CA2397741A1 - Compositions and methods for the therapy and diagnosis of prostate cancer - Google Patents

Info

Publication number

CA2397741A1

CA2397741A1 CA002397741A CA2397741A CA2397741A1 CA 2397741 A1 CA2397741 A1 CA 2397741A1 CA 002397741 A CA002397741 A CA 002397741A CA 2397741 A CA2397741 A CA 2397741A CA 2397741 A1 CA2397741 A1 CA 2397741A1

Authority

CA

Canada

Prior art keywords

seq

sequence

cdna sequence

polypeptide

sequences

Prior art date

2000-01-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 166
• 239000000203 mixture Substances 0.000 title claims abstract description 111
• 206010060862 Prostate cancer Diseases 0.000 title abstract description 29
• 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract description 28
• 238000002560 therapeutic procedure Methods 0.000 title abstract description 11
• 238000003745 diagnosis Methods 0.000 title abstract description 9
• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 383
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 354
• 229920001184 polypeptide Polymers 0.000 claims abstract description 343
• 102000040430 polynucleotide Human genes 0.000 claims abstract description 158
• 108091033319 polynucleotide Proteins 0.000 claims abstract description 158
• 239000002157 polynucleotide Substances 0.000 claims abstract description 158
• 210000004027 cell Anatomy 0.000 claims abstract description 120
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 119
• 210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 71
• 201000011510 cancer Diseases 0.000 claims abstract description 59
• 210000000612 antigen-presenting cell Anatomy 0.000 claims abstract description 24
• 238000011282 treatment Methods 0.000 claims abstract description 16
• 108090000623 proteins and genes Proteins 0.000 claims description 183
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 108
• 102000004169 proteins and genes Human genes 0.000 claims description 106
• 230000014509 gene expression Effects 0.000 claims description 82
• 230000027455 binding Effects 0.000 claims description 70
• 239000000427 antigen Substances 0.000 claims description 64
• 108091007433 antigens Proteins 0.000 claims description 64
• 102000036639 antigens Human genes 0.000 claims description 64
• 239000011230 binding agent Substances 0.000 claims description 58
• 239000000523 sample Substances 0.000 claims description 56
• 239000012634 fragment Substances 0.000 claims description 50
• 108091034117 Oligonucleotide Proteins 0.000 claims description 31
• 239000012472 biological sample Substances 0.000 claims description 29
• 239000013604 expression vector Substances 0.000 claims description 23
• 102000037865 fusion proteins Human genes 0.000 claims description 23
• 108020001507 fusion proteins Proteins 0.000 claims description 23
• 238000001514 detection method Methods 0.000 claims description 21
• 239000003153 chemical reaction reagent Substances 0.000 claims description 17
• 125000006853 reporter group Chemical group 0.000 claims description 15
• 230000028993 immune response Effects 0.000 claims description 13
• 238000011161 development Methods 0.000 claims description 10
• 230000002401 inhibitory effect Effects 0.000 claims description 10
• 230000000638 stimulation Effects 0.000 claims description 10
• 230000003308 immunostimulating effect Effects 0.000 claims description 9
• 239000000969 carrier Substances 0.000 claims description 8
• 229960001438 immunostimulant agent Drugs 0.000 claims description 8
• 239000003022 immunostimulating agent Substances 0.000 claims description 8
• 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims description 6
• 238000009007 Diagnostic Kit Methods 0.000 claims description 4
• 230000004936 stimulating effect Effects 0.000 claims description 4
• 210000002307 prostate Anatomy 0.000 abstract description 73
• 230000002163 immunogen Effects 0.000 abstract description 49
• 201000010099 disease Diseases 0.000 abstract description 16
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 16
• 230000002265 prevention Effects 0.000 abstract description 3
• 239000002299 complementary DNA Substances 0.000 description 585
• 235000018102 proteins Nutrition 0.000 description 101
• 235000001014 amino acid Nutrition 0.000 description 67
• 108020004414 DNA Proteins 0.000 description 66
• 229940024606 amino acid Drugs 0.000 description 65
• 150000001413 amino acids Chemical class 0.000 description 65
• 208000023958 prostate neoplasm Diseases 0.000 description 63
• 210000001519 tissue Anatomy 0.000 description 61
• 239000013598 vector Substances 0.000 description 56
• 239000013615 primer Substances 0.000 description 53
• 241000282414 Homo sapiens Species 0.000 description 44
• 108091028043 Nucleic acid sequence Proteins 0.000 description 40
• 238000003556 assay Methods 0.000 description 39
• 150000007523 nucleic acids Chemical group 0.000 description 38
• 238000003752 polymerase chain reaction Methods 0.000 description 37
• 239000002773 nucleotide Substances 0.000 description 33
• 125000003729 nucleotide group Chemical group 0.000 description 33
• 230000004927 fusion Effects 0.000 description 32
• 238000009396 hybridization Methods 0.000 description 32
• 239000008194 pharmaceutical composition Substances 0.000 description 32
• 239000003795 chemical substances by application Substances 0.000 description 31
• 108020004999 messenger RNA Proteins 0.000 description 30
• 102000039446 nucleic acids Human genes 0.000 description 30
• 108020004707 nucleic acids Proteins 0.000 description 30
• 239000002671 adjuvant Substances 0.000 description 29
• 230000000295 complement effect Effects 0.000 description 26
• 102000053642 Catalytic RNA Human genes 0.000 description 25
• 108090000994 Catalytic RNA Proteins 0.000 description 25
• 108091092562 ribozyme Proteins 0.000 description 25
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 24
• 230000003321 amplification Effects 0.000 description 24
• 210000004443 dendritic cell Anatomy 0.000 description 24
• 125000005647 linker group Chemical group 0.000 description 24
• 238000003199 nucleic acid amplification method Methods 0.000 description 24
• 238000009472 formulation Methods 0.000 description 22
• -1 vaccines Substances 0.000 description 22
• 230000015572 biosynthetic process Effects 0.000 description 21
• 229960005486 vaccine Drugs 0.000 description 20
• 108091093037 Peptide nucleic acid Proteins 0.000 description 19
• 238000004458 analytical method Methods 0.000 description 19
• 238000003786 synthesis reaction Methods 0.000 description 19
• 238000012384 transportation and delivery Methods 0.000 description 18
• 238000007792 addition Methods 0.000 description 17
• 238000013459 approach Methods 0.000 description 17
• 150000001875 compounds Chemical class 0.000 description 17
• 230000001965 increasing effect Effects 0.000 description 17
• 208000026310 Breast neoplasm Diseases 0.000 description 16
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 16
• 108700026244 Open Reading Frames Proteins 0.000 description 16
• 239000004793 Polystyrene Substances 0.000 description 16
• 210000001072 colon Anatomy 0.000 description 16
• 210000004072 lung Anatomy 0.000 description 16
• 241000700605 Viruses Species 0.000 description 15
• 238000000746 purification Methods 0.000 description 15
• 150000003839 salts Chemical class 0.000 description 15
• 238000012360 testing method Methods 0.000 description 15
• 230000014616 translation Effects 0.000 description 15
• 108020004705 Codon Proteins 0.000 description 14
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 14
• 102000053602 DNA Human genes 0.000 description 14
• 108010072866 Prostate-Specific Antigen Proteins 0.000 description 14
• 102100038358 Prostate-specific antigen Human genes 0.000 description 14
• 238000012217 deletion Methods 0.000 description 14
• 230000037430 deletion Effects 0.000 description 14
• 239000003814 drug Substances 0.000 description 14
• 239000002245 particle Substances 0.000 description 14
• 239000007787 solid Substances 0.000 description 14
• 239000000243 solution Substances 0.000 description 14
• 238000006467 substitution reaction Methods 0.000 description 14
• 206010006187 Breast cancer Diseases 0.000 description 13
• 102000004127 Cytokines Human genes 0.000 description 13
• 108090000695 Cytokines Proteins 0.000 description 13
• 230000001900 immune effect Effects 0.000 description 13
• 238000002955 isolation Methods 0.000 description 13
• 239000002502 liposome Substances 0.000 description 13
• 238000004519 manufacturing process Methods 0.000 description 13
• 230000004048 modification Effects 0.000 description 13
• 238000012986 modification Methods 0.000 description 13
• 230000001225 therapeutic effect Effects 0.000 description 13
• 238000013519 translation Methods 0.000 description 13
• 230000000692 anti-sense effect Effects 0.000 description 12
• 210000004556 brain Anatomy 0.000 description 12
• 238000005516 engineering process Methods 0.000 description 12
• 210000003734 kidney Anatomy 0.000 description 12
• 210000000496 pancreas Anatomy 0.000 description 12
• 230000008569 process Effects 0.000 description 12
• 238000002741 site-directed mutagenesis Methods 0.000 description 12
• 239000000126 substance Substances 0.000 description 12
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 11
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
• 210000001185 bone marrow Anatomy 0.000 description 11
• 230000000694 effects Effects 0.000 description 11
• 230000002255 enzymatic effect Effects 0.000 description 11
• 239000012528 membrane Substances 0.000 description 11
• 210000004379 membrane Anatomy 0.000 description 11
• 238000002360 preparation method Methods 0.000 description 11
• 239000000047 product Substances 0.000 description 11
• 230000004044 response Effects 0.000 description 11
• 108091060211 Expressed sequence tag Proteins 0.000 description 10
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 10
• 239000002585 base Substances 0.000 description 10
• 230000003993 interaction Effects 0.000 description 10
• 210000004185 liver Anatomy 0.000 description 10
• 239000013612 plasmid Substances 0.000 description 10
• 210000002027 skeletal muscle Anatomy 0.000 description 10
• 238000010561 standard procedure Methods 0.000 description 10
• 239000000758 substrate Substances 0.000 description 10
• 238000013518 transcription Methods 0.000 description 10
• 230000035897 transcription Effects 0.000 description 10
• 241000588724 Escherichia coli Species 0.000 description 9
• 238000006243 chemical reaction Methods 0.000 description 9
• 238000010367 cloning Methods 0.000 description 9
• 239000012636 effector Substances 0.000 description 9
• 238000009169 immunotherapy Methods 0.000 description 9
• 239000003550 marker Substances 0.000 description 9
• 230000036961 partial effect Effects 0.000 description 9
• 239000002987 primer (paints) Substances 0.000 description 9
• 238000003757 reverse transcription PCR Methods 0.000 description 9
• 210000003491 skin Anatomy 0.000 description 9
• 239000003981 vehicle Substances 0.000 description 9
• 230000003612 virological effect Effects 0.000 description 9
• 108091026890 Coding region Proteins 0.000 description 8
• 108060003951 Immunoglobulin Proteins 0.000 description 8
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 8
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 8
• 241001465754 Metazoa Species 0.000 description 8
• 239000002253 acid Substances 0.000 description 8
• 239000000074 antisense oligonucleotide Substances 0.000 description 8
• 238000012230 antisense oligonucleotides Methods 0.000 description 8
• 230000001580 bacterial effect Effects 0.000 description 8
• 238000003776 cleavage reaction Methods 0.000 description 8
• 230000001419 dependent effect Effects 0.000 description 8
• 230000018109 developmental process Effects 0.000 description 8
• 210000002950 fibroblast Anatomy 0.000 description 8
• 102000018358 immunoglobulin Human genes 0.000 description 8
• 238000000338 in vitro Methods 0.000 description 8
• 239000000463 material Substances 0.000 description 8
• 230000035755 proliferation Effects 0.000 description 8
• 230000009257 reactivity Effects 0.000 description 8
• 230000007017 scission Effects 0.000 description 8
• 241000894007 species Species 0.000 description 8
• 239000003155 DNA primer Substances 0.000 description 7
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 7
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 7
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 7
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 7
• 125000000539 amino acid group Chemical group 0.000 description 7
• 239000000872 buffer Substances 0.000 description 7
• 239000003623 enhancer Substances 0.000 description 7
• 230000005847 immunogenicity Effects 0.000 description 7
• 238000001727 in vivo Methods 0.000 description 7
• 210000002429 large intestine Anatomy 0.000 description 7
• 210000004962 mammalian cell Anatomy 0.000 description 7
• 239000002751 oligonucleotide probe Substances 0.000 description 7
• 229930182490 saponin Natural products 0.000 description 7
• 235000017709 saponins Nutrition 0.000 description 7
• 150000007949 saponins Chemical class 0.000 description 7
• 241000701161 unidentified adenovirus Species 0.000 description 7
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
• 108020000948 Antisense Oligonucleotides Proteins 0.000 description 6
• 102000004190 Enzymes Human genes 0.000 description 6
• 108090000790 Enzymes Proteins 0.000 description 6
• 239000004471 Glycine Substances 0.000 description 6
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 6
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 6
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 6
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 6
• 239000004472 Lysine Substances 0.000 description 6
• 241000283984 Rodentia Species 0.000 description 6
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 6
• 206010046865 Vaccinia virus infection Diseases 0.000 description 6
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
• 150000007513 acids Chemical class 0.000 description 6
• 230000004913 activation Effects 0.000 description 6
• 210000004369 blood Anatomy 0.000 description 6
• 239000008280 blood Substances 0.000 description 6
• 230000008859 change Effects 0.000 description 6
• 238000012512 characterization method Methods 0.000 description 6
• 208000029742 colonic neoplasm Diseases 0.000 description 6
• 230000001186 cumulative effect Effects 0.000 description 6
• 229940079593 drug Drugs 0.000 description 6
• 239000003937 drug carrier Substances 0.000 description 6
• 229940088598 enzyme Drugs 0.000 description 6
• 238000001415 gene therapy Methods 0.000 description 6
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 6
• 238000003780 insertion Methods 0.000 description 6
• 230000037431 insertion Effects 0.000 description 6
• 238000007918 intramuscular administration Methods 0.000 description 6
• 238000001990 intravenous administration Methods 0.000 description 6
• 239000007788 liquid Substances 0.000 description 6
• 238000012775 microarray technology Methods 0.000 description 6
• 210000003470 mitochondria Anatomy 0.000 description 6
• 230000035772 mutation Effects 0.000 description 6
• 239000000546 pharmaceutical excipient Substances 0.000 description 6
• 229920000056 polyoxyethylene ether Polymers 0.000 description 6
• 230000001105 regulatory effect Effects 0.000 description 6
• 238000012552 review Methods 0.000 description 6
• 230000035945 sensitivity Effects 0.000 description 6
• 239000003826 tablet Substances 0.000 description 6
• 238000001890 transfection Methods 0.000 description 6
• 201000008827 tuberculosis Diseases 0.000 description 6
• 210000004881 tumor cell Anatomy 0.000 description 6
• 208000007089 vaccinia Diseases 0.000 description 6
• 239000004475 Arginine Substances 0.000 description 5
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 5
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 5
• 108020004635 Complementary DNA Proteins 0.000 description 5
• 238000002965 ELISA Methods 0.000 description 5
• 108010002350 Interleukin-2 Proteins 0.000 description 5
• 102000000588 Interleukin-2 Human genes 0.000 description 5
• 238000012408 PCR amplification Methods 0.000 description 5
• 208000004403 Prostatic Hyperplasia Diseases 0.000 description 5
• 108020004511 Recombinant DNA Proteins 0.000 description 5
• 108091081024 Start codon Proteins 0.000 description 5
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 5
• 239000004473 Threonine Substances 0.000 description 5
• 241000700618 Vaccinia virus Species 0.000 description 5
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 5
• 125000000217 alkyl group Chemical group 0.000 description 5
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 5
• 229960001230 asparagine Drugs 0.000 description 5
• 235000009582 asparagine Nutrition 0.000 description 5
• 210000003719 b-lymphocyte Anatomy 0.000 description 5
• 210000004899 c-terminal region Anatomy 0.000 description 5
• 238000000576 coating method Methods 0.000 description 5
• 230000008878 coupling Effects 0.000 description 5
• 238000010168 coupling process Methods 0.000 description 5
• 238000005859 coupling reaction Methods 0.000 description 5
• 238000010790 dilution Methods 0.000 description 5
• 239000012895 dilution Substances 0.000 description 5
• RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 5
• 230000001976 improved effect Effects 0.000 description 5
• 230000001939 inductive effect Effects 0.000 description 5
• 239000007924 injection Substances 0.000 description 5
• 238000002347 injection Methods 0.000 description 5
• 230000003834 intracellular effect Effects 0.000 description 5
• 238000007912 intraperitoneal administration Methods 0.000 description 5
• 208000020816 lung neoplasm Diseases 0.000 description 5
• 208000037841 lung tumor Diseases 0.000 description 5
• 210000002540 macrophage Anatomy 0.000 description 5
• 238000013507 mapping Methods 0.000 description 5
• 239000011159 matrix material Substances 0.000 description 5
• 230000001404 mediated effect Effects 0.000 description 5
• 239000004005 microsphere Substances 0.000 description 5
• 238000010369 molecular cloning Methods 0.000 description 5
• 210000001672 ovary Anatomy 0.000 description 5
• 210000005259 peripheral blood Anatomy 0.000 description 5
• 239000011886 peripheral blood Substances 0.000 description 5
• 229920001282 polysaccharide Polymers 0.000 description 5
• 239000005017 polysaccharide Substances 0.000 description 5
• 150000004804 polysaccharides Chemical class 0.000 description 5
• 238000012216 screening Methods 0.000 description 5
• 239000002904 solvent Substances 0.000 description 5
• 210000002784 stomach Anatomy 0.000 description 5
• 238000007920 subcutaneous administration Methods 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• 210000001550 testis Anatomy 0.000 description 5
• 241000894006 Bacteria Species 0.000 description 4
• 241000196324 Embryophyta Species 0.000 description 4
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 4
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 4
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 4
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 4
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
• 102100034681 Myeloblastin Human genes 0.000 description 4
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 4
• 101700011394 P29 Proteins 0.000 description 4
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 4
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 108090000190 Thrombin Proteins 0.000 description 4
• 102000003790 Thrombin receptors Human genes 0.000 description 4
• 108090000166 Thrombin receptors Proteins 0.000 description 4
• 102000006601 Thymidine Kinase Human genes 0.000 description 4
• 108020004440 Thymidine kinase Proteins 0.000 description 4
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 4
• 230000009471 action Effects 0.000 description 4
• 239000004480 active ingredient Substances 0.000 description 4
• 229960003767 alanine Drugs 0.000 description 4
• 235000004279 alanine Nutrition 0.000 description 4
• 125000003277 amino group Chemical group 0.000 description 4
• 230000004071 biological effect Effects 0.000 description 4
• 238000001574 biopsy Methods 0.000 description 4
• 210000000481 breast Anatomy 0.000 description 4
• 239000011575 calcium Substances 0.000 description 4
• 239000002775 capsule Substances 0.000 description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
• 235000018417 cysteine Nutrition 0.000 description 4
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
• 108010023472 cytochrome C oxidase subunit II Proteins 0.000 description 4
• 230000009089 cytolysis Effects 0.000 description 4
• 238000013461 design Methods 0.000 description 4
• 230000004069 differentiation Effects 0.000 description 4
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
• 239000006185 dispersion Substances 0.000 description 4
• 238000010494 dissociation reaction Methods 0.000 description 4
• 230000005593 dissociations Effects 0.000 description 4
• 239000012530 fluid Substances 0.000 description 4
• 238000001476 gene delivery Methods 0.000 description 4
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
• 235000011187 glycerol Nutrition 0.000 description 4
• 230000012010 growth Effects 0.000 description 4
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
• 210000000987 immune system Anatomy 0.000 description 4
• 238000003018 immunoassay Methods 0.000 description 4
• 238000011534 incubation Methods 0.000 description 4
• 230000006698 induction Effects 0.000 description 4
• 239000003112 inhibitor Substances 0.000 description 4
• 230000002452 interceptive effect Effects 0.000 description 4
• 229960000310 isoleucine Drugs 0.000 description 4
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 4
• 150000002632 lipids Chemical class 0.000 description 4
• 230000007246 mechanism Effects 0.000 description 4
• 244000005700 microbiome Species 0.000 description 4
• 238000012544 monitoring process Methods 0.000 description 4
• 210000001616 monocyte Anatomy 0.000 description 4
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 4
• 239000002088 nanocapsule Substances 0.000 description 4
• 230000007935 neutral effect Effects 0.000 description 4
• 238000010647 peptide synthesis reaction Methods 0.000 description 4
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 4
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 4
• 239000002953 phosphate buffered saline Substances 0.000 description 4
• 239000000843 powder Substances 0.000 description 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
• 238000012545 processing Methods 0.000 description 4
• 230000000069 prophylactic effect Effects 0.000 description 4
• 108010043671 prostatic acid phosphatase Proteins 0.000 description 4
• 102000005962 receptors Human genes 0.000 description 4
• 108020003175 receptors Proteins 0.000 description 4
• 230000006798 recombination Effects 0.000 description 4
• 238000011160 research Methods 0.000 description 4
• 210000003079 salivary gland Anatomy 0.000 description 4
• 210000000813 small intestine Anatomy 0.000 description 4
• 239000007790 solid phase Substances 0.000 description 4
• 238000001179 sorption measurement Methods 0.000 description 4
• 210000000278 spinal cord Anatomy 0.000 description 4
• 235000000346 sugar Nutrition 0.000 description 4
• 229940124597 therapeutic agent Drugs 0.000 description 4
• 229960004072 thrombin Drugs 0.000 description 4
• 238000011269 treatment regimen Methods 0.000 description 4
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 4
• 210000003932 urinary bladder Anatomy 0.000 description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
• 108700028369 Alleles Proteins 0.000 description 3
• 102100030988 Angiotensin-converting enzyme Human genes 0.000 description 3
• 241000271566 Aves Species 0.000 description 3
• 241000700663 Avipoxvirus Species 0.000 description 3
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
• 241000759568 Corixa Species 0.000 description 3
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 3
• 101710177611 DNA polymerase II large subunit Proteins 0.000 description 3
• 101710184669 DNA polymerase II small subunit Proteins 0.000 description 3
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 3
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 3
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 3
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
• 102100031780 Endonuclease Human genes 0.000 description 3
• 102100029727 Enteropeptidase Human genes 0.000 description 3
• 108010013369 Enteropeptidase Proteins 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• 101710103262 Glandular kallikrein Proteins 0.000 description 3
• 102000005720 Glutathione transferase Human genes 0.000 description 3
• 108010070675 Glutathione transferase Proteins 0.000 description 3
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 3
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 3
• 108010074032 HLA-A2 Antigen Proteins 0.000 description 3
• 102000025850 HLA-A2 Antigen Human genes 0.000 description 3
• 108091027305 Heteroduplex Proteins 0.000 description 3
• 102100039856 Histone H1.1 Human genes 0.000 description 3
• 101001035402 Homo sapiens Histone H1.1 Proteins 0.000 description 3
• 108091092195 Intron Proteins 0.000 description 3
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 3
• 101710125418 Major capsid protein Proteins 0.000 description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 description 3
• 101710182846 Polyhedrin Proteins 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 102100035703 Prostatic acid phosphatase Human genes 0.000 description 3
• 101710188053 Protein D Proteins 0.000 description 3
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 3
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 3
• 101710132893 Resolvase Proteins 0.000 description 3
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
• 108091008874 T cell receptors Proteins 0.000 description 3
• 230000005867 T cell response Effects 0.000 description 3
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 3
• 108700012920 TNF Proteins 0.000 description 3
• 102000057032 Tissue Kallikreins Human genes 0.000 description 3
• 241000723873 Tobacco mosaic virus Species 0.000 description 3
• UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 3
• 210000004100 adrenal gland Anatomy 0.000 description 3
• 238000001042 affinity chromatography Methods 0.000 description 3
• 230000000259 anti-tumor effect Effects 0.000 description 3
• 239000007864 aqueous solution Substances 0.000 description 3
• 229940009098 aspartate Drugs 0.000 description 3
• 239000011324 bead Substances 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 229960002685 biotin Drugs 0.000 description 3
• 235000020958 biotin Nutrition 0.000 description 3
• 239000011616 biotin Substances 0.000 description 3
• 201000008275 breast carcinoma Diseases 0.000 description 3
• 229910052791 calcium Inorganic materials 0.000 description 3
• 230000015556 catabolic process Effects 0.000 description 3
• 238000004113 cell culture Methods 0.000 description 3
• 239000007795 chemical reaction product Substances 0.000 description 3
• 239000011248 coating agent Substances 0.000 description 3
• 230000001461 cytolytic effect Effects 0.000 description 3
• 230000001086 cytosolic effect Effects 0.000 description 3
• GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 238000002405 diagnostic procedure Methods 0.000 description 3
• 239000003085 diluting agent Substances 0.000 description 3
• 230000002708 enhancing effect Effects 0.000 description 3
• 238000000605 extraction Methods 0.000 description 3
• 125000000524 functional group Chemical group 0.000 description 3
• 239000007789 gas Substances 0.000 description 3
• 230000002068 genetic effect Effects 0.000 description 3
• 229930195712 glutamate Natural products 0.000 description 3
• 230000013595 glycosylation Effects 0.000 description 3
• 238000006206 glycosylation reaction Methods 0.000 description 3
• 210000002216 heart Anatomy 0.000 description 3
• 208000006454 hepatitis Diseases 0.000 description 3
• 231100000283 hepatitis Toxicity 0.000 description 3
• 239000000833 heterodimer Substances 0.000 description 3
• 210000004408 hybridoma Anatomy 0.000 description 3
• 230000007062 hydrolysis Effects 0.000 description 3
• 238000006460 hydrolysis reaction Methods 0.000 description 3
• 230000002209 hydrophobic effect Effects 0.000 description 3
• 208000015181 infectious disease Diseases 0.000 description 3
• 230000005764 inhibitory process Effects 0.000 description 3
• 238000002372 labelling Methods 0.000 description 3
• 239000003446 ligand Substances 0.000 description 3
• 230000007774 longterm Effects 0.000 description 3
• 238000012423 maintenance Methods 0.000 description 3
• 229910052751 metal Inorganic materials 0.000 description 3
• 239000002184 metal Substances 0.000 description 3
• 230000001394 metastastic effect Effects 0.000 description 3
• 206010061289 metastatic neoplasm Diseases 0.000 description 3
• 229930182817 methionine Natural products 0.000 description 3
• 238000002493 microarray Methods 0.000 description 3
• 239000011859 microparticle Substances 0.000 description 3
• 238000002703 mutagenesis Methods 0.000 description 3
• 231100000350 mutagenesis Toxicity 0.000 description 3
• 201000000050 myeloid neoplasm Diseases 0.000 description 3
• 239000006187 pill Substances 0.000 description 3
• 229920000642 polymer Polymers 0.000 description 3
• 229940051841 polyoxyethylene ether Drugs 0.000 description 3
• 238000001243 protein synthesis Methods 0.000 description 3
• 150000003212 purines Chemical group 0.000 description 3
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 3
• 239000011541 reaction mixture Substances 0.000 description 3
• 238000010188 recombinant method Methods 0.000 description 3
• 238000011084 recovery Methods 0.000 description 3
• 230000001177 retroviral effect Effects 0.000 description 3
• 238000010839 reverse transcription Methods 0.000 description 3
• 230000002441 reversible effect Effects 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• 210000004989 spleen cell Anatomy 0.000 description 3
• 238000001356 surgical procedure Methods 0.000 description 3
• 230000002194 synthesizing effect Effects 0.000 description 3
• 229960001295 tocopherol Drugs 0.000 description 3
• 239000011732 tocopherol Substances 0.000 description 3
• 229930003799 tocopherol Natural products 0.000 description 3
• 235000010384 tocopherol Nutrition 0.000 description 3
• 230000000699 topical effect Effects 0.000 description 3
• 239000003053 toxin Substances 0.000 description 3
• 231100000765 toxin Toxicity 0.000 description 3
• 108700012359 toxins Proteins 0.000 description 3
• 230000002103 transcriptional effect Effects 0.000 description 3
• 239000004474 valine Substances 0.000 description 3
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
• VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 2
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
• IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
• 108700023418 Amidases Proteins 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 241000201370 Autographa californica nucleopolyhedrovirus Species 0.000 description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
• 101710132601 Capsid protein Proteins 0.000 description 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
• 241001227713 Chiron Species 0.000 description 2
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• 108700010070 Codon Usage Proteins 0.000 description 2
• 229920002261 Corn starch Polymers 0.000 description 2
• 108010017826 DNA Polymerase I Proteins 0.000 description 2
• 102000004594 DNA Polymerase I Human genes 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• QRLVDLBMBULFAL-UHFFFAOYSA-N Digitonin Natural products CC1CCC2(OC1)OC3C(O)C4C5CCC6CC(OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9OC%10OC(CO)C(O)C(OC%11OC(CO)C(O)C(O)C%11O)C%10O)C8O)C(O)C7O)C(O)CC6(C)C5CCC4(C)C3C2C QRLVDLBMBULFAL-UHFFFAOYSA-N 0.000 description 2
• 206010014611 Encephalitis venezuelan equine Diseases 0.000 description 2
• 108010074860 Factor Xa Proteins 0.000 description 2
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
• 208000000666 Fowlpox Diseases 0.000 description 2
• 108010010803 Gelatin Proteins 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• 108010024636 Glutathione Proteins 0.000 description 2
• 108091027874 Group I catalytic intron Proteins 0.000 description 2
• 241000238631 Hexapoda Species 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101000582320 Homo sapiens Neurogenic differentiation factor 6 Proteins 0.000 description 2
• 101001072881 Homo sapiens Phosphoglucomutase-like protein 5 Proteins 0.000 description 2
• 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 description 2
• 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 2
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 2
• SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
• 108010065805 Interleukin-12 Proteins 0.000 description 2
• 102000013462 Interleukin-12 Human genes 0.000 description 2
• 102000004388 Interleukin-4 Human genes 0.000 description 2
• 108090000978 Interleukin-4 Proteins 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical class [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 description 2
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 108010047702 MPG peptide Proteins 0.000 description 2
• 241000699670 Mus sp. Species 0.000 description 2
• 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
• LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
• 102100030589 Neurogenic differentiation factor 6 Human genes 0.000 description 2
• 241000221960 Neurospora Species 0.000 description 2
• 239000000020 Nitrocellulose Substances 0.000 description 2
• 108091005461 Nucleic proteins Proteins 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• 206010036790 Productive cough Diseases 0.000 description 2
• 108010076504 Protein Sorting Signals Proteins 0.000 description 2
• 108010041520 Pulmonary Surfactant-Associated Proteins Proteins 0.000 description 2
• 102000000528 Pulmonary Surfactant-Associated Proteins Human genes 0.000 description 2
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
• 241000220317 Rosa Species 0.000 description 2
• 241000714474 Rous sarcoma virus Species 0.000 description 2
• 238000012300 Sequence Analysis Methods 0.000 description 2
• 102000012479 Serine Proteases Human genes 0.000 description 2
• 108010022999 Serine Proteases Proteins 0.000 description 2
• 241000251131 Sphyrna Species 0.000 description 2
• 241000256251 Spodoptera frugiperda Species 0.000 description 2
• 229930006000 Sucrose Natural products 0.000 description 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
• 230000006044 T cell activation Effects 0.000 description 2
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
• 108091023040 Transcription factor Proteins 0.000 description 2
• 102000040945 Transcription factor Human genes 0.000 description 2
• 108060008539 Transglutaminase Proteins 0.000 description 2
• 241000255985 Trichoplusia Species 0.000 description 2
• 102100040247 Tumor necrosis factor Human genes 0.000 description 2
• DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 2
• 208000002687 Venezuelan Equine Encephalomyelitis Diseases 0.000 description 2
• 201000009145 Venezuelan equine encephalitis Diseases 0.000 description 2
• FHICGHSMIPIAPL-HDYAAECPSA-N [2-[3-[6-[3-[(5R,6aS,6bR,12aR)-10-[6-[2-[2-[4,5-dihydroxy-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]ethoxy]ethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carbonyl]peroxypropyl]-5-[[5-[8-[3,5-dihydroxy-4-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]octoxy]-3,4-dihydroxy-6-methyloxan-2-yl]methoxy]-3,4-dihydroxyoxan-2-yl]propoxymethyl]-5-hydroxy-3-[(6S)-6-hydroxy-2,6-dimethylocta-2,7-dienoyl]oxy-6-methyloxan-4-yl] (2E,6S)-6-hydroxy-2-(hydroxymethyl)-6-methylocta-2,7-dienoate Chemical compound C=C[C@@](C)(O)CCC=C(C)C(=O)OC1C(OC(=O)C(\CO)=C\CC[C@](C)(O)C=C)C(O)C(C)OC1COCCCC1C(O)C(O)C(OCC2C(C(O)C(OCCCCCCCCC3C(C(OC4C(C(O)C(O)CO4)O)C(O)CO3)O)C(C)O2)O)C(CCCOOC(=O)C23C(CC(C)(C)CC2)C=2[C@@]([C@]4(C)CCC5C(C)(C)C(OC6C(C(O)C(O)C(CCOCCC7C(C(O)C(O)CO7)OC7C(C(O)C(O)CO7)O)O6)O)CC[C@]5(C)C4CC=2)(C)C[C@H]3O)O1 FHICGHSMIPIAPL-HDYAAECPSA-N 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 230000035508 accumulation Effects 0.000 description 2
• 238000009825 accumulation Methods 0.000 description 2
• 230000021736 acetylation Effects 0.000 description 2
• 238000006640 acetylation reaction Methods 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 2
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
• 229940024545 aluminum hydroxide Drugs 0.000 description 2
• 102000005922 amidase Human genes 0.000 description 2
• 239000003098 androgen Substances 0.000 description 2
• 210000004102 animal cell Anatomy 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 239000003429 antifungal agent Substances 0.000 description 2
• 229940121375 antifungal agent Drugs 0.000 description 2
• 230000000890 antigenic effect Effects 0.000 description 2
• 239000012736 aqueous medium Substances 0.000 description 2
• 235000003704 aspartic acid Nutrition 0.000 description 2
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
• 230000001588 bifunctional effect Effects 0.000 description 2
• 238000004166 bioassay Methods 0.000 description 2
• 229960000074 biopharmaceutical Drugs 0.000 description 2
• 229940098773 bovine serum albumin Drugs 0.000 description 2
• 210000004900 c-terminal fragment Anatomy 0.000 description 2
• 150000001720 carbohydrates Chemical group 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 235000012000 cholesterol Nutrition 0.000 description 2
• 238000012875 competitive assay Methods 0.000 description 2
• 230000021615 conjugation Effects 0.000 description 2
• 238000010276 construction Methods 0.000 description 2
• 238000011109 contamination Methods 0.000 description 2
• 238000013270 controlled release Methods 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 239000008120 corn starch Substances 0.000 description 2
• 229940099112 cornstarch Drugs 0.000 description 2
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
• 238000006731 degradation reaction Methods 0.000 description 2
• 239000000551 dentifrice Substances 0.000 description 2
• UVYVLBIGDKGWPX-KUAJCENISA-N digitonin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O[C@H]5[C@@H]([C@@H](O)[C@@H](O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)CO7)O)[C@H](O)[C@@H](CO)O6)O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O7)O)[C@@H](O)[C@@H](CO)O6)O)[C@@H](CO)O5)O)C[C@@H]4CC[C@H]3[C@@H]2[C@@H]1O)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 UVYVLBIGDKGWPX-KUAJCENISA-N 0.000 description 2
• UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 description 2
• 230000003292 diminished effect Effects 0.000 description 2
• 239000002612 dispersion medium Substances 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 238000005538 encapsulation Methods 0.000 description 2
• 229940011399 escin Drugs 0.000 description 2
• 238000012869 ethanol precipitation Methods 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 210000004700 fetal blood Anatomy 0.000 description 2
• 239000000796 flavoring agent Substances 0.000 description 2
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
• 235000013355 food flavoring agent Nutrition 0.000 description 2
• 238000001502 gel electrophoresis Methods 0.000 description 2
• 239000008273 gelatin Substances 0.000 description 2
• 229920000159 gelatin Polymers 0.000 description 2
• 235000019322 gelatine Nutrition 0.000 description 2
• 235000011852 gelatine desserts Nutrition 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 235000013922 glutamic acid Nutrition 0.000 description 2
• 239000004220 glutamic acid Substances 0.000 description 2
• 229960003180 glutathione Drugs 0.000 description 2
• 239000003102 growth factor Substances 0.000 description 2
• 150000004820 halides Chemical class 0.000 description 2
• 230000005802 health problem Effects 0.000 description 2
• 238000002744 homologous recombination Methods 0.000 description 2
• 230000006801 homologous recombination Effects 0.000 description 2
• 230000028996 humoral immune response Effects 0.000 description 2
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
• 229940127121 immunoconjugate Drugs 0.000 description 2
• 238000002991 immunohistochemical analysis Methods 0.000 description 2
• 238000011065 in-situ storage Methods 0.000 description 2
• 239000000411 inducer Substances 0.000 description 2
• 230000036512 infertility Effects 0.000 description 2
• 238000001802 infusion Methods 0.000 description 2
• 150000007529 inorganic bases Chemical class 0.000 description 2
• 238000007689 inspection Methods 0.000 description 2
• 230000009545 invasion Effects 0.000 description 2
• 239000007951 isotonicity adjuster Substances 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 210000001165 lymph node Anatomy 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 239000006249 magnetic particle Substances 0.000 description 2
• 238000005259 measurement Methods 0.000 description 2
• 229960000485 methotrexate Drugs 0.000 description 2
• 239000002480 mineral oil Substances 0.000 description 2
• 235000010446 mineral oil Nutrition 0.000 description 2
• 229920001220 nitrocellulos Polymers 0.000 description 2
• 231100000252 nontoxic Toxicity 0.000 description 2
• 230000003000 nontoxic effect Effects 0.000 description 2
• 238000007899 nucleic acid hybridization Methods 0.000 description 2
• 239000007764 o/w emulsion Substances 0.000 description 2
• 150000007530 organic bases Chemical class 0.000 description 2
• 244000052769 pathogen Species 0.000 description 2
• 239000012071 phase Substances 0.000 description 2
• 150000003904 phospholipids Chemical class 0.000 description 2
• 230000026731 phosphorylation Effects 0.000 description 2
• 238000006366 phosphorylation reaction Methods 0.000 description 2
• 239000004033 plastic Substances 0.000 description 2
• 229920003023 plastic Polymers 0.000 description 2
• 229920001223 polyethylene glycol Polymers 0.000 description 2
• 229920000136 polysorbate Polymers 0.000 description 2
• 229920002223 polystyrene Polymers 0.000 description 2
• 239000004800 polyvinyl chloride Substances 0.000 description 2
• 229920000915 polyvinyl chloride Polymers 0.000 description 2
• 230000001323 posttranslational effect Effects 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 235000007686 potassium Nutrition 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 230000002250 progressing effect Effects 0.000 description 2
• 230000002285 radioactive effect Effects 0.000 description 2
• 239000000700 radioactive tracer Substances 0.000 description 2
• 238000003127 radioimmunoassay Methods 0.000 description 2
• 238000001959 radiotherapy Methods 0.000 description 2
• 238000005215 recombination Methods 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 230000003362 replicative effect Effects 0.000 description 2
• 108091008146 restriction endonucleases Proteins 0.000 description 2
• 239000006152 selective media Substances 0.000 description 2
• 210000002966 serum Anatomy 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• 238000010532 solid phase synthesis reaction Methods 0.000 description 2
• 210000000952 spleen Anatomy 0.000 description 2
• 239000007921 spray Substances 0.000 description 2
• 210000003802 sputum Anatomy 0.000 description 2
• 208000024794 sputum Diseases 0.000 description 2
• 238000010186 staining Methods 0.000 description 2
• 238000003860 storage Methods 0.000 description 2
• 125000001424 substituent group Chemical group 0.000 description 2
• 239000005720 sucrose Substances 0.000 description 2
• 150000008163 sugars Chemical class 0.000 description 2
• 229910052717 sulfur Inorganic materials 0.000 description 2
• 239000004094 surface-active agent Substances 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 239000006188 syrup Substances 0.000 description 2
• 235000020357 syrup Nutrition 0.000 description 2
• 230000008685 targeting Effects 0.000 description 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
• 210000001541 thymus gland Anatomy 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 230000001052 transient effect Effects 0.000 description 2
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
• 241000701447 unidentified baculovirus Species 0.000 description 2
• 241001515965 unidentified phage Species 0.000 description 2
• 241001430294 unidentified retrovirus Species 0.000 description 2
• 238000011144 upstream manufacturing Methods 0.000 description 2
• 210000002700 urine Anatomy 0.000 description 2
• 235000012431 wafers Nutrition 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• AHOKKYCUWBLDST-QYULHYBRSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=CC=C1 AHOKKYCUWBLDST-QYULHYBRSA-N 0.000 description 1
• OCUSNPIJIZCRSZ-ZTZWCFDHSA-N (2s)-2-amino-3-methylbutanoic acid;(2s)-2-amino-4-methylpentanoic acid;(2s,3s)-2-amino-3-methylpentanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O OCUSNPIJIZCRSZ-ZTZWCFDHSA-N 0.000 description 1
• KPYXMALABCDPGN-HYOZMBHHSA-N (4s)-5-[[(2s)-6-amino-1-[[(2s,3s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2r)-1-[[2-[[2-[[(1s)-3-amino-1-carboxy-3-oxopropyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]a Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN)CC1=CC=C(O)C=C1 KPYXMALABCDPGN-HYOZMBHHSA-N 0.000 description 1
• AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 1
• UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical compound NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• 108010076057 2-arylpropionyl-CoA epimerase Proteins 0.000 description 1
• BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
• TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
• WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 1
• 239000013607 AAV vector Substances 0.000 description 1
• 108010066676 Abrin Proteins 0.000 description 1
• 229930024421 Adenine Natural products 0.000 description 1
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
• 102100029457 Adenine phosphoribosyltransferase Human genes 0.000 description 1
• 108010024223 Adenine phosphoribosyltransferase Proteins 0.000 description 1
• 229920000936 Agarose Polymers 0.000 description 1
• BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 description 1
• RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 108010025188 Alcohol oxidase Proteins 0.000 description 1
• 241000710929 Alphavirus Species 0.000 description 1
• 241000024188 Andala Species 0.000 description 1
• 102000006306 Antigen Receptors Human genes 0.000 description 1
• 108010083359 Antigen Receptors Proteins 0.000 description 1
• 241000272478 Aquila Species 0.000 description 1
• 101000980998 Arabidopsis thaliana Phosphatidate cytidylyltransferase 4, chloroplastic Proteins 0.000 description 1
• 241000239290 Araneae Species 0.000 description 1
• 206010003445 Ascites Diseases 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 102100032306 Aurora kinase B Human genes 0.000 description 1
• 108090000749 Aurora kinase B Proteins 0.000 description 1
• 108090001008 Avidin Proteins 0.000 description 1
• WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 description 1
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 241000167854 Bourreria succulenta Species 0.000 description 1
• 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
• 108010029697 CD40 Ligand Proteins 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• 102100032937 CD40 ligand Human genes 0.000 description 1
• 102000000905 Cadherin Human genes 0.000 description 1
• 108050007957 Cadherin Proteins 0.000 description 1
• 101100281516 Caenorhabditis elegans fox-1 gene Proteins 0.000 description 1
• 101100421200 Caenorhabditis elegans sep-1 gene Proteins 0.000 description 1
• 101000909256 Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) DNA polymerase I Proteins 0.000 description 1
• 241000178270 Canarypox virus Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 208000014392 Cat-eye syndrome Diseases 0.000 description 1
• 241000701489 Cauliflower mosaic virus Species 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 240000006162 Chenopodium quinoa Species 0.000 description 1
• 235000015493 Chenopodium quinoa Nutrition 0.000 description 1
• 229920001661 Chitosan Polymers 0.000 description 1
• 239000005496 Chlorsulfuron Substances 0.000 description 1
• 102000009016 Cholera Toxin Human genes 0.000 description 1
• 108010049048 Cholera Toxin Proteins 0.000 description 1
• 108010009685 Cholinergic Receptors Proteins 0.000 description 1
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
• 101710094648 Coat protein Proteins 0.000 description 1
• 102100038385 Coiled-coil domain-containing protein R3HCC1L Human genes 0.000 description 1
• 108091035707 Consensus sequence Proteins 0.000 description 1
• 102100031673 Corneodesmosin Human genes 0.000 description 1
• 101710139375 Corneodesmosin Proteins 0.000 description 1
• 241000557626 Corvus corax Species 0.000 description 1
• 108091029430 CpG site Proteins 0.000 description 1
• 108050006400 Cyclin Proteins 0.000 description 1
• 102000016736 Cyclin Human genes 0.000 description 1
• 229920000858 Cyclodextrin Polymers 0.000 description 1
• UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
• IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 1
• YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 1
• 101150074155 DHFR gene Proteins 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• 230000006820 DNA synthesis Effects 0.000 description 1
• CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
• 102000016911 Deoxyribonucleases Human genes 0.000 description 1
• 108010053770 Deoxyribonucleases Proteins 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• 108010024212 E-Selectin Proteins 0.000 description 1
• 102100023471 E-selectin Human genes 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 101000686777 Escherichia phage T7 T7 RNA polymerase Proteins 0.000 description 1
• 241001524679 Escherichia virus M13 Species 0.000 description 1
• 229920001917 Ficoll Polymers 0.000 description 1
• BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
• 241000700662 Fowlpox virus Species 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 102000027484 GABAA receptors Human genes 0.000 description 1
• 108091008681 GABAA receptors Proteins 0.000 description 1
• 108700004714 Gelonium multiflorum GEL Proteins 0.000 description 1
• 102000053187 Glucuronidase Human genes 0.000 description 1
• 108010060309 Glucuronidase Proteins 0.000 description 1
• 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
• 239000007995 HEPES buffer Substances 0.000 description 1
• 241000606768 Haemophilus influenzae Species 0.000 description 1
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
• 101000783783 Homo sapiens ATP-binding cassette sub-family F member 1 Proteins 0.000 description 1
• 101000743767 Homo sapiens Coiled-coil domain-containing protein R3HCC1L Proteins 0.000 description 1
• 101000935587 Homo sapiens Flavin reductase (NADPH) Proteins 0.000 description 1
• 101001001372 Homo sapiens Gamma-aminobutyric acid receptor-associated protein Proteins 0.000 description 1
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
• 101001108330 Homo sapiens Natural resistance-associated macrophage protein 2 Proteins 0.000 description 1
• 101100406818 Homo sapiens PAGE4 gene Proteins 0.000 description 1
• 101000851176 Homo sapiens Pro-epidermal growth factor Proteins 0.000 description 1
• 101000655476 Homo sapiens Probable mitochondrial glutathione transporter SLC25A39 Proteins 0.000 description 1
• 101000666131 Homo sapiens Protein-glutamine gamma-glutamyltransferase 4 Proteins 0.000 description 1
• 101000897979 Homo sapiens Putative spermatid-specific linker histone H1-like protein Proteins 0.000 description 1
• 101100140242 Homo sapiens RDH11 gene Proteins 0.000 description 1
• 101000580092 Homo sapiens RNA-binding protein 10 Proteins 0.000 description 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
• 101000711466 Homo sapiens SAM pointed domain-containing Ets transcription factor Proteins 0.000 description 1
• 101000881168 Homo sapiens SPARC Proteins 0.000 description 1
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
• 101000777156 Homo sapiens UBX domain-containing protein 4 Proteins 0.000 description 1
• 101000818836 Homo sapiens Zinc finger protein 609 Proteins 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• 102000004157 Hydrolases Human genes 0.000 description 1
• 108090000604 Hydrolases Proteins 0.000 description 1
• AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 108020005350 Initiator Codon Proteins 0.000 description 1
• 229930010555 Inosine Natural products 0.000 description 1
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
• 108090000174 Interleukin-10 Proteins 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 108010002616 Interleukin-5 Proteins 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 108010002586 Interleukin-7 Proteins 0.000 description 1
• 102100021592 Interleukin-7 Human genes 0.000 description 1
• 102100027612 Kallikrein-11 Human genes 0.000 description 1
• 108010009384 L-Iditol 2-Dehydrogenase Proteins 0.000 description 1
• 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 description 1
• 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
• 125000000773 L-serino group Chemical group [H]OC(=O)[C@@]([H])(N([H])*)C([H])([H])O[H] 0.000 description 1
• 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 241000713666 Lentivirus Species 0.000 description 1
• 240000007472 Leucaena leucocephala Species 0.000 description 1
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
• 108090001030 Lipoproteins Proteins 0.000 description 1
• 102000004895 Lipoproteins Human genes 0.000 description 1
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
• DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
• 108091054438 MHC class II family Proteins 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 108010031099 Mannose Receptor Proteins 0.000 description 1
• 102000018697 Membrane Proteins Human genes 0.000 description 1
• 108010052285 Membrane Proteins Proteins 0.000 description 1
• 244000246386 Mentha pulegium Species 0.000 description 1
• 235000016257 Mentha pulegium Nutrition 0.000 description 1
• 235000004357 Mentha x piperita Nutrition 0.000 description 1
• 206010027476 Metastases Diseases 0.000 description 1
• 101100261636 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) trpB2 gene Proteins 0.000 description 1
• 206010048723 Multiple-drug resistance Diseases 0.000 description 1
• MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
• 241000699666 Mus <mouse, genus> Species 0.000 description 1
• 101100335081 Mus musculus Flt3 gene Proteins 0.000 description 1
• UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 description 1
• 241000238367 Mya arenaria Species 0.000 description 1
• 241000187488 Mycobacterium sp. Species 0.000 description 1
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
• KTHDTJVBEPMMGL-VKHMYHEASA-N N-acetyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(C)=O KTHDTJVBEPMMGL-VKHMYHEASA-N 0.000 description 1
• KTHDTJVBEPMMGL-UHFFFAOYSA-N N-acetyl-L-alanine Natural products OC(=O)C(C)NC(C)=O KTHDTJVBEPMMGL-UHFFFAOYSA-N 0.000 description 1
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
• 108091061960 Naked DNA Proteins 0.000 description 1
• 102100021867 Natural resistance-associated macrophage protein 2 Human genes 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 238000000636 Northern blotting Methods 0.000 description 1
• 102000007999 Nuclear Proteins Human genes 0.000 description 1
• 108010089610 Nuclear Proteins Proteins 0.000 description 1
• 101710163270 Nuclease Proteins 0.000 description 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
• 101710141454 Nucleoprotein Proteins 0.000 description 1
• XDMCWZFLLGVIID-SXPRBRBTSA-N O-(3-O-D-galactosyl-N-acetyl-beta-D-galactosaminyl)-L-serine Chemical compound CC(=O)N[C@H]1[C@H](OC[C@H]([NH3+])C([O-])=O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 XDMCWZFLLGVIID-SXPRBRBTSA-N 0.000 description 1
• 240000007817 Olea europaea Species 0.000 description 1
• 108010038807 Oligopeptides Proteins 0.000 description 1
• 102000015636 Oligopeptides Human genes 0.000 description 1
• 102100023240 P antigen family member 4 Human genes 0.000 description 1
• 102100029181 PDZ and LIM domain protein 5 Human genes 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 102100035593 POU domain, class 2, transcription factor 1 Human genes 0.000 description 1
• 101710084414 POU domain, class 2, transcription factor 1 Proteins 0.000 description 1
• 108010067035 Pancrelipase Proteins 0.000 description 1
• 108090000526 Papain Proteins 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 108010067902 Peptide Library Proteins 0.000 description 1
• 108010013639 Peptidoglycan Proteins 0.000 description 1
• 102100036635 Phosphoglucomutase-like protein 5 Human genes 0.000 description 1
• 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
• 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
• 101100124346 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) hisCD gene Proteins 0.000 description 1
• 240000007643 Phytolacca americana Species 0.000 description 1
• 235000009074 Phytolacca americana Nutrition 0.000 description 1
• 241000276498 Pollachius virens Species 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 101000621511 Potato virus M (strain German) RNA silencing suppressor Proteins 0.000 description 1
• 101710083689 Probable capsid protein Proteins 0.000 description 1
• 102100032871 Probable mitochondrial glutathione transporter SLC25A39 Human genes 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 102000002020 Protease-activated receptors Human genes 0.000 description 1
• 108050009310 Protease-activated receptors Proteins 0.000 description 1
• 108010029485 Protein Isoforms Proteins 0.000 description 1
• 102000001708 Protein Isoforms Human genes 0.000 description 1
• 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
• 102100021861 Putative spermatid-specific linker histone H1-like protein Human genes 0.000 description 1
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
• 101000902592 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) DNA polymerase Proteins 0.000 description 1
• 108010066717 Q beta Replicase Proteins 0.000 description 1
• 108010013845 RNA Polymerase I Proteins 0.000 description 1
• 102000017143 RNA Polymerase I Human genes 0.000 description 1
• 108010009460 RNA Polymerase II Proteins 0.000 description 1
• 102000009572 RNA Polymerase II Human genes 0.000 description 1
• 108010078067 RNA Polymerase III Proteins 0.000 description 1
• 102000014450 RNA Polymerase III Human genes 0.000 description 1
• 108020004518 RNA Probes Proteins 0.000 description 1
• 239000003391 RNA probe Substances 0.000 description 1
• 230000007022 RNA scission Effects 0.000 description 1
• 230000006819 RNA synthesis Effects 0.000 description 1
• 102100027514 RNA-binding protein 10 Human genes 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 241000700157 Rattus norvegicus Species 0.000 description 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
• 102100023916 Retinol dehydrogenase 11 Human genes 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 108010003581 Ribulose-bisphosphate carboxylase Proteins 0.000 description 1
• 108010039491 Ricin Proteins 0.000 description 1
• 108091006618 SLC11A2 Proteins 0.000 description 1
• 102100037599 SPARC Human genes 0.000 description 1
• 241000710961 Semliki Forest virus Species 0.000 description 1
• 229920001800 Shellac Polymers 0.000 description 1
• 108010079723 Shiga Toxin Proteins 0.000 description 1
• 241000700584 Simplexvirus Species 0.000 description 1
• 241000710960 Sindbis virus Species 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 102100026974 Sorbitol dehydrogenase Human genes 0.000 description 1
• 238000002105 Southern blotting Methods 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 108010090804 Streptavidin Proteins 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 101710172711 Structural protein Proteins 0.000 description 1
• 230000024932 T cell mediated immunity Effects 0.000 description 1
• 230000006052 T cell proliferation Effects 0.000 description 1
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
• 206010043376 Tetanus Diseases 0.000 description 1
• 241000906446 Theraps Species 0.000 description 1
• 102100036407 Thioredoxin Human genes 0.000 description 1
• 101710120037 Toxin CcdB Proteins 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 102100031989 Transmembrane protease serine 2 Human genes 0.000 description 1
• 101710081844 Transmembrane protease serine 2 Proteins 0.000 description 1
• 101800001690 Transmembrane protein gp41 Proteins 0.000 description 1
• 101710152431 Trypsin-like protease Proteins 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 102100031308 UBX domain-containing protein 4 Human genes 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• 108020000999 Viral RNA Proteins 0.000 description 1
• IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical class [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• 102100021355 Zinc finger protein 609 Human genes 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000003082 abrasive agent Substances 0.000 description 1
• 239000003070 absorption delaying agent Substances 0.000 description 1
• 230000001133 acceleration Effects 0.000 description 1
• 102000034337 acetylcholine receptors Human genes 0.000 description 1
• 108020002494 acetyltransferase Proteins 0.000 description 1
• 102000005421 acetyltransferase Human genes 0.000 description 1
• 238000005903 acid hydrolysis reaction Methods 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 125000003172 aldehyde group Chemical group 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 230000000735 allogeneic effect Effects 0.000 description 1
• 239000012637 allosteric effector Substances 0.000 description 1
• 230000004075 alteration Effects 0.000 description 1
• 229940037003 alum Drugs 0.000 description 1
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
• 229940024546 aluminum hydroxide gel Drugs 0.000 description 1
• SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 229940126575 aminoglycoside Drugs 0.000 description 1
• 229960003896 aminopterin Drugs 0.000 description 1
• 150000008064 anhydrides Chemical class 0.000 description 1
• 235000010208 anthocyanin Nutrition 0.000 description 1
• 239000004410 anthocyanin Substances 0.000 description 1
• 229930002877 anthocyanin Natural products 0.000 description 1
• 150000004636 anthocyanins Chemical class 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 230000005809 anti-tumor immunity Effects 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 239000002246 antineoplastic agent Substances 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 230000005975 antitumor immune response Effects 0.000 description 1
• 210000000709 aorta Anatomy 0.000 description 1
• 239000008135 aqueous vehicle Substances 0.000 description 1
• 238000002820 assay format Methods 0.000 description 1
• 125000004429 atom Chemical group 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 230000003416 augmentation Effects 0.000 description 1
• 230000006472 autoimmune response Effects 0.000 description 1
• 230000037429 base substitution Effects 0.000 description 1
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
• DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
• 239000000227 bioadhesive Substances 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 239000013060 biological fluid Substances 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 230000006287 biotinylation Effects 0.000 description 1
• 238000007413 biotinylation Methods 0.000 description 1
• 239000002981 blocking agent Substances 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• 229910021538 borax Inorganic materials 0.000 description 1
• 229950004398 broxuridine Drugs 0.000 description 1
• 229940046011 buccal tablet Drugs 0.000 description 1
• 239000006189 buccal tablet Substances 0.000 description 1
• 239000007975 buffered saline Substances 0.000 description 1
• 238000010804 cDNA synthesis Methods 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• 239000012830 cancer therapeutic Substances 0.000 description 1
• 238000001818 capillary gel electrophoresis Methods 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 230000021523 carboxylation Effects 0.000 description 1
• 238000006473 carboxylation reaction Methods 0.000 description 1
• 125000002843 carboxylic acid group Chemical group 0.000 description 1
• 231100000504 carcinogenesis Toxicity 0.000 description 1
• 108020001778 catalytic domains Proteins 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• 238000012832 cell culture technique Methods 0.000 description 1
• 230000022131 cell cycle Effects 0.000 description 1
• 230000007910 cell fusion Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 238000001516 cell proliferation assay Methods 0.000 description 1
• 239000006285 cell suspension Substances 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 239000013522 chelant Substances 0.000 description 1
• 239000002738 chelating agent Substances 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 229940044683 chemotherapy drug Drugs 0.000 description 1
• 235000019693 cherries Nutrition 0.000 description 1
• 229960005091 chloramphenicol Drugs 0.000 description 1
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• YTRQFSDWAXHJCC-UHFFFAOYSA-N chloroform;phenol Chemical compound ClC(Cl)Cl.OC1=CC=CC=C1 YTRQFSDWAXHJCC-UHFFFAOYSA-N 0.000 description 1
• VJYIFXVZLXQVHO-UHFFFAOYSA-N chlorsulfuron Chemical compound COC1=NC(C)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)Cl)=N1 VJYIFXVZLXQVHO-UHFFFAOYSA-N 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• 101150087654 chrnd gene Proteins 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 229910052804 chromium Inorganic materials 0.000 description 1
• 239000011651 chromium Substances 0.000 description 1
• 230000002759 chromosomal effect Effects 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• 239000000084 colloidal system Substances 0.000 description 1
• 230000009918 complex formation Effects 0.000 description 1
• 238000009833 condensation Methods 0.000 description 1
• 230000005494 condensation Effects 0.000 description 1
• 239000000356 contaminant Substances 0.000 description 1
• 230000000139 costimulatory effect Effects 0.000 description 1
• 238000012926 crystallographic analysis Methods 0.000 description 1
• 239000012228 culture supernatant Substances 0.000 description 1
• 210000004748 cultured cell Anatomy 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 238000011461 current therapy Methods 0.000 description 1
• WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
• 229940097362 cyclodextrins Drugs 0.000 description 1
• 229960003067 cystine Drugs 0.000 description 1
• UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 1
• 210000000805 cytoplasm Anatomy 0.000 description 1
• 238000012303 cytoplasmic staining Methods 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 101150047356 dec-1 gene Proteins 0.000 description 1
• 239000003405 delayed action preparation Substances 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 210000001787 dendrite Anatomy 0.000 description 1
• 238000000432 density-gradient centrifugation Methods 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• 229960002086 dextran Drugs 0.000 description 1
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
• 229940038472 dicalcium phosphate Drugs 0.000 description 1
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• 239000000539 dimer Substances 0.000 description 1
• 238000006073 displacement reaction Methods 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 238000010828 elution Methods 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 229930186222 escin Natural products 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 125000001033 ether group Chemical group 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 230000000763 evoking effect Effects 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 210000001808 exosome Anatomy 0.000 description 1
• 210000003754 fetus Anatomy 0.000 description 1
• 239000000835 fiber Substances 0.000 description 1
• 239000011152 fibreglass Substances 0.000 description 1
• 239000004088 foaming agent Substances 0.000 description 1
• 229940014144 folate Drugs 0.000 description 1
• 235000019152 folic acid Nutrition 0.000 description 1
• 239000011724 folic acid Substances 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 238000006062 fragmentation reaction Methods 0.000 description 1
• 239000012458 free base Substances 0.000 description 1
• 230000005714 functional activity Effects 0.000 description 1
• 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 238000002523 gelfiltration Methods 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 102000054766 genetic haplotypes Human genes 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 239000001963 growth medium Substances 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 239000001307 helium Substances 0.000 description 1
• 229910052734 helium Inorganic materials 0.000 description 1
• SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 208000002672 hepatitis B Diseases 0.000 description 1
• 210000003494 hepatocyte Anatomy 0.000 description 1
• 230000002363 herbicidal effect Effects 0.000 description 1
• 239000004009 herbicide Substances 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• 101150113423 hisD gene Proteins 0.000 description 1
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
• 235000001050 hortel pimenta Nutrition 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 210000004754 hybrid cell Anatomy 0.000 description 1
• 235000011167 hydrochloric acid Nutrition 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 150000004679 hydroxides Chemical class 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 229940072221 immunoglobulins Drugs 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 238000007901 in situ hybridization Methods 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
• RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
• 239000003701 inert diluent Substances 0.000 description 1
• 230000001524 infective effect Effects 0.000 description 1
• 206010022000 influenza Diseases 0.000 description 1
• 208000037798 influenza B Diseases 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 239000007972 injectable composition Substances 0.000 description 1
• 229960003786 inosine Drugs 0.000 description 1
• 238000002743 insertional mutagenesis Methods 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 229940079322 interferon Drugs 0.000 description 1
• 238000007917 intracranial administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 238000007852 inverse PCR Methods 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 101150066555 lacZ gene Proteins 0.000 description 1
• 239000004816 latex Substances 0.000 description 1
• 229920000126 latex Polymers 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 230000021633 leukocyte mediated immunity Effects 0.000 description 1
• 238000007834 ligase chain reaction Methods 0.000 description 1
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
• 230000029226 lipidation Effects 0.000 description 1
• 229910052744 lithium Inorganic materials 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 210000003810 lymphokine-activated killer cell Anatomy 0.000 description 1
• 230000002132 lysosomal effect Effects 0.000 description 1
• 159000000003 magnesium salts Chemical class 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• MIKKOBKEXMRYFQ-WZTVWXICSA-N meglumine amidotrizoate Chemical compound C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I MIKKOBKEXMRYFQ-WZTVWXICSA-N 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 229910021645 metal ion Inorganic materials 0.000 description 1
• 229910044991 metal oxide Inorganic materials 0.000 description 1
• 150000004706 metal oxides Chemical class 0.000 description 1
• 150000002739 metals Chemical class 0.000 description 1
• 230000009401 metastasis Effects 0.000 description 1
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
• 238000010208 microarray analysis Methods 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• ZAHQPTJLOCWVPG-UHFFFAOYSA-N mitoxantrone dihydrochloride Chemical compound Cl.Cl.O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO ZAHQPTJLOCWVPG-UHFFFAOYSA-N 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 239000002324 mouth wash Substances 0.000 description 1
• 229940051866 mouthwash Drugs 0.000 description 1
• 239000003471 mutagenic agent Substances 0.000 description 1
• 230000000869 mutational effect Effects 0.000 description 1
• 229950006780 n-acetylglucosamine Drugs 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• 239000002077 nanosphere Substances 0.000 description 1
• 239000007922 nasal spray Substances 0.000 description 1
• 210000000822 natural killer cell Anatomy 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 238000012758 nuclear staining Methods 0.000 description 1
• 239000002853 nucleic acid probe Substances 0.000 description 1
• 238000001821 nucleic acid purification Methods 0.000 description 1
• 238000001668 nucleic acid synthesis Methods 0.000 description 1
• 230000000269 nucleophilic effect Effects 0.000 description 1
• 230000030648 nucleus localization Effects 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 229920001542 oligosaccharide Polymers 0.000 description 1
• 150000002482 oligosaccharides Chemical class 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 229940100688 oral solution Drugs 0.000 description 1
• 239000000668 oral spray Substances 0.000 description 1
• 229940041678 oral spray Drugs 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 230000002018 overexpression Effects 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000001717 pathogenic effect Effects 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
• 210000003200 peritoneal cavity Anatomy 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 229960003742 phenol Drugs 0.000 description 1
• 238000002205 phenol-chloroform extraction Methods 0.000 description 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
• 150000004633 phorbol derivatives Chemical class 0.000 description 1
• 239000002644 phorbol ester Substances 0.000 description 1
• 150000004713 phosphodiesters Chemical group 0.000 description 1
• 235000011007 phosphoric acid Nutrition 0.000 description 1
• 150000003016 phosphoric acids Chemical class 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 229940023488 pill Drugs 0.000 description 1
• 210000002826 placenta Anatomy 0.000 description 1
• 239000013600 plasmid vector Substances 0.000 description 1
• 230000010118 platelet activation Effects 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
• 229920002627 poly(phosphazenes) Polymers 0.000 description 1
• 229920000058 polyacrylate Polymers 0.000 description 1
• 230000008488 polyadenylation Effects 0.000 description 1
• 229920002851 polycationic polymer Polymers 0.000 description 1
• 230000000379 polymerizing effect Effects 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
• 235000015497 potassium bicarbonate Nutrition 0.000 description 1
• 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
• 239000011736 potassium bicarbonate Substances 0.000 description 1
• TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 229940116317 potato starch Drugs 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 238000002953 preparative HPLC Methods 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 150000003141 primary amines Chemical class 0.000 description 1
• 238000007639 printing Methods 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• 210000001236 prokaryotic cell Anatomy 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 230000000644 propagated effect Effects 0.000 description 1
• 201000001514 prostate carcinoma Diseases 0.000 description 1
• 210000005267 prostate cell Anatomy 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 238000000159 protein binding assay Methods 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• 239000002510 pyrogen Substances 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 150000003248 quinolines Chemical class 0.000 description 1
• 230000005855 radiation Effects 0.000 description 1
• 230000003439 radiotherapeutic effect Effects 0.000 description 1
• 230000000601 reactogenic effect Effects 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 239000011347 resin Substances 0.000 description 1
• 229920005989 resin Polymers 0.000 description 1
• 230000000284 resting effect Effects 0.000 description 1
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
• 229940081974 saccharin Drugs 0.000 description 1
• 235000019204 saccharin Nutrition 0.000 description 1
• 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
• 238000003345 scintillation counting Methods 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 238000013207 serial dilution Methods 0.000 description 1
• 230000000405 serological effect Effects 0.000 description 1
• 239000004208 shellac Substances 0.000 description 1
• ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
• 229940113147 shellac Drugs 0.000 description 1
• 235000013874 shellac Nutrition 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 235000010339 sodium tetraborate Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 125000006850 spacer group Chemical group 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
• 230000010473 stable expression Effects 0.000 description 1
• 238000012289 standard assay Methods 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 210000000130 stem cell Anatomy 0.000 description 1
• 230000000707 stereoselective effect Effects 0.000 description 1
• 210000002536 stromal cell Anatomy 0.000 description 1
• 125000004434 sulfur atom Chemical group 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 230000008093 supporting effect Effects 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 238000012385 systemic delivery Methods 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 108060008226 thioredoxin Proteins 0.000 description 1
• 229940094937 thioredoxin Drugs 0.000 description 1
• 229940104230 thymidine Drugs 0.000 description 1
• 238000012090 tissue culture technique Methods 0.000 description 1
• 230000005030 transcription termination Effects 0.000 description 1
• 238000006276 transfer reaction Methods 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 102000003601 transglutaminase Human genes 0.000 description 1
• 230000010474 transient expression Effects 0.000 description 1
• 230000014621 translational initiation Effects 0.000 description 1
• 239000001226 triphosphate Substances 0.000 description 1
• 235000011178 triphosphate Nutrition 0.000 description 1
• 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
• BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
• 101150081616 trpB gene Proteins 0.000 description 1
• 101150111232 trpB-1 gene Proteins 0.000 description 1
• 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 1
• 150000003668 tyrosines Chemical class 0.000 description 1
• 239000011882 ultra-fine particle Substances 0.000 description 1
• 231100000402 unacceptable toxicity Toxicity 0.000 description 1
• DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
• 229940045145 uridine Drugs 0.000 description 1
• 238000002255 vaccination Methods 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1
• 239000009637 wintergreen oil Substances 0.000 description 1
• QAOHCFGKCWTBGC-QHOAOGIMSA-N wybutosine Chemical compound C1=NC=2C(=O)N3C(CC[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QAOHCFGKCWTBGC-QHOAOGIMSA-N 0.000 description 1
• QAOHCFGKCWTBGC-UHFFFAOYSA-N wybutosine Natural products C1=NC=2C(=O)N3C(CCC(NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O QAOHCFGKCWTBGC-UHFFFAOYSA-N 0.000 description 1
• 239000011701 zinc Chemical class 0.000 description 1
• 229910052725 zinc Chemical class 0.000 description 1