CA2356841A1 - Composes alicycliques substitues a base d'azote et de soufre et methodes de synthese desdits composes - Google Patents

Composes alicycliques substitues a base d'azote et de soufre et methodes de synthese desdits composes Download PDF

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Publication number
CA2356841A1
CA2356841A1 CA002356841A CA2356841A CA2356841A1 CA 2356841 A1 CA2356841 A1 CA 2356841A1 CA 002356841 A CA002356841 A CA 002356841A CA 2356841 A CA2356841 A CA 2356841A CA 2356841 A1 CA2356841 A1 CA 2356841A1
Authority
CA
Canada
Prior art keywords
optionally substituted
substituted
compound
alkyl
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002356841A
Other languages
English (en)
Inventor
Arindam Talukdar
Mukund Keshao Gurjar
Mukund Shankar Chorghade
Batchu Venkateswara Rao
Kashinath Sadalapure
Radha Palakodety Krishna
Sista Venkata Sai Lalitha
Susanta Sekhar Adhikari
Andappan Murugaiah Subbaiah Murugaiah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2356841A1 publication Critical patent/CA2356841A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

L'invention concerne de nouvelles méthodes de préparation de différents composés qui comprennent des groupes alicycliques ayant l'azote et le soufre comme éléments du noyau. Ces composés comprennent des tétrahydrothiophènes 2,5-disubstituées, des pyrrolidines 2,5-disubstituées, des thianes 2,6-disubstituées, des hexahydropyridines 2,6-disubstituées, des thiépanes 2,7-disubstituées, des hexahydroazépines 2,7-disubstituées, des thiocanes 2,8-disubstituées et des octahydroazocines 2,8-disubstituées. L'invention concerne également de nouveaux composés, des compositions pharmaceutiques ainsi que des méthodes thérapeutiques qui comprennent ces composés et compositions.
CA002356841A 1998-07-03 1999-07-02 Composes alicycliques substitues a base d'azote et de soufre et methodes de synthese desdits composes Abandoned CA2356841A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9171098P 1998-07-03 1998-07-03
US60/091,710 1998-07-03
PCT/US1999/015050 WO2000001670A1 (fr) 1998-07-03 1999-07-02 Composes alicycliques substitues a base d'azote et de soufre et methodes de synthese desdits composes

Publications (1)

Publication Number Publication Date
CA2356841A1 true CA2356841A1 (fr) 2000-01-13

Family

ID=22229271

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002356841A Abandoned CA2356841A1 (fr) 1998-07-03 1999-07-02 Composes alicycliques substitues a base d'azote et de soufre et methodes de synthese desdits composes

Country Status (6)

Country Link
EP (1) EP1115702A4 (fr)
JP (1) JP2002519410A (fr)
AU (1) AU4856199A (fr)
CA (1) CA2356841A1 (fr)
MX (1) MXPA01000233A (fr)
WO (1) WO2000001670A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7038073B2 (en) 2002-05-15 2006-05-02 Genzyme Corporation Synthesis of 2-alkyl amino acids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543531A (en) * 1987-06-16 1996-08-06 Sandoz Ltd. Thiophen compounds and their preparation
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
PT650485E (pt) * 1992-07-13 2001-03-30 Millennium Pharm Inc 2,5-diaril-tetra-hidro-tiofenos -furanos e analogos para o tratamento de desordens inflamatorias e imunitarias
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
JP3777408B2 (ja) * 1994-12-28 2006-05-24 株式会社カネカ カルボン酸誘導体の製造法

Also Published As

Publication number Publication date
EP1115702A4 (fr) 2002-04-17
AU4856199A (en) 2000-01-24
WO2000001670A1 (fr) 2000-01-13
EP1115702A1 (fr) 2001-07-18
MXPA01000233A (es) 2003-02-10
JP2002519410A (ja) 2002-07-02

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