CA2398184A1 - Methode et compositions de traitement d'une maladie inflammatoire - Google Patents

Methode et compositions de traitement d'une maladie inflammatoire Download PDF

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Publication number
CA2398184A1
CA2398184A1 CA002398184A CA2398184A CA2398184A1 CA 2398184 A1 CA2398184 A1 CA 2398184A1 CA 002398184 A CA002398184 A CA 002398184A CA 2398184 A CA2398184 A CA 2398184A CA 2398184 A1 CA2398184 A1 CA 2398184A1
Authority
CA
Canada
Prior art keywords
pde
rolipram
sodium
inhibitor
pde4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002398184A
Other languages
English (en)
Inventor
Elizabeth T. Keating
James M. Kanagy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2398184A1 publication Critical patent/CA2398184A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une méthode de traitement d'une maladie inflammatoire, consistant à administrer au sujet un inhibiteur de phosphodiestérase 4 associé à un inhibiteur de la synthèse de prostaglandine, par exemple, des AINS.
CA002398184A 2000-02-08 2001-02-08 Methode et compositions de traitement d'une maladie inflammatoire Abandoned CA2398184A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18087900P 2000-02-08 2000-02-08
US60/180,879 2000-02-08
PCT/US2001/003972 WO2001058441A1 (fr) 2000-02-08 2001-02-08 Methode et compositions de traitement d'une maladie inflammatoire

Publications (1)

Publication Number Publication Date
CA2398184A1 true CA2398184A1 (fr) 2001-08-16

Family

ID=22662062

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002398184A Abandoned CA2398184A1 (fr) 2000-02-08 2001-02-08 Methode et compositions de traitement d'une maladie inflammatoire

Country Status (16)

Country Link
EP (1) EP1253919A4 (fr)
JP (1) JP2003522142A (fr)
KR (1) KR20020073577A (fr)
CN (1) CN1398181A (fr)
AU (1) AU7205701A (fr)
BR (1) BR0108087A (fr)
CA (1) CA2398184A1 (fr)
CZ (1) CZ20022682A3 (fr)
HK (1) HK1051319A1 (fr)
HU (1) HUP0300689A3 (fr)
IL (1) IL150963A0 (fr)
MX (1) MXPA02007688A (fr)
NO (1) NO20023737L (fr)
PL (1) PL356447A1 (fr)
WO (1) WO2001058441A1 (fr)
ZA (1) ZA200206252B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7338971B2 (en) 2001-08-30 2008-03-04 El-Naggar Mawaheb M Treatment of inflammatory, cancer, and thrombosis disorders
DK1429807T3 (da) * 2001-09-19 2007-06-18 Altana Pharma Ag Kombination af et NSAID og en PDE4-inhibitor
SK1862004A3 (en) * 2001-10-31 2004-08-03 Type 4 phosphodiesterase inhibitors and uses thereof
WO2004098605A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition pharmaceutique comprenant un inhibiteur de pde4 et il-1 trap
WO2005020926A2 (fr) * 2003-08-28 2005-03-10 Pharmacia Corporation Traitement ou prevention de troubles vasculaires au moyen d'inhibiteurs de cox-2 associee a des inhibiteurs de la phosphodiesterase specifique de l'amp cyclique
CA2753597A1 (fr) * 2009-02-27 2010-09-02 Boehringer Ingelheim International Gmbh Combinaisons de medicaments contenant des inhibiteurs de pde4 et des ains
US9161927B2 (en) * 2009-02-27 2015-10-20 Boehringer Ingelheim International Gmbh Drug combinations containing PDE4 inhibitors and NSAIDs
SI2593452T1 (sl) 2010-07-14 2017-06-30 Novartis Ag Heterociklične spojine agonisti receptorja IP
ES2565826T3 (es) 2012-01-13 2016-04-07 Novartis Ag Pirroles fusionados como agonistas del receptor IP para el tratamiento de hipertensión arterial pulmonar (PAH) y trastornos relacionados
WO2014125413A1 (fr) 2013-02-13 2014-08-21 Novartis Ag Composés hétérocycliques agonistes du récepteur ip

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061779A (en) * 1973-09-11 1977-12-06 Beecham Group Limited Naphthalene derivatives having anti-inflammatory activity
GB9108128D0 (en) * 1991-04-15 1991-06-05 Zambeletti Spa L Novel formulation
SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
US6005118A (en) * 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
FR2753706B1 (fr) * 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
CN1398181A (zh) 2003-02-19
CZ20022682A3 (cs) 2003-09-17
JP2003522142A (ja) 2003-07-22
WO2001058441A1 (fr) 2001-08-16
IL150963A0 (en) 2003-02-12
MXPA02007688A (es) 2002-12-13
NO20023737L (no) 2002-09-27
EP1253919A4 (fr) 2007-03-14
ZA200206252B (en) 2003-08-26
BR0108087A (pt) 2002-10-29
KR20020073577A (ko) 2002-09-27
PL356447A1 (en) 2004-06-28
AU7205701A (en) 2001-08-20
EP1253919A1 (fr) 2002-11-06
HUP0300689A2 (hu) 2003-07-28
HUP0300689A3 (en) 2003-09-29
NO20023737D0 (no) 2002-08-07
HK1051319A1 (zh) 2003-08-01

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued