JP2003532675A - 癌細胞の増殖を阻害しそのアポトーシスを誘導する方法 - Google Patents

癌細胞の増殖を阻害しそのアポトーシスを誘導する方法

Info

Publication number
JP2003532675A
JP2003532675A JP2001581820A JP2001581820A JP2003532675A JP 2003532675 A JP2003532675 A JP 2003532675A JP 2001581820 A JP2001581820 A JP 2001581820A JP 2001581820 A JP2001581820 A JP 2001581820A JP 2003532675 A JP2003532675 A JP 2003532675A
Authority
JP
Japan
Prior art keywords
leukotriene
alkyl
compound
ethyl
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001581820A
Other languages
English (en)
Japanese (ja)
Inventor
アドリアン，トーマス，イー．
Original Assignee
クレイトン ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クレイトン ユニバーシティ filed Critical クレイトン ユニバーシティ
Publication of JP2003532675A publication Critical patent/JP2003532675A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001581820A 2000-05-09 2001-05-08 癌細胞の増殖を阻害しそのアポトーシスを誘導する方法 Pending JP2003532675A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21934400P 2000-05-09 2000-05-09
US60/219,344 2000-05-09
PCT/US2001/040697 WO2001085166A1 (en) 2000-05-09 2001-05-08 Methods for inhibiting proliferation and inducing apoptosis in cancer cells

Publications (1)

Publication Number Publication Date
JP2003532675A true JP2003532675A (ja) 2003-11-05

Family

ID=22818912

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001581820A Pending JP2003532675A (ja) 2000-05-09 2001-05-08 癌細胞の増殖を阻害しそのアポトーシスを誘導する方法

Country Status (11)

Country Link
EP (1) EP1326605A4 (ko)
JP (1) JP2003532675A (ko)
KR (1) KR20030019372A (ko)
CN (1) CN1237968C (ko)
AU (1) AU2001261832A1 (ko)
BR (1) BR0110473A (ko)
CA (1) CA2408622A1 (ko)
MX (1) MXPA02010974A (ko)
NO (1) NO20025343L (ko)
NZ (1) NZ522387A (ko)
WO (1) WO2001085166A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5858391B2 (ja) * 2013-04-22 2016-02-10 株式会社栃木臨床病理研究所 抗腫瘍剤

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797723B1 (en) 1999-11-11 2004-09-28 Eli Lilly And Company Heterocycle substituted diphenyl leukotriene antagonists
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
EP2034022A1 (en) 2007-09-10 2009-03-11 Universite Libre De Bruxelles Leukotriene B4 binding soluble lipocalin receptor from ixodes ricinus
CN104011012B (zh) 2012-01-10 2016-01-20 伊莱利利公司 白三烯b4拮抗剂化合物
NZ719169A (en) 2013-12-20 2018-08-31 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
WO1996006604A2 (en) * 1994-08-31 1996-03-07 Eli Lilly And Company Methods for identifying and treating resistant tumors
US5910505A (en) * 1997-03-21 1999-06-08 Eli Lilly And Company Leukotriene antagonists for use in the treatment or inhibition of oral squamous cell carcinoma
WO2001034198A2 (en) * 1999-11-11 2001-05-17 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
AU1916501A (en) * 1999-11-11 2001-06-06 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
EP1231938A2 (en) * 1999-11-11 2002-08-21 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
EP1231939A2 (en) * 1999-11-11 2002-08-21 Eli Lilly And Company Oncolytic combinations for the treatment of cancer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5858391B2 (ja) * 2013-04-22 2016-02-10 株式会社栃木臨床病理研究所 抗腫瘍剤
JP2016094403A (ja) * 2013-04-22 2016-05-26 株式会社栃木臨床病理研究所 抗腫瘍剤
US9775836B2 (en) 2013-04-22 2017-10-03 Tochigi Institute Of Clinical Pathology Antitumor agent
US10149846B2 (en) 2013-04-22 2018-12-11 Tochigi Institute Of Clinical Pathology Antitumor agent
US10729683B2 (en) 2013-04-22 2020-08-04 Tochigi Institute Of Clinical Pathology Antitumor agent

Also Published As

Publication number Publication date
NO20025343L (no) 2003-01-09
BR0110473A (pt) 2003-04-01
EP1326605A4 (en) 2004-03-17
EP1326605A1 (en) 2003-07-16
CA2408622A1 (en) 2001-11-15
NZ522387A (en) 2003-09-26
CN1429111A (zh) 2003-07-09
MXPA02010974A (es) 2004-09-06
KR20030019372A (ko) 2003-03-06
WO2001085166A1 (en) 2001-11-15
NO20025343D0 (no) 2002-11-07
AU2001261832A1 (en) 2001-11-20
CN1237968C (zh) 2006-01-25

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