CA2371728C - High dose radionuclide complexes for bone marrow suppression - Google Patents
High dose radionuclide complexes for bone marrow suppression Download PDFInfo
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- CA2371728C CA2371728C CA002371728A CA2371728A CA2371728C CA 2371728 C CA2371728 C CA 2371728C CA 002371728 A CA002371728 A CA 002371728A CA 2371728 A CA2371728 A CA 2371728A CA 2371728 C CA2371728 C CA 2371728C
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- bone
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- bone marrow
- cancer
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- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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| US60/139,065 | 1999-06-11 | ||
| US13906599P | 1999-07-11 | 1999-07-11 | |
| US14378099P | 1999-07-13 | 1999-07-13 | |
| US60/143,780 | 1999-07-13 | ||
| US14982199P | 1999-08-19 | 1999-08-19 | |
| US60/149,821 | 1999-08-19 | ||
| PCT/US2000/016052 WO2000076556A2 (en) | 1999-06-11 | 2000-06-12 | High dose radionuclide complexes for bone marrow suppression |
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| CA2371728A1 CA2371728A1 (en) | 2000-12-21 |
| CA2371728C true CA2371728C (en) | 2009-06-02 |
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| US (6) | US6767531B2 (OSRAM) |
| EP (1) | EP1191948A2 (OSRAM) |
| JP (1) | JP2003501488A (OSRAM) |
| AU (1) | AU5871000A (OSRAM) |
| CA (1) | CA2371728C (OSRAM) |
| WO (1) | WO2000076556A2 (OSRAM) |
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| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| WO2001091806A2 (en) * | 2000-05-31 | 2001-12-06 | Steven Mccullough | Measurement of the therapeutic dose for bone marrow ablation therapy |
| NO313180B1 (no) * | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Bensökende alfapartikkel emitterende radiofarmasöytika |
| JP2004536034A (ja) | 2001-01-08 | 2004-12-02 | ネオルクス コーポレイション | 治療的および診断的化合物、組成物および方法 |
| US7045116B2 (en) | 2001-12-13 | 2006-05-16 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
| CA2509328A1 (en) * | 2002-12-10 | 2004-06-24 | University Of Miami | Radioablation of hemolymphopoietic cell populations |
| US20070092440A1 (en) * | 2003-05-09 | 2007-04-26 | Edgar Braendle | Bone localising radiopharmaceutical and tubulin-interacting compound combinatorial |
| EP1475105A1 (en) * | 2003-05-09 | 2004-11-10 | Schering AG | Bone localising radiopharmaceutical and tubulin-interacting compound combinatorial radiotherapy |
| WO2007008232A2 (en) * | 2004-09-03 | 2007-01-18 | Board Of Regents, The University Of Texas System | Locoregional internal radionuclide ablation of abnormal tissues. |
| US8709380B1 (en) * | 2006-02-07 | 2014-04-29 | Sirius Medicine, Llc | Targeting agents for enhancing radiation therapy |
| US20090252675A1 (en) * | 2006-03-29 | 2009-10-08 | Frank R Keith | Radionuclide Therapy for Urinary Bladder Cancer |
| WO2008060663A2 (en) * | 2006-04-14 | 2008-05-22 | Thorenco, Llc | Compact neutron generator for medical and commercial isotope production, fission product purification and controlled gamma reactions for direct electric power generation |
| US8198264B2 (en) * | 2006-04-28 | 2012-06-12 | National Cancer Center | Method for treating head and neck cancer |
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| US9993437B2 (en) | 2007-12-06 | 2018-06-12 | The Regents Of The University Of California | Mesoporous silica nanoparticles for biomedical applications |
| US20100310465A1 (en) * | 2008-01-23 | 2010-12-09 | The Regents Of The University Of California | Nano-devices having releasable seals for controlled release of molecules |
| WO2010011927A1 (en) | 2008-07-25 | 2010-01-28 | Noventis, Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
| WO2010078569A2 (en) * | 2009-01-05 | 2010-07-08 | Stc.Unm | Porous nanoparticle supported lipid bilayer nanostructures |
| JP5542791B2 (ja) * | 2009-02-18 | 2014-07-09 | 久光製薬株式会社 | 経皮吸収製剤 |
| US20120207795A1 (en) * | 2010-07-13 | 2012-08-16 | The Regents Of The University Of California | Cationic polymer coated mesoporous silica nanoparticles and uses thereof |
| CN108420827A (zh) | 2010-07-22 | 2018-08-21 | 雷文制药有限公司 | 包含磁偶极子稳定化溶液的组合物及其用途 |
| JP2014512409A (ja) | 2011-04-28 | 2014-05-22 | エスティーシー． ユーエヌエム | 標的送達用の多孔性ナノ粒子に担持された脂質二重層（プロトセル）及びその使用方法 |
| US10220004B2 (en) | 2011-07-14 | 2019-03-05 | The Regents Of The University Of California | Method of controlled delivery using sub-micron-scale machines |
| SI3054996T1 (sl) * | 2013-10-07 | 2023-11-30 | Igl Pharma, Inc. | Postopek za pripravo terapevtskih sredstev za kosti visoke čistote |
| RU2599874C2 (ru) * | 2014-10-13 | 2016-10-20 | Михаил Сергеевич АНОСОВ | Способ лечения хронического одонтогенного остеомиелита у наркозависимых больных |
| US11369700B2 (en) | 2015-05-25 | 2022-06-28 | IGL Pharma Inc. | DOTMP kit formulations for radioisotopes |
| WO2016191413A1 (en) * | 2015-05-25 | 2016-12-01 | Iso Therapeutics Group, Llc | Dotmp kit formulations for radioisotopes |
| JP6831853B2 (ja) | 2015-12-07 | 2021-02-17 | ジェネラル オンコロジー，インコーポレイテッド | 患者における転移性癌の有効な治療のための組合せ |
| WO2017120504A1 (en) | 2016-01-08 | 2017-07-13 | Durfee Paul N | Osteotropic nanoparticles for prevention or treatment of bone metastases |
| US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
| JP7191938B2 (ja) | 2017-05-05 | 2022-12-19 | センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション | Ｉｇｆ－１ｒモノクローナル抗体及びその使用 |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| RU2019139432A (ru) | 2017-05-05 | 2021-06-07 | Сентр фор Проуб Девелопмент энд Коммерсиализэйшн | Фармакокинетическая оптимизация бифункциональных хелатов и их применение |
| CR20200291A (es) | 2017-12-07 | 2020-11-18 | Reven Ip Holdco Llc | Composiciones y métodos para el tratamiento de enfermedades metabólicas |
| WO2020068798A1 (en) | 2018-09-24 | 2020-04-02 | Guo Jimin | Living mammalian cells modified with functional modular nanoparticles |
| AU2019373133A1 (en) * | 2018-10-29 | 2021-06-17 | Molecular Stethoscope, Inc. | Characterization of bone marrow using cell-free messenger-RNA |
| US12208164B2 (en) | 2019-02-28 | 2025-01-28 | Unm Rainforest Innovations | Modular metal-organic polyhedra superassembly compositions |
| AR120059A1 (es) * | 2019-06-12 | 2022-02-02 | Reven Ip Holdco Llc | Métodos y composiciones para mejorar resultados de pacientes con cáncer |
| WO2021154746A1 (en) | 2020-01-28 | 2021-08-05 | Reflexion Medical, Inc. | Joint optimization of radionuclide and external beam radiotherapy |
Family Cites Families (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US410436A (en) * | 1889-09-03 | packham | ||
| US96393A (en) * | 1869-11-02 | Improved furniture-caster | ||
| US470753A (en) * | 1892-03-15 | William grunow | ||
| US587451A (en) * | 1897-08-03 | James douglas o neill | ||
| US158393A (en) * | 1875-01-05 | Improvement in grates | ||
| US589190A (en) * | 1897-08-31 | Apparatus for compressing air | ||
| US118508A (en) * | 1871-08-29 | Improvement in flour-bolts | ||
| US716818A (en) * | 1901-04-13 | 1902-12-23 | James A Ekin Criswell | Machine for making matches. |
| US937333A (en) * | 1909-06-26 | 1909-10-19 | William H Shugart | Rail-joint. |
| GB750155A (en) * | 1953-03-17 | 1956-06-13 | Nat Res Dev | Substituted alanines |
| US3032585A (en) * | 1954-12-03 | 1962-05-01 | Nat Res Dev | Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine |
| US3398097A (en) * | 1965-07-30 | 1968-08-20 | Progressive Products Co | Cleaning composition, and method of cleaning and sequestering metal ions |
| BE744394A (en) * | 1970-01-14 | 1970-07-14 | Elphiac Sa | Zone refining process |
| US3726912A (en) * | 1970-07-02 | 1973-04-10 | Dow Chemical Co | Substituted alkanolamine chelating agents |
| US3989730A (en) * | 1972-06-15 | 1976-11-02 | Research Corporation | Bone-seeking technetium-99m complex |
| US3852414A (en) * | 1972-09-13 | 1974-12-03 | New England Nuclear Corp | Bone seeking technetium 99m stannous phosphate complex |
| PH12898A (en) * | 1973-05-23 | 1979-10-04 | Procter & Gamble | A composition for the treatment of calcific tumors |
| US3965254A (en) * | 1973-05-23 | 1976-06-22 | The Procter & Gamble Company | Compositions for the treatment of calcific tumors |
| US3931396A (en) * | 1973-05-31 | 1976-01-06 | Commissariat A L'energie Atomique | Method of preparation of a composition having a base of 99m technetium for diagnosis by scintigraphy |
| US4058704A (en) * | 1974-12-27 | 1977-11-15 | Taeo Kim | Coilable and severable heating element |
| US4017596A (en) * | 1975-03-03 | 1977-04-12 | Research Corporation | Radiopharmaceutical chelates and method of external imaging |
| US3974268A (en) * | 1975-05-30 | 1976-08-10 | Research Corporation | Bone-seeking technetium-99m imidodiphosphonate complex |
| DE2543349C2 (de) | 1975-09-29 | 1984-05-10 | Henkel KGaA, 4000 Düsseldorf | Preaparate zur herstellung von99m technetium-radiagnostica |
| US4075314A (en) * | 1976-04-29 | 1978-02-21 | Mallinckrodt, Inc. | Stannous pyrophosphate technetium-99m compositions |
| CA1078731A (en) | 1976-12-16 | 1980-06-03 | Charles E. Frosst And Co. | Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid) |
| US4399817A (en) * | 1981-06-30 | 1983-08-23 | The Procter & Gamble Company | Boron containing polyphosphonates for the treatment of calcific tumors |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| US4508625A (en) * | 1982-10-18 | 1985-04-02 | Graham Marshall D | Magnetic separation using chelated magnetic ions |
| US4707353A (en) * | 1982-12-08 | 1987-11-17 | Mallinckrodt, Inc. | Radiographic imaging agents |
| DE3247054C1 (de) * | 1982-12-20 | 1984-05-10 | Goetze Ag, 5093 Burscheid | Spritzpulver fuer die Herstellung verschleissfester Beschichtungen |
| SE8301395L (sv) | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
| US4515767A (en) * | 1983-06-20 | 1985-05-07 | The Dow Chemical Company | Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine) |
| US4676950A (en) * | 1984-02-03 | 1987-06-30 | Foster Research Corporation | Indicator and test device for detecting occult blood |
| US4560548A (en) * | 1984-04-10 | 1985-12-24 | The Dow Chemical Company | Bone seeking Tc-99m complexes of phosphonate derivatives of bis(aminoalkyl)piperazine |
| US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
| US5059412A (en) | 1984-06-04 | 1991-10-22 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors |
| US5066478A (en) * | 1984-06-04 | 1991-11-19 | The Dow Chemical Company | Radio labeled organic amine phosphonic acid complexes for the treatment of calcific tumors |
| US4898724A (en) * | 1984-06-04 | 1990-02-06 | The Dow Chemical Company | Organis amine phosphonic acid complexes for the treatment of calcific tumors |
| IL74902A (en) | 1984-06-04 | 1990-12-23 | Dow Chemical Co | Organic amine phosphonic acid complexes with particle-emitting radionuclides for the treatment of calcific tumors |
| US4606907A (en) * | 1984-07-02 | 1986-08-19 | The Dow Chemical Company | Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines |
| US4897254A (en) * | 1984-09-21 | 1990-01-30 | The Dow Chemical Company | Radioactive compositions for the treatment of calcific tumors |
| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| US4678687A (en) * | 1984-10-31 | 1987-07-07 | Xerox Corporation | Thermal transfer printing sheets containing certain coating compositions thereof |
| US5556982A (en) * | 1985-01-14 | 1996-09-17 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5393512A (en) * | 1985-01-14 | 1995-02-28 | Vanderheyden; Jean-Luc | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| US5288497A (en) * | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
| US4752464A (en) * | 1985-06-07 | 1988-06-21 | Cadema Medical Products, Inc. | Treatment of arthritis, including rheumatoid arthritis, with radioactive isotopes |
| US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
| GB8518300D0 (en) | 1985-07-19 | 1985-08-29 | Amersham Int Plc | Contrast agent |
| EP0232751B1 (en) | 1986-01-23 | 1991-09-11 | E.R. Squibb & Sons, Inc. | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| DE3625417C2 (de) | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
| AU608759B2 (en) | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| FR2614020B1 (fr) | 1987-04-14 | 1989-07-28 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands. |
| US4853209A (en) * | 1987-05-18 | 1989-08-01 | The Dow Chemical Company | Bone marrow suppressing agents |
| US5089249A (en) * | 1988-06-10 | 1992-02-18 | Neorx Corporation | Conjugates for bone imaging and bone cancer therapy |
| US5202109A (en) * | 1988-06-10 | 1993-04-13 | Neorx Corporation | Conjugates for bone imaging and bone cancer therapy |
| US4882142A (en) * | 1988-12-19 | 1989-11-21 | The Dow Chemical Company | Bone marrow suppressing agents |
| US4976950A (en) | 1988-12-19 | 1990-12-11 | The Dow Chemical Company | Bone marrow suppressing agents |
| US4937333A (en) | 1989-08-04 | 1990-06-26 | The Dow Chemical Company | Method for purifying aminomethylenephosphonic acids for pharmaceutical use |
| GB8903023D0 (en) | 1989-02-10 | 1989-03-30 | Parker David | Chemical compounds |
| US5714467A (en) * | 1989-04-12 | 1998-02-03 | The Rockefeller University | Antibacterial and antimalarial hybrid peptides |
| GB9002375D0 (en) * | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
| US5064433A (en) * | 1990-03-05 | 1991-11-12 | Helix Medical, Inc. | Voice prosthesis insertion assemblies |
| AU654951B2 (en) | 1990-04-18 | 1994-12-01 | Celltech Limited | Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging |
| WO1991016075A1 (en) * | 1990-04-20 | 1991-10-31 | Australian Nuclear Science & Technology Organisation | Bone marrow treatments |
| DK0535060T3 (da) * | 1990-06-15 | 1995-07-17 | Hoechst Schering Agrevo Gmbh | Antifungisk polypeptid samt fremgangsmåde til dets fremstilling |
| MC2260A1 (fr) * | 1990-06-18 | 1993-04-26 | Dow Chemical Co | Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation |
| US5219556A (en) * | 1990-07-09 | 1993-06-15 | Mallinckrodt Medical, Inc. | Stabilized therapeutic radiopharmaceutical complexes |
| RU2051919C1 (ru) * | 1990-08-20 | 1996-01-10 | Сантори Лимитед | Соединения пенема и фармацевтическая композиция на их основе |
| US5286497A (en) * | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
| US5503840A (en) | 1991-08-09 | 1996-04-02 | E. I. Du Pont De Nemours And Company | Antimicrobial compositions, process for preparing the same and use |
| US5861430A (en) * | 1991-12-17 | 1999-01-19 | Jasmine Fockerman | Benzopyran phenol derivates for use as antibacterial, antiviral or immunostimulating agents |
| US5919925A (en) * | 1992-01-22 | 1999-07-06 | Pfizer Inc. | 2-isocephem and oxacephem derivatives and use as antibacterial agents |
| CA2134239C (en) | 1992-06-09 | 2004-11-23 | Donald B. Axworthy | Pretargeting methods and compounds |
| CA2086874E (en) * | 1992-08-03 | 2000-01-04 | Renzo Mauro Canetta | Methods for administration of taxol |
| NZ257765A (en) * | 1992-10-28 | 1996-09-25 | Den Mat Corp | Antibacterial mouthwash/oral hygiene composition |
| US5714604A (en) | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| DK0715495T3 (da) * | 1993-08-24 | 1998-09-28 | Janssen Pharmaceutica Nv | Antibakterielle og antiforurenende oxatiaziner og deres oxider |
| US5587451A (en) | 1993-11-26 | 1996-12-24 | The Dow Chemical Company | Process for preparing polyazamacrocycles |
| FR2719481B1 (fr) * | 1994-05-05 | 1996-05-31 | Oreal | Composition à base de composés antifongiques et de composés antibactériens halogènes pour diminuer la chute des cheveux. |
| EP0787720B1 (en) * | 1994-10-20 | 2003-07-16 | Wakunaga Seiyaku Kabushiki Kaisha | Pyridonecarboxylate derivative or salt thereof and antibacterial containing the same as active ingredient |
| BR9506473A (pt) * | 1994-11-08 | 1997-10-07 | Glaxo Wellcome Sa | Composto processo para a preparação de compostos utilização de um composto composição farmacêutica e processo para o tratamento de infecções anti-fúngicas |
| JPH09512831A (ja) * | 1994-11-17 | 1997-12-22 | エフ・ホフマン−ラ ロシュ アーゲー | ジベンズイミダゾール誘導体 |
| CA2206315A1 (en) * | 1994-11-29 | 1996-06-06 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof |
| US5773421A (en) * | 1995-01-10 | 1998-06-30 | Abbott Laboratories | Antifungal fusacandins |
| DE69615535T2 (de) * | 1995-01-26 | 2002-05-02 | Merck & Co., Inc. | Neue fungizide cyclohexapeptide |
| US5849956A (en) * | 1995-02-08 | 1998-12-15 | Plant Biological Defense System Laboratories | Antifungal terpene compounds and process for producing the same |
| JP3081773B2 (ja) * | 1995-03-31 | 2000-08-28 | 株式会社資生堂 | Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤 |
| US5786325A (en) * | 1995-05-26 | 1998-07-28 | Eli Lilly And Company | Cyclic peptide antifungal agents and methods of making and using |
| AU6788996A (en) * | 1995-08-02 | 1997-02-26 | J. Uriach & Cia S.A. | New carboxamides with antifungal activity |
| EP0783501B9 (en) * | 1995-08-02 | 2001-07-25 | J. URIACH & CIA. S.A. | pyrimidone derivatives with antifungal activity |
| US5681430A (en) * | 1995-08-23 | 1997-10-28 | Thermo Fibertek Inc. | Activity induction in papermaking |
| US5872249A (en) * | 1995-09-01 | 1999-02-16 | Korea Institute Of Science And Technology | 3-ammoniopropenyl cephalosporin compounds as antibacterial agents and process for preparing the same |
| EP0881878A4 (en) * | 1995-09-15 | 2004-08-04 | Anadys Pharmaceuticals Inc | ARYLHYDRAZONE DERIVATIVES AS AN ANTIBACTERIAL AGENT |
| DK0863890T3 (da) * | 1995-09-15 | 2003-03-24 | Upjohn Co | 5-amidomethyl alfa, beta-mættede og -umættede 3-aryl-butyrolacetone antibakterielle midler |
| US5837726A (en) * | 1995-11-01 | 1998-11-17 | Millennium Pharmaceuticals, Inc. | Antifungal agents derived from aspergillus fumigatus |
| DE69632996T2 (de) * | 1995-12-26 | 2005-07-21 | Toyo Boseki K.K. | In organischen Lösungsmitteln lösliche Mucopolysaccharide, antibakterielles antithrombogenes Mittel und medizinisches Material |
| US5756472A (en) * | 1996-01-31 | 1998-05-26 | Merck & Co., Inc. | Antifungal agent obtained from hormonema |
| JP4058129B2 (ja) * | 1996-03-18 | 2008-03-05 | 株式会社資生堂 | ピリジン誘導体及び抗潰瘍剤、抗菌剤 |
| US5770617A (en) * | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
| US5773696A (en) * | 1996-03-29 | 1998-06-30 | Monsanto Company | Antifungal polypeptide and methods for controlling plant pathogenic fungi |
| JP3693449B2 (ja) * | 1996-04-05 | 2005-09-07 | 三菱製紙株式会社 | 抗菌防黴剤およびそれを含有する繊維状物質 |
| JP4150435B2 (ja) * | 1996-04-18 | 2008-09-17 | 株式会社資生堂 | アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤 |
| US5756725A (en) * | 1996-04-24 | 1998-05-26 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US5917084A (en) * | 1996-07-03 | 1999-06-29 | Millennium Pharmaceuticals, Inc. | Antifungal agents |
| GB2315489A (en) * | 1996-07-17 | 1998-02-04 | Merck & Co Inc | Antifungal agent |
| US5837253A (en) * | 1996-07-26 | 1998-11-17 | Agrogene Ltd. | Preparation and use of Inula extracts as a fungicide for the control of plant diseases |
| US5908862A (en) * | 1996-07-31 | 1999-06-01 | Abbot Laboratories | Water-miscible esters of mono--and diglycerides having antibacterial activity and their use in inhibiting infection |
| UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| US5830855A (en) * | 1996-09-12 | 1998-11-03 | Utah State University | Lipodepsipeptides as antifungal and fungicidal agents |
| US5876738A (en) * | 1996-10-29 | 1999-03-02 | Toagosei Co., Ltd. | Antifungal phyllosilicate |
| US6005083A (en) * | 1997-03-28 | 1999-12-21 | Neorx Corporation | Bridged aromatic substituted amine ligands with donor atoms |
| JP4090087B2 (ja) * | 1997-04-04 | 2008-05-28 | 株式会社資生堂 | ベンズアミド誘導体及び抗潰瘍剤、抗菌剤 |
| US5863773A (en) * | 1997-09-30 | 1999-01-26 | Abbott Laboratories | Antifungal corynecandin |
| DE19911329A1 (de) * | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
| CA2371728C (en) | 1999-06-11 | 2009-06-02 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
| US7094885B2 (en) | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| WO2001091806A2 (en) | 2000-05-31 | 2001-12-06 | Steven Mccullough | Measurement of the therapeutic dose for bone marrow ablation therapy |
| JP2004536034A (ja) | 2001-01-08 | 2004-12-02 | ネオルクス コーポレイション | 治療的および診断的化合物、組成物および方法 |
| US7045116B2 (en) * | 2001-12-13 | 2006-05-16 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
-
2000
- 2000-06-12 CA CA002371728A patent/CA2371728C/en not_active Expired - Fee Related
- 2000-06-12 AU AU58710/00A patent/AU5871000A/en not_active Abandoned
- 2000-06-12 JP JP2001502887A patent/JP2003501488A/ja active Pending
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- 2000-06-12 EP EP00944644A patent/EP1191948A2/en not_active Withdrawn
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2004
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| US20050063905A1 (en) | 2005-03-24 |
| CA2371728A1 (en) | 2000-12-21 |
| US7696331B2 (en) | 2010-04-13 |
| JP2003501488A (ja) | 2003-01-14 |
| WO2000076556A2 (en) | 2000-12-21 |
| US20050129667A1 (en) | 2005-06-16 |
| WO2000076556A9 (en) | 2001-11-08 |
| WO2000076556A3 (en) | 2001-10-11 |
| US7408046B2 (en) | 2008-08-05 |
| US20020176818A1 (en) | 2002-11-28 |
| US7097823B2 (en) | 2006-08-29 |
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