CA2408622A1 - Methods for inhibiting proliferation and inducing apoptosis in cancer cells - Google Patents

Methods for inhibiting proliferation and inducing apoptosis in cancer cells Download PDF

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Publication number
CA2408622A1
CA2408622A1 CA002408622A CA2408622A CA2408622A1 CA 2408622 A1 CA2408622 A1 CA 2408622A1 CA 002408622 A CA002408622 A CA 002408622A CA 2408622 A CA2408622 A CA 2408622A CA 2408622 A1 CA2408622 A1 CA 2408622A1
Authority
CA
Canada
Prior art keywords
leukotriene
alkyl
compound
cancer cells
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002408622A
Other languages
English (en)
French (fr)
Inventor
Thomas E. Adrian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Creighton University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2408622A1 publication Critical patent/CA2408622A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002408622A 2000-05-09 2001-05-08 Methods for inhibiting proliferation and inducing apoptosis in cancer cells Abandoned CA2408622A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21934400P 2000-05-09 2000-05-09
US60/219,344 2000-05-09
PCT/US2001/040697 WO2001085166A1 (en) 2000-05-09 2001-05-08 Methods for inhibiting proliferation and inducing apoptosis in cancer cells

Publications (1)

Publication Number Publication Date
CA2408622A1 true CA2408622A1 (en) 2001-11-15

Family

ID=22818912

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002408622A Abandoned CA2408622A1 (en) 2000-05-09 2001-05-08 Methods for inhibiting proliferation and inducing apoptosis in cancer cells

Country Status (11)

Country Link
EP (1) EP1326605A4 (ko)
JP (1) JP2003532675A (ko)
KR (1) KR20030019372A (ko)
CN (1) CN1237968C (ko)
AU (1) AU2001261832A1 (ko)
BR (1) BR0110473A (ko)
CA (1) CA2408622A1 (ko)
MX (1) MXPA02010974A (ko)
NO (1) NO20025343L (ko)
NZ (1) NZ522387A (ko)
WO (1) WO2001085166A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797723B1 (en) 1999-11-11 2004-09-28 Eli Lilly And Company Heterocycle substituted diphenyl leukotriene antagonists
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
EP2034022A1 (en) * 2007-09-10 2009-03-11 Universite Libre De Bruxelles Leukotriene B4 binding soluble lipocalin receptor from ixodes ricinus
EA023067B1 (ru) 2012-01-10 2016-04-29 Эли Лилли Энд Компани Соединение, представляющее собой антагонист лейкотриена b
CN105307682B (zh) 2013-04-22 2020-10-02 株式会社栃木临床病理研究所 抗肿瘤剂
SI3083564T1 (sl) 2013-12-20 2018-10-30 Novartis Ag Derivati heteroarilbutanojske kisline kot inhibitorji LTA4H

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
EP0777472A2 (en) * 1994-08-31 1997-06-11 Eli Lilly And Company Methods for identifying and treating resistant tumors
US5910505A (en) * 1997-03-21 1999-06-08 Eli Lilly And Company Leukotriene antagonists for use in the treatment or inhibition of oral squamous cell carcinoma
AU1916601A (en) * 1999-11-11 2001-06-06 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
WO2001034197A2 (en) * 1999-11-11 2001-05-17 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
PL355172A1 (en) * 1999-11-11 2004-04-05 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
JP2003513914A (ja) * 1999-11-11 2003-04-15 イーライ・リリー・アンド・カンパニー 癌の処置のための腫瘍崩壊薬の組み合わせ

Also Published As

Publication number Publication date
NO20025343D0 (no) 2002-11-07
EP1326605A4 (en) 2004-03-17
EP1326605A1 (en) 2003-07-16
AU2001261832A1 (en) 2001-11-20
KR20030019372A (ko) 2003-03-06
JP2003532675A (ja) 2003-11-05
CN1237968C (zh) 2006-01-25
NO20025343L (no) 2003-01-09
CN1429111A (zh) 2003-07-09
NZ522387A (en) 2003-09-26
BR0110473A (pt) 2003-04-01
MXPA02010974A (es) 2004-09-06
WO2001085166A1 (en) 2001-11-15

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