CA2354599C - Binding molecules for human factor viii and factor viii-like proteins - Google Patents

Binding molecules for human factor viii and factor viii-like proteins Download PDF

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Publication number
CA2354599C
CA2354599C CA2354599A CA2354599A CA2354599C CA 2354599 C CA2354599 C CA 2354599C CA 2354599 A CA2354599 A CA 2354599A CA 2354599 A CA2354599 A CA 2354599A CA 2354599 C CA2354599 C CA 2354599C
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CA
Canada
Prior art keywords
cys
phe
pro
trp
ser
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2354599A
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English (en)
French (fr)
Other versions
CA2354599A1 (en
Inventor
Jinan Yu
M. Daniel Potter
Brian D. Kelley
Jeffrey S. Deetz
James E. Booth
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Dyax Corp
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Publication of CA2354599A1 publication Critical patent/CA2354599A1/en
Application granted granted Critical
Publication of CA2354599C publication Critical patent/CA2354599C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Reciprocating Pumps (AREA)
CA2354599A 1999-01-04 2000-01-03 Binding molecules for human factor viii and factor viii-like proteins Expired - Lifetime CA2354599C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/224,785 1999-01-04
US09/224,785 US6197526B1 (en) 1999-01-04 1999-01-04 Polypeptides for binding human factor VIII and fragments of human factor VIII
PCT/US2000/000043 WO2000040602A1 (en) 1999-01-04 2000-01-03 Binding molecules for human factor viii and factor viii-like proteins

Publications (2)

Publication Number Publication Date
CA2354599A1 CA2354599A1 (en) 2000-07-13
CA2354599C true CA2354599C (en) 2013-03-12

Family

ID=22842198

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2354599A Expired - Lifetime CA2354599C (en) 1999-01-04 2000-01-03 Binding molecules for human factor viii and factor viii-like proteins

Country Status (12)

Country Link
US (2) US6197526B1 (https=)
EP (5) EP2090582B1 (https=)
JP (3) JP4733272B2 (https=)
AT (1) ATE433992T1 (https=)
AU (3) AU769745B2 (https=)
CA (1) CA2354599C (https=)
DE (1) DE60042430D1 (https=)
DK (4) DK2090582T3 (https=)
ES (4) ES2390360T3 (https=)
HK (1) HK1038756A1 (https=)
PT (3) PT2298791E (https=)
WO (1) WO2000040602A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820796B2 (en) * 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
FR2830865B1 (fr) * 2001-10-17 2004-10-22 Centre Nat Rech Scient Leurres peptidiques pour la preparation de medicaments destines a la prevention ou au traitement des pathologies auto-immunes, ou des troubles lies a l'apparition d'anticorps diriges contre des proteines exogenes
US20030149246A1 (en) * 2002-02-01 2003-08-07 Russell John C. Macromolecular conjugates and processes for preparing the same
US20050170446A1 (en) * 2002-04-29 2005-08-04 Niklas Ahlborg Sandwich assay and kit
CN101379077A (zh) * 2005-12-07 2009-03-04 夏洛特·豪泽 因子ⅷ和因子ⅷ-类似蛋白的小肽或者拟肽亲合性配体
TW200745163A (en) * 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
AU2008236694B2 (en) 2007-04-04 2014-01-23 The Regents Of The University Of California Compositions, devices, systems, and methods for using a nanopore
MX2010001363A (es) 2007-08-09 2010-03-09 Syntonix Pharmaceuticals Inc Peptidos inmunomoduladores.
TWI573806B (zh) 2008-04-17 2017-03-11 巴克斯歐塔公司 生物活性胜肽
WO2010014909A1 (en) * 2008-08-01 2010-02-04 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
CA2838833A1 (en) * 2011-06-10 2012-12-13 Biogen Idec Ma Inc. Pro-coagulant compounds and methods of use thereof
AU2014348683B2 (en) 2013-11-18 2020-11-05 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
CN116731197A (zh) 2016-09-19 2023-09-12 豪夫迈·罗氏有限公司 基于补体因子的亲和层析
KR102929672B1 (ko) 2017-08-04 2026-02-25 다케다 야쿠힌 고교 가부시키가이샤 수지 비드 세척 장치

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
SE8501050D0 (sv) 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
ATE72838T1 (de) 1985-04-12 1992-03-15 Genetics Inst Neue prokoagulierungsproteine.
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0436597B1 (en) * 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5661008A (en) 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
SE468050C (sv) * 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
AU1757592A (en) * 1991-03-27 1992-11-02 Scripps Research Institute, The Therapeutic fragments of von willebrand factor
IL126044A (en) * 1996-03-20 2006-08-01 Dyax Corp Engineering affinity ligands for macromolecules
US5817752A (en) 1996-06-06 1998-10-06 La Jolla Pharmaceutical Company Cyclic polypeptides comprising a thioether linkage and methods for their preparation
KR20000016414A (ko) 1996-06-06 2000-03-25 와이즈먼 앤드루 Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법
PT1095143E (pt) * 1998-05-08 2008-11-28 Sanquin Bloedvoorziening Inibidor para o diagnóstico e tratamento de doentes com hemofilia a
US5994310A (en) 1998-09-03 1999-11-30 Bayer Corporation Peptide ligands for affinity purification of human Factor VIII
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII

Also Published As

Publication number Publication date
ES2524965T3 (es) 2014-12-16
DK2298791T3 (en) 2014-12-08
JP2010254694A (ja) 2010-11-11
JP4733272B2 (ja) 2011-07-27
HK1038756A1 (zh) 2002-03-28
ES2328722T3 (es) 2009-11-17
EP2298791B8 (en) 2014-12-24
ES2390360T3 (es) 2012-11-12
PT2301953E (pt) 2014-09-15
EP2301953B1 (en) 2014-07-30
DE60042430D1 (de) 2009-07-30
EP2090582B1 (en) 2012-09-19
EP2298791B1 (en) 2014-11-12
EP2301953A1 (en) 2011-03-30
ATE433992T1 (de) 2009-07-15
HK1155756A1 (en) 2012-05-25
JP2013079272A (ja) 2013-05-02
PT2298791E (pt) 2014-12-16
EP1705183A1 (en) 2006-09-27
EP2090582A2 (en) 2009-08-19
ES2499040T3 (es) 2014-09-26
US20010014456A1 (en) 2001-08-16
WO2000040602A1 (en) 2000-07-13
DK1705183T3 (da) 2009-10-19
AU2598200A (en) 2000-07-24
US6197526B1 (en) 2001-03-06
EP2090582A3 (en) 2009-11-11
AU2004201810A1 (en) 2004-05-27
HK1131398A1 (en) 2010-01-22
JP2002536297A (ja) 2002-10-29
AU2004201830A1 (en) 2004-05-27
PT1705183E (pt) 2009-07-31
EP2298791A1 (en) 2011-03-23
DK2301953T3 (da) 2014-09-22
CA2354599A1 (en) 2000-07-13
EP1705183B1 (en) 2009-06-17
AU769745B2 (en) 2004-02-05
JP5572207B2 (ja) 2014-08-13
EP1147128A1 (en) 2001-10-24
US6492105B2 (en) 2002-12-10
AU2004201830B2 (en) 2007-04-05
EP1147128A4 (en) 2004-10-13
JP5368371B2 (ja) 2013-12-18
HK1155182A1 (en) 2012-05-11
DK2090582T3 (da) 2012-10-15

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Effective date: 20200103