112424A/pt not_active Application Discontinuation
- 2001-07-10 DE DE60115654T patent/DE60115654T2/de not_active Expired - Lifetime
- 2001-07-10 AU AU7333001A patent/AU7333001A/xx active Pending
- 2001-07-10 JP JP2002508454A patent/JP2004502737A/ja active Pending
- 2001-07-10 IL IL15350301A patent/IL153503A0/xx active IP Right Grant
- 2001-07-10 CN CNA2005101193271A patent/CN1823848A/zh active Pending
- 2001-07-10 CA CA2412600A patent/CA2412600C/fr not_active Expired - Lifetime
- 2001-07-10 DK DK01952597T patent/DK1301191T3/da active
- 2001-07-10 AT AT01952597T patent/ATE311892T1/de active
- 2001-07-10 EP EP01952597A patent/EP1301191B1/fr not_active Expired - Lifetime
- 2001-07-10 AU AU2001273330A patent/AU2001273330C1/en not_active Expired
- 2001-07-10 ES ES01952597T patent/ES2254451T3/es not_active Expired - Lifetime
- 2001-07-10 KR KR1020037000323A patent/KR100831408B1/ko active IP Right Grant
-
2002
- 2002-12-17 IL IL153503A patent/IL153503A/en not_active IP Right Cessation
- 2002-12-19 NO NO20026130A patent/NO329221B1/no not_active IP Right Cessation
-
2003
- 2003-02-06 ZA ZA200301050A patent/ZA200301050B/en unknown
-
2007
- 2007-04-05 US US11/697,038 patent/US20070264271A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2412600C (fr) | Immunostimulants puissants provenant de microalgues | |
AU2001273330A1 (en) | Potent immunostimulants from microalgae | |
JP2004502737A5 (fr) | ||
US20100003275A1 (en) | Immunostimulatory Composition comprising Lipoprotein in Microalgae Extract | |
US7767655B2 (en) | High Molecular weight polysaccharide fraction from Aloe vera with immunostimulatory activity | |
US7846452B2 (en) | Potent immunostimulatory extracts from microalgae | |
JPH0645643B2 (ja) | エキナセアプルプレアまたはエキナセアアングスティフォリアの細胞培養物からの免疫刺激作用性ポリサッカライド、その製造方法及びこれを含む製剤 | |
Tabarsa et al. | The activation of RAW264. 7 murine macrophage and natural killer cells by glucomannogalactan polysaccharides from Tornabea scutellifera | |
RU2308460C2 (ru) | Полисахарид из корней echinacea angustifolia, способ его получения, фармацевтическая композиция | |
JPH0539305A (ja) | アストラガルス・メンブラナセウスから抽出した免疫 変調性多糖類及びこれらを含有する薬剤組成物 | |
JP2011522911A (ja) | 免疫調節特性を有するクロレラ抽出物から得られる組成物 | |
JP3051073B2 (ja) | 抗腫瘍活性物質 | |
Pugh | Isolation, structure elucidation, and biological characterization of immunostimulants from dietary supplements and natural products | |
JP2008273911A (ja) | 顆粒球コロニー刺激因子産生促進物質 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20210712 |